The discovery of LY293111, a novel, potent and orally active leukotriene B4 receptor antagonist of the biphenylphenol class

Advances in Experimental Medicine and Biology

Volumn 400, Issue A, 1997, Pages 381-386

  Sofia, M J ^a   Floreancig, P ^a   Bach, N ^a   Baker, S R ^a   Nelson, K ^a   Sawyer, J S ^a   Baldwin, R ^a   Cockerham, S L ^a   Fleisch, J H ^a   Froelich, L L ^a   Jackson, W T ^a   Marder, P ^a   Roman, C R ^a   Saussy Jr , D L ^a   Silbaugh, S A ^a   Spaethe, S M ^a   Stengel, P W ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 PROPYL 3 [3 [2 ETHYL 4 (4 FLUOROPHENYL) 5 HYDROXYPHENOXY]PROPOXY]PHENOXY]BENZOIC ACID; HYDROXYBIPHENYL; LEUKOTRIENE B4 RECEPTOR;

ARACHIDONIC ACID METABOLISM; ARTHRITIS; ASTHMA; CONFERENCE PAPER; DATA ANALYSIS; ENTERITIS; ENZYME ACTIVITY; INFLAMMATORY DISEASE; PRIORITY JOURNAL; PSORIASIS;

ADMINISTRATION, ORAL; ANIMALS; BENZOATES; BENZOIC ACIDS; BRONCHOCONSTRICTION; CELL MEMBRANE; GUINEA PIGS; HUMANS; LEUKOTRIENE B4; LUNG; NEUTROPHILS; PHENOLS; RECEPTORS, LEUKOTRIENE B4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031421290     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5325-0_51     Document Type: Article

References (9)

1. Ford-Hutchinson, A.W. Crit. Rev. Immunol. 10:1-12, 1990.
2. Kingsbury, W., Daines, R. and Gleason, J. In: Comprehensive Medicinal Chemistry Vol 3 (C. Hansch, P.G. Sammes and J.B. Taylor, eds.), Pergamon Press, New York, 1990, pp. 782-796.
3. Sofia, M.J. and Silbaugh, S.A. In: Annual Reports in Medicinal Chemistry Vol 28 (Ed. J.A. Bristol), Academic Press, New York, 1993, Ch. 12.
4. Herron, D.K., Goodson, T., Bollinger, N.G., Swanson-Bean, D., Wright, I., Staten, G., Thompson, A.R., Froelich, L.L. and Jackson, W.T. J. Med. Chem. 35:1818-1828, 1992.
5. Sofia, M.J., Nelson, K., Froelich, L.L., Goodson, T., Herron, D.K., Marder, P., Saussy, D.K., Jr., Spaethe, S.M., Roman, C., Wikel, J. and Fleisch, J.H. In: Abstracts of Papers 205th Nat'l Meeting of the American Chemical Society, Washington, D.C., March 28-April 2, 1993, MEDI No.135.
6. Sofia, M.J., Jackson, W.T., Saussy, D.L., Jr., Silbaugh, S.A., Froelich, L.L., Cockerham, S.L. and Stengel, P.W. BioMed. Chem. Lett. 2:1669-1674, 1992.
7. Sofia, M.J., Floreancig, P., Jackson, W.T., Marder, P., Saussy, D.L., Jr., Silbaugh, S.A., Cockerham, S.L., Froelich, L.L., Roman, C., Stengel, P.W. and Fleisch, J.H. BioMed. Chem. Lett. 3:1147-1152.
8. Sawyer, J.S., Baldwin, R.F., Saussy, D.L., Jr., Froelich, L.L. and Jackson, W.T. BioMed. Chem. Lett. 3:1993 in press.
9. Sawyer, J.S., Baldwin, R.F., Froelich, L.L. and Jackson, W.T. BioMed. Chem. Lett. 3:1993 in press.