Mutational bias provides a model for the evolution of huntington's disease and predicts a general increase in disease prevalence

Nature Genetics

Volumn 7, Issue 4, 1994, Pages 525-530

  Rubinsztein, David C ^a   Amos, William ^b   Leggo, Jayne ^a   Goodburn, Sandy ^a   Ramesar, Rajkumar S ^c   Old, John ^d   Bontrop, Ronald ^e   McMahon, Robert ^a   Barton, David E ^a   Ferguson Smith, Malcolm A ^a,b  

^a CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^e TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; COMPUTER SIMULATION; EVOLUTION; GENE MUTATION; GENOTYPE; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MARKER GENE; MUTATION RATE; NATURAL SELECTION; PREDICTION; PREVALENCE; PRIORITY JOURNAL; TANDEM REPEAT;

ALLELES; ANIMALS; BASE SEQUENCE; COMPUTER SIMULATION; DNA PRIMERS; EVOLUTION; GENE FREQUENCY; HAPLOTYPES; HUMANS; HUNTINGTON DISEASE; LINKAGE DISEQUILIBRIUM; MEIOSIS; MINISATELLITE REPEATS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; OLIGODEOXYRIBONUCLEOTIDES; PRIMATES;

PRIMATES;

EID: 0027982426     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng0894-525     Document Type: Article

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