Anti-carcinogenic activity of simvastatin during the promotion phase of radiation-induced mammary tumorigenesis of rats

Carcinogenesis

Volumn 18, Issue 9, 1997, Pages 1723-1727

  Inano, Hiroshi ^a   Suzuki, Keiko ^a   Onoda, Makoto ^a   Wakabayashi, Katsumi ^b  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60; DIETHYLSTILBESTROL; ESTRADIOL; PROLACTIN; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; BREAST CARCINOGENESIS; CANCER INCIDENCE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; RADIATION CARCINOGENESIS; RAT; TUMOR PROMOTION; WHOLE BODY RADIATION;

ADMINISTRATION, ORAL; ANIMALS; ANTICARCINOGENIC AGENTS; CHOLESTEROL; FEMALE; GONADAL STEROID HORMONES; IMMUNOHISTOCHEMISTRY; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASMS, RADIATION-INDUCED; PITUITARY GLAND; PREGNANCY; PROLACTIN; RATS; RATS, WISTAR; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; SIMVASTATIN; TRIGLYCERIDES;

EID: 0031409639     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.9.1723     Document Type: Article

References (29)

1. Alberts, A.W., Chen, J., Kuron, G., Hunt, V., Huff, J., Hoffman, C., Rothrock, J., Lopez, M., Joshua, H., Harris, E., Patchett, A., Monaghan, R., Currie, S., Stapley, E., Albers-Schonberg, G., Hensens, O., Hirshfield, J., Hoogsteen, K., Liesch, J. and Springer, J. (1980) Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc. Natl Acad. Sci. USA, 77, 3957-3961.
2. Puppo, M.D., Rauli, S. and Kienle, M.G. (1995) Inhibition of cholesterol synthesis and hepatic 3-hydroxy-3-methylglutaryl-CoA reductase in rats by simvastatin and pravastatin. Lipids, 30, 1057-1061.
3. Khan, S.G., Saxena, R., Bickers, D.R., Mukhtar, H. and Agarwal, R. (1995) Inhibition of ras p21 membrane localization and modulation of protein kinase c isozyme expression during regression of chemical carcinogen-induced murine skin tumours by lovastatin. Mol. Carcinogenesis, 12, 205-212.
4. Girgert, R., Marini, P., Janssa, A., Bruchelt, G., Treuner, J. and Schweizer, P. (1994) Inhibition of the membrane localization of p21ras proteins by lovastatin in tumour cells possessing a mutated N-ras gene. Oncology, 51, 320-322.
5. Addeo, R., Altucci, L., Battista, T., Bonapace, IM., Cancemi, M., Cicatiello, L., Germano, D., Pacilio, C., Salzano, S., Bresciani, F. and Weisz, A. (1996) Stimulation of human breast cancer MCF-7 cells with oestrogen prevents cell cycle arrest by HMG-CoA reductase inhibitors. Biochem. Biophys. Res. Commun., 220, 864-870.
6. Kyprianou, N., English, H.F., Davidson, N.E. and Isaacs, J.T. (1991) Programmed cell death during regression of the MCF-7 human breast cancer following oestrogen ablation. Cancer Res., 51, 162-166.
7. Inano, H., Suzuki, K., Ishii-Ohba, H., Yamanouchi, H. Takahashi, M. and Wakabayashi, K. (1993) Promotive effects of diethylstilbestrol, it metabolite (Z,Z-dienestrol) and a stereoisomer of the metabolite (E,E-dienestrol) in tumorigenesis of rat mammary glands pregnancy-dependently initiated with the radiation. Carcinogenesis, 14, 2157-2163.
8. Inano, H., Suzuki, K., Onoda, M. and Yamanouchi, H. (1996) Susceptibility of fetal, virgin, pregnant, lactating rats for the induction of mammary tumours by gamma rays. Radiat. Res., 145, 708-713.
9. Iball, J. (1939) The relative potency of carcinogenic compounds. Am. J. Cancer, 35, 188-190.
10. Watanabe, G., Taya, K. and Sasamoto, S. (1990) Dynamics of ovarian inhibin secretion during the oestrous cycle of the rat. J. Endocrinol., 126, 151-157.
11. Rothschild, T.C., Boylan, E.S., Calhoon, R.E. and Vonderhaar, B.K. (1987) Transplacental effects of diethylstilbestrol on mammary development and tumorigenesis in female ACI rats. Cancer Res., 47, 4508-4516.
12. Young, S. and Hallowes, R.C. (1973) Tumours of the mammary glands. In Turusov, V.S. (ed.) Pathology of Tumours in Laboratory Animals, Vol. I Tumours of the Rat, Part 1, IARC Scientific Publication 5. IARC, Lyon, pp. 31-55.
13. Johnson, R.B., Nakamura, R.M. and Libby, R.M. (1975) Simplified Scatchard plot assay for oestrogen receptor in human breast cancer. Clin. Chem., 21, 1725-1730.
14. Johnson, R.B. and Nakamura, R.M. (1978) Simplified Scatchard plot assay for progesterone receptor in breast cancer: comparison with single-point and multipoint assay. Clin. Chem., 24, 1170-1176.
15. Scatchard, G. (1949) The attractions of proteins for small molecules and ions. Ann. NY Acad. Sci. USA, 51, 660-672.
16. Inano, H., Ishii-Ohba, H., Suzuki, K., Yamanouchi, H., Onoda, M. and Wakabayashi, W. (1995) Chemoprevention by dietary dehydroepiandrosterone against promotion/progression phase of radiation-induced mammary tumorigenesis in rats. J. Steroid Biochem. Mol. Biol., 54, 47-53.
17. Inano, H., Suzuki, K. and Wakabayashi, K. (1996) Chemoprevention of radiation-induced mammary tumours by bezafibrate administered together with diethylstilbestrol as promoter. Carcinogenesis, 17, 2641-2646.
18. Dandekar, S., Sukumar, S., Zarbl, H., Young, L.J.T. and Cardiff, R.D. (1986) Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumours. Mol. Cell. Biol., 6, 4104-4108.
19. Zarbl, H., Sukumar, S., Arthur, A.V., Martin-Zanca, D. and Barbacid, M. (1985) Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature (Land.), 315, 382-385.
20. Ohuchi, N., Thor, A., Page, D.L., Hand, P.H., Halter, S.A. and Schlom, J. (1986) Expression of the 21,000 molecular weight ras protein in a spectrum of benign and malignant human mammary tissues. Cancer Res., 46, 2511-2519.
21. Hancock, J.F., Magee, A.I., Childs, J.E. and Marshall, C.J. (1989) All ras proteins are polyisoprenylated but only some are palmitoylated. Cell, 57, 1167-1177.
22. Goldstein, J.L. and Brown, M.S. (1990) Regulation of the mevalonate pathway. Nature (Lond.), 343, 425-430.
23. Ura, H., Obara, T., Nishino, N., Tanno, S., Okamura, K. and Namiki, M. (1994) Cytotoxicity of simvastatin to pancreatic adenocarcinoma cells containing mutant ras gene. Jpn. J. Cancer Res. 85, 633-638.
24. Larsson, O. and Blegen, H. (1993) Regulatory role of mevalonate in the growth of normal and neoplastic human mammary epithelial cells. Anticancer Res., 13, 1075-1080.
25. Singer, I.I., Kawka, D.W., Kazazis, D.M., Alberts, A.W., Chen, J.S., Huff, J.W. and Ness, G.C. (1984) Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers. Proc. Natl Acad. Sci. USA, 81, 5556-5560.
26. Clarke, C.F., Edwards, P.A., Lan, S-F., Tanaka, R.D. and Fogelman, A.M. (1983) Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver. Proc. Natl Acad. Sci. USA, 80, 3305-3308.
27. Edwards, P.A., Lan, S.-F. and Fogelman, A.M. (1983) Alterations in the rates of synthesis and degradation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase produced by cholestyramine and mevinolin. J. Biol. Chem., 258, 10219-10222.
28. DeClue, J.E., Vass, W.C., Papageorge, A.G., Lowy, D.R. and Willumsen, B.M. (1991) Inhibition of cell growth by lovastatin is independent of ras function. Cancer Res., 51, 712-717.
29. Bonapace, I.M., Addeo, R., Altucci, L., Ciatiello, L., Bifulco, M., Laezza, C., Salzano, S., Sica, V., Bresciani, F. and Weiz, A. (1996) 17β-Estradiol overcomes a G1 block induced by HMG-CoA reductase inhibitors and fosters cell cycle progression without inducing ERK-1 and -2 MAP kinases activation. Oncogene, 12, 753-776.