HIV-1: Gambling on the evolution of drug resistance?

Nature Medicine

Volumn 3, Issue 3, 1997, Pages 268-271

  Leigh Brown, Andrew J ^a   Richman, Douglas D ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; DIDANOSINE; INDINAVIR; NUCLEOSIDE DERIVATIVE; RITONAVIR; STAVUDINE; ZALCITABINE; ZIDOVUDINE;

DRUG RESISTANCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTATION RATE; PRIORITY JOURNAL; SHORT SURVEY; VIRUS INFECTION; VIRUS MUTATION;

DRUG RESISTANCE, MICROBIAL; EVOLUTION, MOLECULAR; HIV INFECTIONS; HIV-1; HUMANS; MUTATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031054436     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0397-268     Document Type: Short Survey

References (15)

1. Havlir, D.V. & Richman, D.D. Viral dynamics of HIV: Implications for drug development and therapeutic strategies. Ann. Intern. Med. 124, 984-994 (1996).
2. Embretson, J. et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 363, 359-362 (1993).
3. Pantaleo, G. et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362, 355-358 (1993).
4. Piatak, M., Jr. et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259, 1749-1754 (1993).
5. Perelson, A.S., Neumann, A.U., Markowitz, M., Leonard, J.M. & Ho, D.D. HIV-1 dynamics in vivo: Virion clearance rate, infected cell lifetime, and viral generation time. Science 271, 1582-1586 (1996).
6. Eigen, M. New concepts for dealing with the evolution of nucleic acids. Cold Spring Harbor Symposia on Quantitative Biology 111, 307-320 (1987).
7. Drake, J.W. Rates of spontaneous mutation among RNA viruses. Proc. Natl. Acad. Sci. USA 90, 4171-4175 (1993).
8. Mansky, L.M. & Temin, H.M. Lower in vivo mutation rate of human immunodeficiency virus-type 1 than that predicted from the fidelity of purified reverse transcriptase. J. Virol. 69, 5087-5094 (1995).
9. Wain-Hobson, S. The fastest genome evolution ever described: HIV variation in situ. Curr. Op. Genet. Devel. 3, 878-883 (1993).
10. Leigh-Brown, A.J. & Holmes, E.C. The evolutionary biology of human immunodeficiency virus. Ann. Rev. Ecol. Sys. 25, 127-165 (1994).
11. Coffin, J.M. HIV population dynamics in vivo: implications for genetic variation, pathogenesis and therapy. Science 267, 483-489 (1995).
12. Frost, S.D.W. & McLean, A.R. Quasispecies dynamics and the emergence of drug resistance during zidovudine therapy of HIV infection. AIDS 8, 323-332 (1994).
13. Haldane, J.B.S. A mathematical theory of natural and artificial selection. Part V. Selection and mutation. Proc. Camb. Phil. Soc. 28, 838-844 (1937).
14. Crow, J.F. & Kimura, M. An introduction to population genetics theory. Anonymous (Harper and Row, New York, 1970).
15. Wright, S. Evolutionary and the genetics of populations, in The Theory of Gene Frequencies 512 (University of Chicago Press, Chicago, 1969).