Alterations in I(to1), I(Kr) and I(k1) density in the BIO TO-2 strain of Syrian myopathic hamsters

Journal of Molecular and Cellular Cardiology

Volumn 29, Issue 12, 1997, Pages 3211-3221

  Lodge, Nicholas J ^a   Normandin, Diane E ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

Heart failure; Myopathic hamster; Potassium currents; Voltage clamp

Indexed keywords

POTASSIUM ION; DELAYED RECTIFIER POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM CHANNEL; TANDEM PORE DOMAIN POTASSIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC POTENTIAL; HEART DILATATION; HEART FAILURE; MEMBRANE CURRENT; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SYRIAN HAMSTER; ANIMAL; BLOOD PRESSURE; CELL SIZE; CONGESTIVE CARDIOMYOPATHY; DISEASE MODEL; ELECTROPHYSIOLOGY; HAMSTER; HEART; HEART OUTPUT; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR RESISTANCE;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

ANIMALS; BLOOD PRESSURE; CARDIAC OUTPUT; CARDIOMYOPATHY, DILATED; CELL SIZE; CRICETINAE; DELAYED RECTIFIER POTASSIUM CHANNELS; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGY; HEART; HUMANS; MESOCRICETUS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; POTASSIUM CHANNELS, VOLTAGE-GATED; VASCULAR RESISTANCE;

EID: 0031283290     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1997.0548     Document Type: Article

References (22)

1. + currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res 73: 379-385.
2. CAPASSO JM, SONNENBLICK EH, ANVERSA P, 1990. Chronic calcium channel blockade prevents the progression of myocardial contractile and electrical dysfunction in the myopathic Syrian hamster. Circ Res 67: 1381-1393.
3. COULOMBE A, MOMTAZ A, RICHER P, SWYNGHEDAUW B, CORABOEUF E, 1994. Reduction of calcium-independent transient outward potassium current density in DOCA salt hypertrophied rat ventricular myocytes. Pflugers Arch 427: 47-55.
4. CURRAN ME, SPLAWSKI I, TIMOTHY KW, VINCENT GM, GREEN ED, KEATING MT, 1995. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80: 795-803.
5. HAMILL OP, MARTY A, NEHER E, SAKMANN B, SIGWORTH FH, 1981. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflugers Arch 395: 85-100.
6. 2+ exchange activity in cardiomyopathic Syrian hamster. Circ Res 74: 253-261.
7. KÄÄB S, NUSS HB, CHIAMVIMONVAT N, O'ROURKE B, PAK PH, KASS DA, MARBAN E, TOMASELLI GF, 1996. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 78: 262-273.
8. KAMEYAMA M, HOFMANN, F, TRAUTWEIN W, 1985. On the mechanism of β-adrenergic regulation of the Ca channel in the guinea-pig heart. Pflugers Arch 405: 285-293.
9. + channel in human cardiac myocytes. Circulation 92: 164-174.
10. LI G-R, FERRIER GR, HOWLETT SE, 1995. Calcium currents in ventricular myocytes of prehypertrophic cardiomyopathic hamsters. Am J Physiol 268: H999-H1005.
11. ROSSNER KL, 1991. Calcium current in congestive heart failure of hamster cardiomyopathy. Am J Physiol 260: H1179-H1186.
12. ROSSNER KL, SACHS HG, 1978. Electrophysiological study of Syrian hamster hereditary cardiomyopathy. Cardiovasc Res 12: 436-443.
13. Ks. Am J Physiol 40: H2477-H2489.
14. + channel dysfunction in an inherited cardiac arrhythmia. Proc Natl Acad Sci 93: 2208-2212.
15. 2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts. Circ Res 75: 149-155.
16. SEN L, O'NEILL M, MARSH JD, SMITH TW, 1990. Myocyte structure, function, and calcium kinetics in the cardiomyopathic hamster heart. Am J Physiol 259: H1533-H1543.
17. SMITH PL, BAUKROWITZ T, YELLEN G, 1996. The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379: 833-836.
18. + channel. Circ Res 78: 499-503.
19. THURINGER D, COULOMBE A, DEROUBAIX E, CORABOEUF E, MERCADIER JJ, 1996. Depressed transient outward current density in ventricular myocytes from cardiomyopathic Syrian hamsters of different ages. J Mol Cell Cardiol 28: 387-410.
20. TRIPPODO NC, FOX M, NATARAJAN V, PANCHAL BC, DORSO CR, ASAAD MM, 1993. Combined inhibition of neutral endopeptidase and angiotensin converting enzyme in cardiomyopathic hamsters with compensated heart failure. J Pharmacol Exp Ther 267: 108-116.
21. WANG Z, FERMINI B, NATTEL S, 1994. Rapid and slow components of delayed rectifier current in human atrial myocytes. Circ Res 28: 1540-1546.
22. WETTWER E, AMOS G, GATH J, ZERKOWSKI H-R, REIDEMEISTER J-C, RAVENS U, 1993. Transient outward current in human and rat ventricular myocytes. Cardiovasc Res 27: 1662-1669.