Mocardial preconditioning promises to be a novel approach to the treatment of ischemic heart disease

Annual Review of Medicine

Volumn 47, Issue , 1996, Pages 21-29

  Cohen, Michael V ^a   Downey, James M ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Diacylglycerol; Infarct size; Myocardial ischemia; Phospholipase; Protein kinase C

Indexed keywords

ADENOSINE; ANGIOTENSIN; BRADYKININ; DIACYLGLYCEROL; ENDOTHELIN; MEMBRANE PHOSPHOLIPID; PHENYLEPHRINE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELL PROTECTION; CONDITIONING; DOG; ENZYME ACTIVATION; HEART FUNCTION; HEART MUSCLE ISCHEMIA; LIPID METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SURVIVAL;

ANIMALS; CORONARY CIRCULATION; ENERGY METABOLISM; HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROTEIN KINASE C; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 0029996065     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.47.1.21     Document Type: Article

References (52)

1. Murry CE, Jennings RB, Reimer KA. 1986. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124-36
2. Li GC, Vasquez JA, Gallagher KP, et al. 1990. Myocardial protection with preconditioning. Circulation 82:609-19
3. Liu Y, Downey JM. 1992. Ischemic preconditioning protects against infarction in rat heart. Am. J. Physiol. 263:H1107-12
4. Liu GS, Thornton J, Van Winkle DM, et al. 1991. Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation 84:350-56
5. Miura T, Adachi T, Ogawa T, et al. 1992. Myocardial infarct size-limiting effect of ischemic preconditioning: its natural decay and the effect of repetitive preconditioning. Cardiovasc. Pathol. 1:147-54
6. Schott RJ, Rohmann S, Braun ER, et al. 1990. Ischemic preconditioning reduces infarct size in swine myocardium. Circ. Res. 66:1133-42
7. Armstrong S, Downey JM, Ganote CE. 1994. Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor. Cardiovasc. Res. 28: 72-77
8. Ikonomidis JS, Shirai T, Weisel RD, et al. 1995. "Ischemic" or adenosine preconditioning of human ventricular cardiomyocytes is protein kinase C dependent. Circulation 92(Suppl.):In press (Abstr.)
9. Deutsch E, Berger M, Kussmaul WG, et al. 1990. Adaptation to ischemia during percutaneous transluminal coronary angioplasty: clinical, hemodynamic, and metabolic features. Circulation 82:2044-51
10. Cribier A, Korsatz L, Koning R, et al. 1992. Improved myocardial ischemic response and enhanced collateral circulation with long repetitive coronary occlusion during angioplasty: a prospective study. J. Am. Coll. Cardiol. 20:578-86
11. Yellon DM, Alkhulaifi AM, Pugsley WB. 1993. Preconditioning the human myocardium. Lancet 342:276-77
12. Van Winkle DM, Thornton JD, Downey DM, et al. 1991. The natural history of preconditioning: cardioprotection depends on duration of transient ischemia and time to subsequent ischemia. Coron. Artery Dis. 2:613-19
13. Kerensky RA, Kutcher MA, Braden GA, et al. 1995. The effects of intracoronary adenosine on preconditioning during coronary angioplasty. Clin. Cardiol. 18:91-96
14. Murry CE, Richard VJ, Jennings RB, et al. 1991. Myocardial protection is lost before contractile function recovers from ischemic preconditioning. Am. J. Physiol. 260:H796-804
15. Turrens JF, Thornton J, Barnard ML, et al. 1992. Protection from reperfusion injury by preconditioning hearts does not involve increased antioxidant defenses. Am. J. Physiol. 262:H585-89
16. Vander Heide RS, Hill ML, Steenbergen C, et al. 1991. Effect of reversible ischemia on mitochondrial ATPase activity in canine myocardium. Circulation 84(Suppl. II): II-192 (Abstr.)
17. Dorheim TA, Wang T, Mentzer RM Jr, et al. 1990. Interstitial purine metabolites during regional myocardial ischemia. J. Surg. Res. 48:491-97
18. Schömig A. 1990. Catecholamines in myocardial ischemia: systemic and cardiac release. Circulation 82(Suppl. II):13-22
19. Noda K, Sasaguri M, Ideishi M, et al. 1993. Role of locally formed angiotensin II and bradykinin in the reduction of myocardial infarct size in dogs. Cardiovasc. Res. 27: 334-40
20. Baumgarten CR, Linz W, Kunkel G, et al. 1993. Ramiprilat increases bradykinin outflow from isolated hearts of rat. Br. J. Pharmacol. 108:293-95
21. Wang Q-D, Hemsén A, Li X-S, et al. 1995. Local overflow and enhanced tissue content of endothelin following myocardial ischaemia and reperfusion in the pig: modulation by L-arginine. Cardiovasc. Res. 29: 44-49
22. Ytrehus K, Liu Y, Downey JM. 1994. Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am. J. Physiol. 266:H1145-52
23. Liu Y, Cohen MV, Downey JM. 1994. Chelerythrine, a highly selective protein kinase C inhibitor, blocks the antiinfarct effect of ischemic preconditioning in rabbit hearts. Cardiovasc. Drugs Ther. 8:881-82
24. Speechly-Dick ME, Mocanu MM, Yellon DM. 1994. Protein kinase C: its role in ischemic preconditioning in the rat. Circ. Res. 75:586-90
25. Li Y, Kloner RA. 1995. Does protein kinase C play a role in ischemic preconditioning in rat hearts? Am. J. Physiol. 268:H426-31
26. Kitakaze M, Minamino T, Shinozaki Y, et al. 1994. Activation of protein kinase C and subsequent activation of ectosolic 5′-nucleotidase as a major cause for the infarct size-limiting effect of ischemic preconditioning. Circulation 90(Suppl. I):I-207 (Abstr.)
27. Mitchell MB, Parker CG, Meng X, et al. 1993. Protein kinase C mediates preconditioning in isolated rat heart. Circulation 88(Suppl. I):I-633 (Abstr.)
28. Przyklenk K, Kloner RA. 1994. The protein kinase C inhibitor H-7 fails to attenuate the cardioprotective effects of ischemic preconditioning in the canine model. FASEB J. 8:A118 (Abstr.)
29. Przyklenk K, Kloner RA. 1995. The protein kinase C inhibitor polymyxin-B does not block preconditioning-induced cardioprotection in the canine model. J. Am. Coll. Cardiol. 25:43A (Abstr.)
30. Vogt A, Barancik M, Weihrauch D, et al. 1994. Protein kinase C inhibitors reduce infarct size in pig hearts in vivo. Circulation 90(Suppl. I):I-647 (Abstr.)
31. Sadoshima J-i, Izumo S. 1993. Signal transduction pathways of angiotensin II-induced c-fos gene expression in cardiac myocytes in vitro: roles of phospholipid-derived second messengers. Circ. Res. 73: 424-38
32. Kaku T, Lakatta E, Filburn C. 1991. α-Adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes. Am. J. Physiol. 260: C635-42
33. Talosi L, Kranias EG. 1992. Effect of α-adrenergic stimulation on activation of protein kinase C and phosphorylation of proteins in intact rabbit hearts. Circ. Res. 70: 670-78
34. Minshall RD, Nakamura F, Becker RP, et al. 1995. Characterization of bradykinin B2 receptors in adult myocardium and neonatal rat cardiomyocytes. Circ. Res. 76: 773-80
35. Irons CE, Murray SF, Glembotski CC. 1993. Identification of the receptor subtype responsible for endothelin-mediated protein kinase C activation and atrial natriuretic factor secretion from atrial myocytes. J. Biol. Chem. 268:23417-21
36. Liu Y, Tsuchida A, Cohen MV, et al. 1995. Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts. J. Mol. Cell. Cardiol. 27:883-92
37. Thornton JD, Daly JF, Cohen MV, et al. 1993. Catecholamines can induce adenosine receptor-mediated protection of the myocardium but do not participate in ischemic preconditioning in the rabbit. Circ. Res. 73:649-55
38. Tsuchida A, Liu Y, Liu GS, et al. 1994. α1-Adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C. Circ. Res. 75:576-85
39. Goto M, Liu Y, Yang X-M, et al. 1995. Role of bradykinin in protection of ischemic preconditioning in rabbit hearts. Circ. Res. 77: 611-21
40. Wang P, Gallagher K, Downey JM, et al. 1995. Endothelin-1 limits myocardial infarction through PKC activation. J. Mol. Cell. Cardiol. 27:A44 (Abstr.)
41. Li Y, Kloner RA. 1993. The cardioprotective effects of ischemic "preconditioning" are not mediated by adenosine receptors in rat hearts. Circulation 87:1642-48
42. Liu Y, Cordis GA, Das DK, et al. 1995. Protein kinase C may be activated by phospholipase D rather than C in ischemic preconditioning. J. Mol. Cell. Cardiol. 27:A41 (Abstr.)
43. Grover GJ, Dzwonczyk S, Parham CS, et al. 1990. The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs. Cardiovasc. Drugs Ther. 4:465-74
44. Walsh RS, Tsuchida A, Daly JJF, et al. 1994. Ketamine-xylazine anaesthesia permits a KATP channel antagonist to attenuate preconditioning in rabbit myocardium. Cardiovasc. Res. 28:1337-41
45. Gross GJ, Auchampach JA. 1992. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ. Res. 70:223-33
46. Grover GJ, Dzwonczyk S, Sleph PG. 1992. ATP-sensitive K+ channel activation does not mediate preconditioning in isolated rat hearts. Circulation 86(Suppl. I):I-341 (Abstr.)
47. Armstrong SC, Ganote CE. 1992. Flow cytometric analysis of isolated adult cardiomyocytes: vinculin and tubulin fluorescence during metabolic inhibition and ischemia. J. Mol. Cell. Cardiol. 24:149-62
48. Murry CE, Richard VJ, Reimer KA, et al. 1990. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ. Res. 66:913-31
49. Tsuchida A, Thompson R, Olsson RA, et al. 1994. The anti-infarct effect of an adenosine A1-selective agonist is diminished after prolonged infusion as is the cardioprotective effect of ischaemic preconditioning in rabbit heart. J. Mol. Cell. Cardiol. 26: 303-11
50. Hashimi W, Thormon JD, Downey JM, et al. 1994. Chronic adenosine A1-agonist exposure results in adenosine receptor rather than G protein downregulation. Circulation 90(Suppl. I):I-107 (Abstr.)
51. Cohen MV, Yang X-M, Downey JM. 1994. Conscious rabbits become tolerant to multiple episodes of ischemic preconditioning. Circ. Res. 74:998-1004
52. Kloner RA, Shook T, Przyklenk K, et al. 1995. Previous angina alters in-hospital outcome in TIMI 4. A clinical correlate to preconditioning? Circulation 91:37-45