Functional mapping of the orientation for TCR recognition of an H2-Kb-restricted ovalbumin peptide suggests that the β-chain subunit can dominate the determination of peptide side chain specificity

Journal of Immunology

Volumn 159, Issue 5, 1997, Pages 2312-2317

  Turner, Stephen J ^a   Jameson, Stephen C ^b   Carbone, Francis R ^a  

^a MONASH UNIVERSITY MEDICAL SCHOOL   (Australia)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

H 2KB PROTEIN, MOUSE; H-2KB PROTEIN, MOUSE; H2 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; OVALBUMIN; PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; ANIMAL; ANTIGEN PRESENTATION; ARTICLE; CHEMISTRY; GENE REARRANGEMENT; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TRANSGENIC MOUSE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; CRYSTALLOGRAPHY, X-RAY; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; H-2 ANTIGENS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; OVALBUMIN; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031229844     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Hedrick, S. M., and F. J. Eidelman. 1993. T lymphocyte antigen receptors. In Fundamental Immunology. W. E. Paul, ed. Raven Press, New York, p. 383.
2. Davis, M. M., and P. J. Bjorkman. 1988. T-cell antigen receptor gene and T-cell recognition. Nature 33-1:395.
3. Novotny, J., S. Tonegawa, H. Saito, D. N. Kranz, and H. N. Eisen. 1986. Secondary, tertiary and quaternary structure of T-cell specific immunoglobulin-like polypeptide chains. Proc. Natl. Acad. Sci. USA 83:742.
4. Chothia, C., D. R. Boswell, and A. M. Lesk. 1988. The outline structure of T-cell αβ receptor. EMBO J. 7:3745.
5. Claverie, J. M., A. Procknicha-Chalufour, and L. Bougueleret. 1989. Immunological implications of a Fab-like structure of the T-cell receptor. Immunol. Today 10:10.
6. Garcia, K. C., M. Degano, R. L. Stanfield, A. Brunmark, M. R. Jackson, P. A. Peterson, L. Teyton, and I. A. Wilson. 1996. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. Science 274:209.
7. Garboczi, D. N., P. Ghosh, U. Utz, Q. R. Fin, W. E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134.
8. Moore, M. W., F. R. Carbone, and M. J. Bevan. 1988. Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 54:777.
9. Carbone, F. R., and M. J. Bevan. 1990. Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo. J. Exp. Med. 171:377.
10. Jorgensen, J. L., U. Esser, B. F. de St. Groth, P. A. Reay, and M. M. Davis. 1992. Mapping T-cell receptor peptide contacts by variant peptide immunization of single- chain transgenics. Nature 355:224.
11. Sant'Angelo, D. B., G. Waterbury, P. Preston-Hurlburt, S. T. Yoon, R. Medzhitov, S. C. Hong, and C. A. Janeway, Jr. 1996. The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4:367.
12. Kelly, J. M., S. J. Sterry, S. Cose, S. J. Turner, J. Fecondo, S. Rodda, P. J. Fink, and F. R. Carbone. 1993. Identification of conserved T-cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I-bound determinant. Eur. J. Immunol. 23:3318.
13. Turner, S. J., S. C. Cose, and F. R. Carbone. 1996. T cell receptor α-chain usage can determine the extent of TCR β-chain diversity within a dominant T cell response. J. Immunol. 157:4979.
14. Southern, P. J., and P. Berg. 1982. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet. 1:3271.
15. Edlund, T., M. D. Walker, P. J. Barr, and W. J. Rutter. 1985. Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5′ flanking elements. Science 230:912.
16. Dyall, R., L. V. Vasovic, A. Molano, and J. Nikolic-Zugic. 1995. CD4-independent in vivo priming of murine CTL by optimal MHC class I-restricted peptides derived from intracellular pathogens. Int. Immunol. 7:1205.
17. Carbone, F. R., M. W. Moore, J. M. Shell, and M. J. Bevan. 1988. Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides. J. Exp. Med. 167:1767.
18. Gregoire, C., N. Rebai, F. Schweisguth, A. Necker, G. Mazza, N. Auphan, A. Millward, A. M. Schmitt-Vershulst, and B. Malissen. 1991. Engineered secreted T-cell receptor αβ heterodimers. Proc. Natl. Acad. Sci. USA 88:8077.
19. Arden, B., S. P. Clark, D. Kabelitz, and T. W. Mak. 1995. Mouse T-cell receptor variable gene segment families. Immunogenetics 42:50.
20. Gascoigne, N. R., Y. Chien, D. M. Becker, J. Kavaler, and M. M. Davis. 1984. Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes. Nature 310:387. peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell 75:693.
21. Gascoigne, N. R., Y. Chien, D. M. Becker, J. Kavaler, and M. M. Davis. 1984. Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes. Nature 310:387. peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell 75:693.