High and low affinity mutants of platelet-activating factor receptor

Advances in Experimental Medicine and Biology

Volumn 433, Issue , 1997, Pages 249-253

  Ishii, Isao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBOCYTE ACTIVATING FACTOR RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; GUINEA PIG; MOLECULAR RECOGNITION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; RADIOASSAY; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

CAVIA PORCELLUS; SUS SCROFA;

EID: 0031392950     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4899-1810-9_53     Document Type: Article

References (8)

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3. Ali, H., Richardson, R. M., Tomhave, E. D., DuBose, R. A., Haribabu, B. and Snyderman, R. Regulation of stably transfected platelet-activating factor receptor in RBL-2H3 cells. J. Biol. Chem. 269:24557-24563 (1994)
4. Ishii, I., Izumi, T., Tsukamoto, H., Umeyama, H., Ui, M. and Shimizu, T. Alanine exchaneges of polar amino acids in the transmembrane domains of a platelet-activating factor receptor generate both constitutively active and inactive mutants. J. Biol. Chem. 272:7846-7854 (1997)
5. Snyder, F. Platelet-activating Factor and Related Lipid Mediators, Plenum Publishing Corp., New York (1987)
6. Kunz, D., Gerard, N. P. and Gerard, C. The human leukocyte platelet-activating factor receptor. J. Biol. Chem. 267:9101-9106 (1992)
7. Gerard, N. P. and Gerard, C. Receptor-dependent internalization of platelet-activating factor. J. Immunol. 152:793-800 (1994)
8. Samama, P., Cotecchia, S., Costa, T. and Lefkowitz, R. J. A mutation-induced activated state of the β2-adrenergic receptor: extending the ternary complex model. J. Biol. Chem. 268:4625-4636 (1993)