Is the ultrastructural damage caused by subinhibitory concentrations of trimethoprim and sulphadiazine part of their normal mechanism of action?

Microbios

Volumn 92, Issue 372-373, 1997, Pages 183-197

  Richards, R Michael E ^a   Eumkeb, Griangsäk ^a   Marshall, Deborah ^b  

^a ROBERT GORDON UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Electron micrographs; Morphological damage; Outer membrane permeability; Resistant strain; Sub inhibitory concentration; Viable counts

Indexed keywords

ANTIINFECTIVE AGENT; CO TRIMAZINE; CO-TRIMAZINE; DETERGENT; OCTOXINOL; SULFADIAZINE; TRIMETHOPRIM;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COUNT; CELL MEMBRANE PERMEABILITY; DRUG COMBINATION; DRUG EFFECT; ELECTRON MICROSCOPY; ESCHERICHIA COLI; PHYSIOLOGY; ULTRASTRUCTURE;

ANTI-BACTERIAL AGENTS; CELL MEMBRANE PERMEABILITY; COLONY COUNT, MICROBIAL; DETERGENTS; DRUG COMBINATIONS; ESCHERICHIA COLI; MICROSCOPY, ELECTRON; OCTOXYNOL; SULFADIAZINE; TRIMETHOPRIM; TRIMETHOPRIM RESISTANCE;

EID: 0031317769     PISSN: 00262633     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. FLENSBURG J. and Sköld O. 1984. Regulatory changes in formation of chromosomal dihydrofolate reductase causing resistance to trimethoprim. J. Bact. 159 184-90.
2. LAMBERT P. A. 1987. Mechanism of action of antibiotics. In Pharmaceutical Microbiology, pp 199-200. Edited by W. B. Hugo and A. D. Russell. Fourth editn. Blackwell Scientific Publications, Oxford, Great Britain.
3. MARRI L., Dallai R. and Marchini D. 1996. The novel antibacterial peptide ceratotoxin A alters permeability of the inner and outer membrane of Escherichia coli K-12. Curr. Microbiol. 33 40-3.
4. McEVOY G. K. and Litrak K. 1990. AHFS drug information. American Society of Hospital Pharmacists, U.S.A.
5. RICHARDS R. M. E. and Xing D. K. L. 1994. Separation and quantification of mürein and precursors from Enterobacter cloacae after treatment with trimethoprim and sulphadiazine. J. Pharm. Pharmac. 46 690-6.
6. RICHARDS R. M. E., Taylor R. B. and Xing D. K. L. 1991. An evaluation of the antibacterial activities of combinations of sulphonamides, trimethoprim, dibromopropamidine and silver nitrate compared with their uptakes by selected bacteria. J. Pharm. Sci 80 861-7.
7. RICHARDS R. M. E., Taylor R. B. and Zhu Z. Y. 1996. Mechanism for synergism between sulphonamides and trimethoprim clarified. J. Pharm. Pharmac. 48 981-4.
8. RICHARDS R. M. E., Xing J. Z., Gregory D. W. and Marshall D. 1993. An electron microscope study of sulphadiazine and trimethoprim on Enterobacter cloacae. J. med. Microbiol. 38 64-8.
9. RICHARDS R. M. E., Xing J. Z., Gregory D. W. and Marshall D. 1995. Mechanism of sulphadiazine enhancement of trimethoprim activity against sulphadiazine-resistant Enterococcus faecalis. J. Antimicrob. Chemother. 36 607-18.