Mechanism for synergism between sulphonamides and trimethoprim clarified

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 9, 1996, Pages 981-984

  Richards, R M E ^a   Taylor, R B ^a   Zhu, Z Y ^a  

^a ROBERT GORDON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBENZOIC ACID; DAPSONE; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; PYRIMETHAMINE; SULFADIAZINE; SULFAMERAZINE; SULFAMETHOXAZOLE; SULFANILAMIDE; SULFONAMIDE; TRIMETHOPRIM;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL INFECTION; BURKHOLDERIA CEPACIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG UPTAKE; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; NONHUMAN; PSEUDOMONAS AERUGINOSA;

EID: 0029908038     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb06017.x     Document Type: Article

References (15)

1. Lacey, R. W. (1979) Mechanism of action of trimethoprim and sulfonamides: relevance to synergy in vivo. J. Antimicrob. Chemother. 5: 75-83
2. Poe, M. (1976) Antibacterial synergism: a proposal for chemotherapeutic potentiation between trimethoprim and sulfamethoxazole. Science 194: 533-535
3. Rabal, J. J., Simberkoff, M. S., Hyams, P. J. (1973) Pseudomonas cepacia tricuspid endocarditis: treatment with trimethoprim, sulfonamides, and polymyxin B. J. Infect. Dis. 128 (Suppl): 762-767
4. Richards, R. M. E., Taylor, R. B., Xing, D. K. L. (1991a) An evaluation of the antibacterial activities of combinations of sulfonamides, trimethoprim, dibromopropamidine and silver nitrate compared with their uptakes by selected bacteria. J. Pharm. Sci. 80: 861-867
5. Richards, R. M. E., Xing, D. K. L. (1991b) Evaluation of synergistic effects of combinations of antibacterials having relevance to treatment of burn wound infections. Int. J. Pharm. 75: 81-88
6. Richards, R. M. E., Xing, D. K. L. (1992) Enhancement of antibacterial activity by p-aminobenzoic acid and sulphadiazine. Int. J. Pharm. 82: 107-115
7. Richards, R. M. E., Taylor, R. B., Xing, J. Z. (1993a) Investigation of the correlation between bacterial uptakes of trimethoprim and sulphadiazine with antibacterial activities against Enterococcus faecalis. Int. J. Pharm. 92: 237-241
8. Richards, R. M. E., Xing, J. Z., Gregory, D. W., Marshall, D. (1993b) An electronmicroscope study of the effect of sulphadiazine and trimethoprim on Enterobacter cloacae. J. Med. Microbiol. 38: 64-68
9. Richards, R. M. E., Xing, D. K. L. (1993c) Investigation of synergism between combinations of ciprofloxacin, polymyxin, sulphadiazine and p-aminobenzoic acid. J. Pharm. Pharmacol. 45: 171-175
10. Richards, R. M. E., Xing, D. K. L. (1994a) Separation and quantification of murein and precursors from Enterobacter cloacae after treatment with trimethoprim and sulphadiazine. J. Pharm. Pharmacol. 46: 690-696
11. Richards, R. M. E., Xing, D. K. L. (1994b) Capillary zone electrophoresis assay of the uridine diphosphate N-acetylmuramyl peptide precursors and disaccharide pentapeptide derivative of bacterial cell wall peptidoglycan. J. Pharm. Biomed. Anal. 3: 310-305
12. Richards, R. M. E., Reid, R. G., Hamilton, V. E. S., Xing, D. K. L. (1994c) Study of the mutual effects of sulphadiazine and ciprofloxacin on their uptakes by Pseudomonas aeruginosa. J. Pharm. Pharmacol. 46: 530-532
13. Richards, R. M. E., Xing, J. Z., Gregory, D. W., Marshall, D. (1995a) Mechanism of sulphadiazine enhancement of trimethoprim activity against sulphadiazine-resistant Enterococcus faecalis. J. Antimicrob. Chemother. 36: 607-618
14. Richards, R. M. E., Xing, D. K. L. (1995b) Activity of p-aminobenzoic acid compared with other organic acids against selected bacteria. J. Appl. Bacteriol. 78: 209-215
15. Then, R. L. (1977) Synergism between trimethoprim and sulfamethoxazole. Science 197: 1301