Prediction of in vivo drug interaction from in vitro systems exemplified by interaction between verapamil and cimetidine using human liver microsomes and primary hepatocytes

Journal of Clinical Pharmacology

Volumn 37, Issue 12, 1997, Pages 1150-1159

  Fischer, Ulrike ^a   Rohde, Beate ^a   Wacke, Rainer ^a   Stange, Fan ^a   Nitschke, Frank P ^a   Adam, Ulrich ^a   Drewelow, Bernd ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE; CIMETIDINE; CYTOCHROME P450; DRUG METABOLITE; METHANOL; NORVERAPAMIL; REAGENT; SODIUM DIHYDROGEN PHOSPHATE; SULFONIC ACID DERIVATIVE; VERAPAMIL;

ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG INHIBITION; DRUG METABOLISM; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER MICROSOME; PREDICTION;

EID: 0031405609     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1997.tb04300.x     Document Type: Article

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