MRI measurements of water diffusion and cerebral perfusion: Their relationship in a rat model of focal cerebral ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 2, 1997, Pages 183-190

  Pierce, Allen R ^a   Lo, Eng H ^a,b   Mandeville, Joseph B ^a   Gonzalez, R Gilberto ^a   Rosen, Bruce R ^a   Wolf, Gerald L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Apparent diffusion coefficient; Diffusion weighted magnetic resonance imaging; Focal cerebral ischemia; Penumbra; Perfusion sensitive magnetic resonance imaging

Indexed keywords

ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN PERFUSION; DIFFUSION COEFFICIENT; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT;

EID: 0031050067     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199702000-00008     Document Type: Article

References (42)

1. Anderson AW, Gore JC (1995) Using navigator echoes to correct for rigid body motion in diffusion weighted imaging [Abstract]. Soc Magn Res Imag 14:354
2. Belliveau JW, Rosen BR, Kantor HL, Rzedzian RR, Kennedy DN, McKinstry RC, Vevea JM, Cohen MS, Pykeyy IL, Brady TJ (1990) Functional imaging by susceptibility-contrast NMR. Magn Res Med 14:538-546
3. Busza AL, Allen KL, King MD, van Bruggen N, Williams SR, Gadian DG (1992) Diffusion-weighted imaging studies of cerebral ischemia in gerbils: potential relevance to energy failure. Stroke 23:1602-1612
4. de Crespigny AJ, Tsuura M, Moseley ME, Kucharczyk J (1993) Perfusion and diffusion MR imaging of thromboembolic stroke. J Magn Res Imag 3:746-754
5. Dijkhuizen RM, Verheul HB, Tamminga KS, van der Toorn A, Berkelbach van der Sprenkel JW, Tulleken CAF, Nicolay K (1994) Temporal evolution of focal brain ischemia in the cat studied by diffusion-weighted and dynamic susceptibility-contrast MRI [Abstract]. Soc Magn Res Imag 13:443
6. Goetze AHG, Böck JC, Heyer C, Weinmann HJ, Felix R (1994) Experimental validation of susceptibility-contrast cerebral blood flow measurement by a microspheres reference method [Abstract]. Soc Magn Res Imag 13:443
7. Hamberg LM, Macfarlane R, Tasdemiroglu E. Boccalini P. Hunter GJ, Belliveau JW, Moskowitz MA, Rosen BR (1993) Measurement of cerebrovascular changes in cats after transient ischemia using dynamic magnetic resonance imaging. Stroke 24:444-451
8. Hasegawa Y, Fisher M, Latour LL, Dardzinski ME, Sotak CH (1994) MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia. Neurology 44: 1484-1490
9. Hasegawa Y, Latour LL, Formato JE, Sotak CH, Fisher M (1995) Spreading waves of reduced diffusion coefficient of water in normal and ischemic rat brain. J Cereb Blood Flow Metab 15:179-187
10. Hoehn-Berlage M, Norris DG, Kohno K, Mies G, Leibfritz D, Hossmann KA (1995) Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances, J Cereb Blood Flow Metab 15:1002-1011
11. Hossmann K-A, Fischer M, Bockhorst K, Hoehn-Berlage M (1994) NMR imaging of the apparent diffusion coefficient (ADC) for the evaluation of metabolic suppression and recovery after prolonged cerebral ischemia. J Cereb Blood Flow Metab 14:723-731
12. Hugg JW, Nagesh V, Welch KMA, Knight RA, Ewing JR, Levine SR, Chopp M, Helpern JA (1995) Human stroke studied by diffusion-weighted echo planar imaging (DW-EPI) at 3 Tesla [Abstract]. Soc Magn Res Imag 14:1385
13. Jiang Q, Zhang ZG, Chopp M, Helpern JA, Ordidge RJ, Garcia JH, Marchese BA, Qing ZX, Knight RA (1993) Temporal evolution and spatial distribution of the diffusion constant of water in rat brain after transient middle cerebral artery occlusion. J Neurol Sci 120:123-130
14. Kohno K, Hoehn-Berlage M, Mies G, Back T, Hossmann K-A (1995) Relationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction. Magn Res Imag 13:73-80
15. Lassen NA (1984) Cerebral transit of an intravascular tracer may allow measurement of regional blood volume but not regional flow. J Cereb Blood Flow Metab 4:633-634
16. Le Bihan D, Breton E, Lallemand D, Aubin M, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497-505
17. Lo EH, Matsumoto K, Pierce AR, Garrido L, Luttinger D (1994) Pharmacologic reversal of acute changes in diffusion-weighted magnetic resonance imaging in focal cerebral ischemia. J Cereb Blood Flow Metab 14:597-603
18. Lo EH, Rogowska J, Bogorodzki P, Trocha M, Matsumoto K, Saffran B, Wolf GL (1996) Temporal correlation analysis of penumbral dynamics in focal cerebral ischemia. J Cereb Blood Flow Mitab 16:60-68
19. Marks MP, de Crespigny A, Lentz D, Enzmann DR, Albers GW, Moseley ME (1995) Diffusion weighted imaging of stroke using a navigated spin-echo sequence [Abstract]. Soc Magn Res Imag 14:1265
20. Matsumoto K, Lo EH, Pierce AR, Wei H, Garrido L, Kowall NW (1995) Role of vasogenic edema and tissue cavitation in ischemic evolution on diffusion weighted imaging: comparison with multiparameter MRI and immunohistochemistry. AJNR 16:1107-1115
21. Memezawa H, Minamisawa H, Smith M-L, Siesjo BK (1992) Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp Brain Res 89:67-78
22. Minematsu K, Li L, Fisher M, Sotak CH, Davis MA, Fiandaca MS (1992) Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia. Neurology 42:235-240
23. Minematsu K, Fisher M, Li L, Sotak CH (1993) Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-Methyl-d-aspartate antagonist and reperfusion in experimental stroke in rats. Stroke 24:2074-2081
24. Moseley ME, Cohen Y, Mintorovitch J, Chileutt L, Shimizu H, Kucharczyk J, Wendland MF, Weinstein PR (1990a) Early detection of regional cerebral ischemia in cats:Comparison of diffusion- and T2-weighted MRI and spectroscopy. Magn Res Med 14:330-346
25. Moseley ME, Kucharczyk J, Mintorovitch J, Cohen Y, Kurhanewicz J, Derugin N, Asgari H, Norman D (1990b) Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats. AJNR 11:423-429
26. Müller TB, Haraldseth O, Jones RA, Sebastiani G, Godtliebsen F, Lindboe CF, Unsgard G (1995) Combined perfusion and diffusion-weighted magnetic resonance imaging in a rat model of reversible middle cerebral artery occlusion. Stroke 26: 451-458
27. Powers WJ (1991) Cerebral hemodynamics in ischemic cerebrovascular disease. Ann Neurol 29:231-240
28. Quast MJ, Huang NC, Hillman GR, Kent TA (1993) The evolution of acute stroke recorded by multimodal magnetic resonance imaging. Magn Res Med 11:465-471
29. Roberts TPL, Vexler Z, Derugin N, Moseley ME, Kucharczyk J (1993) High-speed MR imaging of ischemic brain injury following stenosis of the middle cerebral artery. J Cereb Blood Flow Metab 13:940-946
30. Rosen BR, Belliveau JW, Aronen HJ, Hamberg LM, Kwong KK, Fordham JA (1993) Functional neuroimaging. In: Magnetic Resonance Neuroimaging (Kucharczyk J. Moseley M, Barkovich AJ, eds). Boca Raton, CRC Press, pp 141-166
31. Rother J, de Crespigny A, D'Arceuil H, Moseley ME (1996) MR detection of cortical spreading depression immediately after focal ischemia in the rat. J Cereb Blood Flow Metab 16:214-220
32. Soher BJ, Gillard JH, Barker PB, Oppenheimer SM, Bryan RN (1995) Dynamic GdDTPA MRI in acute stroke: comparison of relative blood volume and bolus arrival times. ASNR Proc 33:22
33. Sorenson AG, Buonanno FS, Schwamm L, Lev MH, Huang-Hellinger FR, Reese TG, Weisskof RM, Finklestein S, Davis TL, Rosen BR, Gonzalez RG, Koroshetz WJ (1995) Diffusion- and perfusion-weighted MR imaging in the clinical diagnosis of acute stroke [Abstract]. Soc Magn Res Imag 14:81
34. Symon L (1987) Pathological regulation in cerebral ischemia. In: Cerebral Blood Flow: Physiologic and Clinical Aspects ( Wood J. ed), New York, McGraw-Hill, pp 413-424
35. Tamura A, Graham DI, McCulloch J, Teasdale GM (1981) Focal cerebral ischemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1:53-60
36. Tyson GW, Teasdale GM, Graham DI, McCulloch J (1984) Focal cerebral ischemia in the rat: topography of hemodynamic and histopathological changes. Ann Neurol 15:559-567
37. Ulug A, Olivero P, Beauchamp N, Soher B, Bryan RN, Oppenheimer S. van Zijl PCM (1995) Diffusion-weighted and absolute diffusion imaging of human stroke [Abstract]. Soc Magn Res Imag 14:1384
38. van Lookeren Campagne M, Verheul HB, Nicolay K, Balzs R (1994) Early evolution and recovery from excitotoxic injury in the neonatal rat brain: a study combining magnetic resonance imaging, electrical impedance, and histology. J Cereb Blood Flow Metab 14:1011-1023
39. van Zijl PCM, Miyabe M, Mori S, Kirsch JR, Eleff SM, Koehler RC, Traystman RJ (1995) Correlation of water diffusion, cerebral blood flow and ischemic damage after middle cerebral artery occlusion in cats [Abstracts]. J Cereb Blood Flow Metab 15 (suppl 1):S59
40. Warach S, Gaa J, Siewert B, Wielopolski P, Edelman RR (1995) Acute human stroke studied by whole brain echo planar diffusion-weighted magnetic resonance imaging. Ann Neurol 37:231-241
41. Weisskoff RM, Chesler D, Boxerman JL, Rosen BR (1993) Pitfalls in MR measurement of tissue blood flow with intravascular tracers: which mean transit time? Magn Res Med 29:553-559
42. 14C]antipyrme technique. Proc Natl Acad Sci USA 92: 1846-1850