Mechanistic studies on uroporphyrin I-induced photoinactivation of some heme-enzymes

International Journal of Biochemistry and Cell Biology

Volumn 28, Issue 4, 1996, Pages 415-420

  Afonso, Susana G ^a   Polo, César F ^b   De Salamanca, Rafael Enriquez ^a   Batlle, Alcira ^a  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b NONE

Author keywords

Heme enzymes; Photoinactivating mechansm; Photoinactivation; Porphyrin induced photoinactivation; Uroporphyrin

Indexed keywords

CATALASE; CYSTEINE; DEAMINASE; GLUTATHIONE; HISTIDINE; PORPHOBILINOGEN DEAMINASE; PORPHOBILINOGEN SYNTHASE; SODIUM AZIDE; SUPEROXIDE DISMUTASE; UROPORPHYRIN; UROPORPHYRINOGEN DECARBOXYLASE;

ARTICLE; CONTROLLED STUDY; ENZYME INACTIVATION; ERYTHROCYTE; HUMAN; HUMAN CELL; NORMAL HUMAN; PHOTOCHEMISTRY; ULTRAVIOLET IRRADIATION;

EID: 0029985433     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/1357-2725(95)00159-X     Document Type: Review

References (21)

1. Afonso S. G., Chinarro S., Stella A. M., Batlle A. M. del C., Lenczner J. M. and Magnin P. H. (1985) Uroporfirinógeno decarboxilasa eritrocitaria y hepática en pacientes con porfiria cutánea tardia. Rev. Arg. Dermatol. 66, 12-24.
2. Afonso S. G., Chinarro S., Muñoz J. J., Enríquez de Salamanca R. and Batlle A. M. del C. (1987) Light-dependent and light-independent inactivation of red cell porphobilinogenase and deaminase by type I and III porphyrins. Boll. Ist. Der. S. Gallicani XIII, 35-40.
3. Afonso S. G., Chinarro S., Muñoz J. J. and Enríquez de Salamanca R. and Batlle A. M. del C. (1990) Photodynamic and nonphotodynamic action of several porphyrins on the activity of some heme-enzymes. J. Enzyme Inhibit. 3, 303-310.
4. Afonso S. G., Chinarro S., Enríquez de Salamanca R. and Batlle A. M. del C. (1991) Further evidence on the photodynamic and the novel non-photodynamic inactivation of uroporphyrinogen decarboxylase by uroporphyrin I. J. Enzyme Inhibit. 5, 225-233.
5. Afonso S. G., Chinarro S., Enríquez de Salamanca R. and Batlle A. M. del C. (1994) How the atmosophere and the presence of substrate affect the photo and non-photoinactivation of heme enzymes by uroporphyrin I. Int. J. Biochem. 26, 259-262.
6. Bachowski G. J., Morehouse K. M. and Girotti A. W. (1988) Porphyrin-sensitized photoreactions in the presence of ascorbate. Oxidation of cell membrane lipids and hydroxyl radical traps. Photochem. Photobiol. 47, 635-645.
7. Batlle A. M. del C., Ferramola A. M. and Grinstein M. (1967) Purification and general properties of δ-amino-laevulate dehydratase from cow liver. Biochem. J. 104, 244-249.
8. Batlle A. M. del C., Wider E. A. and Stella A. M. (1978) A simple method for measuring erythrocyte porphobilino-genase and its use in the diagnosis of acute intermittent porphyria. Int. J. Biochem. 9, 871-877.
9. Batlle A. M. del C., Enríquez de Salamanca R., Chinarro S., Afonso S. G. and Stella A. M. (1986) Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins. Int. J. Biochem. 18, 143-147.
10. + in deuteriumoxide. J. Biol. Chem. 252, 8554-8560.
11. Butler J. and Halliwell B. (1982) Reaction of iron-EDTA chelates with the superoxide radical Arch. Biochem. Biophys. 218, 174-178.
12. Dalton J., McAuliff C. and Slater D. (1972) Reaction between molecular oxygen and photoexcited protoporphyrin IX. Nature 235, 388-392.
13. Fridovich I. (1974) Superoxide dismulases. In Advances in Enzymology (Edited by Alton Meister), Vol. 41, pp. 35-70. Interscience, New York.
14. Halliwell B. and Gutteridge M. C. (1984) Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219, 1-14.
15. Halliwell B. and Gutteridge M. C. (1986) Free Radicals in Biology and Medicine. Clarendon Press, Oxford. U.K.
16. Llambías E. B. C. and Batlle A. M. del C. (1971) Porphyrin biosynthesis VlII. Avian erithrocyte PBG deaminase-urogen III cosynthetase, its purification, properties and separation of its components. Biochim. Biophys. Acta 227, 180-191.
17. Mauzerall D. and Fehrer G. (1964) A study of the photoinduced porphyrin free radical by electron spin resonance. Biochim. Biophys. Acta 79, 430-432.
18. Poh-Fitzpatrick M. B. (1985) Porphyrin-sensitized cutaneous photosensitivity. Pathogenesis and treatment. In Clinics in Dermatology (Edited by P. B. Disler and M. R. Moore), Vol. 3, pp. 41-82. J. B. Lippincott Company, Philadelphia.
19. Sandberg S., Romslo I., Hogding G. and Bjorndal T. (1982) Porphyrin-induced photodamage as related to the subcellular localization of the porphyrins. Acta Dermatovener. (Stock.) Suppl. 100, 75-80.
20. Spikes J. D. (1975) Porphyrins and related compounds as photodynamic sensitizers. Ann. N.Y. Acad. Sci. 244, 496-507.
21. van Steveninck J., Boegheim J. P. J. and Dubbelman T. M. A. R. (1988) The influence of porphyrins on iron-catalysed generation of hydroxyl radicals. Biochem. J. 250, 197-201.