Platelet membrane phosphatidylinositol-4,5-bisphosphate alterations in bipolar disorder - Evidence from a single case study

Psychiatry Research

Volumn 69, Issue 2-3, 1997, Pages 197-202

  Soares, Jair C ^a   Dippold, Christine S ^a   Mallinger, Alan G ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Bipolar disorder; Neuropharmacology; Pathophysiology; Phosphoinositides; Platelets; Signal transduction

Indexed keywords

LITHIUM; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE;

ADULT; ARTICLE; BIPOLAR DEPRESSION; CASE REPORT; FEMALE; HUMAN; MANIA; PRIORITY JOURNAL; THROMBOCYTE;

EID: 0030889081     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(96)03022-3     Document Type: Article

References (38)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders. 4th edn. American Psychiatric Press, Washington, D.C.
2. Avissar, S. and Schreiber, G. (1992) Ziskind-Somerfeld research award. The involvement of guanine nucleotide binding proteins in the pathogenesis and treatment of affective disorders. Biol Psychiatry 31, 435-459.
3. Baraban, J.M., Worley, P.F. and Snyder, S.H. (1989) Second messenger systems and psychoactive drug action: focus on the phosphoinositide system and lithium. Am J Psychiatry 146, 1251-1260.
4. Bech, P., Bolwig, P.G., Kromp, P. and Rafaelsen, O.J.(1979) The Bech-Rafaelsen Mania Scale and the Hamilton Depression Scale. Acta Psychiatr Scand 59, 420-430.
5. Berk, M., Bodemer, W., van Oudenhove, T. and Butkow, N. (1994) Dopamine increases platelet intracellular calcium in bipolar affective disorder and controls. Int Clin Psychopharmacol 9, 291-293.
6. Berk, M., Bodemer, W., Oudenhove, T.V. and Butkow, N. (1995) The platelet intracellular calcium response to serotonin is augmented in bipolar manic and depressed patients. Hum Psychopharmacol 10, 189-193.
7. Brown, A.S., Mallinger, A.G. and Renbaum, L.C. (1993) Elevated platelet membrane phosphatidylinositol-4,5-bisphosphate in bipolar mania. Am J Psychiatry 150, 1252-1254.
8. Deicken, R.F., Fein, G. and Weiner, M.W. (1995a) Abnormal frontal lobe phosphorus metabolism in bipolar disorder. Am J Psychiatry 152, 915-918.
9. Deicken, R.F., Weiner, M.W. and Fein, G. (1995b) Decreased temporal lobe phosphomonoesters in bipolar disorder. J Affect Disord 33, 195-199.
10. Dubovsky, S.L., Christiano, C., Daniell, L.C., Franks, R.D., Murphy, J., Adler, L., Baker, N. and Harris, R.A. (1989) Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch Gen Psychiatry 46, 632-638.
11. Dubovsky, S.L., Lee, C., Christiano, J. and Murphy, J. (1991) Elevated platelet intracellular calcium concentration in bipolar depression. Biol Psychiatry 29, 441-450.
12. Dubovsky, S.L., Murphy, J. and Christiano, J. (1992a) The calcium second messenger system in bipolar disorders: data supporting new research directions. J Neuropsychiatry Clin Neurosci 4, 3-14.
13. Dubovsky, S.L., Murphy, J., Thomas, M. and Rademacher, J. (1992b) Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am J Psychiatry 149, 118-120.
14. Dubovsky, S.L., Thomas, M., Hijazi, A. and Murphy, J. (1994) Intracellular calcium signalling in peripheral cells of patients with bipolar affective disorder. Eur Arch Psychiatry Clin Neurosci 243, 229-234.
15. Endicott, J. and Spitzer, R.L. (1978) A diagnostic interview; the Schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatry 35, 837-844.
16. Friedman, E., Yan-Wang, H., Levinson, D., Connell, T.A. and Singh, H. (1993) Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. Biol Psychiatry 33, 520-525.
17. Hudson, C.J., Young, L.T., Li, P.P. and Warsh, J.J. (1993) CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia. Synapse 13, 278-293.
18. Kato, T., Shioiri, T., Takahashi, S. and Inubushi, T. (1991) Measurement of brain phosphoinositide metabolism in bipolar patients. J Affect Disord 22, 185-190.
19. Kato, T., Takahashi, S., Shioiri, T. and Inubushi, T. (1992) Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy. J Affect Disord 26, 223-230.
20. Kato, T., Takahashi, S., Shioiri, T. and Inubushi, T. (1993) Alterations in brain phosphorous metabolism in bipolar disorder. J Affect Disord 27, 53-59.
21. Kato, T., Shioiri, T., Murashita, J., Hamakawa, H., Inubushi, T. and Takahashi, S. (1994a) Phosphorus-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder. Psychiatry Res 55, 41-50.
22. Kato, T., Takahashi, S., Shioiri, T., Murashita, J., Hamakawa, H. and Inubushi, T. (1994b) Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. J Affect Disord 31, 125-133.
23. 31P-MRS. Psychol Med 25, 557-566.
24. Kusumi, I., Koyama, T. and Yamashita, I. (1992) Thrombin-induced platelet calcium mobilization is enhanced in bipolar disorders. Biol Psychiatry 32, 731-734.
25. Lachman, H.M. and Papolos, D.F. (1989) Abnormal signal transduction: a hypothetical model for bipolar affective disorder. Life Sci 45, 1413-1426.
26. Lenox, R.H. and Watson, D.G. (1994) Lithium and the brain: a psychopharmacological strategy to a molecular basis of manic depressive illness. Clin Chem 40, 309-314.
27. Mallinger, A.G., Yao, J.K., Brown, A.S. and Dippold, C.S. (1993) Analysis of complex mixtures of phospholipid classes from cell membranes using two-dimensional thin-layer chromatography and scanning laser densitometry. J Chromatrogr 614, 67-75.
28. Manji, H.K., Potter, W.Z. and Lenox, R.H. (1995a) Signal transduction pathways - molecular targets for lithium's actions. Arch Gen Psychiatry 52, 531-543.
29. Manji, H.K., Chen, G., Shimon, H., Hsiao, J.K., Potter, W.Z. and Belmaker, R.H. (1995b) Guanine nucleotide-binding proteins in bipolar affective disorder. Effects of long-term lithium treatment. Arch Gen Psychiatry 52, 135-144.
30. Okamoto, Y., Kagaya, A., Shinno, H., Motohashi, N. and Yamawaki, S. (1995) Serotonin-induced platelet calcium mobilization is enhanced in mania. Life Sci 56, 327-332.
31. Schreiber, G., Avissar, S., Danon, A. and Belmaker, R.H. (1991) Hyperfunctional G proteins in mononuclear leukocytes of patients with mania. Biol Psychiatry 29, 273-280.
32. Snyder, S.H. (1992) Second messengers and affective illness -focus on the phosphoinositide cycle. Pharmacopsychiatry 25, 25-28.
33. Soares, J.C. and Mallinger, A.G. (1996) Abnormal phosphatidylinositol (PI)-signalling in bipolar disorder. Biol Psychiatry 39, 461-462.
34. Wachtel, H. (1989) Dysbalance of neuronal second messenger function in the aetiology of affective disorders: a pathophysiological concept hypothesizing defects beyond first messenger receptors. J Neural Transm 75, 21-29.
35. Wachtel, H. (1990) The second-messenger dysbalance hypothesis of affective disorders. Pharmacopsychiatry 23, 27-32.
36. Young, L.T., Li, P.P., Kish, S.J., Siu, K.P. and Warsh, J.J. (1991) Postmortem cerebral cortex Gs alpha-subunit levels are elevated in bipolar affective disorder. Brain Res 553, 323-326.
37. Young, L.T., Li, P.P., Kish, S.J., Siu, K.P., Kamble, A., Hornykiewicz, O. and Warsh, J.J. (1993) Cerebral cortex Gs alpha protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder. J Neurochem 61, 890-898.
38. Young, L.T., Li, P.P., Kamble, A., Siu, K.P. and Warsh, J.J. (1994) Mononuclear leukocyte levels of G proteins in depressed patients with bipolar disorder or major depressive disorder. Am J Psychiatry 151, 594-596.