Effects of four organohalogen environmental contaminants on cytochrome P450 forms that catalyze 4- and 2-hydroxylation of estradiol in the rat liver

Biochemical and Molecular Medicine

Volumn 60, Issue 2, 1997, Pages 149-154

  Segura Aguilar, Juan ^a   Castro, Victor ^b   Bergman, Åke ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYESTRADIOL; 2,2',4,4' TETRABROMODIPHENYL ETHER; 3,3',4,4',5 PENTACHLOROBIPHENYL; 3,4,5 TRICHLOROGUAIACOL; 4 HYDROXYESTRADIOL; CYTOCHROME P450; ESTRADIOL; ORGANOHALOGEN DERIVATIVE; OXYGENASE; TRIS(4 CHLOROPHENYL)METHANOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG HYDROXYLATION; FEMALE; LIVER MICROSOME; MALE; NONHUMAN; POLLUTANT; RAT;

ANIMALIA;

EID: 0031127680     PISSN: 10773150     EISSN: None     Source Type: Journal    
DOI: 10.1006/bmme.1997.2569     Document Type: Article

References (20)

1. Harrington J M, Rivera R O, Lowry L K. Occupational exposure to synthetic estrogens - The need to establish safety standards. Am Ind Hyg Assoc J. 39:1970;139-143.
2. Liehr J G, Sirbasku D A. Estrogen-dependent kidney tumors. Tissue Culture of Epithelial Cells. 1985;Plenum, New York. p. 205-234.
3. Abul-Hajj Y J, Thijssen J HH, Blankenstein M A. Metabolism of estradiol by human breast cancer. Eur J Cancer Clin Oncol. 24:1988;1171-1178.
4. Bachur N R, Gordon S L, Gee M V, Kon H. NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. Proc Natl Acad Sci USA. 76:1979;954-957.
5. 3+. Chem-Biol Interact. 72:1989;309-324.
6. Sinha B K, Chignell C F. Binding mode of chemically actived semiquinone free radicals from quinone anticancer agents to DNA. Chem-Biol Interact. 28:1979;301-308.
7. Liehr J G, Fang W F, Sibasku D A, Ulubelen A A. Carcinogenicity of catechol estrogens in Syrian hamster. J Steroid Biochem. 24:1986;353-356.
8. Khilström J E, Olsson M, Jensen S, Johansson Å, Ahlbom J, Bergman Å. Effects of PCB and different fractions of PCB on the reproduction of the mink (Mustela vison. Ambio. 21:1992;563-569.
9. Svensson B G, Hallberg T, Nilsson A, Schutz A, Hagmar L. Parameters of immunological competence in subjects with high consumption of fish contaminated with persistent organochlorine compounds. Int Arch Occup Environ Health. 65:1994;351-358.
10. Jacobson J L, Jacobson S W, Humphrey J HEB. Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. Pediatrics. 116:1990;38-45.
11. Hemming H, Flodström S, Wärngård L, Bergman Å, Kronevi T, Nordgren I, Ahlborg U G. Relative tumor promoting activity of three polychlorinated biphenyls in rat liver. Eur J Pharmacol. 248:1993;163-174.
12. Sellström U, Jansson B, Kierkegaard A, de Wit C, Odsjö T, Olsson M. Polybrominated diphenyl ethers (PBDE) in biological samples from the Swedish environment. Chemosphere. 26:1993;1703-1718.
13. Klasson Wehler E, Jakobsson E, Örn U. Metabolism of polychlorinated naphthalenes and a tetrabrominated diphenyl ether. Organohalogen Compounds. 28:1996;495-499.
14. Jarman W M, Simon M, Norstrom R J, Burns S A, Bacon C A, Simonelt B RT, Risebrough R W. Global distribution of Tris(4-chlorophenyl)methanol in high trophic level bird and mammals. Environ Sci Technol. 26:1992;1770-1774.
15. Poon R, Lecavalier P, Bihun C, Bergman Å, Yagminas A, Chu I. Effects of Tris(4-chlorophenyl)methanol on the rat following short-term oral exposure. Chemosphere. 1997.
16. Bergman Å, Wachtmeister C A. Phase transfer mediated synthesis of radiolabelled alkyl aryl ethers and sulphides. J Labelled Comp Radiopharmacol. 24:1987;925-930.
17. Roy D, Weisz J, Liehr J G. The O-methylation of 4-hydroxyestradiol is inhibited by 2-hydroxyestradiol: Implications for estrogen-induced carcinogenesis. Carcinogenesis. 11:1990;459-462.
18. Silberhorn E M, Glauvert H P, Robertson L W. Cacinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Crit Rev Toxicol. 20:1990;440-496.
19. National Board of Health and Welfare, Swedish Cancer Registry, 1992, Cancer Incidence in Sweden, Kommentus Editorial, Helsingborg.
20. Osawa Y, Higashiyama T, Shimizu Y, Yarborough C. Multiple functions of aromatase and the active site structure: Aromatase is the placental estrogen 2-hydroxylase. J Steroid Biochem Molec Biol. 44:1993;469-480.