Compromised blood-nerve barrier, astrogliosis, and myelin disruption in optic nerves during fatal murine cerebral malaria

GLIA

Volumn 19, Issue 2, 1997, Pages 135-151

  Ma, Naili ^a   Madigan, Michele C ^a   Chan Ling, Tailoi ^a   Hunt, Nicholas H ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

axonal degeneration; blood brain barrier; immunopathology; microvasculature; oligodendrocyte; parasitology

Indexed keywords

EID: 0031081451     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1098-1136(199702)19:2<135::aid-glia5>3.0.co;2-%23     Document Type: Article

References (54)

1. Aikawa, M., M. Iseki, J.W. Barnwell, D. Taylor, M.M. Oo, and R.J. Howard (1990) The pathology of human cerebral malaria. Am. J. Trop. Med. Hyg., 43:30-37.
2. Blisard, K.S., F. Follis, R. Wong, K.B. Miller, J.A. Wernly, and O.U. Scremin (1995) Degeneration of axons in the corticospinal tract secondary to spinal cord ischemia in rats. Paraplexia 33:136-140.
3. Brewster, D.R., D. Kwiatkowski, and N.J. White (1990) Neurological sequelae of cerebral malaria in children. Lancet, 336:1039-1043.
4. Brosnan, C.F., K. Selmaj, and C.S. Raine (1988) Hypothesis: A role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis. J. Neuroimmunology, 18:87-94.
5. Butcher, G.A., T. Garland, A. Ajdukiewicz, and I.A. Clark (1990) Serum tumor necrosis factor associated with malaria in patients in the Solomon Islands. Trans. R. Soc. Trop. Med. Hyg., 84:658-661.
6. Butt, A.M. and H.G. Jenkins (1994) Morphological changes in oligodendrocytes in the intact mouse optic nerve following intravitreal injection of tumour necrosis factor. J. Neuroimmunol., 51:27-33.
7. Chan-Ling, T. (1996) A method for studying glial, vascular, and neuronal cytogenesis in whole-mounted cat retina. Res. Micro. Tech., in press.
8. Chan-Ling, T., B. Gock, and J. Stone (1995) The effect of oxygen on vasoformative cell division. Invest. Ophthal. Vis. Sci., 36:1201-1214.
9. Chan-Ling, T., A.L. Neill, and N.H. Hunt (1992a) Early microvascular changes in murine cerebral malaria detected in retinal whole-mounts. Am. J. Pathol., 140:1121-1129.
10. Chan-Ling, T., S. Tout, H. Holländer, and J. Stone (1992b) Vascular changes and their mechanisms in the feline model of retinopathy of prematurity. Invest. Ophthol. Vis. Sci., 33:2128-2147.
11. Claudio, L., J.A. Martiney, and C.F. Brosnan (1994) Ultrastructural studies of the blood-retinal barrier after exposure to interleukin-1β or tumor necrosis factor-α. Lab. Invest., 70:850-861.
12. Davis, M.W., A.L. Vaterlaws, J. Simes, and P. Torzillo (1982) Retinopathy in malaria. Papua New Guinea Med. J., 25:19-22.
13. Fujimura, H., C. Lacroix, and G. Said (1991) Vulnerability of nerve fibres to ischaemia. Brain, 114:1929-1942.
14. Ghigo, D., R. Todde, H. Ginsburg, C. Costamagna, P. Gautret, F. Bussolino, D. Ulliers, G. Giribaldi, E. Deharo, and G. Gabrielli (1995) Erythrocyte stages of Plasmodium falciparum exhibit a high nitric oxide synthase (NOS) activity and release an NOS inducing soluble factor. J. Exp. Med., 182:677-688.
15. Gibbels, E. (1989) Morphometry of unmyelinated nerve fibers. Clin. Neuropathol., 8:179-187.
16. Grau, G.E., L.F. Fajardo, P.F. Piguet, B. Allet, P.H. Lambert, and P. Vassalli (1987) Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science, 237:1210-1212.
17. Grau, G.E., P.F. Piguet, H.D. Engers, J.A. Louis, P. Vassalli, and P.H. Lambert (1986) L3T4 T lymphocytes play a major role in the pathogenesis of murine cerebral malaria. J. Immunol., 137:2348-2354.
18. Grau, G.E., T.E. Taylor, M. Trop, M.E. Molyneux, J.J. Wirima, P. Vassalli, M. Hommel, and P.-H. Lambert (1989a) Tumor necrosis factor and disease severity in children with falciparum malaria. N. Engl. J. Med., 320:1586-1591.
19. Grau, G.E., P.F. Piguet, P. Vassalli, and P.H. Lambert (1989b) Tumornecrosis factor and other cytokines in cerebral malaria: Experimental and clinical data. Immunol. Rev., 112:49-70.
20. Hartung, H.-P., J.J. Archelos, J. Zielasek, R. Gold, M. Koltzenburg, K.H. Reiners, and K.V. Toyka (1995) Circulating adhesion molecules and inflammatory mediators in demyelination: A review. Neurology, 45:S22-S32.
21. Hidayat, A.A., R.M. Nalbandian, D.W. Sammons, J.A. Fleischman, and T.E. Johnson (1993) The diagnostic histopathologic features of ocular malaria. Ophthalmology, 100:1183-1186.
22. Janota, I. and B. Doshi (1979) Cerebral malaria in the United Kingdom. J. Clin. Pathol., 32:769-772.
23. Jenkins, H.G. and H. Ikeda (1992) Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve. J. Neurol. Sci., 108:99-104.
24. Kwiatkowski, D., A.V.S. Hill, I. Sambou, P. Twumasi, J. Castracane, K.R. Manogue, A. Cerami, D.R. Brewster, and R.M. Greenwood (1990) TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet, 336:1201-1204.
25. Lavie, V., M. Murray, and A. Solomon (1990) Growth of injured rabbit optic axons within their degenerating optic nerve. J. Comp. Neurol., 298:293-314.
26. Leibowitz, S., R.S. Morgan, E.M.I. Berkinshaw-Smith, A. Payling, and G. Wright (1961) Cerebral vascular damage in guinea pigs induced by various heterophil antisera injected by the Forsmann intracarotid technique. Br. J. Exp. Pathol., 42:455-463.
27. Lewallen, S., T.E. Talor, M.E. Molymeux, and B.A. Wills (1993a) Courtright P. Ocular fundus findings in Malawian children with cerebral malaria. Ophthalmology, 100:857-861.
28. Lewallen, S., and B.A. Wills (1993b) Retina haemorrhage in children with malaria. Lancet, 341:442.
29. Looareesuwan, S., D.A. Warrell, N.J. White, P. Chanthavanich, M.J. Warrell, S. Chantaratherakitti, S. Changswek, L. Chongmankongcheep, and C. Kanchanaranya (1983) Retinal haemorrhage, a common sign of prognostic significance in cerebral malaria. Am. J. Trop. Med. Hyg., 32:911-915.
30. Ma, N., N.H. Hunt, M.C. Madigan, and T. Chan-Ling (1996) Correlation between enhanced vascular permeability, upregulation of cell adhesion molecules and monocyte adhesion in retina during fatal murine cerebral malaria. Am. J. Pathol. 149:1745-1762.
31. Mackey, L.J., A. Hochmann, C.H. June, C.E. Contreras and P.H. Lambert (1980) Immunopathological aspects of Plasmodium berghei infection in five strains of mice. Clin. Exp. Immunol., 42:412-420.
32. Medana, I.M., T. Chan-Ling, and N.H. Hunt (1996) Redistribution and degeneration of retinal astrocytes in experimental murine cerebral malaria: relationship to disruption of the blood-retinal barrier. Glia, 16:51-64.
33. Medana, I.M., N.H. Hunt, and T. Chan-Ling (1997). Early activation of microglia in the pathogenesis of fatal murine cerebral malaria. Glia, 19:91-103.
34. Mucke, L., and M, Eddleston (1993) Astrocytes in infectious and immune-mediated diseases of the central nervous system. FASEB. J., 7:1226-1232.
35. Myers, R.R., H.M. Keckman, J.A. Galbraith, and H.C. Powell (1991) Subperineurial demyelination associated with reduced nerve blood flow and oxygen tension after epineurial vascular stripping. Lab. Invest., 65:41-50.
36. Nagatake, T., H.V. Thuc, T. Tegoshi, J. Rabbege, T.K. Ann, and M. Aikawa (1992) Pathology of falciparum malaria in Vietnam. Am. J. Trop. Med. Hyg., 47:259-264.
37. Neill, A.L., and N.H. Hunt (1992) Pathology of fatal and resolving Plasmodium berghei cerebral malaria in mice. Parasitology, 195:165-175.
38. Neill, A.L., T. Chan-Ling, and N.H. Hunt (1993) Comparisons between microvascular changes in cerebral and non-cerebral malaria in mice, using the retinal whole-mount technique. Parasitology, 107: 477-487.
39. Norenberg, M.D. (1994) Astrocyte responses to CNS injury. J. Neuropathol. Exp. Neurol., 53:213-220.
40. Nukada, H., H.C. Powell, and R.R. Myers (1993) Spatial Distribution of nerve injury after occlusion of individual major vessels in rat sciatic nerves. J. Neuropathol. Exp. Neurol., 52:452-459.
41. Oo, M.M., M. Aikawa, T. Than, T.M. Aye, P.T. Myint, I. Igarashi, and W.C. Schoene (1987) Human cerebral malaria: a pathological study. J. Neuropathol. Exp. Neurol., 46:223-231.
42. Pongponratn, E., M. Riganti, B. Punpoowong, and M. Aikawa (1991) Microvascular sequestration of parasitized erythrocytes in human falciparum malaria: a pathological study. Am. J. Trop. Med. Hyg., 44:168-175.
43. Rest, J.R., Cerebral malaria in inbred mice. I. A new model and its pathology. Trans. R. Soc. Trop. Med. Hyg., 76:410-415.
44. Rigdon, R.H. and D.E. Fletcher (1945) Lesions in the brain associated with malaria: Pathologic study on man and on experimental animals. Arch. Neurol. Psychol., 53:191-198.
45. Schmid, A.H. (1974) Cerebral malaria: On the nature and significance of vascular changes. Eur. Neurol., 12:197-208.
46. Selmaj, K.W. and C.S. Raine (1988) Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol., 23:339-346.
47. Selmaj, K., C.S. Raine, and A.H. Cross (1991) Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann. Neurol., 30:694-700.
48. Shaffer, N., G.E. Grau, K. Hedberg, F. Davachi, B. Lyamba, A.W. Hightower, J.G. Breman, and P. Nguyen-Dinh (1991) Tumor necrosis factor and severe malaria. J. Infect. Dis., 163:96-101.
49. Spies, J.M., K.W. Westland, J.G. Bonner, and J.D. Pollard (1995) Intraneural activated T cells cause focal breakdown of the blood-nerve barrier. Brain, 118:857-868.
50. Stoll, G., S. Jung, S. Jander, P. Meide, and H.-P. Hartung (1993) Tumor necrosis factor-α in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system. J. Neuroimmunol, 45:175-182.
51. Tachado, S.D., P. Gerold, M.J. McConville, T. Baldwin, D. Qulici, R.T. Schwarz, and L. Schofield (1996) Glycosylphosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signalling pathway. J. Immunol., 156:1897-1907.
52. Thumwood, C.M., N.H. Hunt, I.A. Clark, and W.B. Cowden (1988) Breakdown of the blood-brain barrier in murine cerebral malaria. Parasitology, 96:570-589.
53. Toro, G., and G. Romän (1978) Cerebral malaria. Arch. Neurol., 35:271-275.
54. Waxman, S.G., J.A. Black, P.K. Stys, and B.R. Ransom (1992) Ultrastructural concomitants of axonic injury and early post-axonic recovery in rat optic nerve. Brain Res., 574:105-119.