Hydrocephalus in the Otx2+/- Mutant Mouse

Experimental Neurology

Volumn 148, Issue 1, 1997, Pages 215-221

  Makiyama, Yasushi ^a,b   Shoji, Shin'ichi ^b   Mizusawa, Hidehiro ^b,c  

^a RIKEN TSUKUBA INSTITUTE   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; HOMEODOMAIN PROTEIN; NERVE PROTEIN; OTX2 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR OTX;

ANIMAL; ARTICLE; BODY WEIGHT; C57BL MOUSE; CBA MOUSE; DWARFISM; FEMALE; GENETICS; GENOTYPE; HEAD; HYDROCEPHALUS; LETHAL GENE; MALE; MORPHOGENESIS; MOUSE; MOUSE MUTANT; MULTIPLE MALFORMATION SYNDROME; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; PRENATAL DEVELOPMENT; SKULL; SPHENOID;

ABNORMALITIES, MULTIPLE; ANIMALS; BODY WEIGHT; DWARFISM; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GENES, LETHAL; GENOTYPE; GROWTH HORMONE; HEAD; HOMEODOMAIN PROTEINS; HYDROCEPHALUS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, MUTANT STRAINS; MORPHOGENESIS; NERVE TISSUE PROTEINS; OTX TRANSCRIPTION FACTORS; PHENOTYPE; SKULL; SPHENOID BONE; TRANS-ACTIVATORS;

EID: 0031266452     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6638     Document Type: Article

References (18)

1. Acampora, D., S. Mazan, Y. Lallemand, V. Avantaggiato, M. Maury, A. Simeone, and P. Brulet. 1996. Forebrain and mid-brain regions are deleted in Otx2 7 mutants due to a defective anterior neruroectoderm specification during gastrulation. Development 121: 3279-3290.
2. Berry, R. J. 1961. The inheritance and pathogenesis of hydrocephalus-3 in the mouse. J. Pathol. Bacteriol. 81: 157.
3. Boncinelli, E., M. Gulisano, and V. Broccoli. 1993. Emx and Otx homeobox genes in the developing mouse brain. J. Neurobiol. 24: 1356-1366.
4. Frantz, G. D., M. Weimann, M. E. Levin, and S. K. McConnell. 1994. Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. J. Neurosci. 14: 5725-5740.
5. Harvey, R., and M. D. Nova. 1979. Familial communicating hydrocephalus, posterior cerebellar agenesis, mega cisterna magna, and prt-wine nevi. M. Neurosurg. 51: 862-865.
6. James, H. E. 1992. Hydrocephalus in infancy and childhood. Am. Fam. Physician 45(2): 733-742.
7. Juet, M., A. Rosenthal, G. Armstrong, J. MacFarlane, R. Stevenson, J. Paterson, A. Metzenberg, V. Ionasescu, K. Temple, and S. Kenwrick. 1994. X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations with L1 gene. Nat. Genet. 7(3): 402-407.
8. Kelly, W. L., and M. M. Bryden. 1983. A modified differential stain for cartilage and bone in whole mout preparations of mammalian fetuses and small vertebrates. Stain Technol. 58: 131-134.
9. Lawson, R. F., and A. J. Raimondi. 1973. Hydrocephalus-3, a murine mutant. I. Alterations in fine structure of choroid plexus and ependyma. Surg. Neurol. 1: 115-128.
10. Madeline, L. A., and A. D. Elster. 1995. Postnatal development of the central skull base: Normal variants. Radiology 196: 757-763.
11. Matsuo, I., S. Kuratani, C. Kimura, N. Takeda, and S. Aizawa. 1996. Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev. 9: 2646-2658.
12. McLone, D. G., W. Bondaref, and A. J. Raimondi. 1973. Hydrocephalus-3, a murine mutant. II. Changes in the brain extracellular space. Surg. Neurol. 1: 233-242.
13. Prockop, L. D., and C. P. Shah. 1989. Hydrocephalus. In Merrit's Textbook of Neurology (Rowland, L. P. Eds.), 8th ed., pp. 253-262. Lea and Febiger, Philadelphia.
14. Raimondi, A. J., O. T. Bailey, D. G. McLone, R. F. Lawson, and A. Echeverry. 1973. The pathophysiology and morphology of murine hydrocephalus in hy-3 and ch mutants. Surg. Neurol. 1: 50-55.
15. Schrander-Stumpel, C., E. Legius, J. P. Frayns, and J. J. Cassiman. 1990. MASA syndrome: new clinical features and linkage analysis using DNAprobes. J. Med. Genet. 27: 688-692.
16. Simeone, A., D. Acampora, M. Gulisano, A. Stornaiuolo, and E. Boncinelli. 1992. Nested expression domains of four homeobox genes indeveloping rostral brain. Nature 358: 687-690.
17. Sofer, D., H. W. Grotsky, I. Rapin, and Suzuki, K. 1979. Cockayne syndrome: Unusual pathological findings and review of the literature. Ann. Neurol. 6: 340-348.
18. Yagi, T., T. Tokunaga, Y. Furuta, S. Nada, M. Yoshida, T. Tsukada, Y. Saga, N. Takeda, Y. Ikawa, and S. Aizawa. 1993. A novel ES cell line, TT2, with high germline-differentiating potency. Anal. Biochem. 214: 70-76.