Chemoprevention of radiation-induced mammary tumors in rats by bezafibrate administered together with diethylstilbestrol as a promoter

Carcinogenesis

Volumn 17, Issue 12, 1996, Pages 2641-2646

  Inano, Hiroshi ^a   Suzuki, Keiko ^a   Wakabayashi, Katsumi ^b  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BEZAFIBRATE; CHOLESTEROL ESTER; DIETHYLSTILBESTROL; ESTRADIOL; PROLACTIN; THYROTROPIN; TRIACYLGLYCEROL; TUMOR PROMOTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST DEVELOPMENT; CANCER PREVENTION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; HORMONE BLOOD LEVEL; HYPOPHYSIS TUMOR; LIPID BLOOD LEVEL; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; RADIATION CARCINOGENESIS; RAT; THYROTROPIN BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTILIPEMIC AGENTS; BEZAFIBRATE; CARCINOGENS; DIETHYLSTILBESTROL; FEMALE; GONADAL STEROID HORMONES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASMS, RADIATION-INDUCED; PREGNANCY; PROLACTIN; RATS; RATS, WISTAR; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE;

EID: 0030449820     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.12.2641     Document Type: Article

References (31)

1. Yuan,J-M., Wang,Q-S, Ross,R.K., Henderson,B.E. and Yu,M.C. (1995) Diet and breast cancer in Shanghai and Tianjin, China. Br. J. Cancer, 71, 1353-1358.
2. Gaard,M., Tretli,S. and Loken,E.B. (1995) Dietary fat and the risk of breast cancer: A prospective study of 25 892 Norwegian women. Int. J. Cancer, 63, 13-17.
3. Welsch,C.W. (1992) Relationship between dietary fat and experimental mammary tumorigenesis: A review and critique. Cancer Res., 52, 2040s-2048s.
4. Lu,J., Jiang,C., Fontains,S. and Thompson,H.J. (1995) ras may mediate mammary cancer promotion by high fat. Nutr. Cancer, 23, 283-290.
5. Cohen,L.A., Thompson,D.O., Maeura,Y., Choi,K., Blank,M.E. and Rose,D.P. (1986) Dietary fat and mammary cancer I. Promoting effects of different dietary fats on N-nitrosomethylurea-induced rat mammary tumorigenesis. J. Natl Cancer Inst., 77, 33-42.
6. Alegret,M.A., Cerqueda,E., Ferrando,R., Vazquez,M., Sanchez,R.M., Adzet,T., Merlos,M. and Laguna,J.C. (1995) Selective modification of rat hepatic microsomal fatty acid chain elongation and desaturation by fibrates: Relationship with peroxisome proliferation. Br. J. Pharmacol., 114, 1351-1358.
7. Shand,J.H. and West,D.W. (1994) The effects of clofibrate and bezafibrate on cholesterol metabolism in the liver of the male rat. Lipids, 29, 747-752.
8. 60Co-irradiation. Carcinogenesis, 12, 1085-1090.
9. Inano,H., Suzuki,K., Ishii-Ohba,H., Yamanouchi,H., Takahashi,M. and Wakabayashi,K. (1993) Promotive effects of diethylstilbestrol, its metabolite (Z,Z-dienestrol) and a stereoisomer of the metabolite (E,E-dienestrol) in tumorigenesis of rat mammary glands pregnancy-dependently initiation with radiation. Carcinogenesis, 14, 2157-2163.
10. Holtzman,S., Stone,J.P. and Shellabarger,C.J. (1979) Synergism of diethylstilbestrol and radiation in mammary carcinogenesis in female F344 rats. J. Natl Cancer Inst., 63, 1071-1074.
11. Sumi,C., Yokoro,K. and Matsushima,R. (1983) Suppression of diethylstilbestrol and N-nitrosobutylurea-induced mammary and pituitary tumorigenesis in rats by prolonged treatment with 2-bromoergocryptine. Cancer Res., 43, 4781-4785.
12. Castoldi,D., Monzani,V. and Tofanetti,O. (1985) Determination of bezafibrate in human plasma and urine by high-performance liquid chromatography. J. Chromatog., 344, 259-265.
13. Rothschild,T.C., Boylan,E.S., Calhoon,R.E. and Vonderhaar,B.K. (1987) Transplacental effects of diethylstilbestrol on mammary development and tumorigenesis in female ACI rats. Cancer Res., 47, 4508-4516.
14. World Health Organization (1981) Histological typing of breast tumors. 2nd edn. WHO, Geneva, pp. 15-25.
15. Johnson,R.B., Nakamura,R.M. and Libby,R.M. (1975) Simplified Scatchard plot assay for estrogen receptor in human breast tumor. Clin. Chem., 21, 1715-1730.
16. Johnson,R.B. and Nakamura,R.M. (1978) Simplified Scatchard plot assay for progesterone receptor in breast cancer: comparison with single-point and multipoint assay. Clin. Chem., 24, 1170-1176.
17. Scatchard,G. (1949) The attractions of proteins for small molecules and ions. Ann. N. Y. Acad. Sci. USA, 51, 660-672.
18. Watanabe,G., Taya,K. and Sasamoto,S. (1990) Dynamics of ovarian inhibin secretion during the oestrous cycle of the rat. J. Endocrinol., 126, 151-157.
19. Iball,J. (1939) The relative potency of carcinogenic compounds. Am. J. Cancer, 35, 188-190.
20. Hirst,D.G., Wood,P.J. and Schwartz,H.C. (1987) The modification of hemoglobin affinity for oxygen and tumor radiosensitivity by antilipidemic drugs. Radiat. Res., 112, 164-172.
21. Inano,H., Ishii-Ohba,H., Suzuki,K., Yamanouchi,H., Onoda,M. and Wakabayashi,K. (1995) Chemoprevention by dietary dehydroepiandrosterone against promotion/progression phase of radiation-induced mammary tumorigenesis in rats. J. Steroid Biochem. Mol. Biol., 54, 47-53.
22. Mulligan,H.D. and Tisdale,M.J. (1991) Effect of the lipid-lowering agent bezafibrate on tumor growth rate in vivo. Br. J. Cancer, 64, 1035-1038.
23. Gammal,E.B., Carroll,K.K. and Plunkett,E.R. (1967) Effects of dietary fat on mammary carcinogenesis by 7,12-dimethylbenz[a]anthracene in rats. Cancer Res., 27, 1737-1742.
24. Vessby,B. and Lithell,H. (1990) Interruption of long-term lipid-lowering treatment with bezafibrate in hypertriglyceridaemic patients. Effects on lipoprotein composition, lipase activities and the plasma lipid fatty acid spectrum. Atherosclerosis, 82, 137-143.
25. Ip,C., Carter,C.A. and Ip,M.M. (1985) Requirement of essential fatty acid for mammary tumorigenesis in the rat. Cancer Res., 45, 1997-2001.
26. Fischer,S.M., Leyton,J., Lee,M.L., Locniskar,M., Belury,M.A., Maldve,R.E., Slaga,T.J. and Bechtel,D.H. (1992) Differential effects of dietary linoleic acid on mouse skin-tumor promotion and mammary carcinogenesis. Cancer Res., 52, 2049s-2054s.
27. Rose,D.P. and Connolly,J.M. (1990) Effects of fatty acids and inhibitors of eicosanoid synthesis on the growth of a human breast cancer cell line in culture. Cancer Res., 50, 7139-7144.
28. Hillyard,L.A. and Abraham,S. (1979) Effect of dietary polyunsaturated fatty acids on growth of mammary adenocarcinomas in mice and rats. Cancer Res., 39, 4430-4437.
29. Abraham,S. and Hillyard,L.A. (1983) Effect of dietary 18-carbon fatty acids on growth of transplantable mammary adenocarcinomas in mice. J. Natl Cancer Inst., 71, 601-605.
30. Rao,G.A. and Abraham,S. (1977) Reduced growth rate of transplantable mammary adenocarcinoma in C3H mice fed eicosa-5,8,11,14-tetraynoic acid. J. Natl Cancer Inst., 58, 445-447.
31. Stahlberg,D., Angelin,B. and Einarsson,K. (1989) Effects of treatment with clofibrate, bezafibrate and ciprofibrate on the metabolism of cholesterol in rat liver microsomes. J. Lipid Res., 30, 953-958.