Molecular mechanisms of glucocorticoid action in asthma

Pulmonary Pharmacology and Therapeutics

Volumn 10, Issue 1, 1997, Pages 3-19

  Barnes, P J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CELL ADHESION MOLECULE; CYTOKINE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; LIPOCORTIN 1; NEUROKININ 1 RECEPTOR; NITRIC OXIDE SYNTHASE; TRANSCRIPTION FACTOR;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; CELL FUNCTION; CELL SURVIVAL; CLINICAL FEATURE; DENDRITIC CELL; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME SYNTHESIS; EOSINOPHIL; EPITHELIUM CELL; GENE; GENETIC TRANSCRIPTION; HORMONE RESISTANCE; HORMONE RESPONSIVE ELEMENT; HUMAN; INFLAMMATORY CELL; MACROPHAGE; MAST CELL; MENSTRUAL CYCLE; MUCUS SECRETION; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; REVIEW; T LYMPHOCYTE; VIRUS INFECTION;

EID: 0031075056     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.1997.0074     Document Type: Review

References (159)

1. 1. Barnes P J. Inhaled glucocorticoids for asthma. New Engl J Med 1995; 332: 868-875.
2. 2. Barnes P J. Molecular mechanisms of steroid action in asthma. J Allergy Clin Immunol 1996; 97: 159-168.
3. 3. Barnes P J. Mechanism of action of glucocorticoids in asthma. Am J Respir Crit Care Med 1996; 154: S21-S27.
4. 4. Bamberger C M, Bamberger A M, de Castro M, Chroussos G P. Glucocorticoid receptor β, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 1995; 95: 2435-2441.
5. 5. Muller M, Renkawitz R. The glucocorticoid receptor. Biochim Biophys Acta 1991; 1088: 171-182.
6. 6. Encio P J, Detgra-Wadleigh S D. The genomic structure of the human glucocorticoid receptor. J Biol Chem 1991; 266: 7182-7188.
7. 7. Heck S, Kullmann M, Grast A, et al. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J 1995; 134087: 4087-4095.
8. 8. Orti E, Bodwell J E, Munck A. Phosphorylation of steroid hormone receptors. Endocr Rev 1992; 13: 105-128.
9. 9. Gronemeyer H. Control of transcription activation by steroid hormone receptors. FASEB J 1992; 6: 2524-2529.
10. 10. Truss M, Beato M. Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr Rev 1993; 14: 459-479.
11. 11. Beato M, Herrlich P, Schutz G. Steroid hormone receptors: many actors in search of a plot. Cell 1995; 83: 851-857.
12. 12. Miner J N, Yamamoto K R. Regulatory crosstalk at composite response elements. Trends Biochem Sci 1991; 16: 423-426.
13. 13. Peppel K, Vinci J M, Baglioni C. The AU-rich sequences in the 3′ untranslated region mediate the increased turnover of interferon mRNA induced by glucocorticoids. J Exp Med 1991; 173: 349-355.
14. 14. Ponta H, Cato ACB, Herrlick P. Interference of specific transcription factors. Biochim Biophys Acta 1992; 1129: 255-261.
15. 15. Pfahl M. Nuclear receptor/AP-1 interaction. Endocrine Revs 1993; 14: 651-658.
16. 16. Barnes P J, Adcock I M. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol Sci 1993; 14: 436-441.
17. 17. Yang-Yen H, Chambard J, Sun Y, et al. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 1990; 62: 1205-1215.
18. 18. Schüle R, Rangarajan P, Kliewer S, et al. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 1990; 62: 1217-1226.
19. 19. Jonat C, Rahsdorf H J, Park K K, et al. Anti tumor promotion and antiinflammation: down-modulation of AP-1 (fos/jun) activity by glucocorticoid hormone. Cell 1990; 62: 1189-1204.
20. 20. Adcock I M, Shirasaki H, Gelder C M, Peters M J, Brown C R, Barnes P J. The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung. Life Sci 1994; 55: 1147-1153.
21. 21. Adcock I M, Brown C R, Gelder C M, Shirasaki H, Peters M J, Barnes P J. The effects of glucocorticoids on transcription factor activation in human peripheral blood monoclucear cells. Am J Physiol 1995; 37: C331-C338.
22. 22. Ray A, Prefontaine K E. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc Natl Acad Sci USA 1994; 91: 752-756.
23. 23. Scheinman R I, Gualberto A, Jewell C M, Cidlowski J A, Baldwin A S. Characterization of the mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol Cell Biol 1996; 15: 943-953.
24. 24. Caldenhoven, Liden J, Wissink S, et al. Negative cross-talk between ReIA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol Endocrinol 1995; 9: 401-412.
25. 25. Imai F, Minger J N, Mithcell J A, Yamamoto K R, Granner D K. Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J Biol Chem 1993; 268: 5353-5356.
26. 26. Peters M J, Adcock I M, Brown C R, Barnes P J. β-Agonist inhibition of steroid-receptor DNA binding activity in human lung. Am Rev Respir Dis 1993; 147: A772.
27. 27. Stevens D A, Barnes P J, Adcock I M. β-Agonists inhibit DNA binding of glucocorticoid receptors in human pulmonary and bronchial epithelial cells. Am J Resp Crit Care Med 1995; 151: A195.
28. 28. Adcock I M, Barnes P J. Tumor necrosis factor-α causes retention of activated glucocorticoid receptor within the cytoplasm of A549 cells. Biochem Biophys Res Commun 1996; 225: 1127-1132.
29. 29. Janknecht R, Hunter T. A growing coactivator network. Nature 1996; 383: 22-23.
30. 30. Flower R J, Rothwell N J. Lipocortin-1: cellular mechanisms and clinical relevance. Trends Pharmacol Sci 1994; 15: 71-76.
31. 31. Brönnegard M, Andersson O, Edwall D, Lund J, Norstedt G, Carlstedt-Duke J. Human calpactin II (lipocortin I) messenger ribonucleic acid is not induced by glucocorticoids. Mol Endocrinol 1988; 2: 732-739.
32. 2. J Biol Chem 1994; 269: 13057-13060.
33. 33. Abbinante-Nissen J M, Simpson L G, Leikauf G D. Corticosteroids increase secretory leukocyte protease inhibitor transcript levels in airway epithelial cells. Am J Physiol 1995; 12: L601-L606.
34. 34. Ho A S, Moore K W. Interleukin-10 and its receptor. Ther Immunol 1994; 1: 173-185.
35. 35. Wang P, Wu P, Siegel MI, Egan R W, Billah M M. Interleukin(IL)-10 inhibits nuclear factor kappa B activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem 1995; 270: 9558-9563.
36. 36. Borish L, Aarons A, Rumbyrt J, Cvietusa P, Negri J, Wenzel S. Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol 1996; 97: 1288-1296.
37. 37. John M, Lim S, Seybold J, et al. Inhaled corticosteroids increase IL-10 but reduce MIP-1α, GM-CSF and IFN-g release from alveolar macrophages in asthma. Am J Respir Crit Care Med 1997.
38. 38. Auphan N, DiDonato J A, Rosette C, Helmberg A, Karin M. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 1995; 270: 286-290.
39. 39. Scheinman R I, Cogswell P C, Lofquist A K, Baldwin A S. Role of transcriptional activation of IκBα in mediating immunosuppression by glucocorticoids. Science 1995; 283-286.
40. 40. Brostjan C, Anrather J, Csizmadia V, et al. Glucocorticoid-mediated repression of NFκB activity in endothelial cells does not involve induction of IκBα synthesis. J Biol Chem 1996; 271: 19612-19616.
41. 41. Newton R, Hart L A, Adcock I M, Barnes P J. Effect of glucocorticoids on IL-1β-induced NF-κB binding and expression in type II alveolar cells - no evidence for downregulation by IκB. Am J Respir Crit Care Med 1997.
42. 42. Collins S, Caron M G, Lefkowitz R J. β-Adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. J Biol Chem 1988; 263: 9067-9070.
43. 2-adrenergic receptor transcription in human lung. Am J Physiol 1995; 12: L41-L46.
44. 2-adrenergic receptors in vivo. J Clin Invest 1995; 96: 99-106.
45. 45. Northrop J P, Ullman K S, Crabtree G R. Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT). J Biol Chem 1993; 268: 2917-2923.
46. 46. Paliogianni F, Raptis A, Ahuja S S, Najjar S M, Boumpas D T. Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT. J Clin Invest 1993; 91: 1481-1489.
47. 47. Mukaido N, Morita M, Ishikawa Y, et al. Novel mechanisms of glucocorticoid-mediated gene repression: NFκB is target for glucocorticoid-mediated IL-8 gene expression. J Biol Chem 1994; 269: 13289-13295.
48. 48. Nelson P J, Kim H T, Manning W C, Goralski T J, Krensky A M. Genomic organization and transcriptional regulation of the RANTES chemokine gene. J Immunol 1993; 151: 2601-2612.
49. 49. Linden M, Brattsand R. Effects of a corticosteroid, budesonide, on alveolar macrophages and blood monocyte secretion of cytokines: differential sensitivity of GM-CSF, IL-1β and IL-6. Pulm Pharmacol 1994; 7: 43-47.
50. 50. Barnes P J, Liew F Y. Nitric oxide and asthmatic inflammation. Immunol Today 1995; 16: 128-130.
51. 51. Barnes P J. Nitric oxide and airway disease. Ann Med 1995; 27: 389-393.
52. 52. Ferreira H H A, Medeiros M V, Lima C S P, et al. Inhibition of eosinophil chemotaxis by chronic blockade of nitric oxide biosynthesis. Eur J Pharmacol 1996; 310: 201-207.
53. 53. Robbins R A, Barnes P J, Springall D R, et al. Expression of inducible nitric oxide synthase in human bronchial epithelial cells. Biochem Biophys Res Commun 1994; 203: 209-218.
54. 54. Asano K, Chee C B E, Gaston B, et al. Constitutive and inducible nitric oxide synthase gene expression, regulation and activity in human lung epithelial cells. Proc Natl Acad Sci USA 1994; 91: 10089-10093.
55. 55. Xie Q, Kashiwarbara Y, Nathan C. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J Biol Chem 1994; 269: 4705-4708.
56. 56. Adcock I M, Brown C R, Kwon O J, Barnes P J. Oxidative stress induces NF-κB DNA binding and inducible NOS mRNA in human epithelial cells. Biochem Biophys Res Commun 1994; 199: 1518-1524.
57. 57. Mitchell J A, Belvisi M G, Akarasereemom P, et al. Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br J Pharmacol 1994; 113: 1008-1014.
58. 58. Yamamoto K, Arakawa T, Ueda N, Yamamoto S. Transcriptional roles of nuclear factor kB and nuclear factor-interleukin 6 in the tumor necrosis-α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem 1995; 270: 31315-31320.
59. 59. Newton R, Adcock I M, Barnes P J. Stimulation of COX-2 message by cytokines or phorbol ester is preceded by a massive and rapid induction of NF-κB binding activity. Am J Resp Crit Care Med 1995; 151: A165.
60. 60. Dworski R, Fitzgerald G A, Gates J A, Sheller J R. Effect of oral prednisone on airway inflammatory mediators in atopic asthma. Am J Respir Crit Care Med 1994; 149: 953-959.
61. 4 excretion. Am Rev Respir Dis 1993; 147: 1472-1476.
62. 62. Vittori E, Marini M, Fasoli A, de Franchis R, Mattoli S. Increased expression of endothelin in bronchial epithelial cells of asthmatic patients and effect of corticosteroids. Am Rev Respir Dis 1992; 1461: 1320-1325.
63. 63. Adcock I M, Peters M, Gelder C, Shirasaki H, Brown C R, Barnes P J. Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids. J Mol Endocrinol 1993; 11: 1-7.
64. 64. Ihara H, Nakanishi S. Selective inhibition of expression of the substance P receptor mRNA in pancreatic acinar AR42J cells by glucocorticoids. J Biol Chem 1990; 36: 22441-22445.
65. 65. Colotta F, Re F, Muzio M, et al. Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 1993; 261: 472-475.
66. 66. Owens G P, Hahn W E, Cohen J J. Identification of mRNAs associated with programmed cell death in immature thymocytes. Mol Cel Biol 1991; 11: 4177-4188.
67. 67. Cronstein B N, Kimmel S C, Levin R I, Martiniuk F, Weissmann G. A mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 1992; 89: 9991-9995.
68. 68. Van De Stolpe A, Caldenhoven E, Raaijmakers J A M, Van Der Saag P T, Koendorman L. Glucocorticoid-mediated repression of intercellular adhesion molecule-1 expression in human monocytic and bronchial epithelial cell lines. Am J Respir Cell Mol Biol 1993; 8: 340-347.
69. 4 by human alveolar and peritoneal macrophages in culture. Clin Sci 1984; 67: 693-696.
70. 70. Bergstrand H, Björnson A, Blaschuke E, et al. Effects of an inhaled corticosteroid, budesonide, on alveolar macrophage function in smokers. Thorax 1990; 45: 362-368.
71. 71. Martinet N, Vaillant P, Charles T, Lambert J, Martinet Y. Dexamethasone modulation of tumour necrosis factor-α (cachectin) release by activated normal human alveolar macrophages. Eur Resp J 1992; 5: 67-72.
72. 2 and dexamethasone. Am J Respir Cell Mol Biol 1992; 6: 75-81.
73. 73. Borish L, Mascali J J, Dishuck J, Beam W R, Martin R J, Rosenwasser L J. Detection of alveolar macrophage-derived IL-1β in asthma. Inhibition with corticosteroids. J Immunol 1992; 149: 3078-3082.
74. 74. Kita H, Abu-Ghazaleh R, Sanderson C J, Gleich G J. Effect of steroids on immunoglobulin-induced eosinophil degranulation. J Allergy Clin Immunol 1991; 87: 70-77.
75. 75. Evans P M, Barnes P J, Chung K F. Effect of corticosteroids on human eosinophils in vitro. Eur J Pharmacol 1990; 3: 160S.
76. 76. Lamas A M, Leon O G, Schleimer R P. Glucocorticoids inhibit eosinophil responses to granulocyte-macrophage colony-stimulating factor. J Immunol 1991; 147: 254-259.
77. 77. Wallen N, Kita H, Weiller D, Gleich G J. Glucocorticoids inhibit cytokine-mediated eosinophil survival. J Immunol 1991; 147: 3490-3495.
78. 78. Baigelman W, Chodosh S, Pizzuto D, Cupples L A. Sputum and blood eosinophils during corticosteroid treatment of acute exacerbations of asthma. Am J Med 1983; 75: 929-936.
79. 79. Owen W F, Rothenberg M E, Silberstein D S, et al. Regulation of human eosinophil viability, density and function by granulocyte/macrophage colony stimulating factor in the presence of 3T3 fibroblasts. J Exp Med 1987; 166: 129-141.
80. 80. Wempe J B, Tammeling E P, Köeter G H, Haransson L, Venge P, Postma D S. Blood eosinophil numbers and activity during 24 hours; effects of treatment with budesonide and bambuterol. J Allergy Clin Immunol 1992; 90: 757-765.
81. 81. Evans P M, O'Connor B J, Fuller R W, Barnes P J, Chung K F. Effect of inhaled corticosteroids on peripheral eosinophil counts and density profiles in asthma. J Allergy Clin Immunol 1993; 91: 643-649.
82. 82. Elwood W, Lotvall J O, Barnes P J, Chung K F. Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively-sensitized Brown Norway rats. J Allergy Clin Immunol 1992; 88: 951-960.
83. 83. Elwood W, Lötvall J O, Barnes P J, Chung K F. Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsiveness and inflammatory cell responses in sensitized Brown Norway rats. Am Rev Respir Dis 1992; 145: 1289-1294.
84. 84. Schleimer R P, Schulman E S, MacGlashan D W, et al. Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. J Clin Invest 1983; 71: 1830-1835.
85. 85. Cohan V L, Undem B J, Fox C C, Adkinson N F, Lichtenstein L M, Schleimer R P. Dexamethasone does not inhibit the release of mediators from human lung mast cells residing in airway, intestine or skin. Am Rev Respir Dis 1989; 140: 951-954.
86. 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma. J Allergy Clin Immunol 1992; 90: 32-42.
87. 87. Djukanovic R, Wilson J W, Britten Y M, et al. Effect of an inhaled corticosteroid on airway inflammation and symptoms of asthma. Am Rev Respir Dis 1992; 145: 699-674.
88. 88. Holt P G. Regulation of antigen-presenting cell function(s) in lung and airway tissues. Eur Resp J 1993; 6: 120-129.
89. 89. Nelson D J, McWilliam A S, Raining S, Holt P G. Modulation of airway intraepithelial dendritic cells following exposure to steroids. Am J Respir Crit Care Med 1995; 151: 475-481.
90. 90. Holm A F, Fokkens W J, Godthelp T, Mulder P G, Vroom T M, Rinjntjes E. Effect of 3 months' nasal steroid therapy on nasal T cells and Langerhans cells in patients suffering from allergic rhinitis. Allergy 1995; 50: 204-209.
91. 91. Cox G. Glucocorticoid treatment inhibits apoptosis in human neutrophils. J Immunol 1995; 193: 4719-4725.
92. 92. Schleimer R P. Effects of glucocorticoids on inflammatory cells relevant to their therapeutic application in asthma. Am Rev Respir Dis 1990; 141: S59-S69.
93. 93. Boschetto P, Rogers D F, Fabbri L M, Barnes P J. Corticosteroid inhibition of airway microvascular leakage. Am Rev Respir Dis 1991; 143: 605-609.
94. 94. Erjefalt I, Persson CGA. Pharmacologie control of plasma exudation into tracheobronchial airways. Am Rev Respir Dis 1991; 143: 1008-1014.
95. 95. Carnuccio R, Di Rosa M, Guerrasio B, Iuvone T, Satebin L. Vasocortin: a novel glucocorticoid-induced antiinflammatory protein. Br J Pharmacol 1987; 90: 443-445.
96. 96. Van de Graaf E A, Out T A, Loos C M, Jansen H M. Respiratory membrane permeability and bronchial hyperreactivity in patients with stable asthma. Am Rev Respir Dis 1991; 143: 362-368.
97. 97. Devalia J L, Wang J H, Sapsford R J, Davies R J. Expression of RANTES in human bronchial epithelial cells and the effect of beclomethasone dipropionate (BDP). Eur Resp J 1994; 7 (Suppl 18): 98S.
98. 98. Levine S J. Bronchial epithelial cell-cytokine interactions in airway epithelium. J Invest Med 1995; 43: 241-249.
99. 99. Schweibert L M, Stellate C, Schleimer R P. The epithelium as a target for glucocorticoid action in the treatment of asthma. Am J Respir Crit Care Med 1996; 154: S16-S20.
100. 100. Kwon O J, Au B T, Collins P D, et al. Inhibition of interleukin-8 expression in human cultured airway epithelial cells. Immunology 1994; 81: 389-394.
101. 101. Kwon O J, Au B T, Collins P D, et al. Tumor necrosis factor-induced interleukin 8 expression in cultured human epithelial cells. Am J Physiol 1994; 11: L398-L405.
102. 102. Kwon O J, Jose P J, Robbins R A, Schall T J, Williams T J, Barnes P J. Glucocorticoid inhibition of RANTES expression in human lung epithelial cells. Am J Respir Cell Mol Biol 1995; 12: 488-496.
103. 103. Sousa A R, Poston R N, Lane S J, Narhosteen J A, Lee T H. Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids. Am Rev Respir Dis 1993; 147: 1557-1561.
104. 104. Trigg C J, Manolistas N D, Wang J, et al. Placebo-controlled immunopathological study of four months inhaled corticosteroids in asthma. Am J Respir Crit Care Med 1994; 150: 17-22.
105. 105. Hamid Q, Springall D R, Riveros-Moreno V, et al. Induction of nitric oxide synthase in asthma. Lancet 1993; 342: 1510-1513.
106. 106. Kharitonov S A, Yates D, Robbins R A, Logan-Sinclair R, Shinebourne E, Barnes P J. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994; 343: 133-135.
107. 107. Persson M G, Zetterstrom O, Argenius V, Ihre E, Gustafsson L E. Single-breath oxide measurements in asthmatic patients and smokers. Lancet 1994; 343: 146-147.
108. 108. Yates D H, Kharitonov S A, Robbins R A, Thomas P S, Barnes P J. Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am J Resp Crit Care Med 1995; 152: 892-896.
109. 109. Kharitoniv S A, Yates D H, Barnes P J. Regular inhaled budesonide decreases nitric oxide concentration in the exhaled air of asthmatic patients. Am J Resp Crit Care Med 1996; 153: 454-457.
110. 110. Shimura S, Sasaki T, Ikeda K, Yamauchi K, Sasaki H, Takishima T. Direct inhibitory action of glucocorticoid on glycoconjugate secretion from airway submucosal glands. Am Rev Respir Dis 1990; 141: 1044-1099.
111. 111. Lundgren J D, Hirata F, Marom Z, et al. Dexamethasone inhibits respiratory glycoconjugate secretion from feline airways in vitro by the induction of lipocortin (lipomodulin) synthesis. Am Rev Respir Dis 1988; 137: 353-357.
112. 112. Kai H, Yoshitake K, Hisatsune A, et al. Dexamethasone suppresses mucus production and MUC-2 and MUC-5AC gene expression by NCI-H292 cells. Am J Physiol 1996; 271: L484-L488.
113. 113. Cypcar D, Busse W W. Steroid-resistant asthma. J Allergy Clin Immunol 1993; 92: 362-372.
114. 114. Barnes P J, Adcock I M. Steroid-resistant asthma. Q J Med 1995; 88: 455-468.
115. 115. Barnes P J, Greening A P, Crompton G K. Glucocorticoid resistance in asthma. Am J Respir Crit Care Med 1995; 152: 125S-140S.
116. 116. Kirkham B, Corkill M M, Davison S C, Panayi G S. Response to glucocorticoid treatment in rheumatoid arthritis: in vitro cell mediated immune assays predicts in vivo response. J Rheumatol 1991; 18: 1130-1133.
117. 117. Norbato G, Bevilacqua M, Vago T. Cortisol resistance in acquired immune deficiency syndrome. J Clin Endocrinol Metab 1992; 74: 608-613.
118. 118. Schwartz, Lowell F C, Melby J C. Steroid resistance in bronchial asthma. Am J Int Med 1968; 69: 493-499.
119. 119. Carmichael J, Paterson I C, Diaz P, Crompton G K, Kay A B, Grant IWB. Corticosteroid resistance in chronic asthma. Br Med J 1981; 282: 1419-1422.
120. 120. Woolcock A J. Steroid resistant asthma: what is the clinical definition? Eur Respir J 1993; 6: 743-747.
121. 121. Leung D Y M, Martin R J, Szefler S J, et al. Dysregulation of interleukin 4, interleukin 5, and interferon y gene expression in steroid-resistant asthma. J Exp Med 1995; 181: 33-40.
122. 122. Lane S J, Atkinson B A, Swimanathan R, Lee T H. Hypothalamic-pituitary axis in corticosteroid-resistant asthma. Am J Respir Crit Med 1996; 153: 1510-1514.
123. 123. Lamberts S W J, Kioper J W, de Jong F H. Familial and iatrogenic cortisol receptor resistance. J Steroid Biochem Molec Biol 1992; 43: 385-388.
124. 124. Lane S J, Arm J P, Staynov D Z, Lee T H. Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma. Am J Resp Cell Mol Biol 1994; 11: 42-48.
125. 125. Corrigan C, Brown P H, Barnes N C, et al. Glucocorticoid resistance in chronic asthma. Am Rev Respir Dis 1991; 144: 1016-1025.
126. 126. Lane S J, Palmer J B D, Skidmore I F, Lee T H. Corticosteroid pharmacokinetics in asthma. Lancet 1990; 336: 126S.
127. 127. Alvarez J, Surs W, Leung D Y, Ikle D, Gelfand E W, Szefler S J. Steroid-resistant asthma: immunologic and pharmacologic features. J Allergy Clin Immunol 1992; 89: 714-721.
128. 128. Szefler S. Glucocorticoid therapy for asthma: clinical pharmacology. J Allergy Clin Immunol 1991; 88: 147-165.
129. 129. Goulding N J, Podgorski M R, Hall N D, et al. Autoantibodies to recombinant liportin-1 in rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis 1989; 48: 843-850.
130. 130. Wilkinson J R, Podgorski M R, Godolphin J L, Goulding N J, Lee T H. Bronchial asthma is not associated with auto-antibodies to lipocortin-1. Clin Exp Allergy 1990; 20: 189-192.
131. 131. Chung K F, Podgorski M R, Goulding N J, et al. Circulating autoantibodies to recombinant lipocortin-1 in asthma. Resp Med 1991; 95: 121-124.
132. 132. Poznansky M C, Gordon ACH, Douglas J G, Krajewski A S, Wyllie A H, Grant IWB. Resistance to methylprednisolone in cultures of blood mononuclear cells from glucocorticoid-resistant asthmatic patients. Clin Sci 1984; 67: 639-645.
133. 133. Wilkinson J R W, Lane S J, Lee T H. The effects of corticosteroids on cytokine generation and expression of activation antigens by monocytes in bronchial asthma. Int Arch Allergy Clin Immunol 1991; 94: 220-221.
134. 134. Wilkinson J R W, Crea AEG, Clark T J H, Lee T H. Identification and characterization of a monocyte-derived neutrophil-activating factor in corticosteroid-resistant bronchial asthma. J Clin Invest 1989; 84: 1930-1941.
135. 135. Lane S J, Wilkinson J R W, Cochrane G M, Lee T H, Arm J P. Differential in vitro regulation by glucocorticoids of monocyte-derived cytokine generation in glucocorticoid-resistant bronchial asthma. Am Rev Respir Dis 1993; 147: 690-696.
136. 136. Vecciarelli A, Siracusa A, Cenki E, Pulti M, Abbriti G. Effect of corticoid treatment on interleukin-1 and tumor necrosis factor secretion by monocytes from subjects with asthma. Clin Exp Allergy 1992; 22: 365-370.
137. 137. Corrigan C J, Brown P H, Barnes N C, Tsai J, Frew A J, Kay A B. Peripheral blood T lymphocyte activation and comparison of the T lymphocyte inhibitory effects of glucocorticoids and cyclosporin A. Am Rev Respir Dis 1991; 144: 1026-1032.
138. 138. Brown P H, Teelucksingh S, Matusiewicz S P, Greening A P, Crompton G K, Edwards C R W. Cutaneous vasoconstrictor responses to glucocorticoids in asthma. Lancet 1991; 337: 576-580.
139. 139. Lane S J, Sousa A R, Poston R N, Lee T H. In vivo cutaneous tuberculin response to prednisolone in corticosteroid resistant bronchial asthma. J Allergy Clin Immunol 1993; 91: 222.
140. 140. Lane S J, Lee T H. Glucocorticoid receptor characteristics in monocytes of patients with corticosteroid-resistant bronchial asthma. Am Rev Respir Dis 1991; 143: 1020-1024.
141. 141. Sher E R, Leung Y M, Surs W, et al. Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 1994; 93: 33-39.
142. 142. Kam J C, Szefler S J, Surs W, Sher F R, Leung DYM. Combination IL-2 and IL-4 reduces glucocorticoid-receptor binding affinity and T cell response to glucocorticoids. J Immunol 1993; 151: 3460-3466.
143. 143. Leung DYM, Wenzel S, Szefler S L, et al. Association of steroid resistant (SR) asthma with increased numbers of cells expressing glucocorticoid receptor (GR) β. J Allergy Clin Immunol 1997.
144. 144. Adcock I M, Lane S J, Brown C A, Peters M J, Lee T H, Barnes P J. Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma. J Immunol 1995; 154: 3000-3005.
145. 145. Adcock I M, Lane S J, Brown C A, Lee T H, Barnes P J. Abnormal glucocorticoid receptor/AP-1 interaction in steroid resistant asthma. J Exp Med 1995; 182: 1951-1958.
146. 146. Adcock I M, Brady H, Lim S, Karin M, Barnes P J. Increased JUN kinase activity in peripheral blood monocytes from steroid-resistant asthmatic subjects. Am J Respir Crit Care Med 1997; 155.
147. 147. Rosewicz S, McDonald A R, Maddux B A, Godfine I D, Miesfeld R L, Logsden C D. Mechanism of glucocorticoid receptor down-regulation by glucocorticoids. J Biol Chem 1988; 263: 2581-2584.
148. 148. Adcock I M, Brown C R, Shirasaki H, Barnes P J. Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung. Eur Resp J 1994; 7: 2117-2123.
149. 149. Vacca A, Screpanati I, Maroder M, Petrangeli E, Frati L, Guline A. Tumor promoting phorbol ester and raw oncogene expression inhibit the glucocorticoid-dependent transcription from the mouse mammary tumor virus long terminal repeat. Mol Endo 1989; 3: 1659-1665.
150. 150. Peters M J, Adcock I M, Brown C R, Barnes P J. β-Adrenoceptor agonists interfere with glucocorticoid receptor DNA binding in rat lung. Eur J Pharmacol (Molec Pharmacol Section) 1995; 289: 275-281.
151. 151. Wong C S, Wamedna I, Pavord I D, Tattersfield A E. Effect of regular terbutaline and budesonide on bronchial reactivity to allergen challenge. Am J Resp Crit Care Med 1994; 15047: 1268-1278.
152. 2-agonists in asthma. Trends Pharmacol Sci 1992; 13: 20-23.
153. 153. Taylor D R, Sears M R, Herbison G P, et al. Regular inhaled β-agonist in asthma: effects on exacerbation and lung function. Thorax 1993; 48: 134-138.
154. 154. Suissa S, Ernst P, Boivin J, et al. A cohort analysis of excess mortality in asthma and the use of inhaled β-agonists. Am J Respir Crit Care Med 1994; 149: 604-610.
155. 2-Agonist dose reduction: strategy and early results. Thorax 1993; 48: 1066.
156. 156. Beynon H L C, Garbett N D, Barnes P J. Severe premenstrual exacerbations of asthma: effect of intramuscular progesterone. Lancet 1988; ii: 370-372.
157. 157. Kalkhoveng E, Wissink S, Van Der Saag P T, van der Burg B. Negative interaction between the Re1 A (p65) subunit of NF-κB and the progesterone receptor. J Biol Chem 1996; 271: 6217-6224.
158. 158. Macek V, Soru J, Korpriva S, Marin J. Persistent adenoviral infection and chronic airway obstruction in children. Am J Respir Crit Care Med 1994; 150: 7-10.
159. 159. Whyte P, Buchovich R G, Horovitz J M. Association between an oncogene and an anti-oncogene: the adenovirus EIA protein binds to the retinoblastoma gene product. Nature 1988; 334: 124-129.