Early T Cell Unresponsiveness in Mice with Candidiasis and Reversal by IL-2: Effect on T Helper Cell Development

Journal of Immunology

Volumn 158, Issue 5, 1997, Pages 2294-2302

  Spaccapelo, Roberta ^a   Del Sero, Giuseppe ^a   Mosci, Paolo ^a   Bistoni, Francesco ^a   Romani, Luigina ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; FUNGUS ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 4; L SELECTIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; C3H MOUSE; C57BL MOUSE; CANDIDA ALBICANS; CANDIDIASIS; CELL DIFFERENTIATION; CLASSIFICATION; COMPARATIVE STUDY; DBA MOUSE; DISEASE PREDISPOSITION; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; HELPER CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INNATE IMMUNITY; LYMPHOCYTE ACTIVATION; MOUSE; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD44; ANTIGENS, FUNGAL; CANDIDA ALBICANS; CANDIDIASIS; CELL DIFFERENTIATION; DISEASE SUSCEPTIBILITY; EPITOPES; FEMALE; IMMUNE TOLERANCE; IMMUNITY, NATURAL; INTERLEUKIN-2; INTERLEUKIN-4; L-SELECTIN; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0031091735     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Romani, L., and D. H. Howard. 1995. Mechanisms of resistance to fungal infections. Curr. Opin. Immunol. 7:517.
2. Romani, L., P. Puccetti, and F. Bistoni. 1996. Biological role of helper T-cell subsets in candidiasis. Chem. Immunol. 63:115.
3. Puccetti, P., L. Romani, and F. Bistoni. 1995. A Th1-Th2 cell-like switch in candidiasis: new perspectives for therapy. Trends Microbiol. 3:237.
4. Romani, L., S. Mocci, C. Bietta, L. Lanfaloni, P. Puccetti, and F. Bistoni. 1991. Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Th1 responses with acquired resistance. Infect. Immun. 59:4647.
5. + subset expression in murine candidiasis: Th responses correlate directly with genetically determined susceptibility or vaccine-resistance. J. Immunol. 150:1384.
6. Romani, L., A. Mencacci, L. Tonnetti, R, Spaccapelo, E. Cenci, S. Wolf, P. Puccetti, and F. Bistoni. 1994. Interleukin-12 but not Interferon-γ production correlates with induction of T helper type-1 phenotype in murine candidiasis. Eur. J. Immunol. 22:909.
7. Romani, L., A. Mencacci, L. Tonnetti, R. Spaccapelo, E. Cenci, P. Puccetti, S. F. Wolf, and F. Bistoni. 1994. IL-12 is both required and prognostic in vivo for T helper type-1 differentiation in murine candidiysis. J. Immunol. 152:5167.
8. + subset expression in murine candidiasis. Infect. Immun. 60:4950.
9. Djeu, J. Y. 1993. Modulators of immune responses to fungi. In Fungal Infections and Immune Responses. J. W. Murphy, F. Friedman, and M. Bendinelli, eds. Plenum Publishing Corp., New York, p. 521-532.
10. Romani, L., A. Mencacci, U. Grohmann, S. Mocci, P. Mosci, P. Puccetti, and F. Bistoni. 1992. Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis. J. Exp. Med. 176:19.
11. Romani, L., P. Puccetti, A. Mencacci, E. Cenci, R. Spaccapelo, L. Tonnetti, U. Grohmann, and E. Bistoni. 1994. Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. J. Immunol. 152:3514.
12. Cenci, E., L. Romani, A. Mencacci, R. Spaccapelo, E. Schiaffella, P. Puccetti, and F. Bistoni. 1993. Interleukin 4 and interleukin 10 inhibit nitric oxide-dependent macrophage killing of Candida albicans. Eur. J. Immunol. 9:1034.
13. Powers, G. D., A. K. Abbas, and R. A. Miller. 1988. Frequencies of IL-2- and IL-4-secreting cells in naive and antigen-stimulated lymphokine populations. J. Immunol. 140:3352.
14. Swain, S. L., L. M. Bradley, M. Croft, S. Tonkonogy, G. Atkins, A. D. Weinberg, D. D. Duncan, S. M. Hedrick, R. W. Dutton, and G. Houston. 1991. Helper T cell subsets: phenotype, function, and the role of lymphokines in regulating their development. Immunol. Rev. 123:115.
15. Le Gros, G., S. Z. Ben-Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin 4 (IL-4) producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4 producing cells. J. Exp. Med. 172:921.
16. Chan, S. H., B. Perussia, J. W. Gupta, M. Kobayashi, M. Pospisil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of interferon-γ production by natural killer cell stimulatory factor: characterization of the responding cells and synergy with other inducers. J. Exp. Med. 173:869.
17. + T cells tor IFN-γ but have differential eflect on priming for IL-4. J. Immunol. 156:2413.
18. Schwartz, R. H. 1992. Costimulation of T lymphocytes, the role of CD28, CTLA-4 and B7/BBI in interleukin-2 production and immunotherapy. Cell 71:1065.
19. Linsley, P. S., W. Brady, M. Urnes, L. S. Grossmaire, N. K. Damle, and J. A. Ledbetter. 1991. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 174:561.
20. Mc Arthur, J. G., and D. H. Raulet. 1993. CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4. J. Exp. Med. 178:1645.
21. Odds, F. C. 1988. Candida and Candidosis, 2nd Ed. Baillere-Tindall, London.
22. Rosenberg, S. A., M. T. Lotze, J. C. Yang, P. M. Aebersold, W. M. Linehan, C. Seipp, and D. E. White. 1989. Experience with the use of high-dose interleukin-2 in the treatment of 652 cancer patients. Ann. Surg. 201:474.
23. Teppler, H., G. Kaplan, K. A. Smith, A. L. Montana, P. Meyen, and Z. A. Cohn. 1993. Prolonged immunostimulatory effect of low-dose polyethylene glycol interleukin 2 in patients with human immunodeficiency virus type 1 infection. J. Exp. Med. 177:483.
24. + T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection: a preliminary study. N. Engl. J. Med. 332:567.
25. Ramachandran, R., D. A. Katzeinstein, M. A. Winlhers, S. K. Kundu, and T. C. Merigan. 1996. Polyethylene glycol-modified interleukin-2 and thymosin α1 in human immunodeficiency virus type 1 infection. J. Infect. Dis. 173:1005.
26. Choromanski, L., and R. E. Kuhn. 1987. Use of parasite and interleukin-2 to enhance suppressed immune responses during Trypanosoma cruzi infection in mice. Infect. Immun. 55:403.
27. Sharma, S. D., J. M. Hofflin, and I. S. Remington. 1985. In vivo recombinant interleukin 2 administration enhances survival against a lethal challenge with Toxoplasma gondii. J. Immunol. 135:4160.
28. Haak-Frendscho, M., K. M. Young, and C. J. Czuprynski. 1989. Treatment of mice with recombinant interleukin-2 augments resistance to the facultative intracellular pathogen Listeria monocytogenes. Infect. Immun. 57:3014.
29. Bermudez, L. E. M., P. Stevens, P. Kolonski, M. Wu, and L. S. Young. 1989. Treatment of experimental Mycobacterium avium complex infection in mice with recombinant IL-2 and tumor necrosis factor. J. Immunol. 143:2996.
30. Khol, S., L. S. Loo, D. B. Drath, and P. Cox. 1989. Interleukin-2 protects neonatal mice from lethal herpes simplex virus infection: a macrophage-mediated. γ-interferon-induced mechanism. J. Infect. Dis. 159:239.
31. Murray, H. W., G. D. Miralles, M. Y. Stoeckle, and D. F. McDermott. 1993. Role and effect of IL-2 in experimental visceral leishmaniasis. J. Immunol. 151:929.
32. Heinzel, F. P., M. R. Rerko, F. Hatam, and R. M. Locksley. 1993. IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts. J. Immunol. 150:3924.
33. Corry, D. B., S. L. Reiner, P. S. Linsley, and R. M. Locksley. 1994. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 153:4142.
34. + subset differentiation in Candida albicans-infected mice. Infect. Immun. 61:3769.
35. Zimmerman, R. J., S. L. Aukerman, N. V. Katre, J. L. Winkelnake, and J. D. Young. 1989. Schedule dependency of the anti-tumor activity and toxicity of polyethylene glycol-modified interleukin-2 in murine models. Cancer Res. 49:6521.
36. Spaccapelo, R., L. Romani, L. Tonnetti, E. Cenci, A. Mencacci, G. Del Sero, R. Tognellini, S. G. Reed, P. Puccetti, and F. Bistoni. 1995. TGF-β is important in determining the in vivo patterns of susceptibility or resistance in mice infected with Candida albicans. J. Immunol. 155:1349.
37. Romani, L., P. Puccetti, A. Mencacci, R. Spaccapelo, E. Cenci, L. Tonnetti, and F. Bistoni. 1994. Tolerance of staphylococcal enterotoxin B initiates Th1 cell differentiation in mice infected with Candida albicans. Infect. Immun. 62:4047.
38. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156.
39. Saiki, R. K., S. Scharf, F. Faloona, K. B Mullis, G. T. Horn, H. A. Erlich, and N. Arnheim. 1985. Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230:1350.
40. Malek, T. R., R. G. Ortega, J. P. Jakway, C. Chan, and E. M. Shevach. 1984. The murine IL-2 receptor. II. Monoclonal anti-IL-2 receptor antibodies as specific inhibitors of T cell function in vitro. J. Immunol. 133:1970.
41. Linsley, P. S., W. Brady, L. Grossmaire, A. Aruffo, N. K. Damle, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T-cell proliferation and interleukin-2 mRNA accumulation. J. Exp. Med. 173:721.
42. Seder, R. A., R. N. Germain, P. S. Linsley, and W. E. Paul. 1994. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role cell priming for IL-4 and interferon γ production. J. Exp. Med. 179:299.
43. Bradley, M. L., D. D. Duncan, K. Yoshimoto, and S. L. Swain. 1993. Memory effectors: a potent. IL-4-secreling helper T cell population that develops in vivo alter restimulation with antigen. J. Immunol. 150:3119.
44. + T cells into IL-4-secreting cells. J. Immunol. 152:5180.
45. Paul, W. E., and R. A. Seder. 1994. Lymphocyte responses and cytokines. Cell 76:241.
46. Bradley, L. M., K. Yoshimoto, and S. Swain. 1995. The cytokines IL-4, IFN-γ, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J. Immunol. 155:1713.
47. Mohler, K. M., and L. D. Butler. 1990. Differential production of IL-2 and IL-4 mRNA in vitro after primary sensitization. J. Immunol. 145:1734.
48. + T cells after antigen stimulation: resolution of two populations of memory T cells that both secrete interleukin 4. J. Exp. Med. 169:2245.
49. + effector function against intracellular infection. J. Exp. Med. 183:131.
50. Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349.
51. Ashman, R. B., and I. M. Papadimitriou. 1995. Production and function of cytokines in natural and acquired immunity to Candida albicans infection. Microbiol. Rev. 59:646.
52. Baschieri, S., R. K. Less, A. R. Lussow, and H. R. MacDonald. 1993. Clonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines. Eur. J. Immunol. 23:2661.
53. MacDonald, H. R., R. K. Less, S. Baschieri, T. Herrmann, and A. R. Lussow. 1993. Peripheral T-cell reactivity to bacterial superantigens in vivo: the response/ anergy paradox. Immunol. Rev. 133:105.
54. Lussow, A. R., and R. H. MacDonald. 1994. Differential effects of superantigen-induced "anergy" on priming and effector stages of a T cell-dependent antibody response. Eur. J. Immunol. 24:445.
55. Röcken, M., J. F. Urban, and E. Shevach. 1992. Infection breaks T-cell tolerance. Nature 359:79.
56. Durandy, A., D. Fischer, D. Charron, and C. Griscelli. 1986. Specific binding of antigen onto human T lymphocytes. J. Clin. Invest. 77:1557.
57. + effector fate: transforming growth factor β1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. J. Exp. Med. 182:699.
58. Fraser, J. D., B. A. Irving, G. R. Crabtree, and A. Weiss. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313.
59. Umlauf, S. W., B. Beverley, O. Lantz, and R. H. Schwartz. 1995. Regulation of interleukin-2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics. Mol. Cell. Biol. 15:3197.
60. + T cells. J. Exp. Med. 184:19.
61. Tonnetti, L., R. Spaccapelo, E. Cenci, A. Mencacci, P. Puccetti, R. L. Coffman, F. Bistoni, and L. Romani. 1995. Interleukin-4 and -10 exacerbate candidiasis in mice. Eur. J. Immunol. 25:1559.
62. Holter, W., F. S. Kalthoff, W. F. Pickl, C. Ebner, O. Majidic, D. Kraft, and W. Knapp. 1994. Transforming growth factor-β inhibits IL-4 and IFN-γ production by stimulated human T cells. Int. Immunol. 6:469.
63. Brabletz, T., I. Pfeuffer, E. Schorr, F. Siebelt, T. Wirth, and E. Serfling. 1993. Transforming growth factor β and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site. Mol. Cell. Biol. 193:1155.
64. Schorle, H., T. Koltschke, T. Hunig, A. Schimpl, and I. Horak. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352:621.
65. Whal, S. M., N. McCartney-Francis, D. A. Hunt, P. D. Smith, L. M. Whal, and I. M. Katona. 1988. Monocyte interleukin 2 receptor gene expression and interleukin 2 augmentation of microbicidal activity. J. Immunol. 139:1342.
66. Djeu, J. Y., J. H. Liu, S. Wei, H. Rui, C. A. Pearson, W. L. Leonard, and D. K. Blanchard. 1993. Function associated with IL-2 receptor-β on human neutrophils: mechanism of activation of antifungal activity against Candida albicans by IL-2. J. Immunol. 150:960.
67. Pericle, F., J. H. Liu, J. I. Diaz, D. K. Blanchard, S. Wei, G. Forni, and J. Y. Djeu. 1994. Interleukin-2 prevention of apoptosis in human neutrophils. Eur. J. Immunol. 24:440.