Cellular and metabolic basis of clara cell tolerance to multiple doses of cytochrome P450-activated cytotoxicants. I: Bronchiolar epithelial reorganization and expression of cytochrome P450 monooxygenases in mice exposed to multiple doses of naphthalene

Journal of Pharmacology and Experimental Therapeutics

Volumn 278, Issue 3, 1996, Pages 1408-1418

  Lakritz, Jeffrey ^a   Chang, Aimin ^a   Weir, Alison ^a   Nishio, Susan ^a   Hyde, Dallas ^a   Philpot, Richard ^c   Buckpitt, Alan ^a,b   Plopper, Charles ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORN OIL; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; CYTOTOXIC AGENT; DRUG METABOLITE; GLUTATHIONE DERIVATIVE; NAPHTHALENE; NAPHTHALENE DERIVATIVE; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHIOLE; CLARA CELL; CONTROLLED STUDY; COVALENT BOND; DRUG ACTIVATION; DRUG CYTOTOXICITY; DRUG REEXPOSURE; DRUG TOLERANCE; ENZYME ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG HOMOGENATE; MALE; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; XENOBIOTIC METABOLISM;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BRONCHI; CYTOCHROME P-450 ENZYME SYSTEM; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; EPITHELIAL CELLS; EPITHELIUM; GLUTATHIONE; MALE; MICE; MICROSOMES; NAPHTHALENES; OXIDATION-REDUCTION; STEROID HYDROXYLASES;

EID: 0030433048     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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