Potent induction of human colon cancer cell uptake of chemotherapeutic drugs by N-myristoylated protein kinase C-α (PKC-α) pseudosubstrate peptides through a P-glycoprotein-independent mechanism

Investigational New Drugs

Volumn 15, Issue 4, 1997, Pages 311-318

  Bergman, Philip J ^a   Gravitt, Karen R ^a   Ward, Nancy E ^a   Beltran, Pedro ^a   Gupta, Krishna P ^b   O'Brian, Catherine A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Human colon cancer; Intrinsic drug resistance; MDR reversal; Multidrug resistance (MDR); N myristoylated pseudosubstrate peptides; Protein kinase C (PKC)

Indexed keywords

ANTIINFECTIVE AGENT; CYTOTOXIC AGENT; DOXORUBICIN; FLUOROURACIL; GLYCOPROTEIN P; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; RADIOPHARMACEUTICAL AGENT; VINCRISTINE;

ARTICLE; CANCER CELL; DRUG UPTAKE; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, NORTHERN; BLOTTING, WESTERN; COLONIC NEOPLASMS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; FLUOROURACIL; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; P-GLYCOPROTEIN; PROTEINS; RATS; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 0031424711     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005933401603     Document Type: Article

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