Characterization of gpt deletion mutations in transgenic Chinese hamster cell lines

Environmental and Molecular Mutagenesis

Volumn 30, Issue 4, 1997, Pages 418-428

  Klein, Catherine B ^a   Su, Lin ^a   Singh, Jatinder ^a   Snow, Elizabeth T ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Clastogens; Deletion; gpt; V79 Chinese hamster cells

Indexed keywords

ANIMAL CELL; ARTICLE; CHO CELL; CHROMATIN STRUCTURE; DNA SEQUENCE; GENE DELETION; GENE MUTATION; NONHUMAN;

ALANINE TRANSAMINASE; ANIMALS; BASE SEQUENCE; BLOTTING, SOUTHERN; CELL LINE; CRICETINAE; CRICETULUS; GENE DELETION; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TRANSGENES;

ANIMALIA; BACTERIA (MICROORGANISMS); CRICETINAE; CRICETULUS GRISEUS;

EID: 0031424459     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1997)30:4<418::AID-EM7>3.0.CO;2-E     Document Type: Article

References (91)

1. Aghamohammadi SZ, Morris T, Stevans DL, Thacker J (1992): Rapid screening for deletion mutations in the hprt gene using the polymerase chain reaction: X-ray and α-particle spectra. Mutat Res 269:1-7.
2. Al-Shawi R, Kinnaird J, Burke J, Bishop JO (1990): Expression of a foreign gene in a line of transgenic mice is modulated by a chromosomal position effect. Mol Cell Biol 10:1192-1198.
3. An J, Hsie AW (1993): Polymerase chain reaction-based deletion screening of bleomycin induced 6-thioguanine resistant mutants in Chinese hamster ovary cells: The effects of an inhibitor and a mimic of superoxide dismutase. Mutat Res 289:215-222.
4. Ashman CR, Davidson RL (1987): Sequence analysis of spontaneous mutations in a shuttle vector gene integrated into mammalian chromosomal DNA. Proc Natl Acad Sci USA 84:3354-3358.
5. Backer LC, Allen JW, Harrington-Brock K, Campbell JA, DeMarini DM, Doerr CL, Howard DR, Kligerman AD, Moore MM (1990): Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro. Mutagenesis 5:541-547.
6. Bardwell L (1989): The mutagenic and carcinogenic effects of gene transfer. Mutagenesis 4:245-253.
7. Conn KH, Ornstein DL, Wang F, LaPaix FD, Phipps K, Edelsberg C, Zuna R, Mott LA, Dunn JL (1997): The significance of allelic deletions and aneuploidy in colorectal carcinoma. Results of a 5-year follow-up study. Cancer 79:233-244.
8. Debenham PG, Webb MBT, Atretch A, Thacker J (1988): Examination of vectors with two dominant, selectable genes for DNA repair and mutation studies in mammalian cells. Mutat Res 199:145-158.
9. DeMarini DM, Lawrence BK (1992): Prophage induction by topoisomerase II poisons and reactive-oxygen species: Role of DNA breaks. Mutat Res 267:1-17.
10. DeMarini DM, Doerr CL, Meyer MK, Brock KH, Hozier J, Moore M (1987): Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic mechanism: Possible role of topoisomerase. Mutagenesis 2:349-355.
11. DeMarini DM, Brockman HE, de Serres FJ, Evans HH, Stankowski LF Jr, Hsie AW (1989): Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: A perspective. Mutat Res 220:11-29.
12. Doerr CL, Harrington-Brock K, Moore MM (1989): Micronucleus, chromosome aberration, and small-colony TK mutant analysis to quantitate chromosomal damage in L5178Y mouse lymphoma cells. Mutat Res 222:191-302.
13. DuBridge RB, Calos MP (1988): Recombinant shuttle vectors for the study of mutation in mammalian cells. Mutagenesis 3:1-9.
14. Evans HH, Mencl J, Horng M-F (1987): Poor recovery of mutants harboring multilocus lesions in hemizygous chromosomal regions. In Moore MM, DeMarini DM, de Serres FJ, Tindall KR (eds): "Mammalian Cell Mutagenesis (Banbury Report 28)." New York: Cold Spring Harbor Laboratory, pp 81-92.
15. Fantes JA, Bickmore WA, Fletcher JM, Ballesta F, Hanson IM, van Heyningen V (1992): Submicroscopic deletions at the WAGR locus, revealed by nonradioactive in situ hybridization. Am J Hum Genet 51:1286-1294.
16. Feinberg AP (1996): Multiple genetic abnormalities of 11p15 in Wilms' tumor (Review). Med Pediatr Oncol 27:484-489.
17. Fuscoe JC, Zimmerman LJ, Fekete A, Setzer RW, Rossiter BJ (1992): Analysis of X-ray-induced HPRT mutations in CHO cells: Insertions and deletions. Mutat Res 269:171-183.
18. Ganesh A, North P, Thacker J (1993): Repair and misrepair of site-specific DNA double-strand breaks by human cell extracts. Mutat Res 299:251-259.
19. Gebara MM, Drevon C, Harcourt SA, Steingrimsdottir H, James MR, Burke JF, Arlett CF, Lehmann AR (1987): Inactivation of a transfected gene in human fibroblasts can occur by deletion, amplification, phenotypic switching, or methylation. Mol Cell Biol 7:1459-1464.
20. Gibbs RA, Nguyen PN, Edwards A, Civitello AB, Caskey CT (1990): Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyl-transferase gene in Lesch-Nyhan families. Genomics 7:235-244.
21. Gitschier J (1988): Maternal duplication associated with gene deletion in sporadic hemophilia. Am J Hum Genet 43:274-279.
22. Giver CR, Nelson SJ Jr, Cha MY, Pongsaensook P, Grosovsky AJ (1995): Mutational spectrum of X-ray induced TK-human cell mutants. Carcinogenesis 16:267-275.
23. Gonchorova EI, Rossman TG (1994): A role for metallothionein and zinc in spontaneous mutagenesis. Cancer Res 54:5318-5323.
24. Gonchorova EI, Rossman TG (1995): The antimutagenic effects of metallothionein may involve free radical scavenging. In Sarkar B (ed) "Genetic Response to Metals." New York: Marcel Dekker, pp 87-100.
25. Goodhead DT, Thacker J, Cox R (1993): Weiss lecture. Effects of radiations of different qualities on cells: Molecular mechanisms of damage and repair. Int J Radiat Biol 63:543-556.
26. Han YH, Austin MJ, Pommier Y, Povirk LF (1993): Small deletion and insertion mutations induced by the topoisomerase II inhibitor teniposide in CHO cells and comparison with sites of drug-stimulated DNA cleavage in vitro. J Mol Biol 229:52-66.
27. Hart DW, Tindall KR (1997): Identification of repeat sequences within the gpt integration site in AS52 cells. Environ Mol Mutagen 29(Suppl. 28):19.
28. Hsie AW, Porter RC, Xu Z, Yu Y, Sun J, Meltz ML, Schwartz JL (1996): Molecular markers of ionizing radiation-induced gene mutations in mammalian cells. Environ Health Perspect 104:675-678.
29. Hu LJ, Laporte J, Kress W, Kioschis P, Siebenhaar R, Poustka A, Fardeau M, Metzenberg A, Janssen EA, Thomas N, Mandel JL, Dahl N (1996): Deletions in Xq28 in two boys with myotubular myopathy and abnormal genital development define a new contiguous gene syndrome in a 430 kb region. Hum Mol Genet 5:139-143.
30. Hunter DJ, Gurney EG (1994): The genomic instability associated with integrated simain virus 40 DNA is dependent on the origin of replication and early control region. J Virol 68:787-796.
31. Kargacin B, Klein CB, Costa M (1993): Mutagenic responses of nickel oxides and nickel sulfides in Chinese hamster V79 cell lines at the xanthine-guanine phosphoribosyl transferase locus. Mutat Res 300:63-72.
32. Kato S, Anderson RA, Camerini-Otero RD (1986): Foreign DNA introduced by calcium phosphate is integrated into repetitive DNA elements of the mouse L cell genome. Mol Cell Biol 6:1787-1795.
33. Kendal WS, Frost P (1988): Pitfalls and practice of Luria-Delbrück fluctuation analysis: A review. Cancer Res 48:1060-1065.
34. Kimura H, Iyehara-Ogawa H, Kato T (1994): Slippage-realignment: To what extent does it contribute to mammalian cell mutagenesis? Mutagenesis 9:395-400.
35. Kinzler KW, Vogelstein B (1996): Lessons from hereditary colorectal cancer. Cell 87:159-170.
36. Klein CB, Rossman TG (1990): Transgenic Chinese hamster V79 cell lines which exhibit variable levels of gpt mutagenesis. Environ Mol Mutagen 16:1-12.
37. Klein CB, Snow ET (1993): Localization of the gpt sequence in transgenic G12 cells by fluorescent in situ hybridization. Environ Mol Mutagen 21(Suppl. 22):35.
38. Klein CB, Conway K, Wang XW, Bhamra RK, Lin XH, Cohen MD, Annab L, Barrett JC, Costa M (1991): Senescence of nickel-transformed cells by an X chromosome: Possible epigenetic control. Science 251:796-799.
39. + Chinese hamster cell lines. Environ Mol Mutagen 19(Suppl. 20):29.
40. + V79 cell lines differ in their mutagenic response to clastogens. Mutat Res 304:217-228.
41. Klein CB, Su L, Kargacin BK, Cosentino S, Snow ET, Costa M (1994b): Metal mutagenesis in transgenic Chinese hamster cell lines. Environ Health Perspect 102:63-67.
42. Kronenberg A, Gauny S, Criddle K, Vannais D, Ueno A, Kraemer S, Waldren CA (1995): Heavy ion mutagenesis: Linear energy transfer effects and genetic disease. Radiat Environ Biophys 34:73-78.
43. Lee YW (1995): Molecular mechanisms of 6-thioguanine resistance induced by carcinogenic nickel compounds in transgenic G12 Chinese hamster cells: Relevance to the role of epigenetic mechanisms in nickel carcinogenesis. PhD Thesis, New York University.
44. Lee YW, Pons C, Tummolo DM, Klein CB, Rossman TG, Christie NT (1993): Mutagenicity of soluble and insoluble nickel compounds at the gpt locus in G12 Chinese hamster cells. Environ Mol Mutagen 21:365-371.
45. Lee YW, Klein CB, Kargacin B, Salnikow K, Kitahara J, Dowjat K, Zhitkovitch A, Christie NT, Costa M (1995): Carcinogenic nickel silences gene expression by chromatin condensation and DNA hypermethylation: A new model for epigenetic carcinogens. Mol Cell Biol 15:2547-2557.
46. Lehmann AR, Arlett CF, Harcourt SA, Steingrimsdottir H, Gebara MM (1989): Mutagenic treatments results in inactivation of expression of a transfected bacterial gene integrated into a human cell line. Mutat Res 220:255-262.
47. Liber HL, Call KM, Little JB (1987): Molecular and biochemical analysis of spontaneous and X-ray-induced mutants in human lymphoblastoid cells. Mutat Res 178:143-153.
48. Lichtenauer-Kaligis EGR, Thijssen JCP, den Dulk H, van de Putte P, Tasseron-de Jong J, Giphart-Gassler M (1993): Genome-wide spontaneous mutation in human cells determined by the spectrum of mutations in hprt cDNA. Mutagenesis 8:207-220.
49. Lichtenauer-Kaligis EG, Thijssen J, den Dulk H, van de Putte P, Tasseron-de Jong JG, Giphart-Gassler M (1996): Comparison of spontaneous hprt mutation spectra at the nucleotide sequence level in the endogenous hprt gene and five other genomic positions. Mutat Res 351:147-155.
50. Martus HJ, Dolle ME, Gossen JA, Boerrigter ME, Vijg J (1995): Use of transgenic mouse models for studying somatic mutations of aging. Mutat Res 338:203-213.
51. McCabe RB, Towbin JA, van der Engh G, Trask BJ (1992): Xp21 contiguous gene syndromes: Deletion quantitation with bivariate flow karyotyping allows mapping of patient breakpoints. Am J Hum Genet 51:1277-1285.
52. Meisler MH (1992): Insertional mutation of 'classical' and novel genes in transgenic mice. Trends Genet 8:341-344.
53. Merrihew RV, Marburger MK, Pennington SL, Roth DB, Wilson JH (1996): High-frequency illegitimate integration of transfected DNA at preintegrated target sites in a mammalian genome. Mol Cell Biol 16:10-18.
54. Meuth M (1990): The structure of mutations in mammalian cells. Biochim Biophys Acta 1032:1-17.
55. Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, Nakatsuru S, Aoki T, Miki Y, Mori T, Nakamura Y (1992): Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene. Hum Mol Genet 1:229-233.
56. Monnat RJ, Hackmann AFM, Chiaverotti TA (1992): Nucleotide sequence analysis of human hypoxanthine phosphoribosyltransferase (HPRT) gene deletions. Genomics 13:777-787.
57. Morgan TL, Fleck EW, Poston KA, Denovan BA, Newman CN, Rossitier BJF, Miller JH (1990): Molecular characterization of X-ray induced mutants at the HPRT locus in plateau-phase Chinese hamster ovary cells. Mutat Res 232:171-182.
58. Murnane JP (1990): Influence of cellular sequences on the instability of plasmid integration sites in human cells. Somat Cell Mol Genet 16:195-209.
59. Murnane JP, Yu LC (1993): Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break. Mol Cell Biol 13:977-983.
60. Nairn RS, Adair GM, Porter T, Pennington SL, Smith DG, Wilson JH, Seidman MM (1993): Targeting vector configuration and method of gene transfer influence targeted correction of the APRT gene in Chinese hamster ovary cells. Som Cell Mol Genet 19:363-375.
61. Nelson SL, Jones IM, Fuscoe JC, Burkhart-Schulz K, Grosovsky AJ (1994): Mapping the endpoints of large deletions affecting the hprt locus in human peripheral blood cells and cell lines. Radiat Res 141:2-10.
62. Nicklas JA, Hunter TC, O'Neill JP, Albertini RJ (1991): Fine structure mapping of the hprt gene region of the human X chromosome Xq26. Am J Hum Genet 49:267-278.
63. O'Gorman S, Fox D, Wahl G (1991): Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science 251:1351-1355.
64. Picketts DJ, Mayanil CSK, Gupta RS (1989): Molecular cloning of a Chinese hamster mitochondrial protein related to the "chaperonin" family of bacterial and plant proteins. J Biol Chem 264:12001-12008.
65. Popescu N, DiPaolo J (1989): Preferential sites for viral integration on mammalian genome. Cancer Genet Cytogenet 42:157-171.
66. Povirk LF, Austin MJF (1991): Genotoxicity of bleomycin. Mutat Res 257:127-143.
67. Prior TW (1995): Perspectives and molecular diagnosis of Duchenne and Becker muscular dystrophies (Review). Clin Lab Med 15:927-941.
68. Rassool FV, McKeithan TW, Neilly ME, van Melle E, Espinosa R, Le Beau MM (1991): Preferential integration of marker DNA into the chromosome fragile site at 3p14: An approach to cloning fragile sites. Proc Natl Acad Sci USA 88:6657-6661.
69. Renwick PJ, Birley AJ, McKeown CM, Hulten M (1995): Southern analysis reveals a large deletion at the hypoxanthine phosphoribosyltransferase locus in a patient with Lesch-Nyhan syndrome. Clin Genet 48:80-84.
70. Richardson KK, Fostel J, Skopek TR (1983): Nucleotide sequence of the xanthine guanine phosphoribosyl transferase gene of E. coli. Nucleic Acids Res 11:8809-8816.
71. Romac S, Leong P, Sockett H, Hutchinson F (1989): DNA base sequence changes induced by ultraviolet light mutagenesis of a gene on a chromosome in Chinese hamster cells. J Mol Biol 209:195-204.
72. Schwartz JL, Rotmensch J, Sun J, An J, Xu Z, Yu Y, Hise AW (1994): Multiplex polymerase chain reaction-based deletion analysis of spontaneous, gamma ray- and alpha-induced hprt mutants of CHO-K1 cells. Mutagenesis 9:537-540.
73. Schwartz JL, Porter RC, Hsie AW (1996): The molecular nature of spontaneous mutations at the hprt locus in the radiosensitive CHO mutant xrs-5. Mutat Res 351:53-60.
74. Sege-Peterson K, Chambers J, Page T, Jones O, Nyhan W (1992): Characterization of mutations in phenotypic variants of hypoxanthine phosphoribosyltransferase deficiency. Hum Mol Genet 1:427-432.
75. Simpson P, Morris T, Savage J, Thacker J (1993): High-resolution cytogenetic analysis of X-ray induced mutations of the HPRT gene of primary human fibroblasts. Cytogenet Cell Genet 64:39-45.
76. Skandalis A, Grosovsky AJ, Drobetsky EA, Glickman BW (1992): Investigation of the mutagenic specificity of X-rays using a retroviral shuttle vector in CHO cells. Environ Mol Mutagen 20:271-276.
77. Sockett H, Romac S, Hutchinson F (1991): Mutagenic specificity of N-methyl-N′-nitro-N-nitrosoguanidine in the gpt gene on a chromosome of Chinese hamster ovary cells and of Escherichia coli cells. Mol Gen Genet 227:252-259.
78. Stankowski LF Jr, Hsie AW (1986): Quantitative and molecular analyses of radiation-induced mutation in AS52 cells. Radiat Res 105:37-48.
79. Strehler BL (1995): Deletional mutations are the basic cause of aging: Historical perspectives. Mutat Res 338:3-17.
80. - mutants of transgenic Chinese hamster cell lines. Environ Mol Mutagen 21(Suppl. 22):68.
81. - mutants. Mutat Res 349:33-41.
82. Thomas K, Deng C, Capecchi M (1992): High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. Mol Cell Biol 12:2919-2923.
83. Tindall KR, Stankowski LF Jr (1987): Deletion mutations are associated with the differential induced mutation frequency response of the AS52 and CHO-K1-BH4 cell lines. In Moore MM, DeMarini DM, De Serres FJ, Tindall KR (eds): "Mammalian Cell Mutagenesis (Banbury Report 28)." Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, pp 283-292.
84. Tindall KR, Stankowski LF Jr (1989): Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells. Mutat Res 220:241-253.
85. Tindall KR, Stankowski LF Jr, Machanoff R, Hsie AW (1986): Analyses of mutation in pSV2gpt-transformed CHO cells. Mutat Res 160:121-131.
86. Turker MS, Pieretti M, Kumar S (1997): Molecular evidence for the induction of large interstitial deletions on mouse chromosome 8 by ionizing radiation. Mutat Res 374:201-208.
87. Vos J-M, Hanawalt PC (1989): DNA interstrand cross-links promote chromosomal integration of a selected gene in human cells. Mol Cell Biol 9:2897-2905.
88. Whaley JM, Little JB (1990): Molecular characterization of hprt mutants induced by low- and high-LET radiations in human cells. Mutat Res 243:35-45.
89. Wilson WR, Harris NM, Ferguson LR (1984): Comparison of the mutagenic and clastogenic activity of amsacrine and other DNA-intercalating drugs in cultured V79 Chinese hamster cells. Cancer Res 44:4420-4431.
90. Xu Z, Yu Y, Schwartz JL, Meltz ML, Hsie AW (1995): Molecular nature of spontaneous mutations at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus in Chinese hamster ovary cells. Environ Mol Mutagen 26:127-138.
91. Zhu LX, Waldren CA, Vannais D, Hei TK (1996): Cellular and molecular analysis of mutagenesis induced by charged particles of defined linear energy transfer. Radiat Res 145:251-259.