Aromatase in the normal breast and breast cancer

Journal of Steroid Biochemistry and Molecular Biology

Volumn 61, Issue 3-6, 1997, Pages 281-286

  Brodie, Angela ^a   Lu, Qing ^a   Nakamura, Junji ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE;

ADIPOSE TISSUE; BODY MASS; BREAST; BREAST CANCER; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; ESTROGEN BLOOD LEVEL; ESTROGEN SYNTHESIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; POSTMENOPAUSE;

EID: 0031125661     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(96)00251-8     Document Type: Conference Paper

References (46)

1. McGuire W.L. An update on estrogen and progesterone receptors in prognosis for primary and advanced breast cancer. Iacobelli S. Hormones and Cancer. Vol. 15:1980;337-344 Raven Press, New York.
2. Hemsell D.L., Gordon J., Breuner P.F., Siiteri P.K. Plasma precursors of estrogen. II. Correlation of the extent of conversion of plasma androstenedione to estrone with age. J. Clin. Endocr. Metab. 38:1974;476-479.
3. Longcope C., Pratt J.H., Schneider S.H., Fineberg S.E. Aromatization of androgens by muscle and adipose tissue in vivo. J. Clin. Endocr. Metab. 46:1978;146-152.
4. van Landegham A.A.J., Portman J., Nabauurs M. Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue. Cancer Res. 45:1985;2900-2906.
5. Thorsen T., Tangen M., Stoa K.F. Concentrations of endogenous estradiol as related to estradiol receptor sites in breast tumor cytosol. Eur. J. Cancer Clin. Oncol. 18:1982;333-337.
6. Dorgan J.F., Longcope C., Stephenson C., Franz C., Miller R., Falk R.T., Kahle L., Schatzkin A. Serum estrogens and androgens and breast cancer. Washington DC The Endocrine Society 77th Annual Meeting. 1995;2-664.
7. Vermeulen A., Deslypere J.P., Parideans R., Lecleercq C., Roy F., Heuson J.C. Aromatase, 17β-hydroxysteroid dehydrogenase intratissular sex hormone concentrations in cancerous and normal breast tissue in postmenopausal women. Eur. J. Cancer Clin. Oncol. 22:1986;515-525.
8. Killinger D.W., Strutt B.J., Roncari D.A., Khalil M.W. Estrone formation from dehydroepiandrosterone in cultured human breast adipose stromal cells. J. Steroid Biochem. Molec. Biol. 52:1995;195-201.
9. Koos R.D., Banks P.K., Inkster S.E., Yue W., Brodie A.M.H. Detection of aromatase and keratinocyte growth factor expression in breast tumors using reverse transcription-polymerase chain reaction. J. Steroid Biochem. Molec. Biol. 45:1993;217-225.
10. Bezwoda W.R., Mansoor N., Dansey R. Correlation of breast tumor aromatase activity and response to aromatase inhibitor with aminoglutethimide. Oncology. 44:1987;345-349.
11. Miller W.R., O'Neill J.S. The importance of local synthesis of estrogen within the breast. Steroids. 50:1988;537-548.
12. Miller W.R., Anderson T.J., Jack W.L.J. Relationship between tumor aromatase activity, tumor characteristics and response to therapy. J Steroid Biochem. Molec. Biol. 37:1990;1055-1059.
13. Silva M.C., Rowlands M.G., Dowsett M.D., Gusterson B., McKinna J.A., Fryatt I., Coombes R.C. Intratumoral aromatase as a prognostic factor in human breast carcinoma. Cancer Res. 49:1989;2588-2591.
14. James V.H.T., Reed M.J., Adams E.F., Ghilchik M., Lai L.C., Coldham N.G., Newton C.J., Purohit A., Owen A.M., Singh A., Islam S. Oestrogen uptake and metabolism in vivo. Proc. R. Soc. Edinburgh. 95B:1989;185-193.
15. Reed M.J., Aherne G.W., Ghilchik M.W., Patel S., Chakraborty J. Concentrations of oestrone and 4-hydroxyandrostenedione in malignant and normal breast tissues. Int. J. Cancer. 49:1991;562-565.
16. Lu Q., Nakmura J., Savinov A., Yue W., Weisz J., Dabbs D.J., Wolz G., Brodie A. Expression of aromatase protein and mRNA in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers. Endocrinology. 137:1996;3061-3068.
17. arom) and their use in its purification. Arch. Biochem. Biophys. 243:1985;480-491.
18. Weisz J., Fritz-Wolz G., Dabbs D., Shelley K., Brodie A., Lu Q., Brown T. Expression of aromatase in epithelial and stromal cells in terminal lobular ductal units and in epithelial cells of cysts in normal human mammary gland. Proc. Am. Ass. Cancer Res. 36:1995;273.
19. Esteban J.M., Warsi Z., Haniu M., Hall P., Shively J.E., Chen S. Detection of intratumoral aromatase in breast carcinomas. Am. J. Pathol. 140:1992;337-343.
20. Santen R.J., Martel J., Hoahland F., Naftolin F., Roa L., Harada N., Hafer L., Zaino R., Santner S.J.I. Stromal spindle cells contain aromatase in human breast tumors. J. Clin. Endocr. Metab. 79:1994;627-632.
21. Sasano H., Nagura H., Harada N., Goukon Y., Kimura M. Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Human Pathol. 25:1994;530-535.
22. Inkster S.E., Brodie A.M.H. Immunocytochemical studies of aromatase in early and full term human placental tissues: comparison with biochemical assays. Biol. Reprod. 41:1989;889-898.
23. Inkster S.E., Brodie A.M.H. Expression of aromatase cytochrome P450 in premenopausal and postmenopausal human ovaries: an immunocytochemical study. J. Clin. Endocr. Metab. 73:1991;717-726.
24. Inkster S.E., Brodie A.M.H. Human testicular aromatase: immunocytochemical and biochemical studies. J. Clin. Endocr. Metab. 80:1995;1941-1947.
25. Banks P., Brodie A.M.H., Petersen S., Zoeller T., Barraclough C. Localization of aromatase mRNA in human term placenta by in situ hybrization histochemistry. Seattle, WA The 71st Meeting of Endocrine Society. 1989;76. (Abstract).
26. Reed M.J., Coldham N.G., Patel S., Ghilchik M.W., James V.H.T. Interleukin-1 and interleukin-6 in breast cyst fluid: their role in relegating aromatase activity in breast cancer cells. J. Endocr. 132:1992;R5-R8.
27. Reed M.J., Topping L., Coldham N.G., Purohit A., Ghilchik M.W., James V.H.T. Control of aromatase activity in breast cancer cells: the role of cytokines and growth factors. J. Steroid Biochem. Molec. Biol. 44:1993;589-596.
28. Reed M.J. The role of aromatase in breast tumors. Breast Cancer Res. Treat. 30:1994;7-17.
29. Leuprasitsakul P., Longcope C. Aromatase activity in human adipose tissue stromal cells: the effect of fetal bovine serum fractions on dexamethasone-stimulated aromatization. J. Steroid Biochem. Molec. Biol. 39:1978;353-357.
30. Bradlow H.L. A reassessment of the role of breast tumor aromatization. Cancer Res. 42:1982;3382S-3386S.
31. Miller W.R., Forrest A.P.M. Estradiol synthesis from C19 steroids by human breast cancer. Br. J. Cancer. 33:1974;16-18.
32. Li K., Adams J.B. Aromatization of testosterone and oestrogen receptor levels in human breast cancer. J. Steroid Biochem. Molec. Biol. 14:1981;269-272.
33. Lipton A., Santen R.J., Santen S.J., Harvey H.A., Peil P.D., White-Hershey D., Bartholomew M.J., Antle C.E. Aromatase activity in primary and metastatic human breast cancer. Cancer. 59:1987;779-783.
34. Lipton A., Santen R.J., Santen S.J., Harvey H.A., Sanders S.I., Mathews Y.L. Prognostic value of breast cancer aromatase. Cancer. 70:1992;1951-1955.
35. Robbins B.A., dela Vega D., Ogata K., Tan E.M., Nakamura R.M. Immunohistochemical detection of proliferating cell nuclear antigen in solid human malignancies. Arch. Path. Lab. Med. 111:1987;841-845.
36. Hall P.A., Levison D.A., Woods A.L., Yu C.C.W., Kellock D.B., Wathins J.A., Barnes D.M., Gillett C.E., Camplejohn R., Dover R., Waseem N.H., Lane D.P. Proliferating cell nuclear antigen immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J. Pathol. 162:1990;285-294.
37. Narita T., Funahashi H., Satoh Y., Takagi H. Proliferating cell nuclear antigen immunostaining in breast cancer and its relation to prognosis. Jpn. J. Clin. Oncol. 23:1993;20-25.
38. Aaltomaa S., Lipponoe P., Papinaho S., Syrjanen K. Proliferating-cell nuclear antigen (PC10) immunolabeling and other proliferation indices as prognostic factors in breast cancer. J. Cancer Res. Clin. Oncol. 119:1993;288-294.
39. Vescio R.A., Connors K.M., Youngkin T., Bordin G.M., Robb J.A., Umbreit J.N., Hoffman R.M. Cancer biology for individualized therapy: correlation of growth faction index in native-state histoculture with tumor grade and stage. Proc. Natl. Acad Sci. U.S.A. 87:1990;691-695.
40. Brodie A.M.H., Schwarzel W.C., Shaikh A.A., Brodie H.J. The effect of an aromatase inhibitor, 4-hydroxy-4-androstene-3,17-dione, on estrogen dependent processes in reproduction and breast cancer. Endocrinology. 100:1977;1684-1694.
41. Matsuda S., Kadowaki Y., Ichino M., Akiyama T., Toyoshima K., Yamamoto T. 17β-estradiol mimics ligand activity of the c-erbB2 protooncogene product. Proc. Natl. Acad Sci. U.S.A. 90:1993;10803-10807.
42. Bargmann C.I., Hung M.C., Weinberg R.A. The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature. 319:1986;226-230.
43. Yamamoto T., Ikawa S., Akiyama T., Senba K., Momura N., Miyajima N., Satio S., Toyoshima K. Similarity of protein encoded by the human c-erbB2 gene to epidermal growth factor receptor. Nature. 319:1986;230-234.
44. Slamon D.J., Clark G.M., Wong S.G., Levin W.J., Ullrich A., McGuire W.L. Human breast cancer: correlation of relapse and survival with ampliation of the HER-2/neu oncogene. Science. 235:1987;177-182.
45. Allred D.C., Clark G.M., Molina R., Tandon A.K., Schnitt S.J., Gilchrist K.W. Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer. Hum. Pathol. 23:1992;974-979.
46. Nakamura J., Lu Q., Albrecht E., Brodie A. Aromatase expression and the effect of hormones and locally produced estrogens on the growth of the normal primate mammary gland. Washington DC The 77th. Endocrine Society Meeting. 1995;3-594. Abstract.