Effect of long-term administration of hexarelin on the somatotrophic axis in aged rats

Pharmacological Research

Volumn 36, Issue 1, 1997, Pages 49-54

  Cattaneo, Lorena ^a   Luoni, Marina ^a   Settembrini, Beatriz ^b   Müller, Eugenio E ^a   Cocchi, Daniela ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b Instituto Neurobiologia Ciudad Autonoma de Buenos Aires   (Argentina)

^c UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Ageing; Growth hormone; Growth hormone releasing peptides; Hexarelin

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HEXARELIN; MESSENGER RNA; SOMATOMEDIN C; SOMATOSTATIN;

AGED; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GROWTH HORMONE RELEASE; HYPOPHYSIS; HYPOTHALAMUS; LONG TERM CARE; MALE; MESSENGER RNA SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031187961     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1997.0203     Document Type: Article

References (26)

1. 1. Rudman D. Growth hormone, body composition and aging. J Am Geriatr Soc 1985; 33: 800-7.
2. 2. Shetty KR, Duthie EH. Anterior pituitary function and growth hormone use in the elderly. Endocrinol Metab Clin North Am 1995; 24: 213-31.
3. 3. Müller EE, Cella SG, De Gennaro Colonna V, Parenti M, Cocchi D, Locatelli V. Aspects of the neuroendocrine control of growth hormone secretion in ageing mammals. J Reprod Fert 1993; 46 (suppl.): 99-114.
4. 4. Rudman D, Kutner MK, Rogers CM, Lubin MF, Fleming GA, Bain RP. Impaired growth hormone secretion in the adult population: relation to age and adiposity. J Clin Invest 1990; 67: 1361-9.
5. 5. Marcus R, Butterfield G, Holloway L, Gilliland L, Baylink DJ, Hintz RL, Sherman BM. Effects of short term administration of human growth hormone to elderly people. J Clin Endocrinol Metab 1990; 70: 519-27.
6. 6. Vance ML. Growth hormone for the elderly? N Engl J Med 1990; 323: 52-4.
7. 7. Locatelli V, Arimura A, Torsello A, Cella SG, Müller EE. Somatostatin antiserum antagonizes the impaired ability of hpGRF-40 to stimulate growth hormone release in old unanesthetized male rats. Neuroendocrinol Lett 194; 6: 261-6.
8. 8. Panzeri G, Torsello A, Cella SG, Müller EE, Locatelli V. Age-related modulatory activity by a cholinergic agonist on the growth hormone (GH) response to GH-releasing hormone in the rat. Proc Soc Exp Biol Med 1989; 193: 301-5.
9. 9. Parenti M, Dall'Ara A, Rusconi L, Cocchi D, Müller EE. Different regulation of GHRH-sensitive adenylate cyclase in the anterior pituitary of young and old rats. Endocrinology 1987; 121: 1649-53.
10. 10. Iovino M, Monteleone P, Steardo L. Repetitive growth hormone releasing hormone administration restores the attenuated growth hormone (GH) response to GH-releasing hormone testing in normal aging. J Clin Endocrinol Metab 1989; 69: 910-16.
11. 11. Deghenghi R, Cananzi MM, Torsello A, Battisti C, Müller EE, Locatelli V. GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats. Life Sci 1994; 54: 1321-8.
12. 12. Daughaday WH, Kapadia M, Mariz I. Serum somatomedin binding proteins: physiologic significance and interference in radioligand assay. J Lab Clin Med 1987; 109: 355-63.
13. 13. Ganzetti I, De Gennaro Colonna V, Redaelli M, Müller EE, Cocchi D. Effect of hypophysectomy and growth hormone replacement on hypothalamic GHRH. Peptides 1986: 1011-14.
14. 14. Locatelli V, Torsello A, Redaelli M, Ghigo E, Massara F, Müller EE. Cholinergic agonist and antagonist drugs modulate the growth hormone-releasing hormone in the rat: evidence for mediation by somatostatin. J Endocrinol 1989; 111: 271-8.
15. 15. Cella SG, Cerri CG, Daniel S, Sibilia V, Rigamonti A, Cattaneo L, Deghenghi R, Müller EE. Sixteen weeks of Hexarelin therapy in aged dogs: effects on the somatotrophic axis and muscle morphology, with an examination of bone metabolism during the first month of therapy. J Gerontol 1996; 51A: B439-47.
16. 16. Torsello A, Luoni M, Grilli R, Guidi M, Wehrenberg WB, Deghenghi R, Müller EE, Locatelli V. Hexarelin stimulation of growth hormone release and mRNA levels in an infant and adult rat model of impaired GHRH function. Neuroendocrinology 1997; 65: 91-7.
17. 17. De Gennaro Colonna V, Zoli M, Cocchi D, Maggi A, Marrama P, Agnati LF, Müller EE. Reduced growth hormone releasing factor (GHRF)-like immunoreactivity and GHRF gene expression in the hypothalamus of aged rats. Peptides 1988; 10: 705-8.
18. 18. Mayo KE, Godfrey PA, Suhr ST, Kulik DJ, Rahal JO. Growth hormone-releasing hormone: synthesis and signaling. Rec Progr Horm Res 1994; 50: 35-73.
19. 19. Morimoto N, Kawakami F, Makino S, Chihara K, Hasegawa M, Ibata Y. Age-related changes in growth hormone releasing factor and somatostatin in the rat hypothalamus. Neuroendocrinology 1988; 47: 459-64.
20. 20. Sonntag WE, Boyd RL, Booze RM. Somatostatin gene expression in hypothalamus and cortex of aging male rats. Neurobiol Aging 1990; 11: 409-16.
21. 21. De Gennaro Colonna V, Fidone F, Cocchi D, Müller EE. Feedback effects of growth hormone on growth hormone-relesing hormone and somatostatin are not evident in aged rats. Neurobiol Aging 1993; 14: 503-7.
22. 22. Sonntag WE, Gottschall PE, Meites J. Increased secretion of somatostatin-28 from hypothalamic neurons of aged rats in vitro. Brain Res 1986; 380: 229-34.
23. 23. Ferrara C, Ceresoli G, Marcozzi C, Cocchi D. Hypothalamic-pituitary somatostatinergic system in middle-aged female rats. Horm Metab Res 1991; 23: 243-4.
24. 24. Argente J, Garcia-Segura LM, Pozo J, Chowen JA. Growth hormone-releasing peptides: clinical and basic aspects. Horm Res 1996; 46: 155-9.
25. 25. Walker RF, Yang S-W, Bercu BB. Robust growth hormone (GH) secretion in aged female rats co-administered GH releasing hexapeptide (GHRP-6) and GH-releasing hormone (GHRH). Life Sci 1991; 49: 1499-1504.
26. 26. Müller EE. Neural control of somatotropic function. Physiol Rev 1987; 67: 962-1053.