Molecular analysis of virulence factors of Streptococcus pneumoniae

Journal of Applied Microbiology Symposium Supplement

Volumn 83, Issue , 1997, Pages

  Mitchell, T J ^a,b   Alexander, U E ^a,b   Morgan, P J ^a,b   Andrew, P W ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; ADHESIN; HYALURONIDASE; MEMBRANE PROTEIN; PNEUMOLYSIN; VIRULENCE FACTOR;

DRUG DESIGN; GENETICS; HUMAN; PATHOGENICITY; REVIEW; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; VIRULENCE; BACTERIAL MEMBRANE; BACTERIAL VIRULENCE; CELL WALL; CONFERENCE PAPER; NONHUMAN;

BACTERIAL VACCINES; DRUG DESIGN; HUMANS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; VIRULENCE;

EID: 0031422910     PISSN: 02674440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (93)

1. Alexander, J.E., Lock, R.A., Peelers, C. et al. (1994) Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infection and Immunity. 62, 5683-5688.
2. G-methyli.-arginine protects the guinea pig cochlea from the cytotoxic effects of pneumolysin. Ada Otolaryngologica 115, 386-391.
3. Andersson, B., Dahman, J., Frejd, T. et al. (1983) Identification of an active disaccharide unit of a glycoconjugate receptor for pneumococcal attaching to human pharyngeal epithelial cell. Journal of Experimental Medicine 158, 559-570.
4. Andersson, B., Beachey, E.H., Tomasz, A., Tuomanen, E. and Svanborg-Eden, C. (1988) A sandwich adhesin on Streptococcus pneumonias attaching to human oropharyngeal epithelial cells in vitro. Microbial Pathogenesis 4, 267-278.
5. Andrew, P.W., Boulnois, G.J., Mitchell, TJ. et al. (1994) Pneumococcal vaccines. Zentralalt für Bakteriologie S24, 453-466.
6. Anon. (1985) Acute respiratory infections in under fives: 15 million deaths a year. Lancet 2, 699-701.
7. Austrian, R. (1981) Some observations on the pneumococcus and on the current status of pneumococcal disease and its prevention. Reviews of Infectious Diseases 3 (Suppl.), S1-S17.
8. Austrian, R. (1984) Pneumococcal infections. In Bacterial Vaccina ed. Germanier, R. pp. 257-288. London: Academic Press.
9. Austrian, R. (1986) Some aspects of the pneumococcal carrier state. Journal uj'Antimicrobial Chemotherapy 18, 35-45.
10. Benton, K.A., Everson, M.P. and Briles, D.E. (1995) A pneumolysin-negative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice. Infection and Immunity 63, 448-455.
11. Berry, A.M., Lock, R.A., Hansman, D. and Paton, J.C. (1989a) Contribution of autolysin to virulence of Streptococcus pneumoniae. Infection and Immunity 57, 2324-2330.
12. Berry, A.M., Yother, J., Briles, D.E., Hansman, D. and Paton, J.C. (1989b) Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infection and Immunity 57, 2037-2042.
13. Berry, A.M., Paton, J.C. and Hansman, D. (1992) Effect of insertional inactivation of the genes encoding pneumolysin and autolysin on the virulence of Streptococcus pneumoniae type 3. Microbial Pathogenesis 12, 87-93.
14. Berry, A.M., Lock, R.A., Thomas, S.M., Rajan, D.P., Hansman, D. and Paton, J.C. (1994) Cloning and nucleotide sequence of the Streptococcus pneumoniae hyaluronidase gene and purification of the enzyme from recombinant Escherichia coli. Infection and Immunity 62, 1101-1108.
15. Berry, A.M., Alexander, J.E., Mitchell, T.J., Andrew, P.W., Hansman, D. and Paton, J.C. (1995) Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae. Infection and Immunity 63, 1969-1974.
16. Boulnois, G.J., Paton, J.C., Mitchell, T.J. and Andrew, P.W. (1991) Structure and function of pneumolysin, the multifunctional, thiol-activated toxin of Streptococcus pneumoniae. Molecular Microbiology 5, 2611-2616.
17. Briles, D.E., Yother, J. and McDaniel, L.S. (1988) Role of pneumococcal surface protein A in the virulence of Streptococcus pneumoniae. Reviews of Infectious Diseases 2 (Suppl.), S372-S374.
18. Briles, D.E., Forman, C., Horowitz, J.C. et al. (1989) Antipneumococcal effects of C-reactive protein and monoclonal antibodies to pneumococcal cell wall and capsular antigens. Infection and Immunity 57, 1457-1464.
19. Broome, C.V. (1981) Efficacy of pneumococcal polysaccharide vaccines. Reviews of Infectious Diseases 3 (Suppl.), S82-S88.
20. Cabellos, C., Maclntyre, D.E., Forrest, M., Burroughs, M., Prasad, S. and Tuomanen, E. (1992) Differing roles for platelet-activating factor during inflammation of the lung and sub-arachnoid space: the special case of Streptococcus pneumoniae. Journal of Clinical Investigation 90, 612-618.
21. Camara, M. (1992) Cloning and analysis of the IgAl protease and neuraminidase enzymes from Streptococcus pneumoniae. PhD Thesis, University of Leicester.
22. Camara, M., Mitchell, T.J., Andrew, P.W. and Boulnois, G.J. (1991) Streptococcus pneumoniae produces at least two distinct enzymes with neuraminidase activity: cloning and expression of a second neuraminidase gene in Escherichia coli. Infection and Immunity 59, 2856-2858.
23. Camara, M., Boulnois, G.J., Andrew, P.W. and Mitchell, T.J. (1994)
24. A neuraminidase from Streptococcus pneumoniae has the features of a surface protein. Infection and Immunity 62, 3688-3695.
25. Canvin, J.R., Marvin, A.P., Sivakumaran, M. et al. (1995) The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus. Journal of Infectious Diseases 172, 119-123.
26. Comis, S.D., Osborne, M.P., Stephen, J. et al. (1993) Cytotoxic effects on hair cells of guinea pig cochlea produced by pneumolysin, the thiol activated toxin of Streptococcus pneumoniae. Ada Otolaryngologica 113, 152-159.
27. Grain, M.J., Waltman, W.D., Turner, J.S. et al. (1990) Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniae. Infection and Immunity 58, 3293-3299.
28. Cundell, D.R. and Tuomanen, E.I. (1994) Receptor specificity of adherence aï Streptococcus pneumoniae to human type II pneumocytes and vascular endothelial cells in vitro. Microbial Pathogenesis 17, 361-364.
29. Cundell, D.R., Gerard, N.P., Gerard, G., Idanpaan-Heikkila, I. and Tuomanen, E. (1995a) Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature 377, 435-438.
30. Cundell, D.R., Pearce, B.J., Sandros, J., Naughton, A.M. and Masure, H.R. (1995b) Peptide permeases from Streptococcus pneumoniae affect adherence to eukaryotic cells. Infection and Immunity 63, 2493-2498.
31. Cundell, D.R., Weiser, J.N., Young, A. and Tuomanen, E.I. (1995c) Relationship between colonial morphology and adherence in Streptococcus pneumoniae. Infection and Immunity 63, 757-761.
32. de los Toyos, J.R., Mendez, F.J., Aparicio, J.F. et ai. (1996) Functional analysis of pneumolysin by use of monoclonal antibodies. Infection and Immunity 64, 48CH-84.
33. Douglas, R.M., Hansman, D., Miles, H. and Paton, J.C. (1986) Pneumococcal carriage and type specific antibody. Failure of a 14-valent vaccine to reduce carriage in healthy children. American Journal of Diseases of Children 140, 1183-1185.
34. Feldman, C, Munro, N.C., Jeffrey, O.K. el al. (1991) Pneumolysin induces the salient features of pneumococcal infection in the rat lung; vivo. American Journal of Respiratory, Cellular and Molecular Biology 5, 416-423.
35. Forrester, H.L., Jahigen, D.W. and LaForce, F.M. (1987) Inefficacy of pneumococcal vaccine in high-risk population. American Journal of Medicine 83, 425-430.
36. Friedland, I.R., Paris, M.M., Hickey, S. et al. (1995) The limited role of pneumolysin in the pathogenesis of pneumococcal meningitis. Journal of Infectious Diseases 172, 805-809.
37. Geelen, S., Bhattacharyya, C. and Tuomanen, E. (1993) The cell wall mediates attachment to and cytopathology in human endothelial cells. Infection and Immunity 61, 1538-1543.
38. Gilbert, J.V., Flaut, A.G., Fishman, Y. and Wright, A. (1988) Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli. Infection and Immunity 56, 1961-1966.
39. Heumann, D., Barras, C., Severin, A., Glauser, M.P. and Tomasz, A. (1994) Gram-positive cell walls stimulate synthesis of tumor necrosis factor alpha and interleukin-6 by human monocytes. Infection and Immunity 62, 2715-2721.
40. Houldsworth, S., Andrew, P.W. and Mitchell, T.J. (1994) Pneumolysin
41. stimulates production of tumor necrosis factor alpha and interleukin-lbeta by human mononuclear phagocytes. Infection and Immunity 62, 1501-1503.
42. Johnson, M.K. (1977) Cellular location of pneumolysin. FEMS Microbiology Letters 2, 243-245.
43. Johnson, M.K. (1979) The role of pneumolysin in ocular infections with Streptococcuspneumoniae. Current Eye Research 9, 1107-1114.
44. Johnson, M.K., Callegan, M.C., Engel, L.S. et al. (1995) Growth and virulence of a complement-activation-negative mutant of Streptococcus pneumoniae in the rabbit cornea. Current Eye Research 14, 281-285.
45. Johnston, R. (1991) Pathogenesis of pneumococcal pneumonia. Reviews of Infectious Diseases 13 (Suppl. 6), S509-S517.
46. Kanclerski, K. and Mollby, R. (1987) Production and purification of Streptococcus pneumoniae hemolysin (pneumolysin). Journal of Clinical Microbiology 25, 222-225.
47. Kennedy, W.A., Hoyt, M.J. and McCracken, G.H. (1991) Pneumococcal meningitis and deafness. The role of corticosteroid therapy in children with pneumococcal meningitis. Journal of Diseases of Children 145, 1374-1378.
48. Kim, Y.S., Kennedy, S. and Tauber, M.G. (1995) Toxicity of Streptococcus pneumoniae in neurones, astrocytes, and microglia in vitro. Journal of Infectious Diseases 171, 1363-1368.
49. Kostyukova, N.N., Volkova, M.O., Ivanova, V.V. and Kvetnaya, A.S. (1995) A study of pathogenic factors of Streptococcus pneumoniae strains causing meningitis. FEMS Immunology and Medical Microbiology 10, 133-138.
50. Krivan, H.C., Roberts, D.D. and Ginsberg, V. (1988) Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence Galβ-Gal found in some glycolipids. Proceedings of the National Academy of Sciences USA 85, 6157-6161.
51. Langermann, S., Palaszynski, S.R., Burlein, J.E. et al. (1994) Protective humoral response against pneumococcal infection in mice elicited by recombinant Bacille Calmette-Guerin vaccines expressing pneumococcal surface protein A. Journal of Experimental Medicine 180, 2277-2286.
52. Lee, C.-J., Banks, S.D. and Lee, J.P. (1991) Virulence, immunity, and vaccine related to Streptococcus pneumoniae. Critical Reviews m Microbiology 18, 89-114.
53. Linder, T.E., Daniels, R.L., Lim, D.J. and DeMaria, T.F. (1994) Effect of intranasal inoculation of Streptococcus pneumoniae on the structure of the surface carbohydrates of the chinchilla eustachian tube and middle ear mucosa. Micnbial Pathogenesis 16, 435-441.
54. Lock, R.A., Hansman, D. and Paton, J.C. (1988a) Comparative efficacy of autolysin and pneumolysin as immunogens protecting mice against infection by Streptococcus pneumoniae. Micnbial Pathogenesis 12, 137-143.
55. Lock, R.A., Paton, J.C. and Hansman, D. (1988b) Comparative efficacy of pneumococcal neuraminidase and pneumolysin as immunogens protective against Streptococcus pneumoniae. Micnbial Pathogenesis. 5, 461-467.
56. Lomholt, H. (1995) Evidence of recombination and an antigenically diverse immunoglobulin Al protease among strains of Streptococcus pneumoniae. Infection and Immunity 63, 4238-4243.
57. Mitchell, T.J., Paton, J.C., Andrew, P.W. and Boulnois, GJ. (1990) Comparison of pneumolysin genes and proteins from Streptococcus pneumoniae types 1 and 2. Nucleic Acids Research 18,4010.
58. Mitchell, T.J., Andrew, P.W., Saunders, F.K., Smith, A.N. and
59. Boulnois, G.J. (1991) Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute-phase protein. Molecular Microbiology 5, 1883-1888.
60. Morgan, P.J., Hyman, S.C., Byron, O., Andrew, P.W., Mitchell, T.J. and Rowe, A.J. (1994) Modeling the bacterial protein toxin, pneumolysin, in its monomeric and oligomeric form. Journal of Biological Chemistry 269, 25315-25320.
61. Owen, R.H.G., Boulnois, G.J., Andrew, P.W. and Mitchell, T.J. (1994) A role in cell-binding for the C-terminus of pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae. FEMS Microbiology Letters 121, 217-222.
62. Paton, J.C. and Ferrante, A. (1983) Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin. Infection and Immunity 41, 1212-
63. 1216.
64. Paton, J.C., Rowan-Kelly, B. and Ferrante, A. (1984) Activation of human complement by the pneumococcal toxin pneumolysin. Infection and Immunity 43, 1085-1087.
65. Paton, J.C., Berry, A.M., Lock, R.A., Hansman, D. and Manning, P.A. (1986) Cloning and expression in Escherichia coli of the Streptococcus pneumoniae gene encoding pneumolysin. Infection and Immunity 54, 50-55.
66. Paton, J.C., Andrew, P.W., Boulnois, G.J. and Mitchell, T.J. (1993a) Molecular analysis of the pathogenicity of Streptococcus pneumoniae: the role of pneumococcal proteins. Annual Review of Microbiology 47, 89-115.
67. Paton, J.C., Morona, J.K., Harrer, S., Hansman, D. and Morona, R. (1993b) Immunization of mice with Salmonella typhimurium C5 aroA expressing a genetically toxoided derivative of the pneumococcal toxin pneumolysin. Microbial Pathogenesis 14, 95-
68. 102.
69. Pfister, H.W., Koedel, U. and Haberl, R.L. (1990) Microvascular changes during the early phase of experimental meningitis. Journal of Cerebral Blood Flow and Metabolism 10, 914-922.
70. Riley, I.D. and Douglas, R.M. (1981) An epidemiologic approach to pneumococcal disease. Reviews of Infectious Diseases 3, 233-
71. 245.
72. Rubins, J.B., Mitchell, T.J., Andrew, P.W. and Niewoehner, D.E. (1994) Pneumolysin activates phospholipase A in pulmonary artery endothelial cells. Infection and Immunity 62, 3829-3836.
73. Rubins, J.B., Charboneau, D., Paton, J.C., Mitchell, T.J., Andrew, P.W. and Janoff, E.N. (1995) Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. Journal of Clinical Investigation 95, 142-150.
74. Rubins, J.B., Charboneau, D., Fasching, C. et al. (1996) Distinct role for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia. American Journal oj Respiratory Critical Care Medicine 153, 1339-1346.
75. Saluja, S. and Weiser, J.N. (1995) The genetic basis of colonial opacity in Streptococcus pneumoniae: evidence for the effect of box elements on phenotypic variation. Molecular Microbiology 16, 215-227.
76. Sampson, J.S., O'Connor, S.P., Stinson, A.R., Tharpe, J.A. and Russell, H. (1994) Cloning and nucleotide sequence analysis of psaA, the Streptococcus pneumoniae gene encoding a 37-kilodalton protein homologous to previously reported Streptococcus sp. adhesins. Injection and Immunity 62, 319-324.
77. Sato, K., Quarte}', M.K., Liebeier, C.L., Le, C.T. and Giebink,
78. G.S. (1996) Roles of autolysin and pneumolysin in middle ear inflammation caused by a type 3 Streptococcus pneumoniae strain in the chinchilla otitis media model. Infection and Immunity 64, 1140-1145.
79. Scanion, K.L., Diven, W.F. and Glew, R.H. (1989) Purification and properties of Streptococcus pneumoniae neuraminidase. Enzyme 41, 143-150.
80. Snippe, H., van Houte, A.J., van Dam, J.E.G., de Reuver, M.J., Jansze, M. and Williers, J.M.N. (1983) Immunogenic properties in mice of hexasaccharide from the capsular polysaccharide of Streptococcus pneumoniae type 3. Infection and Immunity 40, 856-
81. 861.
82. Spellerberg, B., Cundell, D.R., Sandros, J. et al. (1996) Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae. Molecular Microbiology 19, 803-813.
83. Spika, J.S., Facklam, R.R., Plikaytis, B.D., Oxtoby, M.J. and Party, P.S.W. (1991) Antimicrobial resistance of Streptococcus pneumoniae in the United States, 1979-198. Infectious Disease 163, 1273-1278.
84. Steinfort, C., Wilson, R., Mitchell, T. et al. (1989) Effect of Streptococcus pneumoniae on human respiratory epithelium in vitro. Infection and Immunity 57, 2006-2013.
85. Takala, A.K., Eskola, J., Leinonen, M. et al. (1991) Reduction of oropharyngeal carriage of Haemophilus influenzae type-b (hib) in children immunized with an hib conjugate vaccine. Journal of Infectious Diseases 164, 982-986.
86. Talkington, D.F., Crimmins, D.L., Voelinger, D.C., Yother, J. and Briles, D.E. ( 1991 ) A 43-kilodalton pneumococcal surface protein, PspA; isolation, protective abilities, and structural analysis of the amino-terminal sequence. Infection and Immunity 59, 1285-
87. 1289.
88. Talkington, D.F., Koenig, A. and Russell, H. (1992) The 37-kDa protein of Streptococcus pneumonias protects mice against fatal challenge. In 92nd General Meeting of the American Society for Microbiology, p. 149. Washington, DC: American Society for Microbiology.
89. Tuomanen, E., Liu, H., Hengstler, B., Zak, O. and Tomasz, A. (1985) The induction of meningeal inflammation by components of the pneumococcal cell wall. Journal of Infectious Diseases 151, 859-868.
90. Tuomanen, E., Rich, R. and Zak, O. (1987) Induction of pulmonary inflammation by components of the pneumococcal cell surface. American Review of Respiratory Diseases 135, 868-874.
91. Walker, J.A., Allen, R.L., Falmagne, P.Johnson, M.K. and Boulnois, G.J. (1987) Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumomae. Injection and Immunity 55, 1184-1189.
92. Watson, D.A. and Musher, D.M. (1990) Interruption of capsule production in Streptococcus pneumoniae type serotype 3 by insertion of Tn916. Infection and Immunity 58, 3135-3138.
93. White, R.T.M. (1988) Pneumococcal vaccine. Thorax 43, 345-348.