Nicotinamide derivatives as a new class of gastric H+/K+-ATPase inhibitors. 1. Synthesis and structure-activity relationships of N- substituted 2-(benzhydryl- and benzylsulfinyl)nicotinamides

Journal of Medicinal Chemistry

Volumn 40, Issue 3, 1997, Pages 313-321

  Terauchi, Hideo ^a   Tanitame, Akihiko ^a   Tada, Keiko ^a   Nakamura, Keiji ^a   Seto, Yasuhiro ^a   Nishikawa, Yoshinori ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(2,4 DIMETHOXYBENZYL)SULFINYL] N (4 PYRIDYL)NICOTINAMIDE; LANSOPRAZOLE; NICOTINAMIDE DERIVATIVE; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INTRADUODENAL DRUG ADMINISTRATION; MALE; NONHUMAN; PYLORUS LIGATION; RABBIT; RAT; STOMACH ACID SECRETION; STOMACH PARIETAL CELL; STRUCTURE ACTIVITY RELATION;

AMINOPYRINE; ANIMALS; BUCLADESINE; ENZYME INHIBITORS; GASTRIC ACID; H(+)-K(+)-EXCHANGING ATPASE; HYDROGEN-ION CONCENTRATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MOLECULAR STRUCTURE; NIACINAMIDE; PARIETAL CELLS, GASTRIC; PYRIDINES; RABBITS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031045342     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9605593     Document Type: Article

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