Specific inhibitor for bitter taste: Inhibition of frog taste nerve responses and human taste sensation to bitter stimuli

Brain Research Protocols

Volumn 1, Issue 3, 1997, Pages 292-298

  Katsuragi, Y ^b   Kashiwayanagi, M ^a   Kurihara, K ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b KAO CORPORATION   (Japan)

Author keywords

Lactoglobulin; Bitterness inhibitor; Frog taste nerve; Human taste sensation; Liporotein; Neurophysiology; Phosphatidic acid

Indexed keywords

ACETIC ACID; ALANINE; AURANTIIN; BERBERINE; BETA LACTOGLOBULIN; BRUCINE; CAFFEINE; DENATONIUM BENZOATE; GALACTOSE; LEUCINE; PAPAVERINE; PHENYLALANINE; PHOSPHATIDIC ACID; PROMETHAZINE; PROPRANOLOL; QUININE; SODIUM CHLORIDE; STRYCHNINE; THEOPHYLLINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FROG; GLOSSOPHARYNGEAL NERVE; HUMAN; HUMAN EXPERIMENT; METHODOLOGY; NEUROPHYSIOLOGY; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; STIMULATION; TASTE;

ANIMALS; ELECTROPHYSIOLOGY; GLOSSOPHARYNGEAL NERVE; HUMANS; LACTOGLOBULINS; LIPOPROTEINS; NEURAL INHIBITION; PHOSPHATIDIC ACIDS; RANA CATESBEIANA; STIMULATION, CHEMICAL; TASTE;

EID: 0031403096     PISSN: 1385299X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1385-299X(97)00002-0     Document Type: Article

References (18)

1. Bartoshuk, L.M., The psychophysics of taste, Am. J. Clin. Nutr., 31 (1978) 1068-1077.
2. Beets, M.G.J., Structure-Activity Relationships in Human Chemoreception, Applied Science Publishers, New York, 1974, pp. 259-344.
3. + chanels in Necturus taste cells; modulation by intracellular factors and taste stimuli, J. Gen. Physiol., 99 (1992) 591-613.
4. Hwang, P.M., Verma, A., Bredt, D.S. and Synder, S.H., Localization of phosphatidyl inositol signaling components in rat taste cells: role in bitter taste transduction, Proc. Natl. Acad. Sci. USA, 87 (1990) 7395-7399.
5. Katsuragi, Y. and Kurihara, K., Specific inhibitor for bitter taste, Nature, 365 (1993) 213-214.
6. Katsuragi, Y. and Kurihara, K., Specific inhibitor for bitter taste. In G.M. Roy (Ed.), Modifying Bitterness: Mechanism, Ingredient, and Applications, Technomic Publishing Co., Lancaster, 1997, pp. 255-281.
7. Katsuragi, Y., Sugiura, Y., Cao, L., Otsuji, K. and Kurihara, K., Selective inhibition of bitter taste of various drugs by lipoprotein, Pharm. Res., 12 (1995) 658-662.
8. Katsuragi, Y., Sugiura, Y., Otsuji, K. and Kurihara, K., Characteristics of phosphatidic acid-containing lipoproteins which selectively inhibit bitter taste; high affinity to frog tongue surface and hydrophobic model membranes, Biochim. Biophys. Acta, 1289 (1996) 322-328.
9. Katsuragi, Y., Yasumasu, T. and Kurihara, K., Lipoprotein that selectively inhibits taste nerve responses to bitter substances, Brain Res., 713 (1996) 240-245.
10. Kolesnikov, S.S. and Margolskee, R.F., A cyclic nucleotide-suppressible conductance activated by transduction in taste cells, Nature, 376 (1995) 85-88.
11. Kusano, K., The influence of cations on the activity of gustatory receptors. I. Effects of KCl, Kumamoto Med. J., 11 (1958) 174-183.
12. Lindemann, B., Taste reception, Physiol. Rev., 76 (1996) 719-766.
13. Margolskee, R.F., Receptor mechanisms in gustation. In R.L. Doty (Ed.), Handbook of Olfaction and Gustation, Marcel Dekker, New York, 1995, pp. 575-595.
14. Ruiz-Avila, L., McLaughlin, S.K., Wildman, D., McKinnon, P.J., Robichon, A., Spickofsky, N. and Margolskee, R.F., Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells, Nature, 376 (1995) 80-85.
15. Spilman, A.I., Mody, I., Brand, J.G., Whitney, G., MacDonald, J.F. and Salter, M.W., A method for isolating and patch-clamping single mammalian taste receptor cells, Brain Res., 503 (1989) 326-329.
16. Ugawa, T., Konosu, S. and Kurihara, K., Enhancing effects of NaCl and Na phosphate on human gustatory responses to amino acids, Chem. Senses, 17 (1992) 811-815.
17. Yang, S.F., Feer, S. and Benson, A.A., Transphosphorylation by phospholipase D, J. Biol. Chem., 242 (1967) 477-484.
18. Yoshii, K., Kobatake, Y. and Kurihara, K., Selective enhancement and suppression of frog gustatory responses to amino acids, J. Gen. Physiol., 77 (1981) 373-385.