Acid unit modifications of 1,2,4,5-substituted hydroxyacetophenones and the effect on in vitro and in vivo LTB4 receptor antagonism

Bioorganic and Medicinal Chemistry Letters

Volumn 3, Issue 6, 1993, Pages 1147-1152

  Sofia, Michael J ^a   Floreancig, Paul ^a   Jackson, William T ^a   Marder, Philip ^a   Saussy Jr , David L ^a   Silbaugh, Steven A ^a   Cockerham, Sandra L ^a   Froelich, Larry L ^a   Roman, Carlos R ^a   Stengel, Peter W ^a   Fleisch, Jerome H ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 ETHYL 2 HYDROXY 4 [6 METHYL 6 (1H TETRAZOL 5 YL)HEPTYLOXY]ACETOPHENONE; 7 [3 (4 ACETYL 2 ETHYL 5 HYDROXYPHENOXY)PROPOXY] 3,4 DIHYDRO 8 PROPYL 2H 1 BENZOPYRAN 2 CARBOXYLIC ACID; 7 [3 (4 ACETYL 3 METHOXY 2 PROPYLPHENOXY)PROPOXY] 3,4 DIHYDRO 8 PROPYL 2H 1 BENZOPYRAN 2 CARBOXYLIC ACID; ACETOPHENONE DERIVATIVE; LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LY 247826; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; LUNG; NEUTROPHIL; NONHUMAN; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION;

EID: 0027273762     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)80304-2     Document Type: Article

References (37)

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2. Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids