Diphenylpropionic acids as new AT1 selective angiotensin II antagonists

Journal of Medicinal Chemistry

Volumn 39, Issue 11, 1996, Pages 2197-2206

  Almansa, Carmen ^a   Gómez, Luis A ^a   Cavalcanti, Fernando L ^a   De Arriba, Alberto F ^a   Rodríguez, Ricardo ^a   Carceller, Elena ^a   García Rafanell, Julián ^a   Forn, Javier ^a  

^a Grupo Uriach   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYL 5,7 DIMETHYL 3 [4 [2 (2H TETRAZOL 5 YL)PHENYL]BENZYL]IMIDAZO[4,5 B]PYRIDINE; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; LOSARTAN; PHENYLPROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UR 7198;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BINDING AFFINITY; BIOAVAILABILITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HYPERTENSION; NONHUMAN; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SODIUM ABSORPTION; STRUCTURAL CHROMOSOME ABERRATION;

ADMINISTRATION, ORAL; ADRENAL GLANDS; ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA, THORACIC; BIPHENYL COMPOUNDS; BLOOD PRESSURE; DIET, SODIUM-RESTRICTED; FUROSEMIDE; IMIDAZOLES; INDICATORS AND REAGENTS; KINETICS; LIVER; LOSARTAN; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUSCLE, SMOOTH, VASCULAR; PHENYLPROPIONATES; RABBITS; RATS; RECEPTORS, ANGIOTENSIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 0029899587     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9508853     Document Type: Article

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