Nimodipine's protection against corticosterone-induced morphological changes in the hippocampus of young rats

Brain Research

Volumn 748, Issue 1-2, 1997, Pages 175-183

  Dachir, Shlomit ^a   Kadar, Tamar ^a   Robinzon, Boaz ^b   Levy, Aharon ^a,c  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c IIBR   (Israel)

Author keywords

aging; Alzheimer's disease; calcium; cognition; glucocorticoid; memory; morphometry; stress

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CORTICOSTERONE; NEUROPROTECTIVE AGENT; NIMODIPINE; PLACEBO;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; HISTOLOGY; LEARNING; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS;

AGING; ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; CALCIUM CHANNEL BLOCKERS; CORTICOSTERONE; HIPPOCAMPUS; MALE; NEUROPROTECTIVE AGENTS; NIMODIPINE; RATS; RATS, INBRED F344;

EID: 0031058222     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01296-6     Document Type: Article

References (53)

1. Amaral, D.G., Ishizuka, N. and Claiborne, B., Neurons, numbers and the hippocampal network. In J. Storm-Mathisen, J. Zimmer and O.P. Ottersen (Eds.), Understanding the Brain Through the Hippocampus (Progress in Brain Research, Vol. 83), Elsevier, Amsterdam, 1990, pp. 1-12.
2. Arbel, I., Kadar, T., Silbermann, M. and Levy, A., The effects of long-term corticosterone administration on hippocampal morphology and cognitive performance of middle-aged rats, Brain Res., 657 (1994) 227-235.
3. Bodnoff, S.R., Humphreys, A.G., Lehman, J.C., Diamond, D.M., Rose, G.M. and Meaney, M.J., Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity and hippocampal neuropathology in young and mid-aged rats, J. Neurosci., 15 (1995) 61-69.
4. Cameron, H. and Gould, E., Distinct population of cells in the adult dentate gyrus undergo mitosis or apoptosis in response to adrenalectomy, J. Comperative Neurol., 369 (1996) 56-63.
5. Dachir, S., Kadar, T., Robinzon, B. and Levy, A., Cognitive deficits induced in young rats by long-term corticosterone administration, Behav. Neural Biol., 60 (1993) 103-109.
6. De Kloet, E.R., Reul, J.M.H.M. and Sutanto, W., Corticosteroids and the brain, J. Steroid Biochem. Mol. Biol., 37 (1990) 387-394.
7. De Kloet, E.R., Corticosteroids, stress and aging. In C. Franceschi, G. Crepaldi, V.J. Cristofalo and J. Vijg (Eds.) Aging and Cellular Defense Mechanisms, (Annals of the New York Academy of Science Series, 663) New York Academy of Science, New York, 1992, pp. 357-371.
8. Dellow, M. and Beauchene, R.E., The effect of exercise, diet restriction, and aging on the pituitary-adrenal axis in the rats, Exp. Gerontol., 25 (1990) 553-562.
9. Disterhoft, J.F., Thompson, L.T., Weiss, C., Moyer, J.R., Van der Zee, E., Carrillo, M., Kronforst-Collins, M. and Power, J., The calcium hypothesis for Alzheimer's disease: insights from animal and human studies, Neurosci. Res. Commun., 17 (1995) 121-131.
10. Ehlers, C.L., Chaplin, R.I. and Kaneko, W.M., Effects of chronic corticosterone treatment on electrophysiological and behavioral measures in the rat, Psychoneuroendocrinology, 17 (1992) 691-699.
11. Elliott, E. and Sapolsky, R.M., Glucocorticoids, neurotoxicity and calcium regulation. In E. Costa and S.M. Paul (Eds.), Neurosteroids and Brain Function (Fidia Research Foundation Symposium Series, Vol. 8), Thieme Medical Publishers, New York, 1991, pp. 47-54.
12. Elliott, E. and Sapolsky, R.M., Corticosterone impairs hippocampal neuronal calcium regulation - possible mediating mechanisms, Brain Res., 602 (1993) 84-90.
13. Gould, E., Wooley, C.S. and McEwen, B.S., Short term glucocorticoid manipulations affect neuronal morphology and survival in the adult dentate gyrus, Neuroscience, 37 (1990) 367-375.
14. Hanks, S.D. and Flood, D.G., Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. I. CA1 of hippocampus, Brain Res., 540 (1991) 63-82.
15. Issa, A.M., Rowe, W., Gauthier, S. and Meaney, M.J., Hypothalamic-pituitary-adrenal activity in aged cognitively impaired and cognitively unimpaired rats, J. Neurosci., 10 (1990) 3247-3254.
16. Jacobson, L. and Sapolsky, R.M., The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis, Endocrine Rev., 12 (1991) 118-134.
17. Joels, M. and De Kloet, E.R., Effects of glucocorticoids and norepinephrine on the excitability in the hippocampus, Science, 245 (1989) 1502-1505.
18. Joels, M., Hesen W. and De Kloet, E.R., Long-term control of neuronal excitability by corticosteroid hormones, J. Steroid Biochem. Mol. Biol., 53 (1995) 315-323.
19. Kabuto, H., Yokoi, I., Mori, A., Murakami, M. and Sawada, S., Neurochemical changes related to ageing in the senescence-accelerated mouse brain and the effect of chronic administration of nimodipine, Mechanisms Ageing Develop., 80 (1995) 1-9.
20. Kadar, T., Arbel, I., Silbermann, M. and Levy, A., Morphological hippocampal changes during normal aging and their relation to cognitive deterioration, J. Neural Transm., 44 (1994) 133-143.
21. Kerr, D.S., Campbell, L.W., Hao, S.Y. and Landfield, P.W., Corticosteroid modulation of hippocampal potentials: increased effect with aging, Science, 245 (1989) 1505-1509.
22. Kerr. D.S., Campbell, L.W., Applegate, M.D., Brodish, A. and Landfield, P.W., Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging, J. Neurosci., 11 (1991) 1316-1324.
23. Kerr, D.S., Campbell, L.W., Applegate, M.D., Brodish, A. and Landfield, P.W., Chronic glucocorticoid receptor activation enhances voltage-dependent Ca conductances: relevance to brain aging, Proc. Natl. Acad. Sci. USA, 89 (1992) 8527-8531.
24. Kupsch, A., Gerlach, M., Pupeter, S.C., Sautter, J., Dirr, A., Arnold, G., Opitz, W., Przuntek, H., Riederer, P. and Oertel, W.H., Pretreatment with nimodipine prevents MPTP-induced neurotoxicity at the nigral, but not at the striatal level in mice, NueroReport, 6 (1995) 621-625.
25. Landfield, P.W., Waymire, J.C. and Lynch, G., Hippocampal aging and adrenocorticoids: quantitative correlations, Science, 202 (1978) 1098-1102.
26. Landfield, P.W., Review: hippocampal neurobiological mechanisms of age-related memory dysfunction, Neurobiol. Aging, 9 (1998) 571-579.
27. Landfield, P.W. and Eldridge, J.C., The glucocorticoid hypothesis of brain aging and neurodegeneration: recent modifications, Acta Endocrinol., 125 (1991) 54-64.
28. Landfield, P.W., The role of glucocorticoids in brain aging and Alzheimer's disease: and integrative physiological hypothesis, Exp. Gerontol., 29 (1994) 3-11.
29. Landfield, P.W. and Eldridge, J.C., Evolving aspects of the glucocorticoid hypothesis of brain aging: hormonal modulation of neuronal calcium homeostasis, Neurobiol. Aging, 15 (1994) 579-588.
30. Levy, A., Dachir, S., Arbel, I. and Kadar, T., Aging, stress and cognitive function. In I. Nagi, D. Harman and K. Kitani (Eds.), Pharmacology of Aging Processes (Ann. NY Acad. Sci., Vol. 717), The New York Academy of Science, New York, 1994, pp. 79-88.
31. 2+ antagonist nimodipine, influence of aging and developmental drug treatment, Neurodegeneration, 4 (1995) 307-314.
32. Lupien, S., Lecours, A.R., Lussier, I., Schwartz, G., Nair, N.P.V. and Meaney, M.J., Basal cortisol levels and cognitive deficits in human aging, J. Neurosci., 14 (1994) 2893-2903.
33. Lupien, S., Lecours, A.R., Schwartz, G., Sharma, S., Hauger, R.L., Meaney, M.J. and Nair, N.P.V., Longitudinal study of basal cortisol levels in healthy elderly subjects: evidence for subgroups, Neurobiol. Aging, 17 (1996) 95-105.
34. Maeda, K., Tanimoto, K., Terada, T., Shintani, T. and Kakigi, T., Elevated urinary free cortisol in patients with dementia, Neurobiol. Aging, 12 (1991) 161-163.
35. Mazzanti, M.L., Thibault, O. and Landfield, P.W., Diopyridine modulation of normal hippocampal physiology in young and aged rats, Neurosci. Res. Commun., 9 (1991) 117-126.
36. Moghaddan, B., Bolinao, M.L., Stein-Behrens, B. and Sapolsky, R.M., Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate, Brain Res., 655 (1994) 251-254.
37. Paxinos, G. and C. Watson, The Rat Brain in Stereotaxic Coordinates, Second Edition, Academic Press, San Diego, 1986.
38. Rami, A. and Krieglstein, J., Neuronal protective effects of calcium antagonists in cerebral ischemia, Life Sci., 55 (1994) 2105-2113.
39. Raskind, M.A., Peskind, E.R., Pascualy, M., Edland S.D., Dobie, D.J., Murray, S., Sikkema, C. and Wilkinson, C.W., The effects of normal aging on cortisol and adrenocorticotropin responses to hypertonic saline infusion, Psychoneuroendocrinol., 20 (1995) 637-644.
40. Ratka, A., Sutanto, W., Boemers, M. and De Kloet, E.R., On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation, Neuroendocrinology, 50 (1989) 116-123.
41. Reul, J.M.H.M. and De Kloet, E.T., Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation, Endocrinology, 117 (1985) 25050-2511.
42. Reul, J.M.H.M. and De Kloet, E.T., Anatomical resolution of two types of corticosterone receptor sites in rats brain with in vitro autoradiography and computerized image analysis, J. Steroid Biochem., 24 (1986) 269-272.
43. Sapolsky, R.M., Krey, L.C. and McEwen, B.S., The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis, Endocrine Rev., 7 (1986) 284-301.
44. Sapolsky, R.M., Brooke, S. and Stein-Behrens, B., Methodological issues in studying glucocorticoid-induced damage to neurons, J. Neurosci. Meth., 58 (1995) 1-15.
45. Scriabine, A., Schuurman, T. and Traber, J., Pharmacological basis for the use of nimodipine in central nervous system disorders, FASEB J., 3 (1989) 1799-1806.
46. Schwartzkroin, P.A., Scharfman, H.E. and Sloviter, R.S., Similarities in circuitry between Ammon's horn and dentate gyrus: local interactions and parallel processing. In J. Storm-Mathisen, J. Zimmer and O.P. Ottersen (Eds.), Understanding the Brain Through the Hippocampus (Prog. Brain Res., Vol. 83), Elsevier, Amsterdam, 1990, pp. 269-286.
47. Shen, J. and Barnes, C.A., Age-related decrease in cholinergic synaptic transmission in three hippocampal subfields, Neurobiol. Aging, 17 (1996) 439-451.
48. Sloviter, R., Valiquette, G., Abrams, G.M., Ronk, E.C., Solls, A.I., Paul, L.A. and Neubort, S.L., Selective loss of hippocampal ganule cells in the mature rat brain after adrenalectomy, Science, 243 (1989) 535-538.
49. Sloviter, R.S., Sollas, A.L. and Neubort, S., Hippocampal dentate granule cell degeneration after adrenalectomy in the rat is not reversed by dexamethasone, Brain Res., 682 (1995) 227-230.
50. Talmi, M., Carlier, E., Bengelloun, W. and Soumireu-Mourat, B., Chronic RU486 treatment reduces age-related alterations of mouse hippocampal function, Neurobiol. Aging, 17 (1996) 9-14.
51. Uno, H., Tarara, R., Else, J.G., Suleman, M.A. and Sapolsky, R.M, Hippocampal damage associated with prolonged and fatal stress in primates, J. Neurosci, 9 (1989) 1705-1711.
52. Virgin, C.E., Jr., Ha, T.P.T., Packan, D.R., Tombauch, G.C., Yang, S.H., Horner, H.C. and Sapolsky, R.M., Glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: implications for glucocorticoid neurotoxicity, J. Neurochem., 57 (1991) 1422-1428.
53. Wickelgren, I., Is hippocampal cell death a myth?, Science, 271 (1996) 1229-1230.