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Volumn 1, Issue 1, 1997, Pages 21-28

Multiple sclerosis: A polygenic disease involving epistatic interactions, germline rearrangements and environmental effects

Author keywords

Autoimmunity; Epistasis; Genetic rearrangement; Linkage; Multiple sclerosis

Indexed keywords

AUTOIMMUNITY; BIOLOGICAL MODEL; DNA SEQUENCE; ENVIRONMENTAL EXPOSURE; GENE REARRANGEMENT; GENETIC EPISTASIS; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HUMAN; MULTIPLE SCLEROSIS; REVIEW;

EID: 0031128770     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100480050003     Document Type: Review
Times cited : (24)

References (39)
  • 1
    • 0027328370 scopus 로고
    • Autoimmune disease
    • Steinman, L. (1993) Autoimmune disease. Sci. Am. 269, 106-114.
    • (1993) Sci. Am. , vol.269 , pp. 106-114
    • Steinman, L.1
  • 2
    • 0027430218 scopus 로고
    • Autoimmunity: The environment strikes back
    • Todd, J.A. and Steinman, L. (1993) Autoimmunity: the environment strikes back. Curr. Opin. Immunol. 5, 863-865.
    • (1993) Curr. Opin. Immunol. , vol.5 , pp. 863-865
    • Todd, J.A.1    Steinman, L.2
  • 3
    • 0031034665 scopus 로고    scopus 로고
    • Genes versus environment in insulin dependent diabetes: The phoney war
    • Hattersley, A.T. (1997) Genes versus environment in insulin dependent diabetes: the phoney war. Lancet 349, 147-148.
    • (1997) Lancet , vol.349 , pp. 147-148
    • Hattersley, A.T.1
  • 4
    • 0029643619 scopus 로고
    • More genes versus environment
    • Waksman, B. (1995) More genes versus environment. Nature 377, 105-106.
    • (1995) Nature , vol.377 , pp. 105-106
    • Waksman, B.1
  • 5
    • 0027468174 scopus 로고
    • Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
    • Goverman, J., Woods, A., Larson, L., Weiner, L., Hood, L. and Zaller, D. (1993) Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72, 551-560.
    • (1993) Cell , vol.72 , pp. 551-560
    • Goverman, J.1    Woods, A.2    Larson, L.3    Weiner, L.4    Hood, L.5    Zaller, D.6
  • 6
    • 0027985358 scopus 로고
    • The role of genetic factors in multiple sclerosis susceptibility
    • Ebers, G.C. and Sadovnick, A.D. (1994) The role of genetic factors in multiple sclerosis susceptibility. J. Neuroimmunol., 54, 1-17.
    • (1994) J. Neuroimmunol. , vol.54 , pp. 1-17
    • Ebers, G.C.1    Sadovnick, A.D.2
  • 8
    • 0029121088 scopus 로고
    • A genetic basis for familial aggregation in MS
    • Ebers, G.C., Sadovnick, A.D., Risch, N.J. and the Canadian Collaborative Study Group (1995) A genetic basis for familial aggregation in MS. Nature, 377, 151-151.
    • (1995) Nature , vol.377 , pp. 151-151
    • Ebers, G.C.1    Sadovnick, A.D.2    Risch, N.J.3
  • 9
    • 0030007661 scopus 로고    scopus 로고
    • Evidence for genetic basis of multiple sclerosis
    • Sadovnick, A.D., Ebers, G.C., Dyment, D.A., Risch, N.J. and the Canadian Collaborative Study Group (1996) Evidence for genetic basis of multiple sclerosis. Lancet, 347, 1728-1730.
    • (1996) Lancet , vol.347 , pp. 1728-1730
    • Sadovnick, A.D.1    Ebers, G.C.2    Dyment, D.A.3    Risch, N.J.4
  • 10
    • 13344284286 scopus 로고
    • Genetic susceptibility models in multiple sclerosis
    • Rosenberg, R.N., Prusiner, S.B., DiMauro, S., Barchi, R.L. and Kunkel, L.M. (eds.), Butterworth-Heinemann, Boston
    • Phillips, J.T. (1993) Genetic susceptibility models in multiple sclerosis. In Rosenberg, R.N., Prusiner, S.B., DiMauro, S., Barchi, R.L. and Kunkel, L.M. (eds.), The molecular and genetic basis of neurological disease. Butterworth-Heinemann, Boston, pp 41-46.
    • (1993) The Molecular and Genetic Basis of Neurological Disease , pp. 41-46
    • Phillips, J.T.1
  • 11
    • 0025019555 scopus 로고
    • Linkage strategies for genetically complex traits. I. Multilocus models
    • Risch, N. (1990) Linkage strategies for genetically complex traits. I. Multilocus models. Am. J. Hum. Genet., 46, 222-228.
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 222-228
    • Risch, N.1
  • 14
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus
    • Spielman, R.S., McGinnis, R.E. and Ewens, W.J. (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus. Am. J. Hum. Genet., 52, 506-516.
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 506-516
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 15
    • 0024582686 scopus 로고
    • Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction
    • Weber, J.L. and May, P.E. (1989) Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am. J. Hum. Genet., 44, 388-396.
    • (1989) Am. J. Hum. Genet. , vol.44 , pp. 388-396
    • Weber, J.L.1    May, P.E.2
  • 18
    • 0025695910 scopus 로고
    • Extensions to sib-pair linkage test applicable to disorders characterized by delayed onset
    • Dawson, D.V., Kaplan, E.B. and Elston, R.C. (1990) Extensions to sib-pair linkage test applicable to disorders characterized by delayed onset. Genet. Epid., 7, 453-456.
    • (1990) Genet. Epid. , vol.7 , pp. 453-456
    • Dawson, D.V.1    Kaplan, E.B.2    Elston, R.C.3
  • 20
    • 0009573338 scopus 로고    scopus 로고
    • A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex
    • The Multiple Sclerosis Genetics Group (1996) A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nature Genet., 13, 469-471.
    • (1996) Nature Genet. , vol.13 , pp. 469-471
  • 24
    • 0005015308 scopus 로고    scopus 로고
    • Molecular and genetic aspects of multiple sclerosis
    • Rosenberg, R.N., Prusiner, S.B., DiMauro, S., Barchi, R.L. and Kunkel, L.M. (eds.), Butterworth-Heinemann, Boston, In press
    • Seboun, E., Oksenberg, J.R. and Hauser, S.L. (1996) Molecular and genetic aspects of multiple sclerosis. In Rosenberg, R.N., Prusiner, S.B., DiMauro, S., Barchi, R.L. and Kunkel, L.M. (eds.), The molecular and genetic basis of neurological disease. 2nd edition. Butterworth-Heinemann, Boston, In press.
    • (1996) The Molecular and Genetic Basis of Neurological Disease. 2nd Edition
    • Seboun, E.1    Oksenberg, J.R.2    Hauser, S.L.3
  • 25
    • 0029785817 scopus 로고    scopus 로고
    • Inheritance of susceptibility to experimental autoimmune encephalomyelitis
    • Encinas, J.A., Weiner, H.L. and Kuchroo, V.K. (1996) Inheritance of susceptibility to experimental autoimmune encephalomyelitis. J. Neurosc. Res., 45, 655-669.
    • (1996) J. Neurosc. Res. , vol.45 , pp. 655-669
    • Encinas, J.A.1    Weiner, H.L.2    Kuchroo, V.K.3
  • 26
    • 0029955004 scopus 로고    scopus 로고
    • Immunogenetics and heterogeneity in multiple sclerosis
    • Oksenberg, J.R. (1996) Immunogenetics and heterogeneity in multiple sclerosis. Ann. Neurol., 40, 557-558.
    • (1996) Ann. Neurol. , vol.40 , pp. 557-558
    • Oksenberg, J.R.1
  • 28
    • 0028864784 scopus 로고
    • Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: The minimal B cell epitope and a model of its unique features
    • Warren, K.G., Catz, I. and Steinman, L. (1995) Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: the minimal B cell epitope and a model of its unique features. Proc. Natl. Acad. Sci. USA, 92, 11061-11065.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11061-11065
    • Warren, K.G.1    Catz, I.2    Steinman, L.3
  • 29
    • 0029939467 scopus 로고    scopus 로고
    • Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
    • Steinman, L. (1996) Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell, 85, 299-302.
    • (1996) Cell , vol.85 , pp. 299-302
    • Steinman, L.1
  • 30
    • 0023753713 scopus 로고
    • Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
    • Acha-Orbea, H., Mitchell, D.J., Timmerman, L., Wraith, D.C., Waldor, M.K., Tausch, G.S., Zamvil, S.S., McDevitt, H.O. and Steinman, L. (1988) Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell, 54, 263-273.
    • (1988) Cell , vol.54 , pp. 263-273
    • Acha-Orbea, H.1    Mitchell, D.J.2    Timmerman, L.3    Wraith, D.C.4    Waldor, M.K.5    Tausch, G.S.6    Zamvil, S.S.7    McDevitt, H.O.8    Steinman, L.9
  • 31
  • 33
    • 0028023506 scopus 로고
    • Detection of HTLV-1 proviral DNA and analysis of TCR Vβ CDR3 sequences in spinal cord lesions of HTLV-1-associated myelopathy/tropical spastic paraparesis
    • Hara, H., Morita, M., Iwaki, T., Hatae, T., Itoyama, Y., Kitamoto, T., Akizuki, Si., Gotyo, I. and Watanabe, T. (1994) Detection of HTLV-1 proviral DNA and analysis of TCR Vβ CDR3 sequences in spinal cord lesions of HTLV-1-associated myelopathy/tropical spastic paraparesis. J. Exp. Med. 180, 831-836.
    • (1994) J. Exp. Med. , vol.180 , pp. 831-836
    • Hara, H.1    Morita, M.2    Iwaki, T.3    Hatae, T.4    Itoyama, Y.5    Kitamoto, T.6    Akizuki, Si.7    Gotyo, I.8    Watanabe, T.9
  • 34
    • 0028242718 scopus 로고
    • Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis
    • Allegretta, M., Albertini, R.J., Howell, M.D., Smith, L.R., Martin, R., McFarland, H.F., Brostoff, S. and Steinman, L. (1994) Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis. J. Clin. Invest., 94, 105-109.
    • (1994) J. Clin. Invest. , vol.94 , pp. 105-109
    • Allegretta, M.1    Albertini, R.J.2    Howell, M.D.3    Smith, L.R.4    Martin, R.5    McFarland, H.F.6    Brostoff, S.7    Steinman, L.8
  • 35
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig, K. and Strominger, J. (1995) Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell, 80, 695-705.
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.1    Strominger, J.2
  • 36
    • 0002905451 scopus 로고
    • Major T cell responses in multiple sclerosis
    • Steinman, L., Waisman, A. and Altmann, A. (1995) Major T cell responses in multiple sclerosis. Mol. Med. Today, 1, 79-83.
    • (1995) Mol. Med. Today , vol.1 , pp. 79-83
    • Steinman, L.1    Waisman, A.2    Altmann, A.3
  • 37
    • 0027454052 scopus 로고
    • Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen
    • Brocke, S., Gaur, A., Piercy, C., Gautam, A., Gijbels, K., Fathman, C.G. and Steinman, L. (1993) Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen. Nature, 365, 642-644.
    • (1993) Nature , vol.365 , pp. 642-644
    • Brocke, S.1    Gaur, A.2    Piercy, C.3    Gautam, A.4    Gijbels, K.5    Fathman, C.G.6    Steinman, L.7
  • 38
    • 0029021967 scopus 로고
    • Activation and clonal expansion of human myelin basic protein-reactive T cells by bacterial superantigens
    • Zhang, J., Vandevyver, C., Stinissen, P. et al. (1995) Activation and clonal expansion of human myelin basic protein-reactive T cells by bacterial superantigens. J. Autoimmunol. 8, 1-18.
    • (1995) J. Autoimmunol. , vol.8 , pp. 1-18
    • Zhang, J.1    Vandevyver, C.2    Stinissen, P.3
  • 39
    • 0027486499 scopus 로고
    • Myelin basic protein-specific T cell responses in identical twins discordant or concordant for MS
    • Martin, R., Voskuhl, R., Flerlage, M., McFarlin, D. and McFarland, H. (1993) Myelin basic protein-specific T cell responses in identical twins discordant or concordant for MS. Ann. Neurol. 34, 524-535.
    • (1993) Ann. Neurol. , vol.34 , pp. 524-535
    • Martin, R.1    Voskuhl, R.2    Flerlage, M.3    McFarlin, D.4    McFarland, H.5


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