Factors contributing to relief of exertional breathlessness during hyperoxia in chronic airflow limitation

American Journal of Respiratory and Critical Care Medicine

Volumn 155, Issue 2, 1997, Pages 530-535

  O'Donnell, Denis E ^a,b,c   Bain, Douglas J ^a   Webb, Katherine A ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b ONTARIO MINISTRY OF HEALTH AND LONG TERM CARE   (Canada)

^c KINGSTON GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AIR CONDITIONING; ARTICLE; BREATHING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; DYSPNEA; EXERCISE; FEMALE; HUMAN; HYPEROXIA; HYPOXEMIA; LACTATE BLOOD LEVEL; LUNG VOLUME; MALE; PRIORITY JOURNAL; RATING SCALE;

EID: 0031058778     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.155.2.9032190     Document Type: Article

References (36)

1. Killian, K. J., P. LeBlanc, D. H. Martin, E. Summers, N. L. Jones, and E. M. J. Campbell. 1992. Exercise capacity and ventilatory, circulatory, and symptom limitation in patients with chronic airflow limitation. Am. Rev. Respir. Dis. 146:935-940.
2. Stein, D. A., B. L. Bradley, and W. Miller. 1982. Mechanisms of oxygen effects on exercise in patients with chronic obstructive pulmonary disease. Chest 81:6-10.
3. Bradley, B. L., A. E. Garner, D. Billiu, J. M. Mestas, and J. Forma. 1978. Oxygen-assisted exercise in chronic obstructive lung disease: the effect on exercise capacity and arterial blood gas tensions. Am. Rev. Respir. Dis. 118:239-243.
4. Bye, P. T. P., S. A. Esau, R. O. Levy, R. J. Shiner, P. T. Macklem, J. G. Martin, and R. L. Pardy. 1985. Ventilatory muscle function during exercise in air and oxygen in patients with chronic air-flow limitation. Am. Rev. Respir. Dis. 132:236-240.
5. Dean, N. C, J. K. Brown, R. B. Himelman, J. J. Doherty, W. M. Gold, and M.S. Stulbarg. 1992. Oxygen may improve dyspnea and endurance in patients with chronic obstructive pulmonary disease and only mild hypoxemia. Am. Rev. Respir. Dis. 148:941-945.
6. Swinburn, C. R., J. M. Wakefield, and P. W. Jones. 1984. Relationship between ventilation and breathlessness during exercise in chronic obstructive airway disease is not altered by prevention of hypoxemia. Clin. Sci. 67:146-149.
7. Lane, R., A. Crockcroft, L. Adams, and A. Guz. 1987. Arterial oxygen saturation and breathlessness in patients with chronic obstructive airway disease. Clin. Sci. 76:693-698.
8. Ward, S. A., and B. J. Whipp. 1989. Effects of peripheral and central chemoreflex activation on the isopneic rating of breathing in exercise in humans. J. Physiol. 411:27-43.
9. Chronos, N., L. Adams, and A. Guz. 1988. Effect of hyperoxia and hypoxia on exercise-induced breathlessness in normal subjects. Clin Sci. 74:531-537.
10. Woodcock, A. A., E. R. Gross, and D. M. Geddes. 1981. Oxygen relieves breathlessness in "pink puffers." Lancet i:907-909.
11. Light, R. W., C. K. Mahutte, D. W. Stansbury, C. E. Fischer, and S. E. Brown. 1989. Relationship between improvement in exercise performance with supplemental oxygen and hypoxic ventilatory drive in patients with chronic airflow obstruction. Chest 95:751-756.
12. Stoller, J. K., R. Ferranti, and A. R. Feinstein. 1986. Further specification and evaluation of a new clinical index for dyspnea. Am. Rev. Respir. Dis. 135:1129-1134.
13. Gardner, R. M., J. L. Hankinson, J. L. Clausen, R. O. Crapo., R. O. Johnson, Jr., and G. R. Epier. 1987. American Thoracic Society standardization of spirometry - 1987 update. Am. Rev. Respir. Dis. 136:1285-1298.
14. Morris, J. F., A. Koski, and L. C. Johnson. 1971. Spirometric standards for healthy nonsmoking adults. Am. Rev. Respir. Dis. 103:57-67.
15. Goldman, H. I., and M. R. Becklake. 1959. Respiratory function tests: normal values at median altitudes and the prediction of normal results. Am. Rev. Tuberc. 79:457-467.
16. Gaensler, E. A., G. W. Wright. 1966. Evaluation of respiratory impairment. Arch. Environ. Health 12:146-189.
17. Hamilton, A. L. Killian, K. J., E. Summers, and N. L. Jones. 1995. Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders. Am. J. Respir. Crit. Care Med. 152:2021-2031.
18. Welch, H.G. and P. K. Pedersen. 1981. Measurement of metabolic rate in hypoxia. J. Appl. Physiol. 51(3):725-731.
19. Jones, N. J. 1988. Clinical Exercise Testing, 3rd ed. W. B. Saunders, Philadelphia.
20. Borg, G. A. V. 1982. Psychophysical basis of perceived exertion. Med. Sci. Sports Exerc. 14:377-381.
21. O'Donnell, D. E., M. McGuire, L. Samis, and K. A. Webb. 1995. The impact of exercise reconditioning on breathlessness in severe chronic airflow limitations. Am. Rev. Respir. Crit. Care Med. 152:2005-2013.
22. Stubbing, D. G., L. D. Pengelly, J. L. C. Morse, and N. L. Jones. 1980. Pulmonary mechanics during exercise in subjects with chronic airflow limitation. J. Appl. Physiol. 49:511-515.
23. O'Donnell, D. E., and K. A. Webb. 1993. Exertional breathlessness in patients with chronic airflow limitation: the role of lung hyperinflation. Am. Rev. Respir. Dis. 148:1351-1357.
24. Burki, N. K. 1979. Breathlessness and mouth occlusion pressure in patients with chronic obstruction of the airways. Chest 76:527-531.
25. Whitelaw, W. A., J. P. Derenne, and J. Milic-Emili. 1975. Occlusion pressure as a measure of respiratory center output in conscious man. Respir. Physiol. 33:181-199.
26. Grizzle, J. E. 1965. The two-period change-over design and its use in clinical trials. Biometrics 21:467-480.
27. Beaver, W. L., K. Wasserman, B. J. Whipp. 1986. A new method for detecting anaerobic threshold by gas exchange. J. Appl. Physiol. 60(2):2020-2027.
28. Whipp, B. J., S. A. Ward, N. Lamarra, J. A. Davis, and K. Wasserman. 1982. Parameters of ventilatory and gas exchange dynamics during exercise. J. Appl. Physiol. 52:1506-1513.
29. Griffiths, T. L., L. C. Henson, and B. J. Whipp. 1986. Influence of inspired oxygen concentration on the dynamics of the exercise hyperpnoea in man. J. Physiol. 380:387-403.
30. Maltais, F., A.-A. Simard, C. Simard, J. Jobin, P. Desgagnes, and P. LeBlanc. 1996. Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD. Am. J. Respir. Crit. Care Med. 153:288-293.
31. Mateika, J. H. and J. Duffin. 1994. The ventilation, lactate and electromyographic thresholds during incremental exercise tests in normoxia, hypoxia and hyperoxia. Eur. J. Appl. Physiol. 69:110-118.
32. Casaburi, R., A. Patessio, F. Ioli, S. Zanaboni, C. F. Donner, and K. Wasserman. 1991. Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease. Am. Rev. Respir. Dis. 143:9-18.
33. 2 on ventilation and blood gases in patients with chronic obstructive pulmonary disease during acute respiratory failure. Am. Rev. Respir. Dis. 122:747-753.
34. Chen, Z., L. Eldridge, and P. G. Wagner. 1991. Respiratory-associated rhythmic firing of midbrain neurons in cats: relation to level of respiratory drive. J. Physiol. (Lond.) 437:305-325.
35. Gandevia, S. C. 1988. Neural mechanisms underlying the sensation of breathlessness: kinesthetic parallels between respiratory and limb muscles. Aust. N.Z. J. Med. 18:83-91.
36. Wilson, B. A., H. G. Welch, J. N. Liles. 1975. Effects of hyperoxic gas mixtures on energy metabolism during prolonged work. J. Appl. Physiol. 39:267-271.