Structural organization and expression of the gene for the mouse G(M2) activator protein

Mammalian Genome

Volumn 8, Issue 2, 1997, Pages 90-93

  Bertoni, C ^a   Appolloni, M G ^a   Stirling, J L ^b   Li, S C ^c   Li, Y T ^c   Orlacchio, A ^a   Beccari, T ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c TULANE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA BINDING PROTEIN; GANGLIOSIDE GM2; GANGLIOSIDE GM2 ACTIVATOR PROTEIN; MESSENGER RNA; PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR SP1;

ANIMAL; ARTICLE; BINDING SITE; CELL STRAIN 3T3; CHROMOSOME MAP; EXON; GENETICS; INTRON; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; RNA TRANSLATION;

3T3 CELLS; ANIMALS; BASE SEQUENCE; BINDING SITES; CHROMOSOME MAPPING; DNA; DNA-BINDING PROTEINS; EXONS; G(M2) ACTIVATOR PROTEIN; G(M2) GANGLIOSIDE; INTRONS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PROMOTER REGIONS (GENETICS); PROTEINS; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS;

ANIMALIA; RODENTIA;

EID: 0031063199     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900364     Document Type: Article

References (24)

1. M2 activator protein expression in mouse tissues. Biochem Biophys Res Commun 204, 741-745
2. M2 activator protein. Biochem J 294, 227-230
3. Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI (1994). Illeal Iipid-binding protein (ILLBP) gene maps to mouse chromosome-11. Mamm Genome 5, 805-806
4. Breathnach R, Chambon P (1981). Organization and expression of eukaryotic split genes coding for proteins. Annu Rev Biochem 50, 349-383
5. M2 degradation by β-hexosaminidase isoenzymes in tissue extracts from different species. Hoppe-Seyler's Z. Physiol Chem 364, 821-829
6. M2 activator protein to chromosome-5. Ann Hum Genet 49, 41-45
7. Cohen-Tannoudji M, Marchand P, Akli S, Sheardown SA, Puech JP, Kress C, Gressens P, Nassogne MC, Beccari T, Muggleton-Harris AL, Evrard P, Stirling JL, Poenaru L, Babinet C (1995). Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease. Mamm Genome 6, 844-849
8. Furst W, Sandhoff K (1992) Activator proteins and topology of lysosomal sphingolipid catabolism. Biochim Biophys Acta 1126, 1-16
9. M2 activator protein. FEBS Lett 289, 260-264
10. Kuwana T, Mullock BM, Luzio JP (1995). Identification of a lysosomal protein causing lipid transfer, using a fluorescence assay designed to monitor membrane fusion between rat liver endosomes and lysosomes. Biochem J 308, 937-946
11. M2 activator protein. Biochem J 282, 807-813
12. Nasrin N, Ercolani L, Denard M, Kong XF, Kang I, Alexander M (1990). Insulin stimulates glyceraldehyde-3-phosphate dehydrogenase gene expression through cis-acting DNA sequences. Proc Natl Acad Sci USA 87, 5273-5277
13. Phaneuf D, Wakamatsu N, Huang JQ, Borowski A, Peterson AC, Fortunato SR, Ritter G, Igdoura SA, Morales CR, Benoit G, Akerman BR, Leclerc D, Hanai N, Marth JD, Trasler JM, Gravel RA (1996) Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases. Hum Mol Genet 5, 1-14
14. Rowe LB, Nadeau JH, Turner R, Frankel WN, Letts VA, Eppig JT, Ko MSH, Thurston SJ, Birkenmeier EH (1994). Maps from 2 interspecific backcross DNA panels available as a community genetic-mapping resource. Mamm Genome 5, 253-274
15. Sambrook J, Fritsch FF, Maniatis T (1989). Molecular Cloning: A Laboratory Manual. 2nd ed. (Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press)
16. M2 gangliosidoses. In The Metabolic Basis of Inherited Diseases. 6th ed. CR Scriver, AL Beaudet, WS Sly, D Valle, eds. (New York: McGraw-Hill), pp. 1807-1839
17. Sanger F, Nicklen S, Coulson AR (1977). DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74, 5463-5467
18. Sango K, Yamanaka S, Hoffmann A, Okuda Y, Grinberg A, Westphal H, McDonald MP, Crawley JN, Sandhoff K, Suzuki K, Proia RL (1995) Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism. Nature Genet 11, 170-176
19. Schroder M, Klima H, Nakano T, Kwan H, Quintem LE, Gartner S, Suzuki K, Sandhoff K (1989). Isolation of a cDNA encoding the human GM2 activator protein. FEBS Lett 251, 197-200
20. Xie B, McInnes B, Neote K, Lamhonwah AM, Mahuran D (1991). Isolation and expression of a full-length cDNA encoding the human GM2 activator protein. Biochem Biophys Res Commun 177, 1217-1223
21. Xie B, Kennedy JL, Mclnnes B, Auger D, Mahuran D (1992). Identification of a processed pseudogene related to the functional gene and encoding the GM2 activator protein: localization of the pseudogene to human chromosome 3 and the functional gene to human chromosome 5. Genomics 14, 796-798
22. Yamanaka S, Johnson ON, Norflus F, Boles DJ, Proia RL (1994a). Structure and expression of the mouse β-hexosaminidase genes, Hexa and Hexb. Genomics 21, 588-596
23. Yamanaka S, Johnson MD, Grinberg A, Westphal H, Crawley JN, Taniike M, Suzuki K, Proia RL (1994b). Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease. Proc Natl Acad Sci USA 91, 9975-9979
24. Yamanaka S, Johnson ON, Lyu MS, Kozak CA, Proia RL (1995). The mouse gene encoding the GM2 activator protein (Gm2a): cDNA sequence, expression, and chromosome mapping. Genomics 24, 601-604