In vivo activation of aflatoxin B1 in C57BL/6N mice carrying a human fetus-specific CYP3A7 gene

Cancer Research

Volumn 57, Issue 4, 1997, Pages 641-645

  Li, Yong ^a   Yokoi, Tsuyoshi ^a   Katsuki, Motoya ^b,d   Wang, Jia Sheng ^c   Groopman, John D ^c   Kamataki, Tetsuya ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN B1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; DNA DAMAGE; DOSE RESPONSE; FETUS; KIDNEY CANCER; LIVER CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING; TRANSGENIC MOUSE;

AFLATOXIN B1; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; DIMETHYL SULFOXIDE; DNA; DNA DAMAGE; FETUS; GUANINE; HUMANS; KIDNEY; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC;

EID: 0031045811     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Nigam, S. K., Ghosh, S. K., and Malaviya, R. Aflatoxin, its metabolism and carcinogenesis - a historical review. J. Toxicol. Toxin Rev., 13: 179-203, 1994.
2. Thorgeirsson, U. P., Dalgard, D. W., Reeves, J., and Adamson, R. H. Tumor incidence in a chemical carcinogenesis study of nonhuman primates. Regul. Toxicol. Pharmacol., 19: 130-151, 1994.
3. Eaton, D. L., and Gallagher, E. P. Mechanisms of aflatoxin carcinogenesis. Annu. Rev. Pharmacol. Toxicol., 34: 135-172, 1994.
4. 1, a hepatocarcinogen in the infant mouse. Cancer Res., 32: 2289-2291, 1972.
5. 1-DNA adducts in human placenta and cordblood. Cancer Res. 55: 1278-1280, 1993.
6. Denning, D. W., Allen, R., Wilkinson, A. P., and Morgan, R. A. Transplacental transfer of aflatoxin in humans. Carcinogenesis (Lond.), 11: 1033-1035, 1990.
7. Grice, H. C., Moodie, C. A., and Smith, D. C. The carcinogenic potential of aflatoxin or its metabolites in rats from dams fed aflatoxin pre- and postpartum. Cancer Res., 33: 262-268, 1973.
8. 1 generations: a contribution to transplacental carcinogenesis. J. Natl. Cancer Inst., 64: 1349-1354, 1980.
9. Roll, R., Matthiaschk, G., and Korte, A. Embryotoxicity and mutagenicity of mycotoxins. J. Environ. Pathol. Toxicol. Oncol., 10: 1-7, 1990.
10. 1 carcinogenicity. Proc. Soc. Exp. Biol. Med., 208: 213-227, 1995.
11. Kitada, M., Kamataki, T., Itahashi, K., Rikihisa, T., and Kanakubo, Y. P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16α-hydroxylase of dehydroepiandrosterone 3-sulfate. J. Biol. Chem., 262: 13534-13537, 1987.
12. Komori, M., Nishio, K., Kitada, M, Shiramatsu, K., Muroya, K., Soma, M., Nagashima, K., and Kamataki, T. Fetus-specific expression of a form of cytochrome P-450 in human livers. Biochemistry, 29: 4430-4433, 1990.
13. Kitamura, R., Sato, K., Sawada, M., Itoh, S., Kitada, M., Komori, M., and Kamataki, T. Stable expression of cytochrome P450IIIA7 cDNA in human breast cancer cell line MCF-7 and its application to cytotoxicity testing. Arch. Biochem. Biophys., 292: 136-140, 1992.
14. Hashimoto, H., Nakagawa, T., Yokoi, T., Sawada, M., Itoh, S., and Kamataki, T. Fetus-specific CYP3A7 and adult-specific CYP3A4 expressed in Chinese hamster CHL cells have similar capacity to activate carcinogenic mycotoxins. Cancer Res., 55: 787-791, 1995.
15. Li, Y., Yokoi, T., Kitamura, R., Sasaki, M., Gunji, M., Katsuki, M., and Kamataki, T. Establishment of transgenic mice carrying human fetus-specific CYP3A7. Arch. Biochem. Biophys., 329: 235-240, 1996.
16. 7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats. Carcinogenesis (Lond.), 13: 101-106, 1992.
17. 1-adducted DNA. Proc. Natl. Acad. Sci. USA, 78: 5445-5449, 1981.
18. Brunborg, G., Holme, J. A., Søderlund, E. J., and Dybing, E. Organ-specific genotoxic effects of chemicals: the use of alkaline elution to detect DNA damage in various organs of in vivo-exposed animals. Prog. Clin. Biol. Res., 340D: 43-52, 1990.
19. Holme, J. A., Brunborg, G., Alexander, J., Trygg, B., and Søderlund, E, J. Genotoxic effects of 2-amino-3,4-dinielhylimidazo(4,5-f)quinoline (MeIQ) in rats measured by alkaline elution. Mutat. Res., 251: 1-6, 1991.
20. Stout D. L., and Becker, F. F. Fluorometric quantitation of single-stranded DNA: a method applicable to the technique of alkaline eiution. Anal Biochem., 127: 302- 307, 1982.
21. Koch, C. J., and Giandomenico, A. R. The alkaline elution technique for measuring DNA single strand breaks: increased reliability and sensitivity. Anal. Biochem., 220: 58-65, 1994.
22. Yanagimoto, T., Itoh, S., Muller-Enoch, D., and Kamataki, T. Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone. Biochim. Biophys. Acta, 1130: 329-332, 1992.
23. Buetler, T. M., and Eaton, D. L. Complementary DNA cloning, messenger RNA expression, and induction of α-class glutathione S-transferases in mouse tissues. Cancer Res., 52: 314-318, 1992.
24. Habig, W. H., Pabsl, M. J., and Jakoby, W. B. Glutathione S-transferase - the first enzymatic step in mercapturic acid formation. J. Biol. Chem., 249: 7130-7139, 1974.
25. 1 with reduced glutathione, catalysed by cytosolic glutathione-S-transferase in livers of rats, mice and guinea pigs. Biochem. Pharmacol., 36: 4269-4276, 1987.
26. Kraynak, A. R., Storer, R. D., Jensen, R. D., Kloss, M. W., Soper, K. A., Clair, J. H., DeLuca, J. G., Nichols, W. W., and Eydelloth, R. S. Extent and persistence of streptozotocin-induced DNA damage and cell proliferation in rat kidney as determined by in vivo alkaline elution and BrdUrd labeling assays. Toxicol. Appl. Pharmacol., 135: 279-286, 1995.
27. Arlen, R. R., and Wells, P. G. Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate. J. Pharmacol. Exp. Ther., 277: 1649-1658, 1996.
28. Salgo, M. G., Bermudez, E., Squadrito, G. L., and Pryor, W. A. Peroxynitrite causes DNA damage and oxidation of thiols in rat thymocytes. Arch. Biochem. Biophys., 322: 500-505, 1995.
29. 1 metabolism in human liver Proc. Natl. Acad. Sci. USA, 87: 8306-8310, 1990.
30. McLean, M., and Dutton, M. F. Cellular interactions and metabolism of aflatoxin: an update. Pharmacol. Ther., 65: 163-192, 1995.
31. 1. Cancer Res., 54: 101-108, 1994.
32. 1 by bacterial recombinant human cytochrome P450 enzymes. Chem. Res. Toxicol., 8: 218-225, 1995.
33. Lamplugh, S. M., Hendrickse, R. G., Apeagyei, F., and Mwanmut, D. D. Aflatoxins in breast milk, neonatal cord blood, and serum of pregnant women. Br. Med. J., 296: 968-968, 1988.
34. Wild, C. P., Rasheed, F. N., Jawla, M. F. B., Hall, A. J., Jansen, L. A. M., and Montesano, R. In utero exposure to aflatoxin in West Africa. Lancet, 337: 1602- 1602, 1991.
35. 7-guanine levels in urine as a biomarker in experimental rat models and humans. Environ. Health Perspect., 99: 107-113, 1993.
36. Groopman, J. D., and Kensler, T. Molecular biomarkers for human chemical carcinogen exposures. Chem. Res. Toxicol., 6: 764-770, 1993.
37. Groopman, J. D., Wogan, G. N., Roebuck, B. D., and Kensler, T. W. Molecular biomarkers for aflatoxins and their application to human cancer prevention. Cancer Res. (Suppl.), 54: 1907s-1911s, 1994.
38. 1 creates alkali-labile lesions in DNA at positions of guamne and adenine. Proc. Natl. Acad. Sci. USA, 75: 4120-4124, 1978.
39. 1. Toxicol. Lett., 61: 233-242, 1992.
40. Wogan, G. N., Croy, R. G., Essigmann, J. M., and Bennett, R. A. In: B. Pullman, R. Ts'o, and H. Gelboin (eds.), Carcinogenesis: Fundamentals and Environmental Effects, pp. 179-191, Amsterdam: Reidel, 1980.
41. 1 carcinogenesis: comparative kinetics of microsomal biolransformation. Cancer Res., 50: 615-620, 1990.
42. Isola, L. M., and Gordon, J. W. Transgenic animals: a new era in developmental biology and medicine. In: N. L. First and F. P. Haseltine (eds.), Transgenic Animals, pp., 3-20. Boston: Butterworth-Heinemann, 1991.
43. Itoh, S., Satoh, M., Abe, Y., Hashimoto, H., Yanagimoto, T., and Kamataki, T. A novel form of mouse cytochrome P450 3A (Cyp3a-16): its cDNA cloning and expression in fetal liver. Eur. J. Biochem., 226: 877-882, 1994.
44. 1 biotransformation in rat liver: implications for human chemointervention. Cancer Res., 56: 2306-2313, 1996.
45. Pineau, T., Fernandez-Salguero, P., Lee, S. S., McPhail, T., Ward, J. M., and Gonzalez, F. J. Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2. Proc. Natl. Acad. Sci. USA, 92: 5134-5138, 1995.
46. 1 metabolism in hepatitis B virus transgenic mice. Mol. Carcinog. 11: 74-80, 1994.
47. 1: the kidney as a site of action in the mouse. Life Sci., 10: 495-501, 1971.
48. 1 in the rat. Toxicol. Appl. Pharmacol., 69: 319-325, 1983.
49. Croy, R. G., and Wogan, G. N. Quantitative comparison of covalent aflatoxin-DNA adducts formed in rat and mouse livers and kidneys. J. Natl. Cancer Inst., 66: 761-768, 1981.
50. 1. Cancer Res., 33: 1608-1614, 1973.
51. 1. Cancer Res., 29: 1045-1050, 1969.
52. 1-8,9-epoxide. Biochem. J., 285: 173-180, 1992.
53. 1 and 2-amino-3-methylimidazo[4,5-f]-quinoline by human adult and fetal livers. Cancer Res., 50: 2641-2645, 1990.