Feeding mice palm carotene prevents DNA damage in bone marrow and reduction of peripheral leukocyte counts, and enhances survival following X-ray irradiation

Carcinogenesis

Volumn 18, Issue 10, 1997, Pages 1943-1947

  Umegaki, Keizo ^a   Uramoto, Hiromi ^a   Suzuki, Junko ^a   Esashi, Takatoshi ^a  

^a NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CAROTENE; BETA CAROTENE; CAROTENE;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CONTROLLED STUDY; DIET; DNA DAMAGE; LEUKOCYTE COUNT; LIVER LEVEL; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; X IRRADIATION;

ANIMALS; BETA CAROTENE; BONE MARROW; CAROTENOIDS; DNA DAMAGE; MALE; MICE; MICE, INBRED ICR; RADIATION INJURIES, EXPERIMENTAL; RETICULOCYTES; WHOLE-BODY IRRADIATION;

EID: 0031417970     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.10.1943     Document Type: Article

References (38)

1. Negri, E., La Vecchia, C., Franceschi, S., D'Avanzo, B. and Parazzini, F. (1991) Vegetable and fruit consumption and cancer risk. Int. J. Cancer, 48, 350-354.
2. Peto, R., Doll, R., Buckley, J.D. and Sporn, M.B. (1981) Can dietary beta-carotene materially reduce human cancer rates? Nature, 290, 201-208.
3. Ziegler, R.G. (1989) A review of the epidemiological evidence that carotenoids reduce the risk of cancer. J. Nutr., 119, 116-122.
4. Ames, BN, Shigenaga, MK, and Hagen, TM. (1993) Oxidants, anti-oxidants, and the degenerative diseases of aging. Proc. Natl Acad. Sci. USA, 90, 7915-7922.
5. Frankel, K. (1989) Oxidation of DNA bases by tumor promoter-activated processes. Environ. Hlth Perspect., 81, 45-54.
6. Burton, G.W. and Ingold, K.U. (1984) β-carotene: unusual type of lipid antioxidant. Science, 224, 569-573.
7. Terao, J. (1989) Antioxidant activity of β-carotene-related carotenoids in solution. Lipids, 24, 659-661.
8. Mascio, P.D., Kaaiser, S. and Sies, H. (1989) Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch. Biochem. Biophys., 274, 532-538.
9. Renner, H.W. (1995) Anticlastogenic effect of β-carotene in Chinese hamsters. Time and dose-response studies with different mutagens. Mutat. Res., 144, 251-256.
10. Mukherjee, A., Agarwal, K., Aguilar, M.A. and Sharma, A. (1991) Anticlastogenic activity of β-carotene against cyclophosphamide in mice in vivo. Mutat. Res., 263, 41-46.
11. Aidoo, A., Lyn-Cook, L.E., Lensing, S. and Wamer, W. (1995) In vivo antimutagenic activity of beta-carotene in rat spleen lymphocytes. Carcinogenesis, 16, 2237-2241.
12. Uehara, N., Iwahori, Y., Asamoto, M., et al. (1996) Decrease levels of 2-amino-3-methlyimidazo[4,5-f]quinoline-DNA adducts in rats treated with β-carotene, α-tocopherol and freeze-dried aloe. Jpn. J. Cancer Res., 87, 324-348.
13. Sarker, A., Mukjerjee, B. and Chetterjee, M. (1994) Inhibitory effect of β-carotene on chronic 2-acetylaminofluorene-induced hepatocarcinogenesis in rat: reflection in hepatic drug metabolism. Carcinogenesis, 15, 1055-1060.
14. Basu, T.K., Temple, N.J. and Ng, J. (1987) Effect of dietary β-carotene on hepatic drug-metabolizing enzymes in mice. J. Clin. Biochem. Nutr., 3, 95-102.
15. Kasai, H., Crain, P.F., Kuchino, Y., Nishimura, S., Ootsuyama, A. and Tanooka, H. (1986) Formation of 8-hydroxydeoxyguanosine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis, 7, 1849-1851.
16. Umegaki, K. and Ichikawa, T. (1994) Decrease in vitamin E levels in the bone marrow of mice receiving whole-body X-ray irradiation. Free Radic. Biol. Med., 17, 439-444.
17. Umegaki, K., Aoki, S. and Esashi, T. (1995) Whole body X-ray irradiation to mice decreases ascorbic acid concentration in bone marrow: Comparison between ascorbic acid and vitamin E. Free Radic. Biol. Med., 19, 493-497.
18. Umegaki, K., Itoh, T. and Ichikawa, T. (1994) Effect of vitamin E on chromosomal damage inbone marrow cells of mice having received low dose of X-ray irradiation. Int. J. Vit. Nutr. Res., 64, 249-252.
19. Ziegler, R.G., Colavito, E.A., Hartge, P., McAdams, M.J., Schoenberg, J.B., Mason, T.J. and Fraumeni, J.F.Jr. (1996) Importance of α-carotene, β-carotene, and other phytochemicals in the etiology of lung cancer. J. Natl Cancer Inst., 88, 612-615.
20. Murakoshi, M., Nishino, H., Satomi, Y. et al. (1992) Potent preventive action of α-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by α-carotene than by β-carotene. Cancer Res., 52, 6583-6587.
21. Umegaki, K., Hirota, S., Aoshima, M., Aoki, S. and Esashi, T. (1995) Feeding of palm oil carotene to mice did not modify X-ray-induced chromosomal damage in bone marrow cells. J. Nutr. Sci. Vitaminol., 41, 33-43.
22. Krinsky, N.I. (1989) Carotenoids and cancer in animal models. J. Nutr., 119, 123-126.
23. Xu, M.J., Plezia, P.M., Alberts, D.S., Emerson, S.S., Peng, Y.M., Sayers, S.M., Liu, Y., Ritenbaugh, C. and Gensler, H.L. (1992) Reduction in plasma or skin alpha-tocopherol concentration with long-term oral administration of beta-carotene in humans and mice. J. Natl Cancer Inst., 84, 1559-1565.
24. Lambert, L.A., Wamer, W.G., Wei, R.R., Lavu, S., Chirtel, S.J. and Kornhauser, A. (1994) The protective but not synergistic effect of dietary β-carotene and vitamin E on skin tumorigenesis in Skh mice. Nutr. Cancer, 21, 1-12.
25. Umegaki, K., Takeuchi, N., Ikegami, S. and Ichikawa, T. (1994) Effect of β-carotene on spontaneous and X-ray-induced chromosomal damage in bone marrow cells of mice. Nutr. Cancer, 22, 277-284.
26. Umegaki, K., Aoshima, M., Hirota, S., Uramoto, H. and Esashi, T. (1995) Simultaneous dietary supplementation of sodium cholate and beta-carotene markedly enhances accumulation of beta-carotene in mice. J. Nutr., 125, 3081-3086.
27. Mokrasch, L.C. and Teschke, E.J. (1984) Glutathione content of cultured cells and rodent brain regions: a specific fluorometric assay. Anal. Biochem., 140, 506-509.
28. Poor, C.L., Bierer, T.L., Merchen, N.R., Fahey, G.C.Jr, Murphy, M.R. and Erdman, J.W., Jr (1992) Evaluation of the preruminant calf as a model for the study of human carotenoid metabolism. J. Nutr. 122, 262-268.
29. Prise, K.M., Davies, S. and Michael, B.D. (1992) A comparison of the chemical repair rates of free radical precursors of DNA damage and cell killing in Chinese hamster V79 cells. Int. J. Radiat. Biol., 61, 721-728.
30. Hall, E.J. (1994). Radiobiology for the Radiologist, 4th edn. J.B. Lippincott, Philadelphia.
31. Abraham, S.K., Sarma, L. and Kesavan, P.C. (1993) Protective effects of chlorogenic acid, curcumin and β-carotene against γ-radiation-induced in vivo chromosomal damage. Mutat. Res., 303, 109-112.
32. Seifter, E., Rettura, G., Padawer, J., Stratford, F., Weinzweig, J., Demetriou, A.A. and Levenson, S.M. (1984) Morbidity and mortality reduction by supplementation vitamin A or β-carotene in CBA mice given total-body γ-radiation. J. Natl Cancer Inst., 73, 1167-1177.
33. Jones, C.S., Sly, L., Chen, L.-C., Ben, T., Brughcollins, M., Lichti, U. and DeLuca, L.M. (1994) Retinol and β-carotene concentrations skin, papillomas and carcinomas, liver, and serum of mice fed retinoic acid or β-carotene to suppress skin tumor formation. Nutr. Cancer, 21, 83-93.
34. Maiani, G., Pappaardo, G., Ferro-Luzzi, A., Azzini, R.E., Guadalaxara, A., Trifero, M., Frommel, T. and Mobarhan, S. (1995) Accumulation of β-carotene in normal colorectal mucosa and colonie neoplastic lesions in humans. Nutr. Cancer, 24, 23-31.
35. Cratas, C., Menot, M.L., Dresch, C. and Chomienne, C. (1993) Retinoid acid supports granulocytic but not erythroid differentiation of myeloid progenitors in normal bone marrow cells. Leukemia, 7, 1156-1162.
36. Brevard, P.B. (1993) Beta-carotene increase monocyte numbers in peripheral rat blood. Int. J. Vit. Nutr. Res., 63, 21-25.
37. Mayne, S.T. (1996) Beta-carotene, carotenoids, and disease prevention in humans. FASEB J., 10, 690-701.
38. Kennedy, A.R. and Krinsky, N.I. (1994) Effects of retinoids, β-carotene and canthaxanthin on UV-and X-ray-induced transformation of C3H10T1/2 cells in vitro. Nutr. Cancer, 22, 219-232.