Effects of the 5-HT receptor antagonists GR127935 (5-HT(1B/1D)) and MDL100907 (5-HT(2A)) in the consolidation of learning

Behavioural Brain Research

Volumn 89, Issue 1-2, 1997, Pages 217-223

  Meneses, Alfredo ^a   Terrón, José A ^a   Hong, Enrique ^a  

^a Depto Farmacol Y Toxicol C   (Mexico)

Author keywords

5 HT(1B 1D); 5 HT(2A 2B 2C); Autoshaping; Learning; Rat; Receptors; Serotonin

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 (1 NAPHTHYL)PIPERAZINE; 1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 3 [3 (2 DIMETHYLAMINOETHYL) 1H INDOL 5 YL] N (4 METHOXYBENZYL)ACRYLAMIDE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; CHLORAMPHETAMINE; KETANSERIN; MESULERGINE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INSTRUMENTAL CONDITIONING; LEARNING; MALE; MEMORY CONSOLIDATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CONDITIONING, OPERANT; DRUG INTERACTIONS; FLUOROBENZENES; LEARNING; MALE; OXADIAZOLES; PIPERAZINES; PIPERIDINES; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0031422516     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(97)00055-7     Document Type: Article

References (40)

1. G.K. Aghajanian, Electrophysiology of serotonin receptor subtypes and signal transduction pathways, in: E.F. Bloom, D.J. Kupfer (Eds.), Psychopharmacology: The Fourth Generation of Progress, Raven Press, New York, 1995, pp. 451-460.
2. Altman H.J., Normile H.J. What is the nature of the role of the serotonergic nervous system in learning and memory? Prospects for development of an effective treatment strategy for senile dementia. Neurobiol. Aging. 9:1988;627-698.
3. 2 receptor subtypes: a family re-united? TIPS. 16:1995;105-110.
4. 1B receptors in the rat. Hippocampus. 5:1995;198-208.
5. 1B/1D receptor ligands. Pharm. Ther. 62:1994;385-405.
6. 1D autoreceptors. Br. J. Pharm. 114:1995;1107-1109.
7. Didriksen M. Effects of antipsychotics on cognitive behavior in rats using the delayed non-match to position paradigm. Eur. J. Pharmacol. 281:1995;241-250.
8. 2B receptor protein in the rat brain. Br. J. Pharm. 115(Proceed. Suppl.):1995;105P.
9. R.A. Glennon, M. Dukat, Serotonin receptor subtypes, in: E.F. Bloom, D.J. Kupfer (Eds.), Psychopharmacology: The Fourth Generation of Progress, Raven Press, New York, 1995, pp. 415-429.
10. A.J. Gower, 5-HT receptors and cognitive function, in: C.A. Marsden, D.J. Heal (Eds.), Central Serotonin Receptor and Psychotropic Drugs, Blackwell, London, 1992, pp. 239-259.
11. Harvey J.A. Serotonergic regulation of associative learning. Behav. Brain Res. 73:1996;47-50.
12. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.P.A. VII International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharm. Rev. 46:1994;157-203.
13. Hoyer D., Martin G.R. Classification and nomenclature of 5-HT receptors: a comment on current issues. Behav. Brain Res. 73:1996;263-268.
14. Jacobs B.L., Azmitia E.C. Structure and function of the brain serotonin system. Physiol. Rev. 72:1992;165-229.
15. 2A receptor ligand. Naunyn-Schemiedeberg's Arch. Pharmacol. 354:1996;205-209.
16. 2A antagonist with a favorable CNS safety profile. J. Pharmacol. Exp. Ther. 277:1996;968-981.
17. Lawlor B.A., Sunderland T., Mellow A.M., Hill J.L., Molchan S.E., Murphy D.L. Hyperresponsivity to the serotonin agonist m-chlorophenylpiperazine in Alzheimer's disease. Arch. Gen. Psychiatry. 46:1989;542-549.
18. Martin G.R., Humphrey P.P.A. Classification review: Receptors for 5-hydroxytryptamine: current perspectives on classification and nomenclature. Neuropharmacology. 33:1996;261-273.
19. Meneses A., Hong E. Modification of 8-OH-DPAT effects on learning by manipulation of the assay conditions. Behav. Neural Biol. 61:1994;29-35.
20. Meneses A., Hong E. Mechanism of action of 8-OH-DPAT on learning and memory. Pharmacol. Biochem. Behav. 49:1994;1083-1086.
21. Meneses A., Hong E. Effects of fluoxetine on learning and memory involve multiple 5-HT systems. Pharmacol. Biochem. Behav. 52:1995;341-346.
22. 2A) on learning. Soc. Neurosci. Abstr. 22:1996;1586.
23. A. Meneses, E. Hong, A pharmacological analysis of serotonergic receptors: effects of their activation or blockade in learning. Prog. Neuro-Psychopharmacol. Biol. Psychiat. 23 (1997a) 273-296.
24. 1A receptors in acquisition, consolidation and retrieval of learning, CNS Drug Rev. 3 (1997b) 68-82.
25. 2C receptors in learning, Behav. Brain Res. (1997c) in press.
26. Meneses A., Castillo C., Ibarra M., Hong E. Effects of aging and hypertension on learning. Memory, and activity in rats. Physiol. Behav. 60:1996;341-345.
27. A. Meneses, J.A. Terrón, M. Ibarra, E. Hong, Effects of nimodipine on learning in normotensive and spontaneously hypertensive rats, Behav. Brain Res. 85 (1997) 121-125.
28. 2A antagonist. Behav. Brain Res. 73:1996;163-167.
29. Nabeshima T.K., Itoh K., Kawashima K., Kameyama T. Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice. Pharmacol. Biochem. Behav. 32:1989;787-790.
30. Noda Y., Ochi Y., Shimada E., Oka M. Involvement of central cholinergic mechanism in RU-24969-induced behavioral deficits. Pharmacol. Biochem. Behav. 38:1991;441-446.
31. 1Dα receptor sites. Neuropharmacology. 34:1995;235-237.
32. 1D receptors regulate 5-HT release in the rat raphe nuclei. Neuropharmacology. 13:1995;249-260.
33. 1D receptors in the rat brain. Synapse. 22:1996;54-62.
34. 2A/2C receptor agonist disrupts initial development of spatial navigation strategies in rats. Soc. Neurosci. Abstr. 20:1994;1546.
35. Sirviö J., Riekkinen P. Jr., Jäkälä P., Riekkinen P.J. Experimental studies on the role of serotonin in cognition. Prog. Neurobiol. 43:1994;363-379.
36. 1D receptors causes hypothermia in guinea-pig. J. Psychopharmacol. 8:1994;14-21.
37. L.O. Wilkinson, C.T. Dourish, Serotonin and animal behavior, in: S.J. Peroutka (Ed.), Serotonin Receptors Subtypes, Wiley-Liss, New York, 1991, pp. 147-210.
38. IA receptors in memory. Pharmacol. Biochem. Behav. 27:1987;625-628.
39. 2 receptor subtype mRNAs in rat brain. J. Comp. Neurol. 351:1995;357-373.
40. Zola-Morgan S., Squire L.R. Neuroanatomy of memory. Annu. Rev. Neurosci. 168:1993;547-563.