Comparative cytotoxicity of monocrotaline and its metabolites in cultured pulmonary artery endothelial cells

Toxicology and Applied Pharmacology

Volumn 143, Issue 1, 1997, Pages 196-204

  Taylor, D W ^a   Wilson, D W ^a   Lame M W ^a   Dunston, S D ^a   Jones, A D ^a   Segall, H J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; LACTATE DEHYDROGENASE; MONOCROTALINE; MONOCROTALINE PYRROLE; PROSTACYCLIN; PYRROLIZIDINE ALKALOID;

ANIMAL CELL; ARTICLE; CATTLE; CELL CULTURE; CELL DENSITY; CONTROLLED STUDY; CYTOLOGY; CYTOTOXICITY; DRUG COMPARISON; ENDOTHELIUM CELL; HYPERTROPHY; IN VITRO STUDY; MEMBRANE PERMEABILITY; NONHUMAN; PULMONARY ARTERY;

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0031106034     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.8083     Document Type: Article

References (50)

1. Amador, E., Dorfman, L. E., and Wacker, W. E. C. (1963). Serum lactic dehydrogenase: An analytical assessment of current assays. Clin. Chem. 9, 391-399.
2. Anders, M. W., Dekant, W., and Vamvakas, S. (1992). Glutathione-dependent toxicity. Xenobiotica 22, 1135-1145.
3. Anders, M. W., Lash, L., Dekant, W., Elfarra, A. A., and Dohn, D. R. (1988). Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. Crit. Rev. Toxicol. 18, 311-341.
4. Baillie, T. A., and Kassahun, K. (1994). Reversibility in glutathione-conjugate formation. Adv. Pharmacol. 27, 163-181.
5. Baillie, T. A., and Slatter, J. G. (1991). Glutathione: A vehicle for the transport of chemically reactive metabolites in vivo. Acct. Chem. Res. 24, 264-270.
6. Boor, P. J., Gotlieb, A. I., Joseph, E. C., Kerns, W. D., Roth, R. A., and Tomaszewski, K. E. (1995). Chemical-induced vasculature injury. Summary of the symposium presented at the 32nd annual meeting of the Society of Toxicology, New Orleans, Louisiana, March 1993. Toxicol. Appl. Pharmacol. 132, 177-195.
7. Bull, L. B., and Culvenor, C. C. J. (1968). The pyrrolizidine alkaloids. In Frontiers of Biology. Amsterdam, North Holland.
8. Chung-Welch, N., Shepro, D., Dunham, B., and Hechtman, H. B. (1988). Prostacyclin and prostaglandin E2 secretions by bovine pulmonary microvessel endothelial cells are altered by changes in culture conditions. J. Cell. Physiol. 135, 224-234.
9. Doukas, J., Shepro, D., and Hechtman, H. B. (1987). Vasoactive amines directly modify endothelial cells to affect polymorphonuclear leukocyte diapedesis in vitro. Blood 69, 1563-1569.
10. Estep, J. E., Lamé, M. W., Jones, A. D., and Segall, H. J. (1990a). N-acetyl-cysteine-conjugated pyrrole identified in rat urine following administration of two pyrrolizidine alkaloids, monocrotaline and senecionine. Toxicol. Lett. 54, 61-69.
11. 14C] senecionine administration in the rat. Toxicology 64, 179-189.
12. Gorfien, S., Spector, A., DeLuca, D., and Weiss, S. (1993). Growth and physiological functions of vascular endothelial cells in a new serum-free medium (SFM). Exp. Cell Res. 206, 291-301.
13. Hincks, J. R., Kim, H. Y., Segall, H. J., Molyneux, R. J., Stermitz, F. R., and Coulombe, R. J. (1991). DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: Structure-activity relationships. Toxicol. Appl. Pharmacol. 111, 90-98.
14. Hoorn, C. M., and Roth, R. A. (1992). Monocrotaline pyrrole alters DNA, RNA and protein synthesis in pulmonary artery endothelial cells. Am. J. Physiol. L740-747.
15. Huxtable, R. J. (1990). Activation and pulmonary toxicity of pyrrolizidine alkaloids. Chem.-Biol. Interact. 76, 19-30.
16. Huxtable, R. J., Bowers, R., Mattocks, A. R., and Michnicka, M. (1991). Sulfur conjugates as putative pneumotoxic metabolites of the pyrrolizidine alkaloid, monocrotaline. Adv. Exp. Med. Biol. 283, 605-612.
17. Kay, J. M., Keane, P. M., Suyama, K. L., and Gauthier, D. (1982). Angiotensin converting enzyme activity and evolution of pulmonary vascular disease in rats with monocrotaline pulmonary hypertension. Thorax 37, 88-96.
18. Kim, H. Y., Stermitz, F. R., and Coulombe, R. J. (1995). Pyrrolizidine alkaloid-induced DNA-protein cross-links. Carcinogenesis 16, 2691-2697.
19. 14C] monocrotaline by isolated perfused rat liver. Drug Metab. Dispos. 19, 516-524.
20. 14C]monocrotaline in the rat. Drug Metab. Dispos. 23, 422-429.
21. Lamé, M. W., Morin, D., Jones, A. D., Segall, H. J., and Wilson, D. W. (1990). Isolation and identification of a pyrrolic glutathione conjugate metabolite of the pyrrolizidine alkaloid monocrotaline. Toxicol. Lett. 51, 321-329.
22. Levine, E. M., Mueller, S. N., Grinspan, J. B., Noveral, J. P., and Rosen, E. M. (1983). Endothelial cell senescence and the aetiology of age-related disease. In Biochemical Interactions at the Endothelium (A. Cryer, Ed.), pp. 313-334. Elsevier, New York.
23. Loscalzo, J. (1992). Endothelial dysfunction in pulmonary hypertension. N. Engl. J. Med. 327, 117-119. [Editorial; comment]
24. Lum, H., and Malik, A. B. (1994). Regulation of vascular endothelial barrier function. Am. J. Physiol. 267, L223-241.
25. Mattocks, A. R. (1986). Chemistry and Toxicology of Pyrrolizidine Alkaloids. Academic Press, London.
26. Mattocks, A. R., Jukes, R., and Brown, J. (1989). Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids. Toxicon 27, 561-567.
27. Meyrick, B., Gamble, W., and Reid, L. (1980). Development of Crotalaria pulmonary hypertension: Hemodynamic and structural study. Am. J. Physiol. 239, H692-702.
28. Mineau-Hanschke, R., Wiles, M. E., Morel, N., Hechtman, H. B., and Shepro, D. (1990). Modulation of cultured pulmonary microvessel and arterial endothelial cell barrier structure and function by serotonin. Microvasc. Res. 39, 140-155.
29. O'Donnell, M. E. (1993). Role of Na-K-Cl cotransport in vascular endothelial cell volume regulation. Am. J. Physiol. 264, C1316-1326.
30. Olson, J. A., Moon, R. C., Anders, M. W., Fenselau, C., and Shane, B. (1992). Enhancement of biological activity by conjugation reactions. J. Nutr. 122, 615-624.
31. Overby, L. H., Nishio, S., Weir, A., Carver, G. T., Plopper, C. G., and Philpot, R. M. (1992a). Distribution of cytochrome P450 1A1 and NADPH-cytochrome P450 reductase in lungs of rabbits treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: Ultrastructural immunolocalization and in situ hybridization. Mol. Pharmacol. 41, 1039-1046.
32. Overby, L., Nishio, S. J., Lawton, M. P., Plopper, C. G., and Philpot, R. M. (1992b). Cellular localization of flavin-containing monooxygenase in rabbit lung. Exp. Lung Res. 18, 131-144.
33. Pan, L. C., Wilson, D. W., Segall, H. J., Lamé, M. W., and Morin, D. (1990). Red blood cells from monocrotaline treated rats decrease serotonin removal in isolated perfused lungs. Toxicologist 10, 101-110.
34. Pan, L. C., Lamé, M. W., Morin, D., Wilson, D.W., and Segall, H. J. (1991). Red blood cells augment transport of reactive metabolites of monocrotaline from liver to lung in isolated and tandem liver and lung preparations. Toxicol. Appl. Pharmacol. 110, 336-346.
35. Pan, L. C., Wilson, D. W., Lamé, M. W., Jones, A. D., and Segall, H. J. (1993). Cor pulmonale is caused by monocrotaline and dehydromonocrotaline, but not by glutathione or cysteine conjugates of dihydropyrrolizine. Toxicol. Appl. Pharmacol. 118, 87-97.
36. Reindel, J. F., Ganey, P. E., Wagner, J. G., Slocombe, R. F., and Roth, R. A. (1990). Development of morphologic, hemodynamic, and biochemical changes in lungs of rats given monocrotaline pyrrole. Toxicol. Appl. Pharmacol. 106, 179-200.
37. Reindel, J. F., Hoorn, C. M., Wagner, J. G., and Roth, R. A. (1991). Comparison of response of bovine and porcine pulmonary arterial endothelial cells to monocrotaline pyrrole. Am. J. Physiol. 261, L406-414.
38. Reindel, J. F., and Roth, R. A. (1991). The effects of monocrotaline pyrrole on cultured bovine pulmonary artery endothelial and smooth muscle cells. Am. J. Pathol. 138, 707-719.
39. Roth, R. A., Dotzlaf, L. A., Baranyi, B., Kuo, C.-H., and Hook, J. B. (1981). Effect of monocrotaline ingestion on liver, kidney and lung of rats. Toxicol. Appl. Pharmacol. 60, 193-203.
40. Roth, R. A., and Reindel, J. F. (1991). Lung vascular injury from monocrotaline pyrrole, a putative hepatic metabolite. Adv. Exp. Med. Biol. 283, 477-487.
41. Ryan, U. S. (1987). Endothelial Cells. CRC Press, Boca Raton, FL.
42. Ryan, U. S., Clements, E., Habliston, D., and Ryan, J. W. (1978). Isolation and culture of pulmonary artery endothelial cells. Tissue Cell. 10, 535-554.
43. Schultze, A. E., Gunaga, K. P., Wagner, J. G., Hoorn, C. M., Moorehead, W. R., and Roth, R. A. (1994). Lactate dehydrogenase activity and isozyme patterns in tissues and bronchoalveolar lavage fluid from rats treated with monocrotaline pyrrole. Toxicol. Appl. Pharmacol. 126, 301-310.
44. Serabjit-Singh, C. J., Wolf, C. R., Philpot, R. M., and Plopper, C. G. (1980). Cytochrome P-450: Localization in rabbit lung. Science 207, 1469-1470.
45. Slatter, J. G., Rashed, M. S., Pearson, P. G., Han, D. H., and Baillie, T. A. (1991). Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities. Chem. Res. Toxicol. 4, 157-161.
46. Thomas, H. C., Lamé, M. W., Wilson, D. W., and Segall, H. J. (1996). Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA. Toxicol. Appl. Pharmacol. 141, 319-329.
47. Turner, J. H., and Lalich, J. J. (1965). Experimental cor pulmonale in the rat. Arch. Pathol. 79, 409-410.
48. Valdivia, E., Sonnad, J., Hayashi, Y., and Lalich, J. J. (1967). Experimental interstitial pulmonary edema. Angiology 18, 378-383.
49. Wilson, D. W., and Segall, H. J. (1990). Changes in type II cell populations in monocrotaline pneumotoxicity. Am. J. Pathol. 136, 1293-1301.
50. Wilson, D. W., Segall, H. J., Pan, L. C. W., and Dunston, S. K. (1989). Progressive inflammatory and structural changes in the pulmonary vasculature of monocrotaline treated rats. Microvasc. Res. 38, 57-80.