A strong thrombin-inhibitory prourokinase derivative with sequence elements from hirudin and the human thrombin receptor

Protein Engineering

Volumn 10, Issue 2, 1997, Pages 169-173

  Wnendt, Stephan ^a   Janocha, Elke ^a   Steffens, Gerd J ^b   Strassburger, Wolfgang ^a  

^a GRÜNENTHAL GMBH   (Germany)

^b Marienh of Laboratorien   (Germany)

Author keywords

Acute myocardial infarction; Fibrinolysis; Prourokinase; Stroke

Indexed keywords

ANTICOAGULANT AGENT; HIRUDIN; HYBRID PROTEIN; PLASMINOGEN ACTIVATOR; PROUROKINASE; THROMBIN INHIBITOR; THROMBIN RECEPTOR;

AMINO ACID SEQUENCE; ANTICOAGULATION; ARTICLE; BLOOD CLOT LYSIS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG DESIGN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 0031042566     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/10.2.169     Document Type: Article

References (28)

1. Bachmann, F (ed.) (1996) Handbook of Experimental Pharmacology: Fibrinolytics and Antifibrinolytics. Springer, Heidelberg, in press.
2. Bode, W., Mayr, I., Baumann, U., Huber, R., Stone, S.R. and Hofsteenge, J. (1989) EMBO J., 8, 3467-3475.
3. Diefenbach, Ch. et al. (1988) Am. J. Cardiol., 61, 966-970.
4. DiMaio, J., Gibbs, B., Munn, D., Lefebvre, J., Ni, F. and Konishi, Y. (1990) J. Biol. Chem., 265, 21698-21703.
5. Dodt, J., Seemüller, A., Maschler, R. and Fritz, H. (1985) Biol. Chem. Hoppe-Seyler, 366, 379-384.
6. Erlanger, B.F. Kokowsky, N. and Cohen, W. (1965) Arch. Biochem. Biophys., 95, 271-278.
7. Hansen, A.P., Petros, A.M., Meadows, R.P., Netterheim, D.G., Mazar, A.P., Olejniczak, E.T., Xu, R.X., Pederson, T.M., Henkin, J. and Fesik, S.W. (1994) Biochemistry, 33, 4847-4864.
8. Klement, P., Borm, A., Hirsh, J., Maraganore, J., Wilson, G. and Weitz, J. (1992) Thromb. Haemostasis, 68, 64-68.
9. Lijnen, H.R., Wnendt, S., Schneider, J., Janocha, E., Van Hoef, B., Collen, D. and Steffens, G.J. (1995) Eur. J. Biochem., 234, 350-357.
10. Maraganore, J.M. Bourdon, P., Jablonski, J., Ramachandran, K.L. and Fenton, J.W., II (1990) Biochemistry, 29, 7095-7101.
11. Rydel, T.J., Ravichandran, K.G., Tulinsky, A., Bode, W., Huber, R., Roitsch, C. and Fenton, J., II (1990) Science, 249, 277-280.
12. Schneider, J. (1991) Thromb. Res., 64, 677-689.
13. Schneider, J., Wnendt, S., Heinzel-Wieland, R., Saunders, D., Wilffert, B. and Steffens, G.J. (1996) Eur. J. Pharmacol., 302, 69-77.
14. Schneider, J., Hauser, R., Hennies, H.-H., Korioth, J., Steffens, G. and Wnendt, S. Thromb. Haemostasis, in press.
15. Segel, J.H. (1975) Biochemical Calculations, 2nd edn. Wiley, New York.
16. Skrzypczak-Jankun, E., Carperos, V.E., Ravichandran, K.G., Tulinsky, A., Westbrook, M. and Maraganore, J.M. (1991) J. Mol. Biol., 221, 1379-1393.
17. Spraggon, G., Phillips, C., Nowak, U.K., Ponting, C.P., Saunders, D., Dobson, C.M., Stuart, D.I. and Jones, E.Y. (1995) Structure, 3, 281-691.
18. Steffens, G.J., Wnendt, S., Schneider, J., Saunders, D. and Heinzel-Wieland, R. (1994) Deutsches Patenamt, Patentschrift DE4323754C1
19. Stubbs, M.T. and Bode, W. (1995) Trends Biochem. Sci., 20, 23-28.
20. Svendsen, L., Blombaeck, B., Blombaeck, M. and Olsson, P. (1972) Thromb. Res., 1, 267-278.
21. Vriend, G. (1990) J. Mol. Graphics, 8, 52-56.
22. Vu, T.-K.H., Hung, D.T., Wheaton, V.I. and Coughlin, S.R. (1991a) Cell, 64, 1057-1068.
23. Vu, T.-K.H., Wheaton, V.I., Hung, D.T., Charo, I. and Coughlin, S.R. (1991b) Nature, 353, 674-677.
24. Wnendt, S., Janocha, E., Steffens, G. and Heinzel-Wieland, R. (1996a) Deutsches Patentamt, Offenlegungsschrift DE4442665.
25. Wnendt, S., Schneider, J., Janocha, E. and Steffens, G.J. (1996b) Protein Engng, 9, 213-223.
26. Yao, S.-K. et al. (1992) Am. J. Physiol., 262, H374-H379.
27. Yue, S.Y., DiMaio, J., Szewczuk, Z., Purisima, E.O., Ni, F. and Konishi, Y. (1992) Protein Engng, 5, 77-82.
28. Zeymer, U. and Neuhaus, K.-L. (1995) Drug Safety, 12, 234-239.