Expression and function of thyroid hormone receptor variants in normal and chronically diseased human liver

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 1, 1996, Pages 360-367

  Chamba, A ^a   Neuberger, J ^a   Strain, A ^a   Hopkins, J ^a   Sheppard, M C ^a   Franklyn, J A ^a,b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RECEPTOR SUBUNIT; SEX HORMONE BINDING GLOBULIN; THYROID HORMONE RECEPTOR; THYROXINE BINDING GLOBULIN;

ALCOHOL LIVER CIRRHOSIS; ARTICLE; BILIARY CIRRHOSIS; CHRONIC DISEASE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; SCLEROSING CHOLANGITIS; TISSUE DISTRIBUTION;

ANIMALS; BLOTTING, WESTERN; CHRONIC DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER DISEASES; MICE; RATS; RECEPTORS, THYROID HORMONE; RNA, MESSENGER; THYROID HORMONES; THYROTROPIN;

EID: 0030068622     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.1.360     Document Type: Article

References (50)

1. Lazar MA. 1993 Thyroid hormone receptors: multiple forms, multiple possibilities. Endocr Rev. 14:184-193.
2. Brent GA. 1994 The molecular basis of thyroid hormone action. N Engl J Med. 331:847-853.
3. Nakai A, Sakurai A, Bell GI, DeGroot LI. 1988 Characterization of a third thyroid hormone receptor co-expressed with other thyroid hormone receptors in several tissues. Mol Endocrinol. 2:1087-1092.
4. Koenig RJ, Warne RL, Brent CA, Harney JW, Larsen PR, Moore DD. 1988 Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci USA. 85:5031-5035.
5. Lazar MA, Hodin RA, Chin WW. 1989 Human carboxyl-terminal variant of α-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone. Proc Natl Acad Sci USA. 86:7771-7774.
6. Torresani J, DeGroot LJ. 1975 Triiodothyronine binding to liver nuclear solubilized proteins in vitro. Endocrinology. 96:1201-1209.
7. DeGroot LJ, Torresani J. 1975 Triiodothyronine binding to isolated liver cell nuclei. Endocrinology. 96:357-369.
8. Venkatraman JT, Lefebvre Y. 1987 Multiple thyroid hormone binding sites on male rat liver nuclear matrices. Biochcm Biophys Res Commun. 148:1496-1502.
9. Lazar MA, Hodin RA, Darling DS, Chin WW. 1988 Identification of a rat c-erbAα-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone. Mol Endocrinol. 2:893-901.
10. Murray MB, Zilz MD, McCreary NL, MacDonald MJ, Towle HC. 1988 Isolation and characterisation of rat cDNA clones for two distinct thyroid hormone receptors. J Biol Chem. 263:12770-12777.
11. Hodin RA, Lazar MA, Chin WW. 1990 Differential and tissue specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone. J Clin Invest. 85:101-105.
12. Falcone M, Miyamato T, Fierro-Renoy F, Macchia E, DeGroot LJ. 1992 Antipeptide polyclonal antibodies specifically recognise each human thyroid hormone receptor isoform. Endocrinology. 131:2419-2429.
13. Tagami T, Nakamura H, Sasaki S, Miyoshi Y, Imura H. 1993 Estimation of the protein content of thyroid hormone receptor α1 and β1 in rat tissues by Western blotting. Endocrinology. 132:275-279.
14. Magnuson MA, Nikodem VW. 1983 Molecular cloning of a cDNA sequence for rat malic enzyme. Direct evidence for induction in vivo of rat liver malic enzyme mRNA by thyroid hormone. J Biol Chem. 258:12712-12717.
15. 3-regulation of mRNA-S14. J Biol Chem. 259:2789-2797.
16. Romney JS, Chan J, Can FE, Mooradian AD, Wong NCW. 1992 Identification of the thyroid hormone-responsive messenger RNA spot 11 as apolipoprotein-A1 messenger RNA and effects of the hormone on the promoter. Mol Endocrinol. 6:943-950.
17. Gick GG, Beigi FI, Edelman IS. 1988 Thyroidal regulation of rat renal and hepatic Na,K-ATPase gene expression. J Biol Chem. 263:16610-16618.
18. Seelig S, Liaw C, Towle HC, Oppenheimer JH. 1981 Thyroid hormone attenuates and augments hepatic gene expression at a pretranslational level. Proc Natl Acad Sci USA. 78:4733-4737.
19. Sakurai A, Nakai A, DeGroot LJ. 1989 Expression of the three forms of thyroid hormone receptor in human tissues. Mol Endocrinol. 3:392-399.
20. Raggat LE, Blok RB, Hamblin PS, Barlow JW. 1992 Effects of thyroid hormone on sex hormone-binding globulin gene expression in human cells. J Clin Endocrinol Metab. 75:116-120.
21. Kabayashi MR, Horiuchi R, Hachisu T, Takikawa H. 1988 Dualistic effects of thyroid hormone on a human hepatoma cell line: inhibition of thyroxine binding globulin synthesis and stimulation of α1-acid glycoprotein synthesis. Endocrinology. 123:631-640.
22. Barlow JW, Crowe TC, Cowen NL, et al. 1993 Stimulation of sex hormone binding globulin mRNA and attenuation of cortisol binding globulin mRNA by triiodothyronine in human hepatoma cells. Eur J Endocrinol. 130:166-170.
23. Loukovaara M, Carson M, Adlercreutz H. 1995 Regulation of production and secretion of sex hormone binding globulin in HepG2 cell cultures by hormones and growth factors. J Clin Endocrinol Metab. 80:160-164.
24. Franklyn JA, King S, Ahlquist JA, Sheppard MC. 1989 Effect of hypothyroidism and thyroid hormone treatment of the rat on hepatic spot 14 and thyroxine binding pre-albumin mRNAs. Acta Endocrinol (Copenh). 121:383-388.
25. Chopra IJ, Hershman JM, Pardridge WM, Nicoloff JT. 1983 Thyroid function in non-thyroidal illness. Ann Intern Med. 98:946-957.
26. Docter R, Krenning EP, de Jong M, Henneman G. 1993 The sick euthyroid syndrome; changes in thyroid hormone serum parameters and hormone metabolism. Clin Endocrinol (Oxf). 39:499-518.
27. Franklyn JA, Black E, Betteridge J, Sheppard MC. 1994 Comparison of second and third generation methods for measurement of serum TSH in patients with overt hyperthyroidism, patients receiving thyroxine therapy and those with non-thyroidal illness. J Clin Endocrinol Metab. 78:1368-1371.
28. 1 cells. J Clin Invest. 53:656-659.
29. Lowry OH, Rosebrough NJ, Lewis Farr A, Randall RJ. 1951 Protein measurement with the Folin phenol reagent. J Biol Chem. 193:265-275.
30. Laemmli UK. 1970 Cleavage of structural proteins during the assembly of the head bacteriophage T4. Nature. 227:680-685.
31. Macchia E, Nakai A, Janiga A, et al. 1990 Characterization of site-specific polyclonal antibodies to c-erb A peptides recognising human thyroid hormone receptors α1, α2, and β and native 3,5,3′-triiodothyronine receptor, and study of tissue distribution of the antigen. Endocrinology. 128:2601-2609.
32. Chomczynski F, Sacchi N, 1987 Single step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:156-159.
33. Aviv H, Leder P. 1972 Purification of biologically active globin messenger RNA by chromatography on oligo-thymidylic acid-cellulose. Proc Natl Acad Sci USA. 69:1408-1412.
34. Prost E, Koenig RJ, Moore DD, Larsen PR, Whalen RG. 1988 Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal cDNA libraries. Nucleic Acids Res. 16:6248.
35. Chan YL, Guttell R, Noller HF. 1984 The nucleotide sequence of the rat 18s ribosomal ribonucleic acid. J Biol Chem. 259:224-230.
36. Strait K, Schwartz H, Perez-Castillo A, Oppenheimer JH. 1990 Relationship of c-erb A mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing adult brain. J Biol Chem. 265:10514-10521.
37. Lin KH, Willingham MC, Liang CM, Cheng SY. 1991 Intracellular distribution of the endogenous and transfected β form of thyroid hormone nuclear receptor visualised by the use of domain specific monoclonal antibodies. Endocrinology. 128:2601-2609.
38. 3, and retinoid signaling. Endocrinology. 135:2375-2385.
39. Schwartz HL, Strait KA, Ling NC, Oppenheimer JH. 1992 Quantitation of rat tissue thyroid hormone binding receptor isoforms by immunoprecipitation of nuclear triiodothyronine binding capacity. J Biol Chem. 267:11794-11799.
40. Robbins J, Bartelena L. 1986 Plasma transport of thyroid hormones. In: Henneman G, ed. Thyroid hormone metabolism. New York: Marcel Dekker; 3.
41. Williams GR, Franklyn JA, Neuberger JM, Sheppard MC. 1989 Thyroid hormone receptor expression in the "sick euthyroid" syndrome. Lancet. 2:1477-1481.
42. Tibaldi JM, Surks MI. 1985 Animal models of nonthyroidal illness. Endoc Rev. 6:87-102.
43. Jolin T. 1988 Response of hepatic mitochondrial α-glycerophosphate dehydrogenase and malic enzyme to triiodothyronine in streptozotocin-diabetic rats. Endocrinology. 123:248-57.
44. Hupart KH, DeFesi CR, Katz CP, Shapiro LE, Surks MI. 1989 Decreased anterior pituitary T3 nuclear receptors in Walker 256 carcinoma-bearing rat model of nonthyroidal disease. Acta Endocrinol (Copenh). 121:811-816.
45. Surks MI, Grajower MM, Tai M, DeFesi CR. 1978 Decreased hepatic nuclear T3 receptors in rats and rats and mice transplantable neoplasms. Endocrinology. 103:2234-2239.
46. Hupart KH, Hodin RA, Lazar MA, Shapiro LE, Chin WW, Surks MI. 1993 c-erb-A mRNA correlates with T3 receptor levels in liver and pituitary of tumor rats. Thyroid. 3:55-58.
47. Lane JT, Godbole M, Strait KA, Schwartz HL, Oppenheimer JH. 1991 Prolonged fasting reduces hepatic β1 thyroid hormone receptor protein without changing the level of its messenger ribonucleic acid. Endocrinology. 129:2881-2885.
48. Kvetney J. 1983 Nuclear thyroxine and triiodothyronine receptors in human mononuclear cells. Diabetologia. 24:428-433.
49. Burman KD, Latham KR, Djuh YY. 1980 Solubilised nuclear thyroid hormone receptors in circulating human mononuclear cells. J Clin Endocrinol Metab. 51:106-116.
50. DeGroot LJ. 1993 Thyroid receptor auxiliary proteins. Endocrinology. 133:963-971.