The effect of CY1503, a sialyl lewis(x) analog blocker of the selectin adhesion molecules, on infarct size and 'no-reflow' in the rabbit model of acute myocardial infarction/reperfusion

Journal of Molecular and Cellular Cardiology

Volumn 29, Issue 8, 1997, Pages 2013-2025

  Birnbaum, Yochai ^a   Patterson, Michael ^a   Kloner, Robert A ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b GOOD SAMARITAN HOSPITAL   (United States)

Author keywords

Leukocytes; Myocardial infarction; No reflow; Reperfusion; Sialyl Lewis(x)

Indexed keywords

CELL ADHESION MOLECULE; CY 1503; SELECTIN; TETRAZOLIUM; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BOLUS INJECTION; CAT; CONTINUOUS INFUSION; CONTROLLED STUDY; DOG; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE REPERFUSION; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RABBIT; STAINING;

ANIMALIA; CANIS FAMILIARIS; FELIDAE; FELIS CATUS; ORYCTOLAGUS CUNICULUS;

EID: 0031214933     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1997.0393     Document Type: Article

References (51)

1. AMBROSIO G, WEISMAN HF, MANSINI JA, BECKER LC, 1989. Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow. Circulation 80: 1846-1861.
2. BIRNBAUM Y, LEOR J, KLONER RA, 1996. Pathobiology and clinical impact of reperfusion injury. J Thrombosis Thrombolysis 2: 177-186.
3. BIRNBAUM Y, HALE SL, KLONER RA, 1997. Differences in reperfusion length following 30 minutes of ischemia in the rabbit influences infarct size, as measured by triphenyltetrazolium chloride staining. J Mol Cell Cardiol 29: 657-666.
4. x-containing oligosaccharide attenuates myocardial reperfusion injury in cats. J Clin Invest 93: 1140-1148.
5. CHATELAIN P, LATOUR JG, TRAN D, LORGERIL MD, DUPRAS G, BOURASSA M, 1987. Neutrophil accumulation in experimental myocardial infarcts: relation with extent of injury and effect of reperfusion. Circulation 75: 1083-1090.
6. ENGLER RL, SCHMID-SCHONBEIN GW, PAVELEC RS, 1983. Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am J Pathol 111: 98-111.
7. ENGLER RL, DAHLGREN MD, MORRIS D, PETERSON MA, DOBBS A, SCHMID-SCHOENBEIN G, 1986. Accumulation of polymorphonuclear leukocytes during 3 hours experimental myocardial ischemia. Am J Physiol (Heart Circ Physiol) 251: H93-H100.
8. ENTMAN ML, SMITH CW, 1994. Postreperfusion inflammation: a model for reaction to injury in cardiovascular disease. Cardiovasc Res 28: 1301-1311.
9. GANZ W, WATANABE I, KANAMASA K, YANO J, HAN D-S, FISHBEIN MC, 1990. Does reperfusion extend necrosis? A study in a single territory of myocardial ischemia-half reperfused and half not reperfused. Circulation 82: 1020-1033.
10. x analogue does not reduce myocardial infarct size after ischemia and reperfusion in dogs. Circulation 94: 542-546.
11. Go LO, MURRY CE, RICHARD VJ, WEISCHEDEL GR, JENNINGS RB, REIMER KA, 1988. Myocardial neutrophil accumulation during reperfusion after reversible or irreversible ischemic injury. Am J Physiol (Heart Circ Physiol) 255: H1188-H1196.
12. HALE SL, KLONER RA, 1991. Time course of infiltration and distribution of neutrophils following coronary artery reperfusion in the rat. Cor Art Dis 2: 373-378.
13. HAN KT, SHARAR SR, PHILLIPS ML, HARLAN JM, WINN RK, 1995. Sialyl Lewis (X) oligosaccharide reduces ischemia-reperfusion injury in the rabbit ear. J Immunol 155: 4011-4015.
14. HANSEN PR, 1995. Role of neutrophils in myocardial ischemia and reperfusion. Circulation 91: 1872-1885.
15. HAWKINS HK, ENTMAN ML, ZHU JY, YOUKER KA, BERENS K, DORÉ M, SMITH CW, 1996. Acute inflammatory reaction after myocardial ischemic injury and reperfusion. Development and use of a neutrophil-specific antibody. Am J Pathol 148: 1957-1969.
16. IVEY CL, WILLIAMS FM, COLLINS PD, JOSE PJ, WILLIAMS TJ, 1995. Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8. J Clin Invest 95: 2720-2728.
17. JEROME SH, DORÉ M, PAULSON JC, SMITH CW, KORTHUIS RJ, 1994. P-selectin and ICAM-1-dependent adherence reactions: role in the genesis of post-ischemic no-reflow. Am J Physiol (Heart Circ Physiol) 266: H1316-H1321.
18. JOLLY SR, KANE WJ, HOOK BR, ABRAMS GD, KUNKEL SL, LUCCHESI BR, 1986. Reduction of myocardial infarct size by neutrophil depletion: effect of duration of occlusion. Am Heart J 112: 682-690.
19. x. J Cardiovasc Pharmacol Therapeut 1: 49-56.
20. KLONER RA, GANOTE CE, JENNINGS RB, 1974. The "no-reflow" phenomenon following temporary coronary occlusion in the dog. J Clin Invest 54: 1496-1508.
21. KLONER RA, PRZYKLENK K, WHITTAKER P, 1989. Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues. Circulation 80: 1115-1127.
22. KLONER RA, GIACOMELLI F, ALKER KJ, HALE SL, MATTHEWS R, BELLOWS S, 1991. Influx of neutrophils into the walls of large epicardial coronary arteries in response to ischemia/reperfusion. Circulation 84: 1758-1772.
23. KLONER RA, 1993. Does reperfusion injury exist in humans? J Am Coll Cardiol 21: 537-545.
24. KUBES P, JUTILA M, PAYNE D, 1995. Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. J Clin Invest 95: 2510-2519.
25. KUROSE I, ANDERSON DC, MIYASAKA M, TAMATANI T, PAULSON JC, TODD RF, RUSCHE JR, GRANGER DN, 1994. Molecular determinants of reperfusion-induced leukocyte adhesion and vascular protein leakage. Circ Res 74: 336-343.
26. LARIGAN JD, TSANG TC, RUMBERGER JM, BURNS DK, 1992. Characterization of cDNA and genomic sequences encoding rabbit ELAM-1: conservation of structure and functional interactions with leukocytes. DNA Cell Biol 11: 149-162.
27. LEFER AM, WEYRICH AS, BUERKE M, 1994a. Role of selectins, a new family of adhesion molecules, in ischemia-reperfusion injury. Cardiovasc Res 28: 289-294.
28. x analog attenuates neutrophil accumulation and myocardial necrosis after ischemia and reperfusion. Circulation 90: 2390-2401.
29. LEFER DJ, FLYNN DM, SALZBERG DB, BUDA AJ, 1996. Effect of a monoclonal antibody directed against P-selectin after myocardial ischemia and reperfusion. Am J Physiol (Heart Circ Physiol) 270: H88-H98.
30. LITT MR, JEREMY RW, WEISMAN HF, WINKELSTEIN JA, BECKER LC, 1989. Neutrophil depletion limited to reperfusion reduces myocardial infarct size after 90 minutes of ischemia. Evidence for neutrophil-mediated reperfusion injury. Circulation 80: 1816-1827.
31. McEVER RP, 1995. Regulation of function and expression of P-selectin. Agents Actions (Suppl.) 47: 117-119.
32. x-oligosaccharide in myocardial ischaemia and reperfusion injury. Cardiovasc Res 30: 965-974.
33. NORMAN KE, MOORE KL, MCEVER RP, LEY K, 1995. Leukocyte rolling in vivo is mediated by P-selectin glycoprotein ligand-1. Blood 86: 4417-4421.
34. PATEL KD, ZIMMERMAN GA, PRESCOTT SM, MCEVER RP, MCINTYRE TM, 1991. Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophols. J Cell Biol 112: 749-759.
35. PEARL JM, DRINKWATER DC, LAKS H, CAPOUYA ER, GATES RN, 1992. Leukocyte depleted reperfusion of transplanted human hearts: a randomized, double-blind clinical trial. J Heart Lung Transplant 11: 1082-1092.
36. POSITION OF THE AMERICAN HEART ASSOCIATION ON RESEARCH ANIMAL USE, 1985. A statement for health professionals by the task force appointed by the board of directors of the American Heart Association. Circulation 71: 849A-850A.
37. REIMER KA, VANDER HEIDE RS, RICHARD VJ, 1993. Reperfusion in acute myocardial infarction: effect of timing and modulating factors in experimental models. Am J Cardiol 72: 13G-21G.
38. SAWA Y, MATSUDA H, SHIMAZAKI Y, KANEKO M, NISHIMURA M, AMEMIYA A, SAKAI K, NAKANO S, 1994. Evaluation of leukocyte-depleted terminal blood cardioplegic solution in patients undergoing elective and emergency coronary artery bypass grafting. J Thorac Cardiovasc Surg 108: 1125-1131.
39. SEEKAMP A, TILL GO, MULLIGAN MS, PAULSON JC, ANDERSON DC, MIYASAKA M, WARD PA, 1994. Role of selectins in local and remote tissue injury following ischemia and reperfusion. Am J Pathol 144: 592-598.
40. SHIRATO C, MIURA T, OOIWA H, TOYOFUKU T, WILBORN WH, DOWNEY JM, 1989. Tetrazolium artifactually indicates superoxide dismutase-induced salvage in reperfused rabbit heart. J Mol Cell Cardiol 21: 1187-1193.
41. SILVER MJ, SUTTON JM, HOOK S, LEE P, MALYCKY JL, PHILLIPS L, ELLIS SG, TOPOL EJ, NICOLINI FA, 1995. Adjunctive selecting blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model. Circulation 92: 492-499.
42. TANAKA M, BROOKS SE, RICHARD VJ, FITZHARRIS GP, STOLER RC, JENNINGS RB, ARFORS KE, REIMER KA, 1993. Effect of anti-CD 18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs. Circulation 87: 526-535.
43. VIEHMAN GE, MA XL, LEFER DJ, LEFER AM, 1991. Time course of endothelial dysfunction and myocardial injury during coronary arterial occlusion. Am J Physiol (Heart Circ Physiol) 261: H874-H881.
44. x-dependent and -independent recognition pathways. Blood 82: 182-191.
45. WARREN WK, NOLLERT MU, MCEVER RP, 1995. P-selectin must extend a sufficient length from the plasma membrane to mediate rolling of neutrophils. J Cell Biol 131: 1893-1902.
46. WELLICOME SM, THORNHILL MH, PITZALIS C, THOMAS DS, LANCHBURY JSS, PANAYI GS, HASKARD DO, 1990. A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1 or lipopolysaccharide. J Immunol 144: 2558-2565.
47. WEYRICH AS, MA X-L, LEFER DJ, ALBERTINE KH, LEFER AM, 1993. In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury. J Clin Invest 91: 2620-2629.
48. WEYRICH AS, BUERKE M, ALBERTINE KH, LEFER AM, 1995. Time course of coronary vascular endothelial adhesion molecule expression during reperfusion of the ischemic feline myocardium. J Leukocyte Biol 57: 45-55.
49. WILLIAMS FM, KUS M, TANDA K, WILLIAMS TJ, 1994. Effect of duration of ischaemia on reduction of myocardial infarct size by inhibition of neutrophil accumulation using an anti-CD 18 monoclonal antibody. Br J Pharmacol 111: 1123-1128.
50. ZAHGER D, YANO J, CHAUX A, FISHBEIN MC, GANZ W, 1995. Absence of lethal reperfusion injury after 3 hours of reperfusion. A study in a single-canine-heart model of ischemia-reperfusion. Circulation 91: 2989-2994.
51. ZUGHAIB ME, TANG X-L, SUN J-Z, BOLLI R, 1994. Myocardial reperfusion injury: fact or myth? A 1993 appriasal of a seemingly endless controversy. Ann N Y Acad Sci 723: 218-228.