Posttranslational regulation of a Leishmania HEXXH metalloprotease (gp63): The effects of site-specific mutagenesis of catalytic, zinc binding, N-glycosylation, and glycosyl phosphatidylinositol addition sites on N-terminal end cleavage, intracellular stability, and extracellular exit

Journal of Biological Chemistry

Volumn 271, Issue 14, 1996, Pages 7903-7909

  McGwire, Bradford S ^a   Chang, Kwang Poo ^a  

^a University of the Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; METALLOPROTEINASE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL; RNA; ZINC;

ARTICLE; BINDING SITE; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE SEQUENCE; GLYCOSYLATION; LEISHMANIA; MOLECULAR CLONING; NONHUMAN; PARASITE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTOZOON; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CELL COMPARTMENTATION; GENE EXPRESSION; GLYCOSYLATION; GLYCOSYLPHOSPHATIDYLINOSITOLS; HISTIDINE; LEISHMANIA; MEMBRANE GLYCOPROTEINS; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTOZOAN PROTEINS; ZINC;

PROTOZOA;

EID: 0029873473     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.14.7903     Document Type: Article

References (48)

1. Rawlings, N. D., and Barrett, A. J. (1995) Methods Enzymol. 248, 183
2. Webb, E. C. (1992) Recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the Nomenclature and Classification of Enzymes, p. 415, Academic Press, New York
3. Etges, R., Bouvier, J., and Bordier, C. (1986) J. Biol. Chem. 261, 9098-9101
4. Bouvier, J., Schneider, P., and Etges, R. (1995) Methods Enzymol. 248, 614-633
5. Chaudhuri, G., Chaudhuri, M., Pan, A., and Chang, K.-P. (1989) J. Biol. Chem. 264, 7483- 7489
6. Chang, K.-P., Chaudhuri, G., and Fong, D. (1990) Annu. Rev. Microbiol. 44, 499-529
7. Medina-Acosta, E., Beverley, S. M., and Russell, D. G. (1993) Infect. Aging Dis. 2, 25-34
8. Chang, C. S., and Chang, K.-P. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 100-104
9. Soteriadou, K. P., Remoundous, M. S., Katsikas, M. C., Tzinia, A. K., Tsikaris, V. Sakarellos, C., and Tzartos, S. J. (1992) J. Biol. Chem. 267, 13980-13985
10. Liu, X., and Chang, K.-P. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 4991-4995
11. Brittingham, A., Morrison, C. J., McMaster, W. C., McGwire, B. S., Chang, K.-P., and Mosser, D. M. (1995) J. Immunol. 155, 3102-3111
12. McGwire, B. S., and Chang, K.-P. (1994) Mol. Biochem. Parasitol. 66, 345-347
13. Button, L. L., and McMaster, W. R. (1988) J. Exp. Med. 167, 724-729
14. Webb, J. R., Button, L. L., and McMaster, W. R. (1991) Mol. Biochem. Parasitol. 48, 173-184
15. Miller, R. A., Reed, S. G., and Parsons, M. (1990) Mol. Biochem. Parasitol. 39, 267-274
16. Ramamoorthy, R., Donelson, J. E., Paetz, K. E., Maybodi, M., Roberts, S. C., and Wilson, M. E. (1992) J. Biol. Chem. 267, 1888-1895
17. Medina-Acosta, E., Karess, R. E., and Russell, D. G. (1993) Mol. Biochem. Parasitol. 57, 31-46
18. Button, L. L., Russell, D. G., Klein, H. L., Medina-Acosta, E., Karess, R. E., and McMaster, W. R. (1989) Mol. Biochem. Parasitol. 32, 271-284
19. Steinkraus, H. B., Greer, J. M., Stephanson, D. C., and Langer, P. J. (1993) Mol. Biochem. Parasitol. 62, 173-186
20. Roberts, S. C., Swihart, K. G., Agey, M. W., Ramamoorthy, R., Wilson, M. E., and Donelson, J. E. (1993) Mol. Biochem. Parasitol. 62, 157-172
21. Wilson, M. E., Paetz, K. E., Ramamoorthy, R., and Donelson, J. E. (1993) J. Biol. Chem. 268, 15731-15736
22. Vanhamme, L., and Pays, E. (1995) Microbiol. Rev. 59, 223-240
23. Van Wart, H. E., and Birkedal-Hansen, H. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 5578-5582
24. Button, L. L., Wilson, G., Astell, C. R., and McMaster, W. R. (1993) Gene (Amst.) 134, 75-81
25. Stetler-Stevenson, W. G., Aznavoorian, S., and Liotta, L. A. (1993) Annu. Rev. Cell Biol. 9, 541-573
26. Englund, P. T. (1993) Annu. Rev. Biochem. 62, 121-138
27. Schneider, P., Ferguson, M. A. J., McConville, M. J., Mehlert, A., Homans, S. W., and Bordier, C. (1990) J. Biol. Chem. 265, 16955-16964
28. Mensa-Wilmot, K., LeBowitz, J. H., Chang, K.-P., Al-Qahtani, A., McGwire, B. S., Tucker, S., and Morris, J. C. (1994) J. Cell Biol. 124, 935-947
29. Micanovic, R., Gerber, L. D., Berger, J., Kodukula, K., and Udenfriend, S. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 157-161
30. Field, M. C., Moran, P., Li, W., Keller, G.-A., and Caras, I. W. (1994) J. Biol. Chem. 269, 10830-10837
31. Kink, J. A., and Chang, K.-P. (1988) Mol. Biochem. Parasitol. 27, 181-190
32. Parekh, R. B., Dwek, R. A., Rudd, P. M., Thomas, J. R., Rademacher, T. W., Warren, T., Wun, T. C., Hebert, B., Reitz, B., Palmier, M., Ramabhadran, T., and Tiemeier, D. C. (1989) Biochemistry 28, 7670-7679
33. LaFrance, M. H., Vezina, C., Wang, Q., Boileau, G., Crine, P., and Lemay, G. (1994) Biochem. J. 302, 451-454
34. Funk, V. A., Jardim, A., and Olafson, R. W. (1994) Mol. Biochem. Parasitol. 63, 23-35
35. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 488-492
36. LeBowitz, J. H., Coburn, C. M., McMahon-Pratt, D., and Beverley, S. M. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 9736-9740
37. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. (eds) (1989) Current Protocols in Molecular Biology, Greene Publishing Associates/Wiley-Interscience, New York
38. Liu, X., and Chang, K.-P. (1994) Mol. Biochem. Parasitol. 66, 201-210
39. Devault, A., Sales, V., Nault, C., Beaumont, A., Roques, B., Crine, P., and Boileau, G. (1988) FEBS Lett. 231, 54-58
40. Wei, L., Alhene-Geles, F., Corval, P., and Clauser, E. (1991) J. Biol. Chem. 266, 9002-9008
41. Becker, A. B., and Roth, R. A. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3835-3839
42. Gehm, B. D., Kuo, W.-L., Perlman, R. K., and Rosner, M. R. (1993) J. Biol. Chem. 268, 7943-7948
43. Watanabe, S., Sato, H., Furuno, A., and Yoshiike, K. (1992) Virology 190, 872-875
44. Mabrouk, T., and Lemay, G. (1994) J. Virol. 68, 5287-5290
45. Su, B., and Bothwell, A. L. (1989) Mol. Cell. Biol. 9, 3369-3376
46. Kink, J. A., and Chang, K.-P. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 1253-1257
47. Imperiali, B., and Rickert, K. W. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 97-101
48. McMaster, W. R., Morrison, C. J., MacDonald, M. H, and Joshi, P. B. (1994) Parasitology 108, S29-S36