Population frequencies of the CKR5 mutant allele of the chemokine receptor gene responsible for HIV infection

Genetika

Volumn 33, Issue 12, 1997, Pages 1724-1726

  Aseev, M V ^a  

^a D O OTT RESEARCH INSTITUTE OF OBSTETRICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; GENE DELETION; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; MUTATION; POLYMERASE CHAIN REACTION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HIV-1; HOMOZYGOTE; HUMANS; MUTATION; POLYMERASE CHAIN REACTION; RECEPTORS, CCR5; SEQUENCE DELETION;

EID: 0031297090     PISSN: 00166758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Frontal M., Sabbadini G., Novelletto A. et al. Genetic fitness in Huntington's disease and spinocerebellar ataxia 1 :a population genetics model for CAG repeat expansions // Ann. Hum. Genet. 1996. V. 60. P. 423-435.
2. Rubinsztein D.C., Amos W., Leggo J. et. al. Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in desease prevalence//Nature Genetics. 1994. V. 7. P. 525-530.
3. Gayther S.A., Warren W., Mazoyer S. et al. Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype-phenotype correlation // Nature Genetics. 1995. V. 11. P. 428-133.
4. Petersen G.M., Francomano C., Kinzler K. et al. Presymptomatic direct detection of adenomatous polyposis coli (APC) gene mutations in familial adenomatous polyposis//Hum. Genet. 1993. V. 91. P. 307-311.
5. Field L.L., Tobias R., Magnus TA. Locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus // Nature Genetics. 1994. V. 8. P. 189-194.
6. Baranov V.S., Ivaschenko T., Bakay M. et al. Proportion of the GSTM1 0/0 genotype in some Slavic populations and its correlation with cyctic fibrosis and some multifactorial diseases // Hum. Genet. 1996. V. 97. P. 516-520.
7. Syvanen A., Aalto-Setala K., Kontula L.H.K. et al. A primer guided nucleotide incorporation assay in the genotyping of apolipoprotein E//Genomics. 1990. V. 8. P. 684-692.
8. Kluijtman L.A.J., van den HeuvelL.P.WJ., Boers G.HJ. etal. Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetranydrofolate reductase gene is a genetic risk factor for cardiovascular disease // Am. J. Hum. Genet. 1996. V. 58. P. 35-41.
9. Choe H., Farzan M., Sun Y. et al. The B-chemokine receptors CCR3 facilate infecion by primary HIV-1 isolates // Cell. 1996. V. 85. P. 1135-1148.
10. Dean M., Carrington M., Winkler C. et al. Genetic restrection of HIV-1 infection and progression to aids by a deletion allele of the CKR5 structural gene // Science. 1996. V. 273. P. 1856-1862.
11. Samson M., Libert F., Doranz BJ. et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene //Nature. 1996. V. 382. P. 722-725.