Effects of an Endotoxin Challenge on Growth Performance, Carcass Accretion Rates, and Serum Hormone and Metabolite Concentrations in Control Pigs and Those Treated with Recombinant Porcine Somatotropin

Journal of Animal Science

Volumn 75, Issue 7, 1997, Pages 1784-1790

  Evock Clover, Christina M ^a   Myers, Michael J ^b   Steele, Norman C ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Carcass composition; Endotoxins; Growth; Hormones; Pigs; Somatotropin

Indexed keywords

BACTERIA (MICROORGANISMS); SUIDAE; SUS SCROFA;

ENDOTOXIN; GROWTH HORMONE; INSULIN; LIPOPOLYSACCHARIDE; NITROGEN; PROTEIN; RECOMBINANT PROTEIN; SOMATOMEDIN C; UREA;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; BODY COMPOSITION; BODY MASS; BODY TEMPERATURE; BODY WEIGHT; COMPARATIVE STUDY; DRUG EFFECT; GLUCOSE BLOOD LEVEL; GROWTH, DEVELOPMENT AND AGING; INTRAMUSCULAR DRUG ADMINISTRATION; LIPID METABOLISM; MALE; MEAT; METABOLISM; PHYSIOLOGY; STANDARD; SWINE;

ANIMALS; BLOOD GLUCOSE; BODY COMPOSITION; BODY MASS INDEX; BODY TEMPERATURE; BODY WEIGHT; ENDOTOXINS; GROWTH HORMONE; INJECTIONS, INTRAMUSCULAR; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LIPID METABOLISM; LIPOPOLYSACCHARIDES; MALE; MEAT; NITROGEN; PROTEINS; RECOMBINANT PROTEINS; SWINE; UREA;

EID: 0031178428     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/1997.7571784x     Document Type: Article

References (23)

1. AOAC. 1970. Official Methods of Analysis (11th Ed.). Association of Official Analytical Chemists, Washington, DC.
2. ARC. 1981. The Nutrient Requirements of Pigs. Commonwealth Agricultural Bureaux, Slough, UK.
3. Ballard, F. J., R. J. Johnson, P. C. Owens, G. L. Francis, F. M. Upton, J. P. McMurtry, and J. C. Wallace. 1990. Chicken insulin-like growth factor-I: Amino acid sequence, radioimmunoassay, and plasma levels between strains and during growth. Gen. Comp. Endocrinol. 79:459.
4. Campbell, R. G., N. C. Steele, T. J. Caperna, J. P. McMurtry, M. B. Solomon, and A. D. Mitchell. 1988. Interrelationships between energy intake and endogenous porcine growth hormone administration on the performance, body composition and protein and energy metabolism of growing pigs weighing 25 to 55 kilograms live weight. J. Anim. Sci. 66:1643.
5. Clark, R., J. Strasser, S. McCabe, K. Robbins, and P. Jardieu. 1993. Insulin-like growth factor-I stimulation of lymphopoiesis. J. Clin. Invest. 92:540.
6. Davila, D. R., S. Brief, J. Simon, R. E. Hammer, R. L. Brinster, and K. W. Kelley. 1987. Role of growth hormone in regulating T-dependent immune events in aged, nude, and transgenic rodents. J. Neurosci. Res. 18:108.
7. Dritz, S. S., K. Q. Owen, R. D. Goodband, J. L. Nelssen, M. D. Tokach, M. M. Chengappa, and F. Blecha. 1996. Influence of lipopolysaccharide-induced immune challenge and diet complexity on growth performance and acute-phase protein production in segregated early-weaned pigs. J. Anim. Sci. 74:1620.
8. Elsasser, T. H., R. Fayer, T. S. Rumsey, and G. F. Hartnell. 1994. Recombinant bovine somatotropin blunts plasma tumor necrosis factor-alpha, cortisol, and thromboxane-B2 responses to endotoxin in vivo. Endocrinology 134:1082.
9. Evock-Clover, C. M., N. C. Steele, T. J. Caperna, and M. B. Solomon. 1992. Effects of frequency of recombinant porcine somatotropin administration on growth performance, tissue accretion rates, and hormone and metabolite concentrations in pigs. J. Anim. Sci. 70:3709.
10. Finck, B. N., D. M. Webel, D. H. Baker, and R. W. Johnson. 1996. Circulating cytokines and swine growth. J. Anim. Sci. 74(Suppl. 1):36(Abstr.).
11. Folch, J., M. Lees, and G. H. Sloane Stanley. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226:497.
12. Goff, B. L., K. P. Flaming, D. E. Frank, and J. A. Roth. 1991. Recombinant porcine somatotropin: An immunotoxicology study. J. Anim. Sci. 69:4523.
13. Green, M. H., and C. W. Vermeulen. 1994. Fever and the control of Gram-negative bacteria. Res. Microbiol. 145:269.
14. Inoue, T., H. Saito, R. Fukushima, T. Inaba, M.-T. Lin, K. Fukatsu, and T. Muto. 1995. Growth hormone and insulinlike growth factor I enhance host defense in a murine sepsis model. Arch. Surg. 130:1115.
15. LeRoith, D., J. Yanowski, E. P. Kaldjian, E. S. Jaffe, T. LeRoith, K. Purdue, B. D. Cooper, R. Pyle, and W. Adler. 1996. The effects of growth hormone and insulin-like growth factor I on the immune system of aged female monkeys. Endocrinology 137: 1071.
16. Matteri, R. L., J. J. Klir, and B. A. Becker. 1996. Lipopolysaccharide (LPS) injection alters pituitary hormone secretion in neonatal pigs. J. Anim. Sci. 74(Suppl. 1):75(Abstr.).
17. Noblet, J., P. Herpin, and S. Dubois. 1992. Effect of recombinant porcine somatotropin on energy and protein utilization by growing pigs: Interaction with capacity for lean tissue growth. J. Anim. Sci. 70:2471.
18. SAS. 1985. SAS User's Guide: Statistics (Version 5 Ed.). SAS Inst. Inc., Cary, NC.
19. Steele, N. C., J. P. McMurtry, and R. W. Rosebrough. 1985. Endocrine adaptations of periparturient swine to alteration of dietary energy source. J. Anim. Sci. 60:1260.
20. Weigent, D.A. 1996. Immunoregulatory properties of growth hormone and prolactin. Pharmacol. & Ther. 69:237.
21. Wise, T., J. Klindt, F. C. Buonomo, and J. T. Yen. 1994. Porcine somatotropic regulation of thymic weight, thymosinβ4, and insulin-like growth factors in lean and obese swing. J. Anim. Sci. 72:2404.
22. Wise, T., J. Klindt, D. D. Lunstra, F. C. Buonomo, and J. T. Yen. 1996. Thymic, gonadal, and endocrine relationships in gilts and boars administered porcine somatotropin. J. Anim. Sci. 74: 2992.
23. Yakar, S., H. Domene, R. Meidan, F. Cassorla, I. Gilad, I. Koch, Z. Laron, C. T. Roberts, Jr., D. LeRoith, and R. Eshet. 1994. Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-binding protein (IGFBP)-2 gene expression in spleens of juvenile rats. Horm. Metab. Res. 26:363.