Immunoregulatory properties of growth hormone and prolactin

Pharmacology and Therapeutics

Volumn 69, Issue 3, 1996, Pages 237-257

  Weigent, Douglas A ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

biosynthesis; growth hormone; immunoregulation; lymphocyte; prolactin; receptors

Indexed keywords

CYTOKINE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; PROLACTIN; PROLACTIN RECEPTOR;

AUTOIMMUNITY; DEFENSE MECHANISM; DRUG ACTIVITY; DRUG EFFECT; DRUG INFORMATION; DRUG SYNTHESIS; HORMONE RELEASE; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0029933802     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(96)00001-0     Document Type: Review

References (252)

1. Abbassi, V. and Bellanti, J. A. (1985) Humoral and cell-mediated immunity in growth hormone-deficient children: effect of therapy with human growth hormone. Pediatr. Res. 19: 299-301.
2. Abdel-Meguid, S. S., Shieh, H.-S., Smith, W. W., Dayringer, H. E., Violand, B. N. and Bentle, L. A. (1987) Three-dimensional structure of a genetically engineered variant of porcine growth hormone. Proc. Natl. Acad. Sci. USA 84: 6434-6437.
3. Adams, T. E., Baker, L., Fiddes, R. J. and Brandon, M. R. (1990) The sheep growth hormone receptor: molecular cloning and ontogeny of mRNA expression in the liver. Mol. Cell. Endocrinol. 73: 135-145.
4. Aguila, M. C., Dees, W. L., Haensly, W. E. and McCann, S. M. (1991) Evidence that somatostatin is localized and synthesized in lymphoid organs. Proc. Natl. Acad. Sci. USA 88: 11485-11489.
5. Argetsinger, L. S., Campbell, G. S., Yang, X., Witthuhn, B. A., Silvennoinen, O., Ihle, J. N. and Carter-Su, C. (1993) Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74: 237-244.
6. Arkins, S., Dantzer, R. and Kelley, K. W. (1993) Somatolactogens, somatomedins, and immunity. J. Dairy Sci. 76: 2437-2450.
7. Baroni, C. (1967) Thymus, peripheral lymphoid tissues, and immunological responsiveness of the pituitary dwarf mouse. Experientia 23: 282-283.
8. Baroni, C., Fabris, N. and Bertoli, G. (1967) Age dependency of the primary immune response in the hereditary pituitary dwarf and normal Snell-Bagg mouse. Experentia 23: 1059-1060.
9. Baroni, C. D., Fabris, N. and Bertoli, G. (1969) Effects of hormones on development and function of lymphoid tissues. Synergistic action of thyroxin and somatotropic hormone in pituitary dwarf mice. J. Immunol. 17: 303-314.
10. Baumann, G. (1991) Growth hormone heterogeneity: genes, isohormones, variants, and binding proteins. Endocr. Rev. 12: 424-449.
11. Baumann, G. (1994) Growth hormone-binding proteins: state of the art. J. Endocrinol. 141: 1-6.
12. Baxter, J. B., Blalock, J. E. and Weigent, D. A. (1991a) Characterization of immunoreactive insulin-like growth factor-I from leukocytes and its regulation by growth hormone. Endocrinology 129: 1727-1734.
13. Baxter, J. B., Blalock, J. E. and Weigent, D. A. (1991b) Expression of immunoreactive growth hormone in leukocytes in vivo. J. Neuroimmunol. 33: 43-54.
14. Bazan, J. F. (1990) Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 87: 6934-6938.
15. Beach, J. E., Smallridge, R. C., Kinzer, C. A., Bernton, E. W., Holaday, J. W. and Fein, H. G. (1989) Rapid release of multiple hormones from rat pituitaries perifused with recombinant interleukin-1. Life Sci. 44: 1-7.
16. Berczi, I. and Nagy, E. (1987) The effect of prolactin and growth hormone on hemolymphopoietic tissue and immune function. In: Hormones and Immunity, pp. 145-171, Berczi, I. and Kovacs, K. (eds.) MTP Press, Lancaster.
17. Berczi, I. and Nagy, E. (1991) Effects of hypophysectomy on immune function. In: Psychoneuroimmunology II, pp. 339-376, Ader, R., Cohen, N. and Felten, D. (eds.) Academic Press, San Diego.
18. Berczi, I., Nagy, E., Asa, S. L. and Kovacs, K. (1984) The influence of pituitary hormones on adjuvant arthritis. Arthritis Rheum. 27: 682-688.
19. Berkenbosch, F., Van Oers, J., Del Rey, A., Tilders, F. and Besedovsky, H. (1987) Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 238: 524-526.
20. Bern, H. A. and Nicoll, C. S. (1968) The comparative endocrinology of prolactin. Recent Prog. Horm. Res. 24: 681-720.
21. Bernton, E. W., Beach, J. E., Holaday, J. W., Smallridge, R. C. and Fein, H. G. (1987) Release of multiple hormones by a direct action of interleukin-1 on pituitary cells. Science 238: 519-522.
22. Bernton, E. W., Meltzer, M. S. and Holaday, J. W. (1988) Suppression of macrophage activation and T-lymphocyte function in hypoprolactinemia. Science 239: 401-404.
23. Bernton, E. W., Bryant, H. U. and Holaday, J. W. (1991) Prolactin and immune function. In: Psychoneuroimmunology, 2nd edn., pp. 403-428, Ader, R., Felten, D. L. and Cohen, N. (eds.) Academic Press, San Diego.
24. Bernton, E., Bryant, H., Holaday, J. and Dave, J. (1992) Prolactin and prolactin secretagogues reverse immunosuppression in mice treated with cysteamine, glucocorticoids, or cyclosporin-A. Brain Behav. Immunol. 6: 394-408.
25. Bichell, D. P., Kikuchi, K. and Rotwein, P. (1992) Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo. Mol. Endocrinol. 6: 1899-1908.
26. Binder, G., Revskoy, S. and Gupta, D. (1994) In vivo growth hormone gene expression in neonatal rat thymus and bone marrow. J. Endocrinol. 140: 137-143.
27. Blalock, J. E. (1989) A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiol. Rev. 69: 1-32.
28. Blalock, J. E. (1994a) The syntax of immune-neuroendocrine communication. Immunol. Today 15: 504-511.
29. Blalock, J. E. (1994b) The immune system: our sixth sense. Immunologist 2: 8-15.
30. Bozzola, M. M., Cisternino, M., Valtorta, A., Moretta, A., Biscaldi, I., Maghnie, M., DeAmici, M. and Schimpff, R. M. (1988a) Effect of biosynthetic methionyl growth hormone therapy on the immune function in GH deficient children. Horm. Res. 31: 153-156.
31. Bozzola, M., Maccario, R., Cisternino, M., de Amici, M., Valtorta, A., Moretta, A., Biscaldi, I. and Schimpff, R. M. (1988b) Immunological and endocrinological response to growth hormone therapy in short children. Acta Paediatr. Scand. 77: 675-680.
32. Bozzola, M., Valtorta, A., Moretta, A., Cisternino, M., Biscaldi, I. and Schimpff, R. M. (1990) In vitro and in vivo effect of growth hormone on cytotoxic activity. J. Pediatr. 117: 596-599.
33. Buckley, A. R., Montgomery, D. W., Kibler, R., Putnam, C. W., Zukoski, C. F., Gout, P. W., Beer, C. T. and Russell, D. H. (1986) Prolactin stimulation of ornithine decarboxylase and mitogenesis in Nb2 node lymphoma cells: the role of protein kinase C and calcium mobilization. Immunopharmacology 12: 37-51.
34. Buckley, A. R., Crowe, P. D. and Russell, D. H. (1988) Rapid activation of protein kinase C in isolated rat liver nuclei by prolactin, a known hepatic mitogen. Proc. Natl. Acad. Sci. USA 85: 8649-8653.
35. Campbell, G. S., Pang, L., Miyasaki, T., Saltiel, A. E. and Carter-Su, C. (1992) Stimulation by growth hormone of MAP kinase activity in 3T3-F422A fibroblasts. J. Biol. Chem. 267: 6074-6080.
36. Casanova, S., Repellin, A. M. and Schimpff, R. M. (1990) Production of interleukin-1 alpha and interleukin-2 by mononuclear cells from children with growth delay in relation to the degree of growth hormone deficiency: effects of substitutive treatment. Horm. Res. 34: 209-214.
37. Cesario, T. C., Yousefi, S., Carandang, G., Sadati, N., Le, J. and Vaziri, N. (1994) Enhanced yields of gamma interferon in prolactin treated human peripheral blood mononuclear cells. Proc. Soc. Exp. Biol. Med. 205: 89-95.
38. Chen, H. W., Meier, H., Heiniger, H. J. and Huebner, R. J. (1972) Tumorigenesis in strain DW-J mice and induction by prolactin of the group-specific antigen of endogenous C-type RNA tumor virus. J. Natl. Cancer Inst. 49: 1145-1154.
39. Chien, Y. H. and Thompson, B. E. (1980) Genomic organization of rat prolactin and growth hormone genes. Proc. Natl. Acad. Sci. USA 77: 4583-4587.
40. Chou, S. Y., Kostyo, J. L. and Adamafio, N. A. (1990) Growth hormone inhibits activation of phosphatidylinositol phospholipase C by insulin in ob/ob mouse adipose tissue. Endocrinology 126: 62-66.
41. Church, J. A., Costin, G. and Brooks, J. (1989) Immune functions in children treated with biosynthetic growth hormone. J. Pediatr. 115: 420-423.
42. Claassen, J. L., Levine, A. D. and Buckley, R. H. (1992) Mechanism of pokeweed mitogen inhibition of rhIL-4-induced human IgE synthesis. Cell. Immunol. 140: 357-369.
43. Clevenger, C. V., Russell, D. H., Appasamy, P. M. and Prystowsky, M. B. (1990a) Regulation of interleukin 2-driven T-lymphocyte proliferation by prolactin. Proc. Natl. Acad. Sci. USA 87: 6460-6464.
44. Clevenger, C. V., Sillman, A. L. and Prystowsky, M. B. (1990b) Interleukin-2 driven nuclear translocation of prolactin in cloned T-lymphocytes. Endocrinology 127: 3151-3159.
45. Clevenger, C. V., Altmann, S. W. and Prystowsky, M. B. (1991) Requirement of nuclear prolactin for interleukin-2-stimulated proliferation of T lymphocytes. Science 253: 77-79.
46. Clodi, M., Svoboda, T., Kotzmann, H., Deyssig, R., Woloszczuk, W., Zielinski, C. C. and Luger, A. (1992) Effect of elevated serum prolactin concentrations on cytokine production and natural killer cell activity. Neuroendocrinology 56: 775-779.
47. Cohen, J. J., Duke, R. C., Fadok, V. A. and Sellins, K. S. (1992) Apoptosis and programmed cell death in immunity. Ann. Rev. Immunol. 10: 267-293.
48. Corpas, E., Harman, S. M. and Blackman, M. R. (1993) Human growth hormone and human aging. Endocr. Rev. 14: 20-39.
49. Crist, D. M., Peake, G. T., Mackinnon, L. T., Sibbitt, W. L., Jr. and Kraner, J. C. (1987) Exogenous growth hormone treatment alters body composition and increases natural killer cell activity in women with impaired endogenous growth hormone secretion. Metab. Clin. Exp. 36: 1115-1117.
50. Cunningham, B. C., Ultsch, M., deVos, A. M., Mulkerrin, M. G., Clauser, K. R. and Wells, J. A. (1991) Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science 254: 821-825.
51. Dardenne, M., Savino, W., Gagnerault, M. C., Itoh, T. and Bach, J. F. (1989) Neuroendocrine control of thymic hormonal production. I. Prolactin stimulates in vivo and in vitro the production of thymulin by human and murine thymic epithelial cells. Endocrinology 125: 3-12.
52. Davila, D. R., Brief, S., Simon, J., Hammer, R. E., Brinster, R. L. and Kelley, K. W. (1987) Role of growth hormone in regulating T-dependent immune events in aged, nude, and transgenic rodents. J. Neurosci. Res. 18: 108-116.
53. Davis, J. R. E., Belayew, A. and Sheppard, M. C. (1988) Prolactin and growth hormone. Baillieres Clin. Endocrinol. Metab. 2: 797-834.
54. Day, R. N. and Day, K. H. (1994) An alternatively spliced form of pit-1 represses prolactin gene expression. Mol. Endocrinol. 8: 374-381.
55. Day, R. N. and Mauer, R. A. (1989) The distal enhancer region of the rat prolactin gene contains elements conferring response to multiple hormones. Mol. Endocrinol. 3: 3-9.
56. Devesa, J., Lima, L. and Tresguerres, J. A. F. (1992) Neuroendocrine control of growth hormone secretion in humans. Trends Endocrinol. Metab. 3: 175-183.
57. DeVito, W. J. (1988) Distribution of immunoreactive prolactin in the male and female brain: effects of hypophysectomy and intraventricular administration of colchicine. Neuroendocrinology 47: 284-289.
58. DiMattia, G. E., Gellersen, B., Bohnet, H. G. and Friesen, H. G. (1988) A human-lymphoblastoid cell line produces prolactin. Endocrinology 122: 2508-2517.
59. Dougherty, T. F. (1952) Effects of hormones on lymphatic tissue. Physiol. Rev. 32: 379-392.
60. Edery, M., Levi-Meyrueis, C., Paly, J., Kelly, P. A. and Dijane, J. (1994) A limited cytoplasmic region of the prolactin receptor critical for signal transduction. Mol. Cell. Endocrinol. 102: 39-44.
61. Edwards, C. K., Ghiasuddin, S. M., Schepper, J. M., Yunger, L. M. and Kelley, K. W. (1988) A newly defined property of somatotropin: priming of macrophages for production of superoxide anion. Science 239: 769-771.
62. Edwards, C. K., Lorence, R. M., Dunham, D. M., Arkins, S., Yunger, L. M., Greager, J. A., Walter, R. J., Dantzer, R. and Kelley, K. W. (1991a) Hypophysectomy inhibits the synthesis of tumor necrosis factor alpha by rat macrophages: partial restoration by exogenous growth hormone or interferon gamma. Endocrinology 128: 989-996.
63. Edwards, C. K., Yunger, L. M., Lorence, R. M., Dantzer, R. and Kelley, K. W. (1991b) The pituitary gland is required for protection against lethal effects of Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 88: 2274-2277.
64. Emanuele, N. V., Metcalfe, L., Lubrano, T., Rubinstein, H., Kirsteins, L. and Lawrence, A. M. (1987) Subcellular distribution of hypothalamic prolactin-like immunoreactivity. Brain Res. 407: 223-229.
65. Emanuele, N. V., Jurgens, J. K., Halloran, M. M., Tentler, J. J., Lawrence, A. M. and Kelley, M. R. (1992) The rat prolactin gene is expressed in brain tissue: detection of normal and alternatively spliced prolactin messenger RNA. Mol. Endocrinol. 6: 35-42.
66. Eriksson, H., Sundler, R. and Donner, J. (1990) Growth hormone increases phosphoinositide turnover in rat adipocytes that are sensitive to the insulin-like action of the hormone. Mol. Cell. Biochem. 97: 181-186.
67. Fabris, N., Pierpaoli, W. and Sorkin, E. (1971) Hormones and the immunological capacity. III. The immunodeficiency disease of the hypopituitary Snell-Bagg dwarf mouse. Clin. Exp. Immunol. 9: 209-225.
68. Fornari, M. C., Scolnik, M. P., Palacios, M. F., Intebi, A. D. and Diez, R. A. (1994) Growth hormone inhibits normal B-cell differentiation and neutrophil chemotaxis in vitro. Int. J. Immunopharmacol. 16: 667-673.
69. Frohman, L. A., Downs, T. R., Chomczynski, P., Brar, A. and Kashio, Y. (1989) Regulation of growth hormone-releasing hormone gene expression and biosynthesis. Yale J. Biol. Med. 62: 427-433.
70. Fu, Y. K., Arkins, S., Wang, B. S. and Kelley, K. W. (1991) A novel role of growth hormone and insulin-like growth factor: priming neutrophils for superoxide anion secretion. J. Immunol. 146: 1602-1608.
71. Fu, Y. K., Arkins, S., Fuh, G., Cunningham, B. C., Wells, J. A., Fong, S., Cronin, M. J., Dantzer, R. and Kelley, K. W. (1992) Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor. J. Clin. Invest. 89: 451-457.
72. Fuh, G., Cunningham, B. C., Fukunaga, R., Nagata, S., Goeddel, D. V. and Wells, J. A. (1992) Rational design of potent antagonists to the human growth hormone receptor. Science 256: 1677-1680.
73. Fuxe, K., Hokfelt, T., Eneroth, P., Gustafsson, J. A. and Skett, P. (1977) Prolactin-like immunoreactivity: localization in nerve terminals of rat hypothalamus. Science 196: 899-900.
74. Gagnerault, M. C., Touraine, P., Savino, W., Kelly, P. A. and Dardenne, M. (1993) Expression of prolactin receptors in murine lymphoid cells in normal and autoimmune situations. J. Immunol. 150: 5673-5681.
75. Gaillard, R. C., Turnill, D., Sappino, P. and Muller, A. F. (1990) Tumor necrosis factor alpha inhibits the hormonal response of the pituitary gland to hypothalamic releasing factors. Endocrinology 127: 101-106.
76. Gala, R. R. (1991) Prolactin and growth hormone in the regulation of the immune system. Proc. Soc. Exp. Biol. Med. 198: 513-527.
77. Gala, R. R. and Shevach, E. M. (1993a) Influence of prolactin and growth hormone on the activation of dwarf mouse lymphocytes in vivo. Proc. Soc. Exp. Biol. Med. 204: 224-230.
78. Gala, R. R. and Shevach, E. M. (1993b) Identification by analytical flow cytometry of prolactin receptors on immunocompetent cell populations in the mouse. Endocrinology 133: 1617-1623.
79. Geffner, M. E., Bersch, N., Lippe, B. M., Rosenfeld, R. G., Hintz, R. L. and Golde, D. W. (1990) Growth hormone mediates the growth of T-lymphoblast cell lines via locally generated insulin-like growth factor-I. J. Clin. Endocrinol. Metab. 71: 464-469.
80. Gellersen, B., DiMattia, G. E., Friesen, H. G. and Bohnet, H. G. (1989a) Prolactin (PRL) mRNA from human decidua differs from pituitary PRL mRNA but resembles the IM-9-P3 lymphoblasts PRL transcript. Mol. Cell. Endocrinol. 64: 127-130.
81. Gellersen, B., DiMattia, G. E., Friesen, H. G. and Bohnet, H. G. (1989b) Phorbol ester stimulates prolactin release but reduces prolactin mRNA in the human-lymphoblastoid cell line IM-9-P. Mol. Cell. Endocrinol. 66: 153-161.
82. Gellersen, B., DiMattia, G. E., Friesen, H. G. and Bohnet, H. G. (1989c) Regulation of prolactin secretion in the human B-lymphoblastoid cell line IM-9-P3 by dexamethasone but not other regulators of pituitary prolactin secretion. Endocrinology 125: 2853-2861.
83. Gellersen, B., Kempf, R., Hartung, S., Bonhoff, A. and DiMattia, G. E. (1992) Posttranscriptional regulation of the human prolactin gene in IM-9-P3 cells by retinoic acid. Endocrinology 131: 1017-1025.
84. Gellersen, B., Kempf, R., Telgmann, R. and DiMattia, G. E. (1994) Non-pituitary human prolactin gene transcription is independent of Pit-1 and differentially controlled in lymphocytes and in endometrial stroma. Mol. Endocrinol. 8: 356-373.
85. Golde, D. W., Bersch, N. and Li, C. H. (1978) Growth hormone: species specific stimulation of erythropoiesis in vitro. Science 196: 1112-1113.
86. Gonzalez, M. C., Aguila, M. C. and McCann, S. M. (1991) In vitro effects of recombinant human gamma-interferon on growth hormone release. Prog. NeuroEndocrinImmunol. 4: 222-227.
87. Gonzalez-Crespo, S. and Boranat, A. (1991) Expression of the rat growth hormone-releasing hormone gene in placenta is directed by an alternative promoter. Proc. Natl. Acad. Sci. USA 88: 8749-8753.
88. Goodman, H. M., Gorin, E. and Honeyman, T. W. (1988) Biochemical basis for the lipolytic activity of growth hormone. In: Human Growth Hormone: Progress and Challenges, pp. 75-111, Underwood, L. E. (ed.) Marcel Dekker, New York.
89. Gorin, E., Tai, L. R., Honeyman, T. W. and Goodman, H. M. (1990) Evidence for a role of protein kinase C in the stimulation of lipolysis by growth hormone and isoproterenol. Endocrinology 126: 2973-2982.
90. Guarcello, V., Weigent, D. A. and Blalock, J. E. (1991) Growth hormone releasing hormone receptors on thymocytes and splenocytes from rats. Cell. Immunol. 136: 291-302.
91. Guler, H. P., Zapf, J., Scheiwiller, E. and Froesch, E. R. (1988) Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats. Proc. Natl. Acad. Sci. USA 85: 4889-4893.
92. Gupta, S., Fikrig, S. M. and Noval, M. S. (1983) Immunological studies in patients with isolated growth hormone deficiency. Clin. Exp. Immunol. 54: 87-90.
93. Hallstrom, I. P., Gustafsson, J. A. and Blanck, A. (1989) Effects of growth hormone on the expression of c-myc and c-fos during early stages of sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model. Carcinogenesis 10: 2339-2343.
94. Hartmann, D. P., Holaday, J. W. and Bernton, E. W. (1989) Inhibition of lymphocyte proliferation by antibodies to prolactin. FASEB J. 3: 2194-2202.
95. Hattori, N., Shimatsu, A., Sugita, M., Kumagai, S. and Imura, H. (1990) Immunoreactive growth hormone (GH) secretion by human lymphocytes: augmented release by exogenous GH. Biochem. Biophys. Res. Commun. 168: 396-401.
96. Hattori, N., Shimormura, K., Ishihara, T., Moridera, K., Hino, M., Ikekubo, K. and Kurahachi, H. (1993) Growth hormone (GH) secretion from human lymphocytes is up-regulated by GH, but not affected by insulin-like growth factor-1. J. Clin. Endocinol. Metab. 76: 937-939.
97. Herington, A. C. (1994) New frontiers in the molecular mechanisms of growth hormone action. Mol. Cell. Endocrinol. 100: 39-44.
98. Hiestand, P. C., Mekler, P., Nordmann, R., Grieder, A. and Permmongkol, C. (1986) Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine. Proc. Natl. Acad. Sci. USA 83: 2599-2603.
99. Hiraoka, Y., Tatsumi, K., Shiozawa, M., Aiso, S., Fukasaua, T., Yasuda, K. and Miyai, K. (1991) A placenta-specific 5′ non-coding exon of human prolactin. Mol. Cell. Endocrinol. 75: 71-80.
100. Hokfelt, T. and Fuxe, K. (1971) Effects of prolactin and ergot alkaloids on the tuberoinfundibular dopamine (DA) neurons. Neuroendocrinology 9: 100-122.
101. Holl, R. W., Thorner, M. O. and Leong, D. A. (1988) Intracellular calcium concentration and growth hormone secretion in individual somatotropes: effects of growth hormone-releasing factor and somatostatin. Endocrinology 122: 2927-2932.
102. Holmdahl, R., Klareskog, L., Rubin, K., Larsson, E. and Wigzell, H. (1985) T lymphocytes in collagen II-induced arthritis in mice: characterization of arthritogenic collagen II-specific T-cell lines and clones. Scand. J. Immunol. 22: 295-306.
103. Horseman, N. D. and Yu-Lee, L.-Y. (1994) Transcriptional regulation by the helix bundle peptide hormones: growth hormone, prolactin, and hematopoietic cytokines. Endocr. Rev. 15: 627-649.
104. Imura, H., Fukata, J. and Mori, T. (1991) Cytokines and endocrine function: an interaction between the immune and neuroendocrine systems. Clin. Endocrinol. 35: 107-115.
105. Intebi, A. D., Palacios, M. F., Sen, L. and Diez, R. A. (1992) Defective B-cell differentiation under PWM induction in acromegaly. Prog. NeuroEndocrinImmunol. 5: 62-69.
106. Ishizaka-Ikeda, E., Dukunaga, R., Wood, W. I., Goeddel, D. V. and Nagata, S. (1993) Signal transduction mediated by growth hormone receptor and its chimeric molecules with the granulocyte colony-stimulating factor receptor. Proc. Natl. Acad. Sci. USA 90: 123-127.
107. Javatilak, P. G., Puryear, T. K., Herz, Z., Fazleabas, A. and Gibori, B. (1989) Prolactin secretion by mesometrial and antimesometrial rat decidual tissue: evidence for differential gene expression. Endocrinology 125: 659-666.
108. Johnson, E. W., Jones, L. A. and Kozak, R. W. (1992) Expression and function of insulin-like growth factor receptors on anti-CD3-activated human T lymphocytes. J. Immunol. 148: 63-71.
109. Johnson, H. M., Downs, M. O. and Pontzer, C. H. (1992) Neuroendocrine peptide hormone regulation of immunity. In: Neuroimmunoendocrinology, 2nd edn., pp. 49-83, Blalock, J. E. (ed.) Karger, Basel.
110. Kao, T. L., Harbour, D. V. and Meyer, W. J., 3d. (1992a) Immunoreactive growth hormone production by cultured lymphocytes. Ann. NY Acad. Sci. 650: 179-181.
111. Kao, T. L., Supowit, S. C., Thompson, E. A. and Meyer, W. J., 3d. (1992b) Immunoreactive growth hormone production by human lymphocyte cell lines. Cell Mol. Neurobiol. 12: 483-498.
112. Karanth, S. and McCann, S. M. (1991) Anterior pituitary hormone control by interleukin 2. Proc. Natl. Acad. Sci. USA 88: 2961-2965.
113. Kasting, N. W. and Martin, J. B. (1982) Altered release of growth hormone and thyrotropin induced by endotoxin in the rat. Am. J. Physiol. 243: E332-E337.
114. Katsuura, G., Gottschall, P. E., Dahl, R. R. and Arimura, A. (1988) Adrenocorticotropin release induced by intracerebroventricular injection of recombinant human interleukin-1 in rats: possible involvement of prostaglandin. Endocrinology 122: 1773-1779.
115. Kelley, K. W. (1989) Growth hormone, lymphocytes and macrophages. Biochem. Pharmacol. 38: 705-713.
116. Kelley, K. W. (1990) The role of growth hormone in modulation of the immune response. Ann. NY Acad. Sci. 594: 95-103.
117. Kelley, K. W., Brief, S., Westly, H. J., Novakofski, J., Bechtel, P. J., Simon, J. and Walker, E. B. (1986) GH3 pituitary adenoma cells can reverse thymic aging in rats. Proc. Natl. Acad. Sci. USA 83: 5663-5667.
118. Kiess, W. and Butenandt, O. (1985) Specific growth hormone receptors on human peripheral mononuclear cells: reexpression, identification, and characterization. J. Clin. Endocrinol. Metab. 60: 740-746.
119. Kiess, W., Holtmann, H., Butenandt, O. and Eife, R. (1983) Modulation of lymphoproliferation by human growth hormone. Eur. J. Pediatr. 140: 47-50.
120. Kiess, W., Malozowski, S., Gelato, M., Butenand, O., Doerr, H., Crisp, B., Eisl, E, Maluish, A. and Belohradsky, B. H. (1988) Lymphocyte subset distribution and natural killer activity in growth hormone deficiency before and during short-term treatment with growth hormone releasing hormone. Clin. Immunol. Immunopathol. 48: 85-94.
121. Kilgour, E. and Anderson, N. G. (1994) Growth hormone induces the tyrosine phosphorylation and nuclear accumulation of components of the ISGF3 transcription factor complex. FEBS Lett. 343: 205-207. Erratum: FEBS Lett. 349: 161.
122. Kishimoto, T. and Hirano, T. (1988) Molecular regulation of B lymphocyte response. Annu. Rev. Immunol. 6: 485-512.
123. Koenig, J. I., Snow, K., Clark, B. D., Toni, R., Cannon, J. G., Shaw, A. R., Dinarello, C. A, Reichlin, S., Lee, S. L. and Lechan, R. M. (1990) Intrinsic pituitary interleukin-1 beta is induced by bacterial lipopolysaccharide. Endocrinology 126: 3053-3058. Erratum: Endocrinology 127: 657.
124. Koh, C. Y. and Phillips, J. T. (1993) Prolactin receptor expression by lymphoid tissues in normal and immunized rats. Mol. Cell. Endocrinol. 92: R21-R25.
125. Kohmoto, K., Tsunasawa, S. and Sakiyama, F. (1984) Complete amino acid sequence of mouse prolactin. Eur. J. Biochem.138: 227-237.
126. Krentz, A. J., Koster, F. T., Crist, D. M., Finn, K., Johnson, L. Z., Boyle, P. J. and Schade, D. S. (1993) Anthropometric, metabolic, and immunological effects of recombinant human growth hormone in AIDS and AIDS-related complex. J. AIDS 6: 245-251.
127. Krown, K. A., Wang, Y. F., Ho, T. W., Kelly, P. A. and Walker, A. M. (1992) Prolactin isoform 2 as an autocrine growth factor for GH3 cells. Endocrinology 131: 595-602.
128. Krown, K. A., Wang, Y. F. and Walker, A. M. (1994) Autocrine interaction between prolactin and its receptor occurs intracellularly in the 235-1 mammotroph cell line. Endocrinology 134: 1546-1552.
129. Lahat. N., Miller, A., Shtiller, R. and Touby, E. (1993) Differential effects of prolactin upon activation and differentiation of human B lymphocytes. J. Neuroimmunol. 47: 35-40.
130. Lamberts, S. W. J. and MacLeod, R. M. (1990) Regulation of prolactin secretion at the level of the lactotroph. Physiol. Rev. 70: 279-318.
131. Larsen, J. L. and Dufau, M. L. (1988) Modulation of prolactin-stimulated Nb2 lymphoma cell mitogenesis by cholera toxin and pertussis toxin. Endocrinology 123: 438-444.
132. Leung, D. W., Spencer, S. A. and Cacianes, G. (1987) Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature 330: 537-543.
133. Lewis, U. J. (1992) Growth hormone: what is it and what does it do. Trends Endocrinol. Metab. 3: 117-121.
134. Li, C. H. (1976) Studies on pituitary lactogenic hormone: the primary structure of the porcine hormone. Int. J. Peptide Protein Res. 8: 205-224.
135. Li, C. H. and Papkoff, H. (1956) Preparation and properties of growth hormone from human and monkey pituitary glands. Science 124: 1293-1294.
136. Li, C. H., Dixon, J. S., Lo, T. B., Schmidt, K. D. and Pakov, Y. A. (1970) Studies on pituitary lactogenic hormone XXX. The primary structure of the sheep hormone. Arch. Biochem. Biophys. 141: 705-737.
137. Li, S., Crenshaw, E. B., 3d., Rawson, E. J., Simmons, D. M., Swanson, L. W. and Rosenfeld, M. G. (1990) Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 347: 528-533.
138. Li, Y. M., Brunke, D. L., Dantzer, R. and Kelley, K. W. (1992) Pituitary epithelial cell implants reverse the accumulation of CD4-CD8-lymphocytes in thymus glands of aged rats. Endocrinology 130: 2703-2709.
139. Lobie, P. E., Garcia-Aragon, J., Wang, B. S., Baumbach, W. R. and Waters, M. J. (1992) Cellular localization of the growth hormone binding protein in the rat. Endocrinology 130: 3057-3065.
140. Lobie, P. E., Mertani, H., Morel, G., Morales-Bustos, O., Norstedt, G. and Waters, M. J. (1994) Receptor-mediated nuclear translocation of growth hormone. J. Biol. Chem. 269: 21330-21339.
141. Lytras, A., Quan, N., Vrontakis, M. E., Shaw, J. E., Cattini, P. A. and Friesen, H. G. (1993) Growth hormone expression in human Burkitt lymphoma serum-free Ramos cell line. Endocrinology 132: 620-628.
142. Maggiano, N., Piantelli, M., Ricci, R., Larocca, L. M., Capelli, A. and Ranelletti, O. (1994) Detection of growth hormone-producing cells in human thymus by immunohistochemistry and non-radioactive in situ hybridization. J. Histochem. Cytochem. 42: 1349-1354.
143. Mahon, J. L., Gunn, H. C., Stobie, K., Gibson, C., Garcia, B., Dupre, J. and Stiller, C. R. (1988) The effect of bromocriptine and cyclosporine on spontaneous diabetes in BB rats. Transplant. Proc. 20 (Suppl.): 197-200.
144. Maier, C. C., LeBoeuf, R. D., Zhou, S. R., Whitaker, J. N., Jarpe, M. A. and Blalock, J. E. (1993) The structure of a myelin basic protein-associated idiotope. J. Neuroimmunol. 46: 235-243.
145. Malarkey, W. B., Jackson, R. and Wortsman, J. (1988) Long-term assessment of patients with macroprolactinemia. Fertil. Steril. 50: 413-418.
146. Mason, W. T., Dickson, S. L. and Leng, G. (1993) Control of growth hormone secretion at the single cell level. Acta Paediatr. Suppl. 388: 84-92; discussion 93.
147. Matera, L., Muccioli, G., Cesano, A., Bellussi, G. and Genazzani, E. (1988) Prolactin receptors on large granular lymphocytes: dual regulation by cyclosporin A. Brain Behav. Immunol. 2: 1-10.
148. Matera, L., Bellone, G. and Cesano, A. (1991) Prolactin and the neuroimmune network. Adv. Neuroimmunol. 1: 158-172.
149. Matera, L., Cesano, A., Bellone, G. and Oberholtzer, E. (1992) Modulatory effect of prolactin on the resting and mitogen-induced activity of T, B, and NK lymphocytes. Brain Behav. Immunol. 6: 409-417.
150. McCann, S. M., Karanth, S., Kamat, A., Dees, W. L., Lyson, K., Gimeno, M. and Rettori, V. (1994) Induction of cytokines of the pattern of pituitary hormone secretion in infection. Neuroimmunomodulation 1: 2-13.
151. McMurray, R. W., Hoffman, R. W. and Walker, S. E. (1991a) In vivo prolactin manipulation alters in vitro IL-2, IL-4, and IFN-gamma mRNA levels in female B/W mice. Clin. Res. 39: 734A.
152. McMurray, R., Keisler, D., Kanuckel, K., Izui, S. and Walker, S. E. (1991b) Prolactin influences autoimmune disease activity in the female B/W mouse. J. Immunol. 147: 3780-3787.
153. Melton, D. A. (1985) Injected antisense RNAs specifically block messenger RNA translation in vivo. Proc. Natl. Acad. Sci. USA 82: 144-148.
154. Mercola, K. E., Cline, M. J. and Golde, D. W. (1981) Growth hormone stimulation of normal and leukemic human T-lymphocyte proliferation in vitro. Blood 58: 337-340.
155. Merimee, T. J., Grant, M. B., Broder, C. M. and Cavalli-Sforza, L. L. (1989) Insulin-like growth factor secretion by human B-lymphocytes: a comparison of cells from normal and pygmy subjects. J. Clin. Endocrinol. Metab. 69: 978-984.
156. Milenkovic, L., Rettori, V., Snyder, G. E., Reutler, B. and McCann, S. M. (1989) Cachectin alters anterior pituitary hormone release by a direct action in vitro. Proc. Natl. Acad. Sci. USA 86: 2418-2422.
157. Montgomery, D. W., Zukowski, C. F., Shah, N. G., Buckley, A. R., Pacholczyk, T. and Russell, D. H. (1987) Concanavalin A-stimulated murine leukocytes produce a factor with prolactin-like bioactivity and immunoreactivity. Biochem. Biophys. Res. Commun. 145: 692-698.
158. Montgomery, D. W., Shen, G. K., Ulrich, E. D., Steiner, L. L., Parrish, P. R. and Zukoski, C. F. (1992) Human thymocytes express a prolactin-like messenger ribonucleic acid and synthesize bioactive prolactin-like protein. Endocrinology 131: 3019-3026.
159. Mukherjee, P., Mastro, A. and Hymer, W. C. (1990) Prolactin induction of interleukin-2 receptors on rat splenic lymphocytes. Endocrinology 126: 88-94.
160. Murphy, L. J., Bell, G. I. and Friesen, H. G. (1987a) Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat. Endocrinology 120: 1279-1282.
161. Murphy, L. J., Bell, G. I. and Friesen, H. G. (1987b) Growth hormone stimulates sequential induction of c-myc and insulin-like growth factor I expression in vivo. Endocrinology 120: 1806-1812.
162. Murphy, W. J., Durum, S. K., Anver, M., Frazier, M. and Longo, D. L. (1992a) Recombinant human growth hormone promotes human lymphocyte engraftment in immunodeficient mice and results in an increased incidence of human Epstein Barr virus-induced B-cell lymphoma. Brain Behav. Immunol. 6: 355-364.
163. Murphy, W. J., Durum, S. K. and Longo, D. L. (1992b) Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice. Proc. Natl. Acad. Sci. USA 89: 4481-4485.
164. Murphy, W. J., Tsarfaty, G. and Longo, D. L. (1992c) Growth hormone exerts hematopoietic growth-promoting effects in vivo and partially counteracts the myelosuppressive effects of azidothymidine. Blood 80: 1443-1447.
165. Nagy, E. and Berczi, I. (1978) Immunodeficiency in hypophysectomized rats. Acta Endocrinol. 89: 530-537.
166. Nagy, E., Berczi, I. and Friesen, H. G. (1983a) Regulation of immunity in rats by lactogenic and growth hormones. Acta Endocrinol. 102: 351-357.
167. Nagy, E., Berczi, I., Wren, G., Asa, S. L. and Kovacs, K. (1983b) Immunomodulation by bromocriptine. Immunopharmacology 6: 231-243.
168. Neidhart, M. (1989) Bromocriptine microcapsules inhibit ornithine decarboxylase activity induced by Freund's complete adjuvant in lymphoid tissues of male rats. Endocrinology 125: 2846-2852.
169. Neidhart, M. and Larson, D. F. (1990) Freund's complete adjuvant induces ornithine decarboxylase activity in the central nervous system of male rats and triggers the release of pituitary hormones. J. Neuroimmunol. 26: 97-105.
170. Neill, J. D. and Nagy, G. M. (1994) Prolactin secretion and its control. In: The Physiology of Reproduction, 2nd edn., pp. 1833-1860, Knobil, E. and Neill, J. D. (eds.) Raven Press, Ltd., New York.
171. Nicoll, C. S. (1980) Ontogeny and evolution of prolactin's functions. Fed. Proc. 39: 2563-2566.
172. Nyman, T. and Pekonen, F. (1993) The expression of insulin-like growth factors and their binding proteins in normal human lymphocytes. Acta Endocrinol. 128: 168-172.
173. Ofenstein, J. P., Rillema, J. A. and Lawson, D. M. (1985) Prolactin stimulation of Nb 2 node lymphoma cell division is inhibited by polyamine biosynthesis inhibitors. Proc. Soc. Exp. Biol. Med. 180: 236-239.
174. O'Neal, K. D., Schwarz, L. A. and Yu-Lee, L. Y. (1991) Prolactin receptor
175. Palestine, A. G., Nussenblatt, R. B. and Gelato, M. (1988) Therapy for autoimmune uveitis with low dose cyclosporine plus bormocriptine. Transplant. Proc 20: 131-136.
176. Payne, L. C., Weigent, D. A. and Blalock, J. E. (1994) Induction of pituitary sensitivity to interleukin-1: a new function for corticotropin-releasing hormone. Biochem. Biophy. Res. Commun. 198: 480-484.
177. Pekhletsky, R. I., Chernov, B. K. and Rubtsov, P. M. (1992) Variants of the 5′-untranslated sequence of human growth hormone receptor mRNA. Mol. Cell. Endocrinol. 90: 103-109.
178. Pellegrini, I., Lebrun, J.-I., Ali, S. and Kelly, P. A. (1992) Expression of prolactin and its receptor in human lymphoid cells. Mol. Endocrinol. 6: 1023-1031.
179. Pierpaoli, W. and Sorkin, E. (1967) Relationship between thymus and hypophysis. Nature 215: 834-837.
180. Pierpaoli, W. and Sorkin, E. (1968) Hormones and immunologic capacity. I. Effect of heterologous anti-growth hormone (ASTH) antiserum on thymus and peripheral lymphatic tissue in mice. Induction of a wasting syndrome. J. Immunol. 101: 1036-1043.
181. Pierpaoli, W., Baroni, C., Fabris, N. and Sorkin, E. (1969) Hormones and immunological capacity. II. Reconstitution of antibody production in hormonally deficient mice by somatotropic hormone, thyrotropic hormone and thyroxin. J. Immunol. 16: 217-230.
182. Pierpaoli, W., Kopp, H. G. and Bianchi, E. (1976) Interdependence of thymic and neuroendocrine functions in ontogeny. Clin. Exp. Immunol. 24: 501-506.
183. Press, M. (1988) Growth hormone and metabolism. Diabetes Metab. Rev. 4: 391-414.
184. Rao, Y., Olson, M. D., Buckley, D. J. and Buckley, A. R. (1993) Nuclear co-localization of prolactin and the prolactin receptor in rat Nb2 node lymphoma cells. Endocrinology 133: 3062-3065.
185. Rapaport, R., Oleske, J., Ahdieh, H., Solomon, S., Delfaus, C. and Denny, T. (1986) Suppression of immune function in growth hormone-deficient children during treatment with human growth hormone. J. Pediatr. 109: 434-439.
186. Rapaport, R., Oleske, J., Ahdieh, H., Skuza, K., Holland, B. K., Passannante, M. R. and Denny, T. (1987) Effects of human growth hormone on immune functions: in vitro studies on cells of normal and growth hormone-deficient children. Life Sci. 41: 2319-2324.
187. Rettori, V., Jurcovicova, J. and McCann, S. M. (1987) Central action of interleukin-1 in altering the release of TSH, growth hormone, and prolactin in the male rat. J. Neurosci. Res. 18: 179-183.
188. Rettori, V., Milenkovic, L., Beutler, B. A. and McCann, S. M. (1989) Hypothalamic action of cachectin to alter pituitary hormone release. Brain Res. Bull. 23: 471-475.
189. Richards, J. F., Beer, C. T., Bourgeault, C., Chen, K. and Gout, P. W. (1982) Biochemical response of lymphoma cells to mitogenic stimulation by prolactin. Mol. Cell. Endocrinol. 26: 41-49.
190. Richards, J. F., Bishop, P. B., Peng, T., Beer, C. T. and Gout, P. W. (1986) An inhibitor of ornithine decarboxylase in lactogen-deprived Nb2 node rat lymphoma cells. Biochim. Biophys. Acta 883: 542-551.
191. Riskind, P. N., Massacesi, L., Doolittle, R. H. and Hauser, S. L. (1991) The role of prolactin in autoimmune demyelination: suppression of experimental allergic encephalomyelitis by bromocriptine. Ann. Neurol. 29: 542-547.
192. Roberts, T. M. (1992) Cell biology. A signal chain of events. Nature 360: 534-535.
193. Rogers, S. A. and Hammerman, M. R. (1989) Growth hormone activates phospholipase C in proximal tubular basolateral membranes from canine kidney. Proc. Natl. Acad. Sci. USA 86: 6363-6366.
194. Rohn, W. M. and Weigent, D. A. (1995) Cloning and nucleotide sequencing of rat lymphocyte growth hormone cDNA. Neuroimmunomodulation 2: 108-114.
195. Rom, W. N., Basset, P., Fells, G. A., Nukiwa, T., Trapnell, B. C. and Crysal, R. G. (1988) Alveolar macrophages release an insulin-like growth factor I-type molecule. J. Clin. Invest. 82: 1685-1693.
196. Roupas, P. and Herington, A. C. (1994) Postreceptor signaling mechanisms for growth hormone. Trends Endocrinol. Metab. 5: 154-158.
197. Rovensky, J., Vigas, M., Marek, J., Blazickova, S., Korcakova, L., Vyletelkova, L. and Takac, A. (1991) Evidence for immunomodulatory properties of prolactin in selected in vitro and in vivo situations. Int. J. Immunopharmacol. 13: 267-272.
198. Russell, D. H., Matrisian, L., Kibler, R., Larson, D. F., Poulos, B. and Magun, B. E. (1984) Prolactin receptors on human lymphocytes and their modulation by cyclosporine. Biochem. Biophys. Res. Commun. 121: 899-906.
199. Russell, D. H., Kibler, R., Matrisian, L., Larson, D. F., Poulos, B. and Magun, B. E. (1985) Prolactin receptors on human T and B lymphocytes: antagonism of prolactin binding by cyclosporine. J. Immunol. 134: 3027-3031.
200. Sabharwal, P., Glaser, R., Lafuse, W., Varma, S., Lin, Q., Arkins, S., Kooijman, R., Kutz, L., Kelley, W. and Malarkey, W. B. (1992) Prolactin synthesized and secreted by human peripheral blood mononuclear cells: an autocrine growth factor for lymphoproliferation. Proc. Natl. Acad. Sci. USA 89: 7713-7716.
201. Scarborough, D. E. (1990) Cytokine modulation of pituitary hormone secretion. Ann. NY Acad. Sci. 594: 169-187.
202. Scarborough, D. E., Lee, S. L., Dinarello, C. A. and Reichlin, S. (1989) Interleukin-1 stimulates somatostatin biosynthesis in primary cultures of fetal rat brain. Endocrinology 124: 549-551.
203. Schimpff, R. M. and Repellin, A. M. (1990) Production of interleukin-1-alpha and interleukin-2 by mononuclear cells in healthy adults in relation to different experimental conditions and to the presence of growth hormone. Horm. Res. 33: 171-176.
204. Schwarz, L. A., Stevens, A. M., Hrachovy, J. A. and Yu-Lee, L. Y. (1992) Interferon regulatory factor-1 is inducible by prolactin, interleukin-2 and concanavalin A in T cells. Mol. Cell. Endocrinol. 86: 103-110.
205. Seeburg, P. H. (1982) The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. DNA 1: 1239-1249.
206. Sharp, B. M., Matta, S. G., Peterson, P. K., Newton, R., Chao, C. and McAllen, K. (1989) Tumor necrosis factor-alpha is a potent ACTH secretogogue: comparison to interleukin-1. Endocrinology 124: 3131-3133.
207. Shiu, R. P. C., Elsholtz, H. P., Tanake, T., Friesen, H. G., Gout, P. W., Geer, C. T. and Noble, R. L. (1983) Receptor mediated mitogenic action of prolactin in a rat lymphoma cell line. Endocrinology 113: 159-165.
208. Shome, B. and Parlow, A. F. (1977) Human pituitary prolactin (hPRL): the entire linear amino acid sequence. J. Clin. Endocrinol. Metab. 45: 1112-1115.
209. Sinha, Y. N. (1992) Prolactin variants. Trends Endocrinol. Metab. 3: 100-106.
210. Slootweg, M. C., de Groot, R. P., Herrmann-Erlee, M. P., Koornneef, I., Kruijer, W. and Kramer, Y. M. (1991) Growth hormone induces expression of c-jun and jun B oncogenes and employs a protein kinase C signal transduction pathway for the induction of c-fos oncogene expression. J. Mol. Endocrinol. 6: 179-188.
211. Smith, E. M., Johnson, H. M. and Blalock, J. E. (1983) Staphylococcus aureus protein A induces the production of interferon-alpha in human lymphocytes and interferon-alpha/beta in mouse spleen cells. J. Immunol. 130: 773-776.
212. Smith, P. E. (1930) The effect of hypophysectomy upon the involution of the thymus in the rat. Anat. Rec. 47: 119-129.
213. Smith, W. C., Kuniyoshi, J. and Talamantes, F. (1989) Mouse serum growth hormone (GH) binding protein has GH receptor extracellular and substituted transmembrane domains. Mol. Endocrinol. 3: 984-990.
214. Snow, E. C., Feldbush, T. L. and Oaks, J. A. (1981) The effect of growth hormone and insulin upon MLC responses and the generation of cytotoxic lymphocytes. J. Immunol. 126: 161-164.
215. Soares, M. J., Faria, T. N., Roby, K. F. and Deb, S. (1991) Pregnancy and the prolactin family of hormones: coordination of anterior pituitary, uterine, and placental expression. Endocr. Rev. 12: 402-423.
216. Southard, J. N., Barrett, B. A., Bikbulatova, L., Ilkbahar, Y., Su, K. and Talamantes, F. (1995) Growth hormone (GH) receptor and GH-binding protein messenger ribonucleic acids with alternative 5′-untranslated regions are differentially expressed in mouse liver and placenta. Endocrinology 136: 2913-2921.
217. Spangelo, B. L., Hall, N. R. S., Ross, P. C. and Goldstein, A. L. (1987) Stimulation of in vivo antibody production and concanavalin-A-induced mouse spleen cell mitogenesis by prolactin. Immunopharmacology 14: 11-20.
218. Spangelo, B. L., Judd, A. M., Isakson, P. C. and MacLeod, R. M. (1989) interleukin-6 stimulates anterior pituitary hormone release in vitro. Endocrinology 125: 575-577.
219. Subramanian, M. G. and Gala, R. R. (1986) Do prolactin levels measured by RIA reflect biologically active prolactin. J. Clin. Immunoassay 9: 42-52.
220. Taub, D. D., Tsarfaty, G., Lloyd, A. R., Durum, S. K., Longo, D. L. and Murphy, W. J. (1994) Growth hormone promotes human T cell adhesion and migration to both human and murine matrix proteins in vitro and directly promotes xenogeneic engraftment. J. Clin. Invest. 94: 293-300.
221. Theill, L. E. and Karin, M. (1993) Transcriptional control of GH expression and anterior pituitary development. Endocr. Rev. 14: 670-689.
222. Torosian, M. H. and Donoway, R. B. (1991) Growth hormone inhibits tumor metastasis. Cancer 67: 2280-2283.
223. Touraine, P., deMoraes, M. D. C. L., Dardenne, M. and Kelly, P. A. (1994) Expression of short and long forms of prolactin receptor in murine lymphoid tissues. Mol. Cell. Endocrinol. 104: 183-190.
224. Treacy, M. N., He, X. and Rosenfeld, M. G. (1991) I-POU: a POU-domain protein that inhibits neuron-specific gene activation. Nature 350: 577-584.
225. Truong, A. T., Duez, C., Belayew, A., Renard, A., Pictet, R., Bell, G. I. and Martial, J. A. (1984) Isolation and characterization of the human prolactin gene. EMBO J. 3: 429-437.
226. Tseng, L., Gav, J. G., Chen, P., Zhu, H. H., Mazela, J. and Powel, D. R. (1992) Effect of progestin, antiprogestin, and relaxin on the accumulation of prolactin and insulin-like growth factor binding protein-1 messenger ribonucleic acid in human endometrial stromal cells. Biol. Reprod. 47: 441-450.
227. Uehara, A., Gottschall, P. E., Dahl, R. R. and Arimura, A. (1988) Interleukin-1 stimulates ACTH release by an indirect action which requires endogenous corticotropin releasing factor. Endocrinology 122: 1773-1779.
228. Van Buul-Offers, S. C., Van den Brande, J. L., Dumoleijn, L., Korteland-van Male, A. M. and Van de Klundert, P. (1978) The Snell-dwarf mouse II. Acta Endocrinol. 89: 646-658.
229. Vanderschueren-Lodeweyckz, M., Staf, B., Van Den Berghe, H., Eggermont, E. and Eeeckels, R. (1973) Growth hormone and lymphocyte transformation. Lancet i: 441.
230. Vankelecom, H., Carmeliet, P., Van Damme, J., Billiau, A. and Denf, C. (1989) Production of interleukin-6 by folliculo-stellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system. Neuroendocrinology 49: 102-106.
231. Varma, S., Sabharwal, P., Sheridan, J. F. and Malarkey, W. B. (1993) Growth hormone secretion by human peripheral blood mononuclear cells detected by an enzyme-linked immunoplaque assay. J. Clin. Endocrinol. Metab. 76: 49-53.
232. Walker, S. E., Allen, S. H. and McMurray, R. W. (1993) Prolactin and autoimmune disease. Trends Endocrinol. Metab. 4: 147-151.
233. Wallis, M. (1974) The primary structure of bovine prolactin. FEBS Lett. 44: 205-208.
234. Warlo, S. K. and Sonta, K. (1992) Prolactin as an immunoregulatory hormone in mammals and birds. Immunol. Lett. 33: 105-122.
235. Weigent, D. A. and Blalock, J. E. (1990a) Immunoreactive growth hormone-releasing hormone in rat leukocytes. J. Neuroimmunol. 29: 1-13.
236. Weigent, D. A. and Blalock, J. E. (1990b) Growth hormone and the immune system. Prog. NeuroEndocrinImmunol. 3: 231-241.
237. Weigent, D. A. and Blalock, J. E. (1991) The production of growth hormone by subpopulations of rat mononuclear leukocytes. Cell. Immunol. 135: 55-65.
238. Weigent, D. A. and Blalock, J. E. (1994) Effect of the administration of growth-hormone-producing lymphocytes on weight gain and immune function in dwarf mice. Neuroimmunomodulation 1: 50-58.
239. Weigent, D. A. and Blalock, J. E. (1995) Growth hormone effects on the immune system. In: Human Growth Hormone Pharmacology: Basic and Clinical Aspects, pp. 141-152, Shiverick, K. T. and Rosenbloom, A. L. (eds.) CRC Press, Boca Raton.
240. Weigent, D. A. and Blalock, J. E. (1996a) Endogenous "neural and endocrine factors" made by immune cells. In: The Molecular Basis of Neuro-Immune Interactions, Hauser, S. and Payan, D. (eds.) Pergamon, Oxford, in press.
241. Weigent, D. A. and Blalock, J. E. (1996b) Neuroendocrine-immune interactions. In: Immunology of the Nervous System, Keane, R. W. and Hickey, W. F. (eds.) Oxford University Press, New York, in press.
242. Weigent, D. A., Baxter, J. B., Wear, W. E., Smith, L. R., Bost, K. L. and Blalock, J. E. (1988) Production of immunoreactive growth hormone by mononuclear leukocytes. FASEB J. 2: 2812-2818.
243. Weigent, D. A., Blalock, J. E. and LeBoeuf, R. D. (1991a) An antisense oligodeoxynucleotide to growth hormone messenger ribonucleic acid inhibits lymphocyte proliferation. Endocrinology 128: 2053-2057.
244. Weigent, D. A., Riley, J. E., Galin, F. S., LeBoeuf, R. D. and Blalock, J. E. (1991b) Detection of growth hormone and growth hormone-releasing hormone-related messenger RNA in rat leukocytes by the polymerase chain reaction. Proc. Soc. Exp. Biol. Med. 198: 643-648.
245. Weigent, D. A., Baxter, J. B. and Blalock, J. E. (1992) The production of growth hormone and insulin-like growth factor-I by the same subpopulation of rat mononuclear leukocytes. Brain Behav. Immunol. 6: 365-376.
246. Whyte, A. and Williams, R. O. (1988) Bromocriptine suppresses postpartum exacerbation of collagen-induced arthritis. Arthritis Rheum. 31: 927-928.
247. Wiedermann, C. J., Reinisch, N., Kahler, C., Geisen, F., Zilian, U., Herold, M. and Braunsteiner, H. (1992) In vivo activation of circulating monocytes by exogenous growth hormone in man. Brain Behav. Immunol. 6: 387-393.
248. Wiedermann, C. J., Reinisch, N., Niedermuhlbichler, M. and Braunsteiner, H. (1993) Inhibition of recombinant human growth hormone-induced and prolactin-induced activation of neutrophils by octreotide. Arch. Pharmacol. 347: 336-341.
249. Wit, J. M., Kooijman, R., Rijkers, G. T. and Zegers, B. J. (1993) Immunological findings in growth hormone-treated patients. Horm. Res 39: 107-110.
250. Yamada, M., Hato, F., Kinoshita, Y., Tominaga, K. and Tsuji, Y. (1994) The indirect participation of growth hormone in the thymocyte proliferation system. Cell Mol. Biol. 40: 111-121.
251. Yoon, J. B., Berry, S. A., Seelig, S. and Towle, H. C. (1990) An inducible nuclear factor binds to a growth hormone-regulated gene. J. Biol. Chem. 265: 19947-19954.
252. Yu-Lee, L. Y., Stevens, A. M., Hrachovy, J. A. and Schwarz, L. A. (1990) Prolactin-mediated regulation of gene transcription in lymphocytes. Ann. NY Acad. Sci. 594: 146-155.