A pharmacological analysis of serotonergic receptors: Effects of their activation of blockade in learning

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 21, Issue 2, 1997, Pages 273-296

  Meneses, Alfredo ^a   Hong, Enrique ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

5 HT receptors; autoshaping; consolidation; learning; rats; serotonin

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 2 (DIETHYLAMINO)ETHYL ESTER; FLUOXETINE; ONDANSETRON; SCOPOLAMINE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; TROPISETRON;

ANIMAL EXPERIMENT; LEARNING; NEUROTRANSMISSION; NONHUMAN; RAT; REVIEW; SEROTONINERGIC SYSTEM;

ANIMALS; FLUOXETINE; LEARNING; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0030980481     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(97)00002-X     Document Type: Review

References (106)

1. AGHAJANIAN, GK. (1995). Electrophysiology of serotonin receptor subtypes and signal transduction pathways. In: Psychopharmacology: The fourth Generation of Progress. EF Bloom, DJ Kupfer (Eds.). pp:451-460. Raven Press Ltd., New York.
2. ALTMAN, H.J. AND NORMILE, H.J. (1988). What is the nature of the role of the serotonergic nervous system in learning and memory: Prospects for development of an effective treatment strategy for senile dementia. Neurobiol Aging 9:627-638.
3. AMARAL., DG., DOLORFO, C. AND ALAVAREZ-ROYO, P. (1991). Organization of CA1 projections to the subiculum: A PHA-L analysis in the rat. Hippocampus 1:415-436.
4. ANDRADE, R. AND CHAPUT, Y. (1995). 5-Hydroxytryptamine-1 receptors mediate the slow excitatory response to serotonin in the rat hippocampus. J Pharmacol Exp Ther 257:930-937.
5. ANGEL, I. (1990). Central receptors and recognition sites mediating the effects of monoamine and anorectics drugs on feeding behavior. Clin Neuropharmacol 13:361-391.
6. BASS, E.W., MEANS, L.W. AND MCMILLEN, B.A. (1992). Buspirone impairs performance of a three-choice working memory water escape task in rats. Brain Res Bull 28:455-461.
7. BLIER, P., LISTA, A. AND DE MONTIGNY, C. (1993). Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: 1. Effect of spiperone. J Pharmacol Exp Ther 265:7-15
8. BLISS, T.V.P. AND LYNCH, M.A. (1988). Long-term potentiation synaptic transmission in the hippocampus: properties and mechanisms. In: Neurology and Neurobiology Ser 35 Long-term potentiation: from biophysic to behavior. PW Landfield, SW Deadwyler (Eds). pp:3-72 Liss. New York.
9. 4 receptor: a place in the sun. TIPS 13:141-145.
10. 4 receptor antagonists, GR113808 and GR125487. 5-HT Third IUPHAR Satellite Meeting on Serotonin. July 30- August 3. Chicago, IL., p: 33.
11. 1B agonists in the rat. 5-HT Third IUPHAR Satellite Meeting on Serotonin. July 30-August 3, Chicago, IL.;p:73.
12. CARLI, M AND SAMANIN, R. (1992). 8-Hydroxy-2-(di-n-propylamino) tetralin impairs spatial learning in a water maze: role of postsynaptic 5-HT1A. Br J Pharmacol 105:720-726.
13. 1A receptors in the dorsal hippocampus impairs acquisition and performance of a spatial task in a water maze. Brain Res 595:50-56.
14. CASSEL, JC. AND JELTSCH, H. (1995). Serotonergic modulation of cholinergic function in the central nervous system: Cognitive implications. Neurosci 69:1-41.
15. CHOPIN, P. AND BRILEY, M. (1987). Animals models of anxiety: the effects of compounds that modify 5-HT neurotransmission. TIPS 8:383-388.
16. 1A receptor antagonists. Current Drugs: Serotonin, pp:99-124
17. 1B receptors. J Pharmacol Exp Ther 277:823-830.
18. CORNFIELD, L.J. AND NELSON, D.L. (1991). Biochemistry of 5-hydroxytryptamine receptor subtypes: Coupling to second messenger systems. In: Serotonin receptor subtypes: Basic and Clinical Aspects. SJ Peroutka (Ed). pp:81-102. Wiley-Liss, New York.
19. 3 receptors. Pharmacol Toxicol 71:401-415.
20. DEACON, RMJ. (1991). Pharmacological studies of a rat spatial delayed nonmatch-to-sample task as an animal model of dementia. Drug Dev Res 24:67-79.
21. DECKER, M.W. AND MCGAUGH, J.L. (1991). The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 7:151-168.
22. DOURISH, CT. (1995). Multiple serotonin receptors: opportunities for new treatments for obesity. Obesity Res 3 (Suppl 4):449S-462S.
23. 2B receptor protein in the rat brain. Br. J Pharmacol 115 (Suppl.,):105.
24. 4 receptors. TiPS 16:391-398
25. ELLIOT, JM., FLANIGAN, TP., NEWBERRY, NR., ZETTERSTRÖM, T AND LESLIE, RA. (1994), 5-HT receptor subtypes: aspects of their regulation and function. Neurochem Int 25:537-543.
26. EVENDEN, J.L. AND ANGEBY, K. (1990). Effects of 8-hydroxy-2-(di-n-propylaminotetralin (8-OH-DPAT) on locomotor activity and rearing of mice and rats. Psychopharmacology 102:485-491.
27. 2C receptors in the stimulus effects of m-chlorophenylpiperazine. Psychopharmacol 119: 222-230.
28. 1A receptor antagonists: utility as research tools and therapeutic agents. TIPS 14:441-448.
29. GALZIN, AM. AND LANGER, SZ. (1991). Modulation of 5-HT release by presynaptic inhibitory and facilitatory 5-HT receptors in brain slices. In: Presynaptic receptors and neuronal transporters. SZ Langer, AM Galzin, J Costentin (Eds.). pp:59-62. Pergamon Press, Oxford.
30. 4 agonists: BIMU1 and BIMU8 on the social learning test in rats. CINP Congress. Washington, DC. June 27-July 1.
31. GHELARDINI, C., MEONI, P., GALEOTTI, N., MALMBERG-AIELLO, O., RIZZI, CA. AND BARTOLINI, A. (1994a). Effect of the two benzimidazolone derivates: BIMU-1 and BIMU-8 on a model of hypoxia-induced amnesia i the mouse. 5-HT Third IUPHAR Satellite Meeting on Serotonin. July 30- August 3. Chicago, IL., p: 55
32. GHELARDINI, C., MALMBERG-AIELLO, O., BARTOLINI, A. AND RIZZI, CA. (1994b). Protective effect of BIMU-1 and BIMU-8 on amnesia induced by hypercapnia. 10th Congress of Eur Soc for Neurochem. Jerusalem. August 14-19.
33. GLENNON, R.A. (1990). Serotonin receptors: clinical implications. Neurosci Biobehav Rev 14:35-47.
34. GLENNON, RA. AND DUKAT, M. (1995). Serotonin receptor subtypes. In: Psychopharmacology: The fourth generation of progress. FE Bloom, DJ Kupfer (eds). pp:415-429. Raven Press, Ltd., New York.
35. GOWER, A.J. (1992). 5-HT receptors and Cognitive function. In: Central serotonin receptors and psychotropic drugs. CA Marsden, DJ Heal (Eds). p:239-259. Blackwell Scientific Publications, Oxford.
36. HANDLEY, SL. (1995). 5-Hydroxytryptamine pathways in anxiety and its treatment. Pharmac Ther 66:103-148.
37. HAAS, HL., SERGUEEVA, OA., VOROBJEV, VS. AND SHARONOVA, IN. (1995). Subcortical modulation of synaptic plasticity in the hippocampus. Behav Brain Res 66:41-44.
38. HARVEY, JA. (1996). Serotonergic regulation of associate learning. Behav Brain Res 73:47-50.
39. 3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats. J Pharmacol Exp Ther 264:1440-1449.
40. 1A presynaptic receptors or an enhancement of 5-HT postsynaptic activity increase learning. Proc West Pharmacol Soc 38:86-86.
41. 1A antagonists. Soc Neurosci Abstr 21:1228.
42. 3 compounds on learning. Pharmacol Biochem Behav 53:765-769.
43. 1A receptor agonists and silent antagonists reversed the decrements in learning induced by dizocilpine and scopolamine. Soc Neurosci Abstr. 22:1586.
44. HOYER, D., HARTIG, P.R. AND HUMPHREY, P.P.A. (1994). International Union of Pharmacology classification for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46:157-203.
45. 1A receptors: Behavioral and Neurochemical Pharmacology. C.T. Dourish, S. Ahlenius, P.H. Hutson (Eds). pp:278-285. Chichester, Ellis Horwood.
46. JACOBS, B.L. AND AZMITIA, E.C. (1992). Structure and function of the brain serotonin system. Physiol. Rev 72:165-229.
47. 1C receptors in the serotonergic control of periqueductual gray induced aversion in rats. Psychopharmacol 100 (Suppl):372-376.
48. KANT, JG., MEININGER, GR., MAUGHAN, KR., WRIGHT, WL., ROBINSON, TN. AND NEELY, TM. (1996). Effects of the serotonin receptor agonists 8-OH-DPAT and TFMPP on learning as assessed using a novel water maze. Pharmacol Biochem Behav 53:385-390.
49. KARASAWA, Y., ARAKI, H. AND OTOMO, S. (1992). Effects of ketanserin and mianserin on delayed neuronal death induced by cerebral ischemia in mongolian gerbils. Psychopharmacol 109:264-270.
50. 2A antagonist with favorable CNS safety profile. J Pharmacol Exp Ther 277:968-981.
51. 1c receptors and their therapeutic relevance. Curr Opin Invest Drugs 2:317-362.
52. 3 receptors in the central nervous system are mainly located on nerve fibers and terminals. Brain Res 612:289-298.
53. KLINT, T. (1991). Effects of 8-OH-DPAT in a passive avoidance test and in elevated plus-maze test in rats. Behav Pharmacol 2:481-489.
54. LAWLOR, BA., SUNDERLAND, T., MELLOW, AM., HILL, JL., MOLCHAN, SE. AND MURPHY, DL. (1989). Hyperresponsivity to the serotonin agonist m-chlorophenylpiperazine in Alzheimer's disease. Arch Gen Psychiat 46:542-549.
55. LEIBOWITZ, SF. (1990). The role of serotonin in eating disorders. Drugs 39:33-48.
56. LI, XC., GIOT, JF., KUHL., HEN, R. AND KANDEL, ER. (1995). Cloning and characterization of two related serotonergic receptors from the brain and the reproductive system of aplysia that activate phospholipase. J Neurosci 15:7585-7591.
57. 1 receptors and behavior. Neurosci Biobehav Rev 16:83-93.
58. MAJ, J., ROGOZ, Z., SKUDA, G. AND SOWINSKA, H. (1992). The effect of antidepressant drugs on the locomotor hyperactivity induced by MK-801, a noncompetitive NMDA receptor antagonist. Neuropharmacol 31:685-691.
59. MCGAUGH, JL. (1989). Dissociating learning and performance: drug and hormone enhancement of memory storage. Brain Res Bull 23:339-345.
60. MAMOUNAS, LA., WILSON, MA., AXT, KJ. AND MOLLIVER, ME. (1992). Morphological aspects of serotonergic innervation. In: Serotonin, CNS receptors and brain function. PB Bradley, SL Handley, SJ Cooper, BJ Key NM Barnes and JH Coote (Eds.). pp:97-118. New York:Pergamon Press.
61. 3 receptors in the control of 5-HT release in rat hippocampus in vivo. Br J Pharmacol 106:139-142.
62. MCENTEE, WJ. AND COOK, TH (1991). Serotonin, memory, and aging brain. Psychopharmacol 103:143-149.
63. 1A receptor agonists induce anterograde amnesia in mice. Eur J Pharmacol 236:177-182.
64. MENESES, A. AND HONG, E. (1991), Effects of serotonergic compounds on associative learning. Proc West Pharmacol Soc 34:461-464.
65. MENESES, A. AND HONG, E. (1994a). Modification of 8-OH-DPAT effect on learning by manipulation of the assay conditions. Behav Neural Biol 61:29-35.
66. MENESES, A. AND HONG, E. (1994b). Mechanisms of action of 8-OH-DPAT on learning and memory. Pharmacol Biochem Behav 49:1083-1086.
67. MENESES, A. AND HONG, E. (1995a). Effect of fluoxetine on learning and memory involves multiple 5-HT systems. Pharmacol Biochem Behav 52:341-346.
68. MENESES, A. AND HONG, E. (1995b). Pharmacological analysis of serotonergic receptors: Activation or blockade on learning. Soc Neurosci Abstract 21:1228.
69. 4 receptor agonists and antagonists in learning. Pharmacol Biochem Behav (in press).
70. 2C receptor in learning. Behav Brain Res (submitted).
71. 2A) on learning. Soc Neurosci Abstract 22:1586.
72. 1A receptors in acquisition, consolidation and retrieval of learning. CNS Drug Rev (submitted).
73. MENESES, A., CASTILLO, C., IBARRA, M. AND HONG, E. (1996a). Effects of aging and hypertension on learning, memory, and activity in rats. Physiol Behav 60:341-345.
74. MENESES, A., TERRÓN, JA., IBARRA, M. AND HONG, E. (1996b). Effects of nimodipine on learning in normotensive and spontaneously hypertensive rats. Behav Brain Res (in press).
75. MIDDLEMISS, DN. AND TRICKLEBANK, MD. (1992). Centrally active 5-HT receptor agonists and antagonists. Neurosci Biobehav Rev 16:75-82.
76. MORET, C. AND BRILEY, M. (1995). In vitro and in vivo activity of 1-(1-naphthyl) pirezazepine at terminal 5-HT autoreceptors in guinea-pig brain. Naunyn-Schmiedebers' Arch Pharmacol 351:337-384.
77. NABESHIMA, T.K., ITOH, K., KAWASHIMA, K. AND KAMEYAMA, T. (1989). Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice. Pharmacol Biochem Behav 32:787-790.
78. NODA, Y., OCHI, Y. SHIMADA, E. AND OKA, M. (1991). Involvement of central cholinergic mechanism in RU-24969-induced behavioral deficits. Pharmacol Biochem Behav 38:441-446.
79. O'CONNOR, J.J., ROWAN, M.J. AND ANWYL, R. (1990) Actions of 5-HT1 ligands on excitatory synaptic transmission in the hippocampus of alert rats. Br. J. Pharmacol 101:171-177.
80. OSCOS A., CAMACHO, JL., MENESES, A., ALEMÁN, V. (1985). The post-trial effect of amphetamine in memory and in cerebral protein amino acid incorporation in the rat. In: Contemporary Psychology: Biological Processes and Theoretical issues. McGaugh JM (Ed.). pp 123-129. Amsterdam, North-Holland.
81. PALACIOS, J.M., WAEBER, C., MENGOD, G. AND HOYER, D. (1991). Autoradiography of 5-HT receptors: A critical appraisal. Neurochem Int 18:17-25
82. PEROUTKA, J.L. (1991). The molecular pharmacology of 5-hydroxytryptamine receptor subtypes. In: Serotonin receptor subtypes: Basic and Clinical Aspects SJ Peroutka (Ed). pp:65-80. Wiley-Liss, New York.
83. PEROUTKA, J.L. (1994). Molecular biology of serotonin (5-HT) receptors Synapse 18:241-260.
84. PIGUET, P. AND GALVAN, M (1994). Transient and long-lasting actions of 5-HT on rat dentate gyrus neurones in vitro. J Physiol 481:629-639.
85. 1D receptors regulate 5-HT release in the rat raphe nuclei. Synapse 22:54-62.
86. 2C receptors. Mol Brain Res 23:163-178.
87. RADJA, F., LAPORTE, A.M., DAVAL, G., VERGE, D., GOZLAN, H. AND HAMON, M. (1991). Autoradiography of serotonin receptor subtypes in the central nervous system. Neurochem Int 18:1-15.
88. RESCORLA, RA. (1988). Behavioral studies of conditioning. Ann Rev Neurosci 11:329-352.
89. RILEY, AL. AND TUCK, DL. (1985). Conditioned food aversion: A bibliography. Annals New York Acad Sci 443:272-292.
90. 4 receptor colocalization on hippocampal pyramidal cells. Neuropharmacol 32:551-557.
91. SANGER, D.J. AND JOLY, D. (1989). Performance of a passive avoidance response is disrupted by compounds acting at 5-HT1A receptors. Behav Pharmacol 1:235-240.
92. SARTER, M., HAGAN, J. AND DUDCHENKO, P. (1992). Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I. Psychopharmacol 107:144-159.
93. SHURLEFF, D. AND AHLERS, ST. (1991). The effects of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) on delayed matching-to-sample performance in rats. Soc Neurosci Abstr 17:1397.
94. SIRVIÖ, J., RIEKKINEN, P., JÄKÄLÄ, P. AND RIEKKINEN, PJ. (1994). Experimental studies on the role of serotonin in cognition. Progress Neurobiol 43:363-379.
95. 1D receptor antagonist. Behav Brain Res 73:157-161.
96. STANHOPE, KJ., MCLENACHAN, AP. AND DOURISH, CT. (1995). Dissociation between cognitive and motor/motivational deficits in the delayed matching to position test: effects of scopolamine, 8-OH-DPAT and EAA antagonists. Psychopharmacol 122:268-280.
97. STAUBLI, U. AND OTAKY, N. (1994). Serotonin controls the magnitude of LTP induced by theta bursts via an action on NMDA-receptor-mediated responses. Brain Res 643:10-16.
98. 3 receptor antagonism on hippocampal theta rhythm, memory, and LTP induction in the freely moving rat. J Neurosci 15:2445-2452.
99. STEINBUSCH, HWM. (1984). Serotonin-immunoreactive neurons and their projections in the CNS. In: Handbook of Chemical Neuroanatomy. Vol 3: Classical Transmitters and Transmitter receptors in the CNS, Part III. A Björklund, T Hökfelt and MJ Kuhar (Eds.). pp:68-125. Elsevier, New York.
100. VAN DER KAR, LD. AND BROWNFIELD, MS. (1993). Serotonergic neurons and neuroendocrine function NIPS 8:202-207.
101. WILKINSON, L.O. AND DOURISH, C.T. (1991). Serotonin and animal behavior. In: Serotonin receptors subtypes, S.J. Peroutka (Ed). pp:147-210. Wiley-Liss, New York.
102. WINTER, J.C. AND PETTI, D.T. (1987). The effects of 8-hydroxy-2-(di-n-propylamino)tetralin and other serotonergic agonists on performance in a radial maze: A possible role for 5-HT1A receptors in memory. Pharmacol Biochem Behav 27:625-628.
103. ZHANG, B. AND HARRIS-WARRICK, RM. (1994). Multiple receptors mediate the modulatory effects of serotonergic neurons in a small neural network. J Exp Biol 190:55-77.
104. 3 receptor agonist 2-methyl-5-HT reduces postsynaptic potentials in rat CA1 pyramidal neurons of the hippocampus in vitro. Brain Res 651:337-341.
105. ZIFA, E. AND FILLION, G. (1992). 5-Hydroxytryptamine receptors. Pharmacol Rev 44:401-458.
106. ZOLA-MORGAN, S. AND SQUIRE, L.R. (1993). Neuroanatomy of memory. Ann Rev Neurosci 16:547-563.