Immunoconjugates and immunotoxins for therapy of solid tumors

Cancer Chemotherapy and Pharmacology, Supplement

Volumn 38, Issue , 1996, Pages

  Hellström, Ingegerd ^a   Trail, Pamela ^a   Siegall, Clay ^a   Firestone, Raymond ^a   Hellström, Karl Erik ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; DOXORUBICIN; IMMUNOTOXIN;

CANCER; CANCER IMMUNOTHERAPY; CONFERENCE PAPER; DRUG CONJUGATION; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; HUMANS; IMMUNOCONJUGATES; IMMUNOTOXINS; NEOPLASMS; NEOPLASMS, EXPERIMENTAL;

EID: 0029791238     PISSN: 09439404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (13)

1. Casazza AM, Trail PA, Hellstrom KE (1994) Drug immunotargeting for carcinomas: a reality at last? Ann Oncol 5: 703
2. Friedman PN, McAndrew SJ, Gawlak SL, Chace D, Trail PA, Brown JP, Siegall CB (1993) BR96 sFv-PE40, a potent single-chain immunotoxin that selectively kills carcinoma cells. Cancer Res 53: 334
3. Friedman PN, Chace DF, Trail PA, Siegall CB (1993) Antitumor activity of the single-chain immunotoxin BR96 sFv-PE40 against established breast and lung tumor xenografts. J Immunol 50: 3054
4. Hellström I, Hellström KE, Siegall CB, Trail PA (1995) Immunoconjugates and immunotoxins for therapy of carcinomas. In: Garattini S (ed) Advances in pharmacology. Academic Press, San Diego, p 349
5. Jain R (1994) Barriers to drug delivery in solid tumors. Sci Am 271: 58
6. Press OW, Eary JF, Appelbaum FR, Martin PJ, Badger CC, Nelp WB, Glenn S, Butchko G, Fisher D, Porter B, Matthews DC, Fisher LD, Bernstein ID (1993) Radiolabeled antibody therapy of B cell lyphoma with autologous bone marrow support. N Engl J Med 329: 1219
7. Riethmuller G, Schneider-Gadicke E, Schlimok G, Schmiegel W, Raab R, Hoffken K, Gruber R, Pichlmaier H, Hirche H, Pichlmayr R, Buggisch P, Witte J, Eigler FW, Facklerschwalbe I, Funke I, Schmidt CG, Schreiber H, Schweiberer L, Eibleibesfeldt B (1994) Randomized trial of monoclonal antibodies for adjuvant therapy of resected Dukes' C colorectal carcinoma. Lancet 343: 1177
8. Siegall CB (1994) Targeted toxins as anticancer agents. Cancer 74 [Suppl 3]: 1006
9. Siegall CB, Chace D, Mixan B, Garrigues U, Wan H, Paul L, Wolff E, Hellström I, Hellström KE (1994) In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats. J Immunol 152: 2377
10. Siegall C, Wolff E, Gawlak S, Paul L, Chace D, Mixan B (1995) Immunotoxins as cancer chemotherapeutic agents. Drug Dev Res 34: 210
11. Trail PA, Willner D, Lasch SJ, Henderson AJ, Greenfield RS, King D, Zoeckler ME, Bralawsky GR (1992) Antigen specific activity of carcinoma reactive BR64-Adriamycin conjugates evaluated in vitro and in human tumor xenograft models. Cancer Res 52: 5693
12. Trail PA, Willner D, Lasch SJ, Henderson AJ, Hofstead S, Cassazza AM, Firestone RA, Hellström I, Hellström KE (1993) Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. Science 261: 212
13. Willner D, Trail PA, Hofstead SJ, King HD, Lasch SJ, Braslawsky GR, Greenfield RS, Kaneko T, Firestone RA (1993) (6-Maleimidocaproyl)hydrazone of doxorubicin - a new derivative for the preparation of immunoconjugates of doxorubicin. Bioconjugate Chem 4: 521