Allelic imbalance on chromosome 13q: Evidence for the involvement of BRCA2 and RB1 in sporadic breast cancer

Cancer Research

Volumn 56, Issue 9, 1996, Pages 1988-1990

  Hamann, Ute ^a   Herbold, Christian ^a   Costa, Serban ^c   Solomayer, Erich Franz ^d   Kaufmann, Manfred ^c   Bastert, Gunther ^d   Ulmer, Hans Ulrich ^e   Frenzel, Hans ^e   Komitowski, Dymitr ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Histodiagnostic P   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^e STÄDTISCHES KLINIKUM KARLSRUHE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CHROMOSOME 13Q; GENE LOCATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ALLELES; BRCA2 PROTEIN; BREAST NEOPLASMS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 13; GENES, RETINOBLASTOMA; GENETIC MARKERS; HUMANS; NEOPLASM PROTEINS; TRANSCRIPTION FACTORS;

EID: 0029920503     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Coles, C., Thompson, A. M., Elder, P. A., Cohen, B. B., Mackenzie, I. M., Cranston, G., Chetty, U., Mackay, J., Macdonald, M., Nakamura, Y., Hoyheim, B., and Steel, C M. Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis. Lancet, 336: 761-763, 1990.
2. Mild, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., Bell, R., Rosenthal, J., Hussey, C., Tran, T., McClure, M., Frye, C , Hattier, T., Phelps, R., Haugen-Strano, A., Katcher, H., Yakumo, K., Gholami, Z., Shaffer, D., Stone, S., Bayer, S., Wray, C , Bogden, R., Dayananth, P., Ward, J., Tonin, P., Narod, S., Bristow, P. K., Norris, F. H., Helvering, L., Morrison, P., Rosteck, P., Lai, M., Barrett, J. C., Lewis, C., Neuhausen, S., Cannon-Albright, L., Goldgar, D., Wiseman, R., Kamb, A., and Skolnick, M. H. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science (Washington DC), 266: 66-71, 1994.
3. Sato, T., Saito, H., Swensen, J., Olifant, A., Wood, C., Danner, D., Sakamoto, T., Takita, K., Kasumi, F., Miki, Y., Skolnick, M., and Nakamura, Y The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer. Cancer Res., 52: 1643-1646, 1992.
4. Bevilacqua, G , Sobel, M. E., Liotta, L. A., and Steeg, P. S Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastaric potential. Cancer Res., 49. 5185-5190, 1989.
5. Wooster, R., Neuhausen, S. L., Mangion, J , Quirk, Y., Ford, D., Collins, N., Nguyen, K., Seal, S , Tran, T , Averill, D., Fields, P., Marshall, G., Narod, S., Lenoir, G. M., Lynch, H., Feunteun, J , Devilee, P., Cornelisse, C. J , Menko, F, H., Daly, P. A., Ormiston, W., McManus, R , Pye, C., Lewis, C. M., Cannon-Albright, L. A., Peto, J., Ponder, B. A. J., Skolnick, M. H., Easton, D. F., Goldgar, D. E , and Stratton, M. R. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science (Washington DC), 265: 2088-2090, 1994.
6. Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S , Gumbs, C., Micklem, G., Barfoot, R , Hamoudi, R , Patel, S., Rice, C., Biggs, P., Hashim, Y., Smith, A., Connor, F., Arason, A., Gudmundsson, J., Ficenec, D., Kelsell, D., Ford, D., Tonin, P., Bishop, D. T., Spurr, N. K., Ponder, B. A. J., Eeles, R., Peto, J., Devilee, P., Cornelisse, C., Lynch, H., Narod, S., Lenoir, G., Egilsson, V , Barkadottir, R. B., Easton, D. F., Bentley, D. R., Futreal, P. A., Ashworth, A. and Stratton, M. R. Identification of the breast cancer suspectibility gene BRCA2. Nature (Lond.), 378: 789-792, 1995.
7. Lundberg, C., Skoog, L., Cavenee, W. K., and Nordenskjöld, M. Loss of heterozygosity in human ductal breast tumors indicates a recessive mutation on chromosome 13. Proc Natl. Acad. Sci. USA, 84: 2372-2376, 1987.
8. Devilee, P., Broek, v.d M., Kuipers-Dijkshoorn, N., Kolluri, R., Khan, P M., Pearson, P. L., and Cornelisse, C J. At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinoma. Genomics, 5: 554-560, 1989
9. Collins, N., McManus, R., Wooster, R., Mangion, J., Seal, S., Lakhani, S. R., Ormiston, W., Daly, P. A., Ford, D., Easton, D. F., and Straften, M. R. Consistent loss of the wild type allele in breast cancers from a family linked to the SRCA2 gene on chromosome 13q12-13 Oncogene, 10: 1673-1675, 1995.
10. T'Ang, A., Varley, J. M., Chakraborty, S., Murphree, A. L., and Fung, Y. K. T. Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science (Washington DC), 242 263-266, 1988.
11. Borg, A., Zhang, Q. X., Alm, P., Olsson, H., and Sellberg, G. The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression. Cancer Res., 52: 2991-2994, 1992.
12. Toguchida, J., McGee, T. L , Paterson, J. C., Eagle, J. R., Tucker, S., Yandell, D. W., and Dryja, T. P. Complete genomic sequence of the human retinoblastoma susceptibility gene. Genomics, 17: 535-543, 1993.
13. Gyapay, G , Morisette, J., Vignal, A., Dib, C., Fizames, C., Millasseau, P., Marc, S., Bernardi, G., Lathrop, M , and Weissenbach, J. The 1992-94 Genéthon human genetic linkage map. Nat. Genet., 7: 246-339, 1994.
14. Devilee, P., Schuuring, E. van de Vijver, M. J., and Comelisse, C. J. Recent developments in the molecular genetic understanding of breast cancer. Crit. Rev. Oncog., 5: 247-270, 1994.
15. Kerangueven, F., Allione, F., Noguchi, T., Adélaide, J., Sobol, H., Jacquemier, J., and Birnbaum, D. Patterns of loss of heterozygosity at loci from chromosome arm 13q suggest a possible involvement of BRCA2 in sporadic breast tumors. Genes Chromosomes & Cancer, 13: 291-294, 1995.
16. Cleton-Jansen, A-M., Collins, N., Lakhani, S. R., Weissenbach, J., Devilee, P., Cornelisse, C. J., and Stratton, M. R. Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13. Br. J. Cancer, 72: 1241-1244, 1995.
17. Lee, E Y. H. P , To, H. Shew, J. Y., Bookstein, R., Scully, P., and Lee, W. H. Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science (Washington DC), 247: 218-221, 1988.
18. Varley, J. M., Armour, J., Swallow, J. E., Jeffreys, A J., Ponder, B A. J., T'Ang, A., Fung, Y. K. T., Brammar, W. J., and Walker, R. A. The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours. Oncogene, 4: 725-729, 1989.
19. Schott, D. R., Chang, J. N., Deng, G, Kurisu, W., Kuo, W. L., Gray, J., and Smith, H. S. A candidate tumor suppressor gene in human breast cancers. Cancer Res., 54: 1393-1396, 1994