The effects of multiple low doses of organophosphates on target enzymes in brain and diaphragm in the mouse

Human & Experimental Toxicology

Volumn 16, Issue 2, 1997, Pages 67-71

  Williams, Faith M ^a   Charlton, C ^a   de Blaquière, Gail E ^a   Mutch, Elaine ^a   Kelly, S S ^a   Blain, P G ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

acetylcholinesterases; brain; dia phragm; multiple exposure; organophosphates

Indexed keywords

ACETYLCHOLINESTERASE; BRAIN ENZYME; ECOTHIOPATE; MIPAFOX; ORGANOPHOSPHATE; PARAOXON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; DIAPHRAGM; MALE; MOUSE; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BRAIN; CARBOXYLIC ESTER HYDROLASES; CHOLINESTERASE INHIBITORS; DIAPHRAGM; ECHOTHIOPHATE IODIDE; INSECTICIDES; ISOFLUROPHATE; MALE; MICE; PARAOXON;

EID: 0031048155     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719701600201     Document Type: Article

References (11)

1. Kelly SS, deBlaquiere G., Williams FM, Blain PG Effects of multiple doses of organophosphates on evoked potentials in mouse diaphragm Submitted to Human and Exper Toxicol (1997).
2. Ellman GL, Courtney K., Andres V. Jr, Featherstone R. A new and rapid colorimetric determination of acetylcholinesterase activity Biochem Pharmacol 1961; 7: 89-95.
3. Mutch E., Kelly SS, Blain PG, Williams FM Comparative studies of two organophosphorus compounds in the mouse Toxicology Letters 1996; 81: 45 - 53.
4. Lintern MC, Smith ME, Ferry CB The effect of repeated treatment with physostigmine on the activity of acetylcholinesterase molecular forms in mouse skeletal muscle Brit J Pharmacol 1995; 116: 814.
5. Gallo MA, Lawryk NJ Organophosphorus pesticides In Handbook of Pesticide Toxicology vol 2 ed Hayes WJ and Laws ER, London: Academic press 2 pp. 917-1123, 1991.
6. Davison AN Return of cholinesterase activity in the rat after inhibition by organophosphorus compounds J Biochem 1955; 60: 339-46.
7. Eigenberg DA, Pozdernik TL, Doull J. Hemoperfusion and pharmacokinetic studies with parathion and paraoxon in the rat and dog Drug Metab Dispos 1983; 11: 366-70.
8. Younkin SG, Rosenstein C., Collins PL, Rosenberry TL Cellular localisation of the molecular forms of acetylcholinesterase in rat diaphragm J Biol Chem 1982; 257: 13630-7.
9. Ogane N., Giacobini E., Messamore E. Preferential inhibition of acetylcholinesterase molecular forms in rat brain Neurochem Res 1992; 17: 489-95.
10. Milatovic D., Dettbarn WD Modification of acetylcholinesterase during adaptation to chronic, subacute paraoxon application in rat Toxicology and Applied Pharmacology 1996; 136: 20-8.
11. Kelly SS et al. Electrophysiological changes in the neuromuscular system and biochemical effects following single doses of organophosphates in the mouse Arch Toxicol 1994; 68: 459-66.