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Volumn 14, Issue 2, 1997, Pages 136-144

HIV-1 drug susceptibilities and reverse transcriptase mutations in patients receiving combination therapy with didanosine and delavirdine

Author keywords

Combination therapy; Drug resistance; Human immunodeficiency virus type 1 (HIV 1) infection; Nonnucleoside reverse transcriptase inhibitors

Indexed keywords

DELAVIRDINE; DIDANOSINE; RNA DIRECTED DNA POLYMERASE;

EID: 0031052425     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199702010-00006     Document Type: Article
Times cited : (31)

References (37)
  • 1
    • 0025980022 scopus 로고
    • BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine
    • Richman D, Rosenthal AS, Skoog M, et al. BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine. Antimicrob Agents Chemother 1991;35:305-8.
    • (1991) Antimicrob Agents Chemother , vol.35 , pp. 305-308
    • Richman, D.1    Rosenthal, A.S.2    Skoog, M.3
  • 2
    • 0025679303 scopus 로고
    • Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor
    • Merluzzi VJ, Hargrave KD, Labadia M, et al. Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. Science 1990;250:1411-3.
    • (1990) Science , vol.250 , pp. 1411-1413
    • Merluzzi, V.J.1    Hargrave, K.D.2    Labadia, M.3
  • 3
    • 0025014499 scopus 로고
    • Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
    • Pauwels R, Andries K, Desmyter J, et al. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives. Nature 1990;343:470-4.
    • (1990) Nature , vol.343 , pp. 470-474
    • Pauwels, R.1    Andries, K.2    Desmyter, J.3
  • 4
    • 0025962924 scopus 로고
    • An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-4,5,1-jk[1,4]benzodiazepin-2(1H)-one and -thione derivatives
    • Debyser Z, Pauwels R, Andries K, et al. An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk[1,4]benzodiazepin-2(1H)-one and -thione derivatives. Proc Natl Acad Sci USA 1991;88:1451-5.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 1451-1455
    • Debyser, Z.1    Pauwels, R.2    Andries, K.3
  • 5
    • 0027466031 scopus 로고
    • Inhibition of HVI-1 reverse transcriptase by pyridinone derivatives: Potency, binding characteristics, and effect of template sequence
    • Carroll SS, Olsen DB, Bennett, CD, et al. Inhibition of HVI-1 reverse transcriptase by pyridinone derivatives: potency, binding characteristics, and effect of template sequence J Biol Chem 1993;268:276-81.
    • (1993) J Biol Chem , vol.268 , pp. 276-281
    • Carroll, S.S.1    Olsen, D.B.2    Bennett, C.D.3
  • 6
    • 0026003110 scopus 로고
    • Pyridinone derivatives: Specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity
    • Goldman ME, Nunberg JH, O'Brien JA, et al. Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity. Proc Natl Acad Sci USA 1991;88:6863-7.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 6863-6867
    • Goldman, M.E.1    Nunberg, J.H.2    O'Brien, J.A.3
  • 7
    • 0025996983 scopus 로고
    • Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency type 1 replication
    • Romero DL, Busso M, Tan C-K, et al. Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency type 1 replication. Proc Natl Acad Sci USA 1991;88:8806-10.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8806-8810
    • Romero, D.L.1    Busso, M.2    Tan, C.-K.3
  • 8
    • 0027178052 scopus 로고
    • U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication
    • Dueweke TJ, Poppe SM, Romero DL, et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother 1993;37:32767.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 32767
    • Dueweke, T.J.1    Poppe, S.M.2    Romero, D.L.3
  • 9
    • 0028925773 scopus 로고    scopus 로고
    • Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
    • 995
    • Spence RA, Kati WM, Anderson KS, Johnson KA. Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Science 995;267:988-93.
    • Science , vol.267 , pp. 988-993
    • Spence, R.A.1    Kati, W.M.2    Anderson, K.S.3    Johnson, K.A.4
  • 10
    • 0026693137 scopus 로고
    • Crystal structure at 3.5 a resolution of HIV-1 reverse transcriptase complexed with an inhibitor
    • Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 1992; 256: 1783-90.
    • (1992) Science , vol.256 , pp. 1783-1790
    • Kohlstaedt, L.A.1    Wang, J.2    Friedman, J.M.3    Rice, P.A.4    Steitz, T.A.5
  • 11
    • 0026333212 scopus 로고
    • Characterization of the binding site for nevirapine (BI-RG-587), a nonnucleoside inhibitor of human immunodeficiency virus type-1 reverse transcriptase
    • Cohen KA, Hopkins J, Ingraham RH, et al. Characterization of the binding site for nevirapine (BI-RG-587), a nonnucleoside inhibitor of human immunodeficiency virus type-1 reverse transcriptase. J Biol Chem 1991;266:14670-4.
    • (1991) J Biol Chem , vol.266 , pp. 14670-14674
    • Cohen, K.A.1    Hopkins, J.2    Ingraham, R.H.3
  • 12
    • 0028172345 scopus 로고
    • Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase
    • Tantillo, C, Ding, J, Jacobo-Molina A, et al. Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. J Mol Biol 1994;243:369-87.
    • (1994) J Mol Biol , vol.243 , pp. 369-387
    • Tantillo, C.1    Ding, J.2    Jacobo-Molina, A.3
  • 13
    • 0026318387 scopus 로고
    • Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture
    • Richman D, Shih C-K, Lowy I, et al. Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc Natl Acad Sci USA 1991;88:11241-5.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 11241-11245
    • Richman, D.1    Shih, C.-K.2    Lowy, I.3
  • 14
    • 0026077832 scopus 로고
    • Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors
    • Nunberg JH, Schlief WA, Boots EJ, et al. Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors J Virol 1991;65:4887-92.
    • (1991) J Virol , vol.65 , pp. 4887-4892
    • Nunberg, J.H.1    Schlief, W.A.2    Boots, E.J.3
  • 15
    • 0027374758 scopus 로고
    • A short-term clinical evaluation of L-697,661, a non-nucleoside inhibitor of HIV-1 reverse transcriptase
    • Saag MS, Emini EA, Laskin OL, et al. A short-term clinical evaluation of L-697,661, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. N Engl J Med 1993;329:1065-72.
    • (1993) N Engl J Med , vol.329 , pp. 1065-1072
    • Saag, M.S.1    Emini, E.A.2    Laskin, O.L.3
  • 16
    • 0027957791 scopus 로고
    • Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy
    • Richman DD, Havlir D, Corbeil J, et al. Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy. J Virol 1994;68:1660-6.
    • (1994) J Virol , vol.68 , pp. 1660-1666
    • Richman, D.D.1    Havlir, D.2    Corbeil, J.3
  • 17
    • 0027957547 scopus 로고
    • Characterization of HIV-1 strains isolated from patients treated with TIBO R82913
    • Vandamme AM, Debyser Z, Pauwels R, et al. Characterization of HIV-1 strains isolated from patients treated with TIBO R82913. AIDS Res Hum Retrovirus 1994;10:39-46.
    • (1994) AIDS Res Hum Retrovirus , vol.10 , pp. 39-46
    • Vandamme, A.M.1    Debyser, Z.2    Pauwels, R.3
  • 18
    • 0028898824 scopus 로고
    • Combination therapy with zidovudine prevents selection of human immunodeficiency virus type 1 variants expressing high-level resistance to L-697,661, a nonnucleoside reverse transcriptase inhibitor
    • Staszewski S, Massari FE, Kober A, et al. Combination therapy with zidovudine prevents selection of human immunodeficiency virus type 1 variants expressing high-level resistance to L-697,661, a nonnucleoside reverse transcriptase inhibitor. J Infect Dis 1995;171:1159-65.
    • (1995) J Infect Dis , vol.171 , pp. 1159-1165
    • Staszewski, S.1    Massari, F.E.2    Kober, A.3
  • 19
    • 0027209906 scopus 로고
    • Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency type 1 reverse transcriptase resistance to nonnucleoside inhibitors
    • Byrnes WV, Sardana VV, Schleif WA, et al. Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency type 1 reverse transcriptase resistance to nonnucleoside inhibitors. Antimicrob Agents Chemother 1993; 37:1576-9.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 1576-1579
    • Byrnes, W.V.1    Sardana, V.V.2    Schleif, W.A.3
  • 20
    • 4243983698 scopus 로고
    • Combination therapy with delavirdine mesylate (DLV) and AZT: Virology data from an European phase II trial
    • Been-Tiktak AMM, Joly V, Sitbon G, et al. Combination therapy with delavirdine mesylate (DLV) and AZT: virology data from an European phase II trial. J Acquir Immune Defic Syndr Hum Retrovir 1995;10:S23-4.
    • (1995) J Acquir Immune Defic Syndr Hum Retrovir , vol.10
    • Been-Tiktak, A.M.M.1    Joly, V.2    Sitbon, G.3
  • 21
    • 3042975058 scopus 로고
    • Phenotypic and genotypic characterization of HIV-1 viral isolates from patients treated with combined AZT and delavirdine mesylate (DLV) therapy
    • Kuai, HI, July
    • Wathen LK, Freimuth WW, Batts DH, Cox SR. Phenotypic and genotypic characterization of HIV-1 viral isolates from patients treated with combined AZT and delavirdine mesylate (DLV) therapy. Third International Workshop on HIV Drug Resistance, Kuai, HI, July 1995, p 42.
    • (1995) Third International Workshop on HIV Drug Resistance , pp. 42
    • Wathen, L.K.1    Freimuth, W.W.2    Batts, D.H.3    Cox, S.R.4
  • 22
    • 0028816484 scopus 로고
    • Phase I study of atevirdine, a nonnucleoside reverse transcriptase inhibitor, in combination with zidovudine for human immunodeficiency virus type 1 infection
    • Reichman RC, Morse OD, Demeter LM, et al. Phase I study of atevirdine, a nonnucleoside reverse transcriptase inhibitor, in combination with zidovudine for human immunodeficiency virus type 1 infection. J Infect Dis 1995;171:297-304.
    • (1995) J Infect Dis , vol.171 , pp. 297-304
    • Reichman, R.C.1    Morse, O.D.2    Demeter, L.M.3
  • 23
    • 0003334866 scopus 로고
    • Phenotypic and Genotypic analysis of atevir0ine susceptibility of HIV-1 isolates obtained from patients receiving atevirdine monotherapy in a phase I clinical trial (ACTG 187): Comparison to patients receiving combination therapy with atevirdine and zidovudine
    • Gaithersburg, MD, Sept
    • Demeter LM, Resnick L, Nawaz T, Timpone JG, Batts D, Reichman RC. Phenotypic and Genotypic analysis of atevir0ine susceptibility of HIV-1 isolates obtained from patients receiving atevirdine monotherapy in a phase I clinical trial (ACTG 187): comparison to patients receiving combination therapy with atevirdine and zidovudine. Third Workshop on Viral Resistance, Gaithersburg, MD, Sept 1993.
    • (1993) Third Workshop on Viral Resistance
    • Demeter, L.M.1    Resnick, L.2    Nawaz, T.3    Timpone, J.G.4    Batts, D.5    Reichman, R.C.6
  • 24
    • 0026454435 scopus 로고
    • 3́-Azido-3́-deoxythymidine resistance sup1 pressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors
    • Larder BA. 3́-Azido-3́-deoxythymidine resistance sup1 pressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother 1992;30:2664-9.
    • (1992) Antimicrob Agents Chemother , vol.30 , pp. 2664-2669
    • Larder, B.A.1
  • 25
    • 0028333887 scopus 로고
    • Susceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reverse transcriptase inhibitors
    • Byrnes VW, Emini EA, Schleif WA, et al. Susceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reverse transcriptase inhibitors. Antimicrob Agents Chemother 1994;38:1401-7.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1401-1407
    • Byrnes, V.W.1    Emini, E.A.2    Schleif, W.A.3
  • 26
    • 0027231438 scopus 로고
    • A mutation in reverse transcriptase of bis(heteraryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors
    • Dueweke TJ, Pushkarskaya T, Poppe SM, et al. A mutation in reverse transcriptase of bis(heteraryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors. Proc Natl Acad Sci USA 1993;90:4713-7.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4713-4717
    • Dueweke, T.J.1    Pushkarskaya, T.2    Poppe, S.M.3
  • 27
    • 85035183284 scopus 로고
    • Delavirdine susceptibility of HIV-1 isolates obtained from patients receiving DLV monotherapy
    • Demeter LM, Shafer RW, Para M, et al. Delavirdine susceptibility of HIV-1 isolates obtained from patients receiving DLV monotherapy. J Acquir Immune Defic Syndrom Hum Retrovir 1995;10:S11.
    • (1995) J Acquir Immune Defic Syndrom Hum Retrovir , vol.10
    • Demeter, L.M.1    Shafer, R.W.2    Para, M.3
  • 28
    • 0003250969 scopus 로고
    • Evaluation of the steady-state pharmacokinetic interaction between didanosine and delavirdine mesylate in HIV-positive patients
    • San Francisco, CA Abstr 131
    • Cox SR, Cohn SE, Greisberger C, et al. Evaluation of the steady-state pharmacokinetic interaction between didanosine and delavirdine mesylate in HIV-positive patients. 35th interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA 1995, Abstr 131.
    • (1995) 35th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Cox, S.R.1    Cohn, S.E.2    Greisberger, C.3
  • 29
    • 0026637014 scopus 로고
    • Standardization of sensitive human immunodeficiency virus coculiure procedures and establishment of a multicenter quality assurance program for the AIDS Clinical Trials Group
    • Hollinger FB, Bremer JW, Myers LE, Gold JWM, McQuay L. NIH/NIAID/DAIDS/ACTG virology Laboratories. Standardization of sensitive human immunodeficiency virus coculiure procedures and establishment of a multicenter quality assurance program for the AIDS Clinical Trials Group. J Clin Microbiol 1992;30:1787-94.
    • (1992) J Clin Microbiol , vol.30 , pp. 1787-1794
    • Hollinger, F.B.1    Bremer, J.W.2    Myers, L.E.3    Gold, J.W.M.4    McQuay, L.5
  • 30
    • 0027270541 scopus 로고
    • Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates
    • Japour AJ, Mayers DL, Johnson VA, et al. Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates. Antimicrob Agents Chemother 1993;37:1095-101.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 1095-1101
    • Japour, A.J.1    Mayers, D.L.2    Johnson, V.A.3
  • 31
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 32
    • 0003113241 scopus 로고
    • Polymerase chain reaction detection of human immunodeficiency virus drug resistance mutations
    • Persing DH, Smith TF, Tenover FC, White TJ, eds. Washington, DC: American Society for Microbiology
    • Larder BA, Boucher CAB. Polymerase chain reaction detection of human immunodeficiency virus drug resistance mutations. In: Persing DH, Smith TF, Tenover FC, White TJ, eds. Diagnostic molecular microbiology. Principles and applications. Washington, DC: American Society for Microbiology, 1993:527-33.
    • (1993) Diagnostic Molecular Microbiology. Principles and Applications , pp. 527-533
    • Larder, B.A.1    Boucher, C.A.B.2
  • 34
    • 0029072544 scopus 로고
    • Simple, rapid and sensitive high-performance liquid Chromatographic determination of delavirdine and its N-desisopropyl metabolite in human plasma
    • Staton BA, Johnson MG, Friis JM, Adams WJ. Simple, rapid and sensitive high-performance liquid Chromatographic determination of delavirdine and its N-desisopropyl metabolite in human plasma. J Chromatogr 1995;8:99-106.
    • (1995) J Chromatogr , vol.8 , pp. 99-106
    • Staton, B.A.1    Johnson, M.G.2    Friis, J.M.3    Adams, W.J.4
  • 35
    • 0028940084 scopus 로고
    • Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides
    • Shirasaka T, Kavlick MF, Ueno T, et al. Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc Natl Acad Sci USA 1995;92: 2398-402.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2398-2402
    • Shirasaka, T.1    Kavlick, M.F.2    Ueno, T.3
  • 36
    • 0028273314 scopus 로고
    • Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations
    • Shafer RW, Kozal MJ, Winters MA, et al. Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations. J Infect Dis 1994;169:722-9.
    • (1994) J Infect Dis , vol.169 , pp. 722-729
    • Shafer, R.W.1    Kozal, M.J.2    Winters, M.A.3
  • 37
    • 0027258564 scopus 로고
    • Effects of discontinuation of zidovudine treatment on zidovudine sensitivity of human immunodeficiency virus type 1 isolates
    • Boucher CAB, van Leeuwen R, Kellam P, et al. Effects of discontinuation of zidovudine treatment on zidovudine sensitivity of human immunodeficiency virus type 1 isolates. Antimicrob Agents Chemother 1993;37:1525-30.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 1525-1530
    • Boucher, C.A.B.1    Van Leeuwen, R.2    Kellam, P.3


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